RU2758007C2 - Доставка терапевтических полипептидов посредством псевдотипированных онколитических вирусов - Google Patents
Доставка терапевтических полипептидов посредством псевдотипированных онколитических вирусов Download PDFInfo
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| US20210386804A1 (en) * | 2020-06-11 | 2021-12-16 | Tibor Bakács | Combination of viral superinfection therapy with subthreshold doses of nivolumab plus ipilimumab in chronic HBV patients |
| CN113832114A (zh) * | 2020-06-23 | 2021-12-24 | 南京大学 | 一种新型溶瘤腺病毒EM/VSV-G Ad5-P及其在制备抗肿瘤药物中的应用 |
| CA3189692A1 (en) | 2020-07-31 | 2022-02-03 | Leidos, Inc. | Lag3 binding peptides |
| AU2021324883A1 (en) | 2020-08-12 | 2023-03-23 | Actym Therapeutics, Inc. | Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms |
| CN112143711B (zh) * | 2020-09-29 | 2021-07-23 | 杭州荣谷生物科技有限公司 | 重组痘瘤病毒、药物组合物及其构建方法和应用 |
| CA3198203A1 (en) | 2020-10-12 | 2022-04-21 | Leidos, Inc. | Immunomodulatory peptides |
| WO2022148736A1 (en) * | 2021-01-05 | 2022-07-14 | Transgene | Vectorization of muc1 t cell engager |
| WO2022151078A1 (zh) * | 2021-01-13 | 2022-07-21 | 嘉兴允英医学检验有限公司 | 溶瘤病毒及其应用 |
| US20240358780A1 (en) * | 2021-04-05 | 2024-10-31 | Implicyte, Inc. | Armed chimeric oncolytic viruses |
| CN113969266B (zh) * | 2021-10-26 | 2023-10-13 | 山东大学齐鲁医院 | 一种重组溶瘤腺病毒及其应用 |
| CN113980915B (zh) * | 2021-11-04 | 2023-07-07 | 江苏省人民医院(南京医科大学第一附属医院) | 一种新型的表达cxcl10的复制型溶瘤腺病毒和应用 |
| EP4429682A2 (en) | 2021-11-09 | 2024-09-18 | Actym Therapeutics, Inc. | Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment |
| CN114249836A (zh) * | 2021-12-27 | 2022-03-29 | 上海鑫湾生物科技有限公司 | 双特异性t细胞衔接器、其重组溶瘤病毒及其用途 |
| WO2023235596A1 (en) * | 2022-06-03 | 2023-12-07 | 10X Genomics, Inc. | Systems and methods for determining antigen binding specificity of antigen binding molecules |
| WO2024055022A2 (en) * | 2022-09-08 | 2024-03-14 | Virogin Biotech Canada Ltd | Oncolytic virus expressing an immune cell engager for tumor targeting |
| TW202426648A (zh) * | 2022-09-30 | 2024-07-01 | 大陸商蘇州亦諾微醫藥科技有限公司 | 用於血液癌治療的基因改造的i型單純皰疹病毒 |
| US20240415978A1 (en) * | 2023-06-14 | 2024-12-19 | Flagship Pioneering Innovations V, Inc. | Anellovectors for delivery of effectors to the central nervous system |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140037584A1 (en) * | 2006-09-15 | 2014-02-06 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Oncolytic rhabdovirus |
| US20140193449A1 (en) * | 2007-05-04 | 2014-07-10 | University Health Network | Compositions and methods for cancer treatment |
| RU2536931C2 (ru) * | 2009-05-06 | 2014-12-27 | Фундасио Институт Д`Инвестигасио Биомедика Де Бельвитге (Идибель) | Онколитический аденовирус для лечения рака, его применение и фармацевтическая композиция, содержащая его |
| US20160000842A1 (en) * | 2013-03-05 | 2016-01-07 | Baylor College Of Medicine | Oncolytic virus |
Family Cites Families (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4476116A (en) | 1982-12-10 | 1984-10-09 | Syntex (U.S.A.) Inc. | Polypeptides/chelating agent nasal compositions having enhanced peptide absorption |
| US5116817A (en) | 1982-12-10 | 1992-05-26 | Syntex (U.S.A.) Inc. | LHRH preparations for intranasal administration |
| US5244792A (en) | 1984-04-06 | 1993-09-14 | Chiron Corporation | Expression of recombinant glyoprotein B from herpes simplex virus |
| JPH0668B2 (ja) | 1985-08-30 | 1994-01-05 | 財団法人化学及血清療法研究所 | 単純ヘルペスウイルス遺伝子が組込まれた組換えプラスミド |
| US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| US5804413A (en) | 1992-07-31 | 1998-09-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains for gene transfer |
