DK2322187T3 - Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser - Google Patents
Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelserInfo
- Publication number
- DK2322187T3 DK2322187T3 DK10075660.0T DK10075660T DK2322187T3 DK 2322187 T3 DK2322187 T3 DK 2322187T3 DK 10075660 T DK10075660 T DK 10075660T DK 2322187 T3 DK2322187 T3 DK 2322187T3
- Authority
- DK
- Denmark
- Prior art keywords
- choline
- uridine
- treatment
- combination
- memory disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9500298P | 1998-07-31 | 1998-07-31 | |
EP09173495.4A EP2145627B1 (en) | 1998-07-31 | 1999-07-30 | Use of uridine in combination with choline for the treatment of mood and emotional disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2322187T3 true DK2322187T3 (da) | 2014-07-21 |
Family
ID=22248474
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09173495.4T DK2145627T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse. |
DK99937631T DK1140104T3 (da) | 1998-07-31 | 1999-07-30 | Behandling af Alzheimer's sygdom ved forögelse af cytidinniveauer in vivo |
DK10075661.8T DK2329829T3 (da) | 1998-07-31 | 1999-07-30 | Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser |
DK07116909T DK1870103T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin i behandling af hukommelsesforsstyrrelse |
DK10075660.0T DK2322187T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09173495.4T DK2145627T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse. |
DK99937631T DK1140104T3 (da) | 1998-07-31 | 1999-07-30 | Behandling af Alzheimer's sygdom ved forögelse af cytidinniveauer in vivo |
DK10075661.8T DK2329829T3 (da) | 1998-07-31 | 1999-07-30 | Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser |
DK07116909T DK1870103T3 (da) | 1998-07-31 | 1999-07-30 | Anvendelse af uridin i kombination med cholin i behandling af hukommelsesforsstyrrelse |
Country Status (11)
Country | Link |
---|---|
US (1) | US6989376B2 (da) |
EP (5) | EP2322187B1 (da) |
JP (1) | JP2003517437A (da) |
AT (2) | ATE446097T1 (da) |
CA (1) | CA2339008C (da) |
CY (1) | CY1110570T1 (da) |
DE (2) | DE69937198T2 (da) |
DK (5) | DK2145627T3 (da) |
ES (5) | ES2477568T3 (da) |
PT (5) | PT2322187E (da) |
WO (1) | WO2000006174A1 (da) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
US8143234B2 (en) * | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
US20060069061A1 (en) * | 1998-07-31 | 2006-03-30 | Dick Wurtman | Compositions containing uridine and choline, and methods utilizing same |
US20070004670A1 (en) * | 1998-07-31 | 2007-01-04 | Richard Wurtman | Compositions containing citicoline, and methods of use thereof |
US8314064B2 (en) | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
US7807654B2 (en) * | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
US8030294B2 (en) * | 2000-03-16 | 2011-10-04 | The Mclean Hospital Corporation | Compounds for the treatment of psychiatric or substance abuse disorders |
US6727231B1 (en) * | 2000-10-12 | 2004-04-27 | Repligen Corporation | Uridine therapy for patients with elevated purine levels |
NL1019368C2 (nl) * | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparaat voor het verbeteren van receptorwerking. |
CN100358533C (zh) * | 2002-07-11 | 2008-01-02 | 雅玛山酱油株式会社 | 用于药物诱导的神经病的药物组合物 |
