PT2329829E - Utilização de uridina em combinação com colina para o tratamento de disfunções neurológicas - Google Patents

Utilização de uridina em combinação com colina para o tratamento de disfunções neurológicas Download PDF

Info

Publication number
PT2329829E
PT2329829E PT100756618T PT10075661T PT2329829E PT 2329829 E PT2329829 E PT 2329829E PT 100756618 T PT100756618 T PT 100756618T PT 10075661 T PT10075661 T PT 10075661T PT 2329829 E PT2329829 E PT 2329829E
Authority
PT
Portugal
Prior art keywords
choline
uridine
treatment
neurological disorders
combination
Prior art date
Application number
PT100756618T
Other languages
English (en)
Inventor
Carol Watkins
Richard J Wurtman
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of PT2329829E publication Critical patent/PT2329829E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT100756618T 1998-07-31 1999-07-30 Utilização de uridina em combinação com colina para o tratamento de disfunções neurológicas PT2329829E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9500298P 1998-07-31 1998-07-31

Publications (1)

Publication Number Publication Date
PT2329829E true PT2329829E (pt) 2014-07-24

Family

ID=22248474

Family Applications (5)

Application Number Title Priority Date Filing Date
PT100756618T PT2329829E (pt) 1998-07-31 1999-07-30 Utilização de uridina em combinação com colina para o tratamento de disfunções neurológicas
PT91734954T PT2145627E (pt) 1998-07-31 1999-07-30 Utilização de uridina em combinação com colina para o tratamento de disfunções de humor e emocionais
PT99937631T PT1140104E (pt) 1998-07-31 1999-07-30 Tratamento da doença de alzheimer, in vivo, por aumento dos níveis de citidina
PT100756600T PT2322187E (pt) 1998-07-31 1999-07-30 Utilização de uridina em combinação com colina para o tratamento de disfunções de memória
PT07116909T PT1870103E (pt) 1998-07-31 1999-07-30 Utilização de uridina em combinação com colina para o tratamento de perturbações da memória

Family Applications After (4)

Application Number Title Priority Date Filing Date
PT91734954T PT2145627E (pt) 1998-07-31 1999-07-30 Utilização de uridina em combinação com colina para o tratamento de disfunções de humor e emocionais
PT99937631T PT1140104E (pt) 1998-07-31 1999-07-30 Tratamento da doença de alzheimer, in vivo, por aumento dos níveis de citidina
PT100756600T PT2322187E (pt) 1998-07-31 1999-07-30 Utilização de uridina em combinação com colina para o tratamento de disfunções de memória
PT07116909T PT1870103E (pt) 1998-07-31 1999-07-30 Utilização de uridina em combinação com colina para o tratamento de perturbações da memória

Country Status (11)