| US6084067A (en) | 1993-07-26 | 2000-07-04 | Dana-Farber Cancer Institute | CTLA4/CD28 ligands and uses therefor |
| GB9415369D0 (en) | 1994-07-29 | 1994-09-21 | Lynxvale Ltd | Mutant virus |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| US6071742A (en) | 1997-03-05 | 2000-06-06 | Board Of Regents Of The University Of Nebraska | Coxsackie virus as a vector for delivery of anti-inflammatory cytokines |
| WO1998040475A1 (en) | 1997-03-11 | 1998-09-17 | Abbott Laboratories | Human matrix metalloprotease gene, proteins encoded therefrom and methods of using same |
| AU6703198A (en) | 1997-03-21 | 1998-10-20 | Brigham And Women's Hospital | Immunotherapeutic ctla-4 binding peptides |
| US6391452B1 (en) | 1997-07-18 | 2002-05-21 | Bayer Corporation | Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations |
| WO1999006583A1 (en) | 1997-07-31 | 1999-02-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Targeted hsv vectors |
| US6989435B2 (en) | 1997-09-11 | 2006-01-24 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| ATE305510T1 (de) | 1997-12-17 | 2005-10-15 | Immunex Corp | Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| JP4169478B2 (ja) | 1998-04-21 | 2008-10-22 | マイクロメット アーゲー | Cd19×cd3特異的ポリペプチドおよびその使用 |
| US6455677B1 (en) | 1998-04-30 | 2002-09-24 | Boehringer Ingelheim International Gmbh | FAPα-specific antibody with improved producibility |
| EP0953639A1 (en) | 1998-04-30 | 1999-11-03 | Boehringer Ingelheim International GmbH | FAPalpha-specific antibody with improved producibility |
| EP1002864A1 (en) | 1998-11-10 | 2000-05-24 | Universita' degli studi di Bologna | HIgR and related V domain for the manufacture of a medicament for preventing or treating HSV-1, HSV-2 and BHV infections |
| SI2112166T1 (sl) | 1998-12-23 | 2019-05-31 | Pfizer Inc. | Človeška monoklonska protitelesa proti CTLA-4 |
| EE05627B1 (et) | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| CN1371416B (zh) | 1999-08-24 | 2012-10-10 | 梅达里克斯公司 | 人ctla-4抗体及其应用 |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| US6897057B1 (en) | 1999-08-31 | 2005-05-24 | The General Hospital Corporation | Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression |
| WO2001029058A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| AU2001233027A1 (en) | 2000-01-27 | 2001-08-07 | Genetics Institute, Llc | Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof |
| JP2003530092A (ja) | 2000-03-17 | 2003-10-14 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | ヒトFAP−α−特異抗体 |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Rna 간섭의 rna 서열 특이적인 매개체 |
| KR100909681B1 (ko) | 2000-12-01 | 2009-07-29 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Rna 간섭을 매개하는 작은 rna 분자 |
| EP1381280B1 (en) | 2001-03-27 | 2011-05-11 | Catherex, Inc. | Viral vectors and their use in therapeutic methods |
| MXPA04003057A (es) | 2001-10-04 | 2005-06-20 | Immunex Corp | Proteina 4 de enlace ul16. |
| KR100900249B1 (ko) | 2001-12-07 | 2009-05-29 | 포항공과대학교 산학협력단 | SIVmac239의 면역원성 플라스미드 및 이들을 함유한AIDS DNA 백신 |
| BR0309254A (pt) | 2002-04-12 | 2005-03-01 | Medarex Inc | Uso de um anticorpo anti-ctla-4 |
| EP1537878B1 (en) | 2002-07-03 | 2010-09-22 | Ono Pharmaceutical Co., Ltd. | Immunopotentiating compositions |
| US8927251B2 (en) | 2002-10-07 | 2015-01-06 | The University Of Chicago | Targeting of herpes simplex virus to specific receptors |
| KR100932340B1 (ko) | 2002-10-17 | 2009-12-16 | 젠맵 에이/에스 | Cd20에 대한 인간 모노클로날 항체 |