UA83011C2 (ru) | 2002-11-08 | 2008-06-10 | Зе Маклин Хоспитал Корпорейшн | Соединения для лечения табачной зависимости и синдрома отмены |
US20040176316A1 (en) * | 2002-12-20 | 2004-09-09 | Renshaw Perry F. | Compounds for the normalization of the sleep/wake cycle |
US20050129710A1 (en) * | 2003-10-08 | 2005-06-16 | Renshaw Perry F. | Methods of treating psychiatric substance abuse, and other disorders using combinations containing omega-3 fatty acids |
WO2005034874A2 (en) * | 2003-10-08 | 2005-04-21 | The Mclean Hospital Corporation | Enhanced efficacy of omega-3 fatty acid therapy in the treatment of psychiatric disorders and other indications |
WO2005112635A2 (en) * | 2004-05-13 | 2005-12-01 | Massachusetts Institute Of Technology | Uridine effects on dopamine release |
EP1765364A4 (en) * | 2004-06-10 | 2010-09-22 | Mclean Hospital Corp | PYRIMIDINES, SUCH AS Z: B: CYTIDINE, IN THE TREATMENT OF PATIENTS WITH BIPOLAR DISORDER |
WO2005122767A1 (en) * | 2004-06-10 | 2005-12-29 | Mclean Hospital Corporation | Pyrimidines, such as uridine, in treatments for patients with bipolar disorder |
WO2006020703A1 (en) * | 2004-08-11 | 2006-02-23 | The Mclean Hospital Corporation | Compounds for the treatment of marihuana dependence, withdrawal, and usage |
JP2008513453A (ja) * | 2004-09-15 | 2008-05-01 | マサチューセッツ インスティテュート オブ テクノロジー | ウリジンを含んだ組成物及びその使用方法 |
AU2011253660B2 (en) * | 2004-09-15 | 2013-12-19 | Massachusetts Institute Of Technology | Compositions containing uridine, and methods utilizing same |
EP1888081B1 (en) | 2005-05-23 | 2016-12-28 | Massachusetts Institute of Technology | Compositions containing pufa and methods of use thereof |
AU2012203650B2 (en) * | 2005-05-23 | 2014-09-18 | Massachusetts Institute Of Technology | Compositions containing PUFA and methods of use thereof |
AU2006293026B2 (en) * | 2005-09-22 | 2012-08-16 | Megmilk Snow Brand Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
EP1951308B1 (de) * | 2005-11-25 | 2013-02-20 | Gisela Susilo | Kombinationspräparate enthaltend physiologische zellmembran-bestandteile, einschliesslich phosphatidylserin, cholin und ein pyrimidinnukleos/tid |
DK1800675T3 (da) | 2005-12-23 | 2011-09-05 | Nutricia Nv | Sammensætninger omfattende polyumættede fedtsyrer, proteiner og mangan og/eller molybdæn og nucleosider/nucleotider til behandling af demens |
US8017594B2 (en) * | 2006-06-27 | 2011-09-13 | Yamasa Corporation | Agent against psychosocial stresses |
US7972633B2 (en) * | 2007-02-07 | 2011-07-05 | Applied Cognitive Sciences, LLC | Nutritional supplements for healthy memory and mental function |
BRPI0817387A2 (pt) | 2007-11-02 | 2015-09-08 | Massachusetts Inst Technology | métodos de conformidade de suplementação dietária de uridina e uso dos mesmos |
US20110160158A1 (en) * | 2008-06-12 | 2011-06-30 | Repligen Corporation | Methods of treatment of bipolar disorder |
US20100041621A1 (en) * | 2008-08-15 | 2010-02-18 | Perry Renshaw | Methods and compositions for improving cognitive performance |
CA2850367C (en) | 2011-09-30 | 2021-06-01 | Tufts University | Uridine diphosphate derivatives, compositions and methods for treating neurodegenerative disorders |
WO2013066152A1 (en) | 2011-10-31 | 2013-05-10 | N.V. Nutricia | Method for improving executive function |
WO2014027882A1 (en) | 2012-08-13 | 2014-02-20 | N.V. Nutricia | Product and method for supporting uridine homeostasis |
