DK2329829T3 - Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser - Google Patents

Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser

Info

Publication number
DK2329829T3
DK2329829T3 DK10075661.8T DK10075661T DK2329829T3 DK 2329829 T3 DK2329829 T3 DK 2329829T3 DK 10075661 T DK10075661 T DK 10075661T DK 2329829 T3 DK2329829 T3 DK 2329829T3
Authority
DK
Denmark
Prior art keywords
choline
uridine
treatment
neurological disorders
utilization
Prior art date
Application number
DK10075661.8T
Other languages
English (en)
Inventor
Carol Watkins
Richard J Wurtman
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK2329829T3 publication Critical patent/DK2329829T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK10075661.8T 1998-07-31 1999-07-30 Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser DK2329829T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9500298P 1998-07-31 1998-07-31
EP09173495.4A EP2145627B1 (en) 1998-07-31 1999-07-30 Use of uridine in combination with choline for the treatment of mood and emotional disorders

Publications (1)

Publication Number Publication Date
DK2329829T3 true DK2329829T3 (da) 2014-07-21

Family

ID=22248474

Family Applications (5)

Application Number Title Priority Date Filing Date
DK10075661.8T DK2329829T3 (da) 1998-07-31 1999-07-30 Anveldelse af uridin i kombination med cholin til behandling af neurologiske lidelser
DK99937631T DK1140104T3 (da) 1998-07-31 1999-07-30 Behandling af Alzheimer's sygdom ved forögelse af cytidinniveauer in vivo
DK10075660.0T DK2322187T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser
DK09173495.4T DK2145627T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse.
DK07116909T DK1870103T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin i behandling af hukommelsesforsstyrrelse

Family Applications After (4)

Application Number Title Priority Date Filing Date
DK99937631T DK1140104T3 (da) 1998-07-31 1999-07-30 Behandling af Alzheimer's sygdom ved forögelse af cytidinniveauer in vivo
DK10075660.0T DK2322187T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser
DK09173495.4T DK2145627T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse.
DK07116909T DK1870103T3 (da) 1998-07-31 1999-07-30 Anvendelse af uridin i kombination med cholin i behandling af hukommelsesforsstyrrelse

Country Status (11)

Country Link
US (1) US6989376B2 (da)
EP (5) EP2145627B1 (da)
JP (1) JP2003517437A (da)
AT (2) ATE374029T1 (da)
CA (1) CA2339008C (da)
CY (1) CY1110570T1 (da)
DE (2) DE69937198T2 (da)
DK (5) DK2329829T3 (da)
ES (5) ES2294850T3 (da)
PT (5) PT2329829E (da)
WO (1) WO2000006174A1 (da)

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US20060069061A1 (en) * 1998-07-31 2006-03-30 Dick Wurtman Compositions containing uridine and choline, and methods utilizing same
US8143234B2 (en) 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
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US7947661B2 (en) 2004-08-11 2011-05-24 The Mclean Hospital Corporation Compounds for the treatment of marihuana dependence, withdrawal, and usage
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AU2011253660B2 (en) * 2004-09-15 2013-12-19 Massachusetts Institute Of Technology Compositions containing uridine, and methods utilizing same
PL1888081T3 (pl) 2005-05-23 2017-07-31 Massachusetts Institute Of Technology Kompozycje zawierające PUFA i sposoby ich zastosowania
AU2012203650B2 (en) * 2005-05-23 2014-09-18 Massachusetts Institute Of Technology Compositions containing PUFA and methods of use thereof
KR101442047B1 (ko) 2005-09-22 2014-09-18 유키지루시 메그밀크 가부시키가이샤 스핑고미엘린 함유 의약, 음식품 또는 사료
EP1951308B1 (de) * 2005-11-25 2013-02-20 Gisela Susilo Kombinationspräparate enthaltend physiologische zellmembran-bestandteile, einschliesslich phosphatidylserin, cholin und ein pyrimidinnukleos/tid
ATE509624T1 (de) 2005-12-23 2011-06-15 Nutricia Nv Zusammensetzung enthaltend mehrfach ungesättigte fettsäuren, proteine, mangan und/oder molybden und nukleotide/nukleoside, zur behandlung von demenz
US8017594B2 (en) * 2006-06-27 2011-09-13 Yamasa Corporation Agent against psychosocial stresses
US7972633B2 (en) * 2007-02-07 2011-07-05 Applied Cognitive Sciences, LLC Nutritional supplements for healthy memory and mental function
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Also Published As

Publication number Publication date
PT2329829E (pt) 2014-07-24
PT1870103E (pt) 2010-02-23
EP2322187B1 (en) 2014-05-14
EP2322187A2 (en) 2011-05-18
ES2477568T3 (es) 2014-07-17
EP1870103A3 (en) 2008-08-06
EP1140104A4 (en) 2004-12-22
DK1870103T3 (da) 2010-01-11
EP2322187A3 (en) 2011-07-20
US6989376B2 (en) 2006-01-24
EP2145627A1 (en) 2010-01-20
ATE374029T1 (de) 2007-10-15
PT2322187E (pt) 2014-07-24
CA2339008A1 (en) 2000-02-10
CY1110570T1 (el) 2015-04-29
EP2329829A3 (en) 2011-07-20
ES2294850T3 (es) 2008-04-01
ES2332669T3 (es) 2010-02-10
EP1140104A1 (en) 2001-10-10
CA2339008C (en) 2009-12-15
PT1140104E (pt) 2007-12-26
EP1870103A2 (en) 2007-12-26
PT2145627E (pt) 2014-07-24
DK2322187T3 (da) 2014-07-21
ES2478044T3 (es) 2014-07-18
DE69937198T2 (de) 2008-07-03
EP2329829B1 (en) 2014-04-16
DK1140104T3 (da) 2008-01-21
DE69937198D1 (de) 2007-11-08
JP2003517437A (ja) 2003-05-27
EP2145627B1 (en) 2014-04-16
ATE446097T1 (de) 2009-11-15
EP1140104B1 (en) 2007-09-26
US20020028787A1 (en) 2002-03-07
EP1870103B1 (en) 2009-10-21
WO2000006174A1 (en) 2000-02-10
EP2329829A2 (en) 2011-06-08
ES2476940T3 (es) 2014-07-15
DK2145627T3 (da) 2014-07-21
DE69941586D1 (de) 2009-12-03

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