| EP1591527B1 (en) * | 2003-01-23 | 2015-08-26 | Ono Pharmaceutical Co., Ltd. | Substance specific to human pd-1 |
| EP1596871A4 (en) | 2003-02-28 | 2006-08-23 | Drew M Pardoll | T-CELL REGULATION |
| CA2518782A1 (en) | 2003-03-12 | 2004-09-23 | Duke University | Oligonucleotide mimetics |
| US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
| KR100845354B1 (ko) | 2004-03-26 | 2008-07-09 | 화이자 프로덕츠 인코포레이티드 | 항-ctla-4 항체의 용도 |
| JP5054522B2 (ja) | 2004-08-20 | 2012-10-24 | ヴィラリティクス リミテッド | 血液ガンを治療するための方法および組成物 |
| EP1793858A4 (en) | 2004-09-08 | 2008-12-10 | Univ Ohio State Res Found | HUMAN MONOCLONAL ANTI-CTLA4 ANTIBODIES FOR CANCER TREATMENT |
| EP1805213B1 (en) | 2004-10-28 | 2015-11-18 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain |
| US20080160031A1 (en) | 2005-01-17 | 2008-07-03 | Viralytics Limited | Method and Composition for Treatment of Neoplasms |
| SI2002003T1 (sl) | 2005-05-27 | 2016-05-31 | Ospedale San Raffaele S.R.L. | Genski vektor, ki vsebuje mi-RNA |
| DK1907000T4 (da) | 2005-06-08 | 2020-03-30 | The President And Fellows Of Harvard College | Fremgangsmåder og sammensætninger til behandling af persisterende HIV-infektioner ved hæmning af reaktionsvejen for programmeret celledød 1 (PD-1). |
| KR101607288B1 (ko) | 2005-07-01 | 2016-04-05 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
| ES2532124T3 (es) | 2005-12-16 | 2015-03-24 | Amgen Research (Munich) Gmbh | Medios y procedimientos para el tratamiento de enfermedades tumorales |
| JP2009521474A (ja) | 2005-12-21 | 2009-06-04 | メディミューン,エルエルシー | EphA2BiTE分子およびその使用 |
| EP1806365A1 (en) | 2006-01-05 | 2007-07-11 | Boehringer Ingelheim International GmbH | Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them |
| AU2007241023B2 (en) | 2006-03-30 | 2013-11-28 | University Of California | Methods and compositions for localized secretion of anti-CTLA-4 antibodies |
| AU2007266306A1 (en) | 2006-05-26 | 2007-12-06 | Apollo Life Sciences Limited | An isolated IL-12 molecule or chimeric molecules thereof |
| CN101104640A (zh) | 2006-07-10 | 2008-01-16 | 苏州大学 | 抗人pd-l1单克隆抗体制备及应用 |
| JP2008066402A (ja) | 2006-09-05 | 2008-03-21 | Fujifilm Corp | 撮像素子および撮像装置 |
| EP2125032A4 (en) | 2007-02-20 | 2011-02-23 | Mayo Foundation | CANCER TREATMENT WITH VIRAL NUCLEIC ACID |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| US8586028B2 (en) | 2007-05-09 | 2013-11-19 | Board Of Supervisors Of Lousiana State University And Agricultural And Mechanical College | Synthetic herpes simplex viruses type-1 for treatment of cancers |
| US9416165B2 (en) | 2007-10-26 | 2016-08-16 | The Regents Of The University Of California | Methods of inhibiting viral replication and improving T cell function employing soluble Tim-3 inhibitors |
| EP2240204A1 (en) | 2008-02-04 | 2010-10-20 | Medarex, Inc. | Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof |
| WO2009111892A1 (en) | 2008-03-14 | 2009-09-17 | Ottawa Health Research Institute | Microrna mediated oncolytic targeting |
| EP2307033A4 (en) | 2008-05-29 | 2012-06-13 | Gen Hospital Corp | USE OF ONCOLYTIC HERPESVIRUS FOR THE KILLING OF CANCER STEM CELLS |
| NO2700405T3 (enExample) | 2008-05-29 | 2018-09-01 | ||
| GB0810912D0 (en) | 2008-06-13 | 2008-07-23 | Inst Animal Health Ltd | Vector |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| HUE030807T2 (en) | 2008-09-26 | 2017-05-29 | Dana Farber Cancer Inst Inc | Human anti-PD-1, anti-PD-L1 and anti-PD-L2 antibodies and their applications |
| TWI729512B (zh) | 2008-12-09 | 2021-06-01 | 美商建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