EP2900680A4 (en) | 2012-09-28 | 2016-06-08 | Univ Tufts | URIDEINDIPHOSPHATE DERIVATIVES, PRODRUGS, COMPOSITIONS AND USES THEREOF |
AR095442A1 (es) | 2013-03-13 | 2015-10-14 | Univ Tufts | Derivados de nucleósido de uridina, composiciones y métodos de uso |
JP6591957B2 (ja) | 2013-03-13 | 2019-10-16 | タフツ・ユニバーシティ | ウリジンヌクレオシド誘導体、組成物および使用方法 |
WO2015115885A1 (en) * | 2014-01-31 | 2015-08-06 | N.V. Nutricia | Method for reducing white matter lesions, white matter hyperintensities (wmh), leukoaraiosis or periventricular white matter disease in elderly |
WO2016053085A1 (en) * | 2014-09-30 | 2016-04-07 | N.V. Nutricia | Composition comprising a uridine source and butyrate producing fibres for preventing gastrointestinal disorders |
WO2016072842A1 (en) * | 2014-11-05 | 2016-05-12 | N.V. Nutricia | Method for preventing, reducing the risk of, or treating behavioral frontotemporal dementia |
WO2017069613A1 (en) | 2015-10-23 | 2017-04-27 | N.V. Nutricia | Method for improving recognition and/or working memory in hyperphenylalanimenia and phenylketonuria patients |
ES2947592T3 (es) | 2016-04-04 | 2023-08-11 | Nutricia Nv | Composición para su uso en la reducción o prevención del retraso global del desarrollo de los niños |
JP2021512061A (ja) * | 2018-02-01 | 2021-05-13 | ウェルスタット セラピューティクス コーポレイション | ウリジンの全身送達のための組成物及びデバイス |
CN114990176A (zh) * | 2022-05-26 | 2022-09-02 | 宁夏华吉生物有限公司 | 一种生产尿嘧啶核苷的方法 |
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DE2508474A1 (de) * | 1975-02-27 | 1976-09-02 | Boehringer Mannheim Gmbh | Infusions- und spuelfluessigkeiten zur behandlung von hirnoedemen |
DE2629845A1 (de) * | 1976-07-02 | 1978-01-05 | Geb Graze Erika Graze | Infusions- bzw. injektionsloesungen bzw. waessrige konzentrate zu deren bereitung zur therapeutischen restituion des zellulaeren energiestoffwechsels und der koerpereigenen regelfunktion |
US4221784A (en) * | 1979-04-05 | 1980-09-09 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering lecithin |
IT1178044B (it) * | 1984-10-09 | 1987-09-03 | Polifarma Spa | Agente attivo farmaceutico per il trattamento di patologie cerebrali a base di uridina |
US4609647A (en) * | 1985-05-28 | 1986-09-02 | Massachusetts Institute Of Technology | Cytidyl diphosphocholine-drug composition and process |
ES2007350A6 (es) * | 1987-05-29 | 1989-06-16 | Ganadera Union Ind Agro | Productos alimenticios enriquecidos con nucleosidos yno nucleotidos para la nutricion infantil y de adultos, y procedimiento para su preparacion. |
US5470838A (en) | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
JP2894610B2 (ja) * | 1987-10-28 | 1999-05-24 | プロ−ニューロン,インコーポレーテッド | アシル化ウリジンおよびシチジンならびにその使用 |
IT1219667B (it) * | 1988-06-21 | 1990-05-24 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
RU2003332C1 (ru) | 1989-06-09 | 1993-11-30 | Борис Витальевич Страдомский | Средство дл лечени депрессий |
JPH0722495B2 (ja) * | 1990-01-30 | 1995-03-15 | 美穂 田中 | クロレラ含有油脂食品 |
US5141943A (en) | 1990-04-12 | 1992-08-25 | Brown University Research Foundation | 5-benzyl barbiturate derivatives |
US5567689A (en) * | 1993-08-13 | 1996-10-22 | The Uab Research Foundation | Methods for increasing uridine levels with L-nucleosides |
US5700590A (en) * | 1994-01-10 | 1997-12-23 | Abbott Laboratories | Nutritional formula with ribo-nucleotides |