Country Link
US (1) US6989376B2 (pt)
EP (5) EP1140104B1 (pt)
JP (1) JP2003517437A (pt)
AT (2) ATE446097T1 (pt)
CA (1) CA2339008C (pt)
CY (1) CY1110570T1 (pt)
DE (2) DE69937198T2 (pt)
DK (5) DK2329829T3 (pt)
ES (5) ES2332669T3 (pt)
PT (5) PT2329829E (pt)
WO (1) WO2000006174A1 (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070004670A1 (en) * 1998-07-31 2007-01-04 Richard Wurtman Compositions containing citicoline, and methods of use thereof
US8314064B2 (en) * 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
US20050203053A1 (en) * 1999-07-30 2005-09-15 Wurtman Richard J. Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
US8518882B2 (en) * 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
US20060069061A1 (en) * 1998-07-31 2006-03-30 Dick Wurtman Compositions containing uridine and choline, and methods utilizing same
US8143234B2 (en) 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US7807654B2 (en) 1998-08-31 2010-10-05 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US7915233B1 (en) 1998-08-31 2011-03-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
ES2425114T3 (es) * 2000-03-16 2013-10-11 The Mclean Hospital Corporation CDP-colina y uridina para el tratamiento del abuso del acohol
US6727231B1 (en) * 2000-10-12 2004-04-27 Repligen Corporation Uridine therapy for patients with elevated purine levels
NL1019368C2 (nl) 2001-11-14 2003-05-20 Nutricia Nv Preparaat voor het verbeteren van receptorwerking.
KR20050044890A (ko) * 2002-07-11 2005-05-13 야마사 쇼유 가부시키가이샤 약제 유발성 신경장해용 의약 조성물
CN100430066C (zh) 2002-11-08 2008-11-05 麦克莱恩医院 用于烟草依赖性和戒断治疗的化合物
WO2004058160A2 (en) * 2002-12-20 2004-07-15 The Mclean Hospital Corporation Compounds for the normalization of the sleep/wake cycle
US20050113449A1 (en) * 2003-10-08 2005-05-26 Renshaw Perry F. Enhanced efficacy of omega-3 fatty acid therapy in the treatment of psychiatric disorders and other indications
JP2007508315A (ja) * 2003-10-08 2007-04-05 ザ マクレーン ホスピタル コーポレーション ω−３脂肪酸を含む組み合わせを用いて、精神障害、物質乱用障害、および他の障害を治療する方法
JP5523669B2 (ja) * 2004-05-13 2014-06-18 マサチューセッツ インスティテュート オブ テクノロジー ドーパミン放出に対するウリジンの効果
WO2005122767A1 (en) * 2004-06-10 2005-12-29 Mclean Hospital Corporation Pyrimidines, such as uridine, in treatments for patients with bipolar disorder
EP1765364A4 (en) * 2004-06-10 2010-09-22 Mclean Hospital Corp PYRIMIDINES, SUCH AS Z: B: CYTIDINE, IN THE TREATMENT OF PATIENTS WITH BIPOLAR DISORDER
EP1784199A4 (en) 2004-08-11 2010-06-23 Mclean Hospital Corp COMPOUNDS FOR TREATING MARIHUANA DEPENDENCE, DEDUCTION AND CONSUMPTION
CN102600199A (zh) * 2004-09-15 2012-07-25 麻省理工学院 含有尿苷的组合物及使用其的方法
AU2011253660B2 (en) * 2004-09-15 2013-12-19 Massachusetts Institute Of Technology Compositions containing uridine, and methods utilizing same
JP5566603B2 (ja) * 2005-05-23 2014-08-06 マサチューセッツ インスティテュート オブ テクノロジー Ｐｕｆａを含有する組成物及びそれを使用した方法
AU2012203650B2 (en) * 2005-05-23 2014-09-18 Massachusetts Institute Of Technology Compositions containing PUFA and methods of use thereof
EP1938824B1 (en) * 2005-09-22 2011-11-30 Snow Brand Milk Products Co., Ltd. Medicine, food and drink or feed containing sphingomyelin
WO2007059762A1 (de) * 2005-11-25 2007-05-31 Gisela Susilo Kombinationspräparate enthaltend physiologische zellmembran-bestandteile, einschliesslich phosphatidylserin, cholin und ein pyrimidinnukleos/tid
DK1800675T3 (da) 2005-12-23 2011-09-05 Nutricia Nv Sammensætninger omfattende polyumættede fedtsyrer, proteiner og mangan og/eller molybdæn og nucleosider/nucleotider til behandling af demens
WO2008001495A1 (fr) 2006-06-27 2008-01-03 Yamasa Corporation Agent contre les contraintes psychosociales
US7972633B2 (en) * 2007-02-07 2011-07-05 Applied Cognitive Sciences, LLC Nutritional supplements for healthy memory and mental function
WO2009059306A1 (en) * 2007-11-02 2009-05-07 Massachusetts Institute Of Technology Uridine dietary supplementation compliance methods and use thereof
US20110160158A1 (en) * 2008-06-12 2011-06-30 Repligen Corporation Methods of treatment of bipolar disorder
US20100041621A1 (en) * 2008-08-15 2010-02-18 Perry Renshaw Methods and compositions for improving cognitive performance
JP6162125B2 (ja) 2011-09-30 2017-07-12 タフツ・ユニバーシティ 神経変性障害を処置するためのウリジン二リン酸誘導体、組成物および方法
WO2013066152A1 (en) 2011-10-31 2013-05-10 N.V. Nutricia Method for improving executive function