| EP3192811A1 (en) | 2009-02-09 | 2017-07-19 | Université d'Aix-Marseille | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| CA2755245A1 (en) | 2009-03-13 | 2010-09-16 | Egen, Inc. | Compositions and methods for the delivery of biologically active rnas |
| US20100297072A1 (en) | 2009-05-19 | 2010-11-25 | Depinho Ronald A | Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy |
| JP2013523162A (ja) | 2010-04-06 | 2013-06-17 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | Cd274/pd−l1遺伝子の発現を阻害するための組成物および方法 |
| CA2795695A1 (en) | 2010-04-09 | 2011-10-13 | The University Of Tokyo | Microrna-controlled recombinant vaccinia virus and use thereof |
| WO2011130749A2 (en) | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors |
| JP2013532153A (ja) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体 |
| WO2012006181A2 (en) | 2010-06-29 | 2012-01-12 | Mount Sinai School Of Medicine | Compositions and methods for inhibiting oncogenic micrornas and treatment of cancer |
| ES2655616T3 (es) | 2010-08-13 | 2018-02-20 | Roche Glycart Ag | Anticuerpos anti-FAP y procedimientos de uso |
| GB201103955D0 (en) | 2011-03-09 | 2011-04-20 | Antitope Ltd | Antibodies |
| DK2699264T3 (en) | 2011-04-20 | 2018-06-25 | Medimmune Llc | ANTIBODIES AND OTHER MOLECULES BINDING B7-H1 AND PD-1 |
| WO2013006490A2 (en) | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
| HRP20182194T1 (hr) * | 2011-09-08 | 2019-02-22 | New York University | Onkolitički herpes simpleks virus i njegova terapeutska uporaba |
| US11951157B2 (en) | 2011-10-11 | 2024-04-09 | Universitat Zurich | Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody |
| EP2591796A1 (en) | 2011-11-10 | 2013-05-15 | Universität Zürich | Combination medicament comprising IL-12 and an anti-CTLA-4 ligand for tumor therapy |
| AU2012322999B2 (en) | 2011-10-11 | 2017-08-10 | Universitat Zurich Prorektorat Mnw | Combination medicament comprising IL-12 and an agent for blockade of T-cell inhibitory molecules for tumour therapy |
| LT2768524T (lt) | 2011-10-17 | 2022-07-25 | Io Biotech Aps | Pd-l1 grindžiama imunoterapija |
| US20130156808A1 (en) | 2011-11-22 | 2013-06-20 | Stipan Jonjic | Vaccine comprising beta-herpesvirus |
| KR101981873B1 (ko) | 2011-11-28 | 2019-05-23 | 메르크 파텐트 게엠베하 | 항-pd-l1 항체 및 그의 용도 |
| DK2806883T3 (da) | 2012-01-25 | 2019-07-22 | Dnatrix Inc | Biomarkører og kombinationsterapier under anvendelse af onkolytisk virus og immunomodulation |
| KR102410078B1 (ko) | 2012-05-31 | 2022-06-22 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Pd-l1에 결합하는 항원 결합 단백질 |
| US20150250837A1 (en) * | 2012-09-20 | 2015-09-10 | Morningside Technology Ventures Ltd. | Oncolytic virus encoding pd-1 binding agents and uses of the same |
| US9365641B2 (en) | 2012-10-01 | 2016-06-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
| EP2964675B1 (en) * | 2013-03-05 | 2018-06-20 | Baylor College Of Medicine | Engager cells for immunotherapy |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
| ES3011466T3 (en) | 2013-04-18 | 2025-04-07 | Tilt Biotherapeutics Oy | Enhanced adoptive cell therapy |
| US20160163211A1 (en) | 2013-05-16 | 2016-06-09 | Pearson Education, Inc. | Accessible content publishing engine |
| JP6588024B2 (ja) | 2013-10-28 | 2019-10-09 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 腫瘍溶解性hsvベクター |
| CA2940570A1 (en) | 2014-02-27 | 2015-09-03 | Viralytics Limited | Combination method for treatment of cancer |
| EP3552615B8 (en) | 2014-07-16 | 2022-03-02 | Transgene | Oncolytic virus for expression of immune checkpoint modulators |
