DK2322187T3 - Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser - Google Patents

Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser

Info

Publication number
DK2322187T3
DK2322187T3 DK10075660.0T DK10075660T DK2322187T3 DK 2322187 T3 DK2322187 T3 DK 2322187T3 DK 10075660 T DK10075660 T DK 10075660T DK 2322187 T3 DK2322187 T3 DK 2322187T3
Authority
DK
Denmark
Prior art keywords
choline
uridine
treatment
combination
memory disorders
Prior art date
Application number
DK10075660.0T
Other languages
English (en)
Inventor
Carol Watkins
Richard J Wurtman
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK2322187T3 publication Critical patent/DK2322187T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/14Quaternary ammonium compounds, e.g. edrophonium, choline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK10075660.0T 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser DK2322187T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9500298P 1998-07-31 1998-07-31
EP09173495.4A EP2145627B1 (en) 1998-07-31 1999-07-30 Use of uridine in combination with choline for the treatment of mood and emotional disorders

Publications (1)

Publication Number Publication Date
DK2322187T3 true DK2322187T3 (da) 2014-07-21

Family

ID=22248474

Family Applications (5)

Application Number Title Priority Date Filing Date
DK09173495.4T DK2145627T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse.
DK99937631T DK1140104T3 (da) 1998-07-31 1999-07-30 Behandling af Alzheimer's sygdom ved forögelse af cytidinniveauer in vivo
DK10075661.8T DK2329829T3 (da) 1998-07-31 1999-07-30 Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser
DK07116909T DK1870103T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin i behandling af hukommelsesforsstyrrelse
DK10075660.0T DK2322187T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DK09173495.4T DK2145627T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse.
DK99937631T DK1140104T3 (da) 1998-07-31 1999-07-30 Behandling af Alzheimer's sygdom ved forögelse af cytidinniveauer in vivo
DK10075661.8T DK2329829T3 (da) 1998-07-31 1999-07-30 Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser
DK07116909T DK1870103T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin i behandling af hukommelsesforsstyrrelse

Country Status (11)

Country Link
US (1) US6989376B2 (da)
EP (5) EP2322187B1 (da)
JP (1) JP2003517437A (da)
AT (2) ATE446097T1 (da)
CA (1) CA2339008C (da)
CY (1) CY1110570T1 (da)
DE (2) DE69937198T2 (da)
DK (5) DK2145627T3 (da)
ES (5) ES2477568T3 (da)
PT (5) PT2322187E (da)
WO (1) WO2000006174A1 (da)

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AU2011253660B2 (en) * 2004-09-15 2013-12-19 Massachusetts Institute Of Technology Compositions containing uridine, and methods utilizing same
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Also Published As

Publication number Publication date
PT2322187E (pt) 2014-07-24
EP2145627B1 (en) 2014-04-16
PT1870103E (pt) 2010-02-23
CY1110570T1 (el) 2015-04-29
EP1870103A3 (en) 2008-08-06
ES2477568T3 (es) 2014-07-17
ATE374029T1 (de) 2007-10-15
ES2476940T3 (es) 2014-07-15
CA2339008A1 (en) 2000-02-10
EP2322187B1 (en) 2014-05-14
EP1140104A1 (en) 2001-10-10
EP1140104A4 (en) 2004-12-22
DE69941586D1 (de) 2009-12-03
EP2322187A2 (en) 2011-05-18
EP2145627A1 (en) 2010-01-20
DK2329829T3 (da) 2014-07-21
EP2329829B1 (en) 2014-04-16
EP2322187A3 (en) 2011-07-20
PT1140104E (pt) 2007-12-26
EP2329829A2 (en) 2011-06-08
EP1140104B1 (en) 2007-09-26
JP2003517437A (ja) 2003-05-27
ATE446097T1 (de) 2009-11-15
ES2294850T3 (es) 2008-04-01
US20020028787A1 (en) 2002-03-07
ES2332669T3 (es) 2010-02-10
PT2329829E (pt) 2014-07-24
PT2145627E (pt) 2014-07-24
ES2478044T3 (es) 2014-07-18
DK2145627T3 (da) 2014-07-21
DK1870103T3 (da) 2010-01-11
EP1870103A2 (en) 2007-12-26
EP2329829A3 (en) 2011-07-20
DE69937198T2 (de) 2008-07-03
DE69937198D1 (de) 2007-11-08
DK1140104T3 (da) 2008-01-21
US6989376B2 (en) 2006-01-24
WO2000006174A1 (en) 2000-02-10
EP1870103B1 (en) 2009-10-21
CA2339008C (en) 2009-12-15

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