WO2014027882A1 (en) 2012-08-13 2014-02-20 N.V. Nutricia Product and method for supporting uridine homeostasis
JP6523958B2 (ja) 2012-09-28 2019-06-05 タフツ・ユニバーシティ ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用
SI2968385T1 (sl) 2013-03-13 2018-10-30 Tufts University Uridin nukleozid derivati, sestavki in metode uporabe
US10138265B2 (en) 2013-03-13 2018-11-27 Tufts University Uridine nucleoside derivatives, compositions and methods of use
WO2015115885A1 (en) * 2014-01-31 2015-08-06 N.V. Nutricia Method for reducing white matter lesions, white matter hyperintensities (wmh), leukoaraiosis or periventricular white matter disease in elderly
WO2016053085A1 (en) * 2014-09-30 2016-04-07 N.V. Nutricia Composition comprising a uridine source and butyrate producing fibres for preventing gastrointestinal disorders
WO2016072842A1 (en) * 2014-11-05 2016-05-12 N.V. Nutricia Method for preventing, reducing the risk of, or treating behavioral frontotemporal dementia
WO2017069613A1 (en) 2015-10-23 2017-04-27 N.V. Nutricia Method for improving recognition and/or working memory in hyperphenylalanimenia and phenylketonuria patients
WO2017176109A1 (en) 2016-04-04 2017-10-12 N.V. Nutricia Method for reducing or preventing global developmental delay in children
BR112020013342A2 (pt) * 2018-02-01 2020-12-01 Wellstat Therapeutics Corporation composições e dispositivos para fornecimento sistêmico de uridina
CN114990176A (zh) * 2022-05-26 2022-09-02 宁夏华吉生物有限公司 一种生产尿嘧啶核苷的方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508474A1 (de) * 1975-02-27 1976-09-02 Boehringer Mannheim Gmbh Infusions- und spuelfluessigkeiten zur behandlung von hirnoedemen
DE2629845A1 (de) * 1976-07-02 1978-01-05 Geb Graze Erika Graze Infusions- bzw. injektionsloesungen bzw. waessrige konzentrate zu deren bereitung zur therapeutischen restituion des zellulaeren energiestoffwechsels und der koerpereigenen regelfunktion
US4221784A (en) * 1979-04-05 1980-09-09 Massachusetts Institute Of Technology Process and composition for treating disorders by administering lecithin
IT1178044B (it) * 1984-10-09 1987-09-03 Polifarma Spa Agente attivo farmaceutico per il trattamento di patologie cerebrali a base di uridina
US4609647A (en) * 1985-05-28 1986-09-02 Massachusetts Institute Of Technology Cytidyl diphosphocholine-drug composition and process
ES2007350A6 (es) * 1987-05-29 1989-06-16 Ganadera Union Ind Agro Productos alimenticios enriquecidos con nucleosidos yno nucleotidos para la nutricion infantil y de adultos, y procedimiento para su preparacion.
JP2894610B2 (ja) * 1987-10-28 1999-05-24 プロ−ニューロン，インコーポレーテッド アシル化ウリジンおよびシチジンならびにその使用
US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
IT1219667B (it) * 1988-06-21 1990-05-24 Polifarma Spa Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico
RU2003332C1 (ru) * 1989-06-09 1993-11-30 Борис Витальевич Страдомский Средство дл лечени депрессий
JPH0722495B2 (ja) * 1990-01-30 1995-03-15 美穂 田中 クロレラ含有油脂食品
US5141943A (en) 1990-04-12 1992-08-25 Brown University Research Foundation 5-benzyl barbiturate derivatives
US5567689A (en) 1993-08-13 1996-10-22 The Uab Research Foundation Methods for increasing uridine levels with L-nucleosides
US5700590A (en) * 1994-01-10 1997-12-23 Abbott Laboratories Nutritional formula with ribo-nucleotides
JPH07215879A (ja) * 1994-02-02 1995-08-15 Otsuka Pharmaceut Factory Inc 抗ストレス組成物
DE9412374U1 (de) * 1994-08-01 1994-09-22 Rauch-Petz, Gisela G., Dr., 80803 München Nahrungsergänzungsmittel
JPH0930976A (ja) * 1995-07-17 1997-02-04 Otsuka Pharmaceut Factory Inc 記憶低下改善剤
US5843024A (en) * 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US5962459A (en) * 1996-05-28 1999-10-05 Polifarma S.P.A. Therapeutic active agent for treatment of neuron degenerative diseases
IT1290781B1 (it) * 1996-05-28 1998-12-10 Polifarma Spa Agente attivo terapeutico per il trattamento di malattie degenerative neuronali.
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
KR100879559B1 (ko) * 1999-02-23 2009-01-22 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 미토콘드리아 장애의 치료 또는 예방용 제약조성물
JP2001233776A (ja) * 2000-02-25 2001-08-28 Yamasa Shoyu Co Ltd 学習・記憶能低下改善剤およびその用途
US20030114415A1 (en) * 2001-12-14 2003-06-19 Wurtman Richard J. Compositions and methods for treating and preventing memory impairment using citicoline