| KR20170063946A (ko) | 2014-10-08 | 2017-06-08 | 에프. 호프만-라 로슈 아게 | Fap 및 dr5에 특이적인 이중특이성 항체와 화학요법제의 병용요법 |
| JP2018503399A (ja) * | 2015-01-14 | 2018-02-08 | コンパス セラピューティクス リミテッド ライアビリティ カンパニー | 多特異性免疫調節抗原結合構築物 |
| ES2994611T3 (en) | 2015-10-19 | 2025-01-27 | Cg Oncology Inc | Methods of treating solid or lymphatic tumors by combination therapy |
| AU2016369485B2 (en) * | 2015-12-17 | 2024-02-01 | Akamis Bio Limited | Group B adenovirus encoding an anti-TCR-complex antibody or fragment |
| CA3010987A1 (en) | 2016-01-08 | 2017-07-13 | Replimune Limited | Oncolytic herpes simplex virus type 1 strain |
| BR112018015390A2 (pt) | 2016-01-27 | 2018-12-18 | Oncorus, Inc. | vetores virais oncolíticos e usos dos mesmos |
| PL3426271T3 (pl) | 2016-03-10 | 2025-11-24 | Cg Oncology, Inc. | Sposoby leczenia guzów litych terapią skojarzoną |
| WO2018006005A1 (en) | 2016-06-30 | 2018-01-04 | Oncorus, Inc. | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| JP7200104B2 (ja) | 2016-08-01 | 2023-01-06 | ヴァイロジン バイオテック カナダ リミテッド | 免疫系刺激分子を発現する腫瘍溶解性単純ヘルペスウイルスベクター |
| CN118436692A (zh) | 2016-08-09 | 2024-08-06 | 图恩斯通有限合伙公司 | 表达il12的溶瘤弹状病毒 |
| TW201825674A (zh) | 2016-09-09 | 2018-07-16 | 美商艾斯合顧問有限公司 | 表現雙特異性接合分子的溶瘤病毒 |
| US20190275092A1 (en) | 2016-11-01 | 2019-09-12 | Dnatrix, Inc. | Combination therapy for treatment of brain cancers |
| WO2018118967A1 (en) | 2016-12-21 | 2018-06-28 | Memgen, Llc | Armed replication-competent oncolytic adenoviruses |
| US11298420B2 (en) | 2016-12-21 | 2022-04-12 | Memgen, Llc | Armed oncolytic viruses |
| GB201700350D0 (en) | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| US11865081B2 (en) | 2017-12-29 | 2024-01-09 | Virogin Biotech Canada Ltd. | Oncolytic viral delivery of therapeutic polypeptides |
-
2017
- 2017-06-30 WO PCT/US2017/040354 patent/WO2018006005A1/en not_active Ceased
- 2017-06-30 CA CA3029426A patent/CA3029426A1/en active Pending
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140037584A1 (en) * | 2006-09-15 | 2014-02-06 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Oncolytic rhabdovirus |
| US20140193449A1 (en) * | 2007-05-04 | 2014-07-10 | University Health Network | Compositions and methods for cancer treatment |
| RU2536931C2 (ru) * | 2009-05-06 | 2014-12-27 | Фундасио Институт Д`Инвестигасио Биомедика Де Бельвитге (Идибель) | Онколитический аденовирус для лечения рака, его применение и фармацевтическая композиция, содержащая его |
| US20160000842A1 (en) * | 2013-03-05 | 2016-01-07 | Baylor College Of Medicine | Oncolytic virus |
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| EP3478321A1 (en) | 2019-05-08 |
| CN109983121A (zh) | 2019-07-05 |
| US20190048082A1 (en) | 2019-02-14 |
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| IL263879A (en) | 2019-01-31 |
| US11078280B2 (en) | 2021-08-03 |
| JP2023174945A (ja) | 2023-12-08 |
| CA3029426A1 (en) | 2018-01-04 |
| IL282216A (en) | 2021-05-31 |
| JP2022048304A (ja) | 2022-03-25 |
| WO2018006005A1 (en) | 2018-01-04 |
| JP2019519245A (ja) | 2019-07-11 |
| US10604574B2 (en) | 2020-03-31 |
| SG11201811600PA (en) | 2019-01-30 |
| AU2017290828A1 (en) | 2019-01-24 |
| US20200157221A1 (en) | 2020-05-21 |
| EP3478321A4 (en) | 2020-04-22 |
| RU2019102391A (ru) | 2020-07-30 |
| RU2021127872A (ru) | 2021-11-09 |
| MX2019000252A (es) | 2019-10-09 |
| BR112019000015A2 (pt) | 2019-04-24 |
| US20180057594A1 (en) | 2018-03-01 |
| IL263879B (en) | 2021-04-29 |
| KR20190035714A (ko) | 2019-04-03 |
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