JPH07215879A (ja) * | 1994-02-02 | 1995-08-15 | Otsuka Pharmaceut Factory Inc | 抗ストレス組成物 |
DE9412374U1 (de) * | 1994-08-01 | 1994-09-22 | Rauch-Petz, Gisela G., Dr., 80803 München | Nahrungsergänzungsmittel |
JPH0930976A (ja) * | 1995-07-17 | 1997-02-04 | Otsuka Pharmaceut Factory Inc | 記憶低下改善剤 |
US5843024A (en) * | 1996-05-17 | 1998-12-01 | Breonics, Inc. | Solution and process for resuscitation and preparation of ischemically damaged tissue |
IT1290781B1 (it) * | 1996-05-28 | 1998-12-10 | Polifarma Spa | Agente attivo terapeutico per il trattamento di malattie degenerative neuronali. |
US5962459A (en) * | 1996-05-28 | 1999-10-05 | Polifarma S.P.A. | Therapeutic active agent for treatment of neuron degenerative diseases |
US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
EP1171137B1 (en) * | 1999-02-23 | 2007-12-26 | The Regents of the University of California | Use of triacetyluridine for the treatment of mitochondrial disorders |
JP2001233776A (ja) * | 2000-02-25 | 2001-08-28 | Yamasa Shoyu Co Ltd | 学習・記憶能低下改善剤およびその用途 |
US20030114415A1 (en) * | 2001-12-14 | 2003-06-19 | Wurtman Richard J. | Compositions and methods for treating and preventing memory impairment using citicoline |
-
1999
- 1999-07-30 AT AT07116909T patent/ATE446097T1/de active
- 1999-07-30 DK DK09173495.4T patent/DK2145627T3/da active
- 1999-07-30 AT AT99937631T patent/ATE374029T1/de active
- 1999-07-30 EP EP10075660.0A patent/EP2322187B1/en not_active Expired - Lifetime
- 1999-07-30 ES ES10075660.0T patent/ES2477568T3/es not_active Expired - Lifetime
- 1999-07-30 WO PCT/US1999/017235 patent/WO2000006174A1/en active IP Right Grant
- 1999-07-30 DK DK99937631T patent/DK1140104T3/da active
- 1999-07-30 PT PT100756600T patent/PT2322187E/pt unknown
- 1999-07-30 ES ES99937631T patent/ES2294850T3/es not_active Expired - Lifetime
- 1999-07-30 DK DK10075661.8T patent/DK2329829T3/da active
- 1999-07-30 PT PT99937631T patent/PT1140104E/pt unknown
- 1999-07-30 EP EP07116909A patent/EP1870103B1/en not_active Expired - Lifetime
- 1999-07-30 EP EP10075661.8A patent/EP2329829B1/en not_active Expired - Lifetime
- 1999-07-30 DE DE69937198T patent/DE69937198T2/de not_active Expired - Lifetime
- 1999-07-30 DK DK07116909T patent/DK1870103T3/da active
- 1999-07-30 ES ES09173495.4T patent/ES2476940T3/es not_active Expired - Lifetime
- 1999-07-30 DE DE69941586T patent/DE69941586D1/de not_active Expired - Lifetime
- 1999-07-30 EP EP09173495.4A patent/EP2145627B1/en not_active Expired - Lifetime
- 1999-07-30 ES ES07116909T patent/ES2332669T3/es not_active Expired - Lifetime
- 1999-07-30 PT PT07116909T patent/PT1870103E/pt unknown
- 1999-07-30 DK DK10075660.0T patent/DK2322187T3/da active
- 1999-07-30 CA CA002339008A patent/CA2339008C/en not_active Expired - Lifetime
- 1999-07-30 PT PT100756618T patent/PT2329829E/pt unknown
- 1999-07-30 JP JP2000562028A patent/JP2003517437A/ja active Pending
- 1999-07-30 ES ES10075661.8T patent/ES2478044T3/es not_active Expired - Lifetime
- 1999-07-30 PT PT91734954T patent/PT2145627E/pt unknown
- 1999-07-30 EP EP99937631A patent/EP1140104B1/en not_active Expired - Lifetime
- 1999-07-30 US US09/363,748 patent/US6989376B2/en not_active Expired - Lifetime
-
2009
- 2009-12-01 CY CY20091101264T patent/CY1110570T1/el unknown
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