Also Published As

Publication number Publication date
EP1140104B1 (en) 2007-09-26
DE69937198T2 (de) 2008-07-03
CA2339008A1 (en) 2000-02-10
ES2294850T3 (es) 2008-04-01
ES2477568T3 (es) 2014-07-17
US20020028787A1 (en) 2002-03-07
ES2476940T3 (es) 2014-07-15
ES2332669T3 (es) 2010-02-10
WO2000006174A1 (en) 2000-02-10
EP1140104A4 (en) 2004-12-22
EP1140104A1 (en) 2001-10-10
DK2145627T3 (da) 2014-07-21
JP2003517437A (ja) 2003-05-27
EP2145627A1 (en) 2010-01-20
ATE374029T1 (de) 2007-10-15
DE69937198D1 (de) 2007-11-08
PT1140104E (pt) 2007-12-26
EP1870103A3 (en) 2008-08-06
EP2329829A2 (en) 2011-06-08
DK2329829T3 (da) 2014-07-21
CY1110570T1 (el) 2015-04-29
PT1870103E (pt) 2010-02-23
EP2329829B1 (en) 2014-04-16
US6989376B2 (en) 2006-01-24
DK1140104T3 (da) 2008-01-21
DK2322187T3 (da) 2014-07-21
EP2322187A3 (en) 2011-07-20
ES2478044T3 (es) 2014-07-18
EP2145627B1 (en) 2014-04-16
PT2322187E (pt) 2014-07-24
DK1870103T3 (da) 2010-01-11
CA2339008C (en) 2009-12-15
PT2145627E (pt) 2014-07-24
EP1870103A2 (en) 2007-12-26
DE69941586D1 (de) 2009-12-03
EP2329829A3 (en) 2011-07-20
EP1870103B1 (en) 2009-10-21
ATE446097T1 (de) 2009-11-15
EP2322187B1 (en) 2014-05-14
EP2322187A2 (en) 2011-05-18

Similar Documents

Publication Publication Date Title
PT2329829E (pt) Utilização de uridina em combinação com colina para o tratamento de disfunções neurológicas
HUP0004439A3 (en) 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
AU4060599A (en) Pharmaceutical composition for treating or preventing sleep disorders
HUP0103856A2 (hu) Gyógyszerkészítmény akut rendellenességek kezelésére
HUP0100069A3 (en) 4(3)substituted-4(3)-aminomethyl-pyran, or -thiopyran-piperidine derivatives, their preparation and their use in the treatment of neurological disorders
IL136294A0 (en) Therapeutic formulation for administering tolterodine with controlled release
EP1471871A4 (en) TREATMENT OF NEUROLOGICAL DYSFUNCTIONS USING FRUCTOPYRANOSIS SULFAMATES AND ERYTHROPOIETIN
ZA9811507B (en) Combination effective for the treatment of impotence.
PL363431A1 (en) The use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
HK1041827A1 (en) Compounds for the treatment of estrogen-defendent illnesses and methods for making and using the dame.
ZA966578B (en) Pharmaceutical composition.
AU4789099A (en) Therapeutic composition based on flavonoids for use in the treatment of tumours with cytotoxic agents
ZA935154B (en) Use of 1,2,5-oxadiazole-2-oxides for the treatment of erectile dysfunctions
ZA200007636B (en) N-Phenyl-N'-Phenylpropylpiperazine derivatives and process for the preparation thereof.
GB9917346D0 (en) Medicament for treating premature ejaculation
ZA991224B (en) The treatment of retinal edema with brinzolamide.
ZA985818B (en) Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders.
HUP0000679A3 (en) Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders
ZA981918B (en) Use of 2,3,4,5-tetrahydro-1H-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders
GR940100324A (en) Therapeutic vaporized mixture and method for the preparation and use thereof.
ZA997090B (en) "A composition for the treatment of wood".
ZA973538B (en) Use of phosphonic acid esters for the treatment of functional disorders of the brain and depression.
GB9817045D0 (en) The 'bed with the hole' sunlounger
GB9816353D0 (en) The treatment of viral disorders
GB9816355D0 (en) The treatment of viral disorders