RU2741120C2 - Лечение рака с использованием химерного антигенного рецептора cll-1 - Google Patents
Лечение рака с использованием химерного антигенного рецептора cll-1 Download PDFInfo
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- RU2741120C2 RU2741120C2 RU2017105161A RU2017105161A RU2741120C2 RU 2741120 C2 RU2741120 C2 RU 2741120C2 RU 2017105161 A RU2017105161 A RU 2017105161A RU 2017105161 A RU2017105161 A RU 2017105161A RU 2741120 C2 RU2741120 C2 RU 2741120C2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
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- Microbiology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014082602 | 2014-07-21 | ||
| CNPCT/CN2014/082602 | 2014-07-21 | ||
| CN2014090500 | 2014-11-06 | ||
| CNPCT/CN2014/090500 | 2014-11-06 | ||
| PCT/US2015/041337 WO2016014535A1 (en) | 2014-07-21 | 2015-07-21 | Treatment of cancer using a cll-1 chimeric antigen receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017105161A RU2017105161A (ru) | 2018-08-21 |
| RU2017105161A3 RU2017105161A3 (https=) | 2019-04-01 |
| RU2741120C2 true RU2741120C2 (ru) | 2021-01-22 |
Family
ID=53761606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017105161A RU2741120C2 (ru) | 2014-07-21 | 2015-07-21 | Лечение рака с использованием химерного антигенного рецептора cll-1 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10568947B2 (https=) |
| EP (1) | EP3171882A1 (https=) |
| JP (2) | JP6736540B2 (https=) |
| KR (1) | KR20170037625A (https=) |
| CN (1) | CN107109420A (https=) |
| AR (1) | AR101829A1 (https=) |
| AU (2) | AU2015292811B2 (https=) |
| BR (1) | BR112017000939A2 (https=) |
| CA (1) | CA2955465A1 (https=) |
| CO (1) | CO2017000506A2 (https=) |
| IL (1) | IL250116B (https=) |
| MX (1) | MX2017001013A (https=) |
| RU (1) | RU2741120C2 (https=) |
| SG (2) | SG11201700418VA (https=) |
| TW (1) | TWI718992B (https=) |
| WO (1) | WO2016014535A1 (https=) |
Families Citing this family (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| TW201446794A (zh) | 2013-02-20 | 2014-12-16 | Novartis Ag | 利用抗-cd123嵌合抗原受體工程化t細胞之初級人類白血病有效靶向 |
| DK2958943T3 (da) | 2013-02-20 | 2019-12-09 | Univ Pennsylvania | Behandling af cancer ved anvendelse af humaniseret anti-EGFRvIII kimær antigenreceptor |
| EP2970426B1 (en) * | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| CN105899232A (zh) * | 2013-11-13 | 2016-08-24 | 诺华股份有限公司 | 用于增强免疫应答的mTOR抑制剂 |
| ES2918501T3 (es) | 2013-12-19 | 2022-07-18 | Novartis Ag | Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos |
| US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| US11028143B2 (en) | 2014-01-21 | 2021-06-08 | Novartis Ag | Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules |
| AU2015244039B2 (en) | 2014-04-07 | 2021-10-21 | Novartis Ag | Treatment of cancer using anti-CD19 chimeric antigen receptor |
| SG10201913765YA (en) | 2014-07-21 | 2020-03-30 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
| US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| TWI750110B (zh) | 2014-07-21 | 2021-12-21 | 瑞士商諾華公司 | 使用人類化抗-bcma嵌合抗原受體治療癌症 |
| KR20170037625A (ko) | 2014-07-21 | 2017-04-04 | 노파르티스 아게 | Cll-1 키메라 항원 수용체를 사용한 암의 치료 |
| ES2791248T3 (es) | 2014-08-19 | 2020-11-03 | Novartis Ag | Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer |
| KR20250067191A (ko) | 2014-09-17 | 2025-05-14 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| KR20170068504A (ko) | 2014-10-08 | 2017-06-19 | 노파르티스 아게 | 키메라 항원 수용체 요법에 대한 치료 반응성을 예측하는 바이오마커 및 그의 용도 |
| CA3197849A1 (en) | 2014-12-29 | 2016-07-07 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| WO2016115482A1 (en) * | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
| ES2869972T3 (es) * | 2015-01-26 | 2021-10-26 | Cellectis | Sistemas de receptores de antígenos quiméricos dirigidos por mAb para clasificar/agotar células inmunitarias genomanipuladas |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| CA2978186A1 (en) | 2015-03-05 | 2016-09-09 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
| MX2017012939A (es) | 2015-04-08 | 2018-05-22 | Novartis Ag | Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. |
| SG11201708516YA (en) | 2015-04-17 | 2017-11-29 | David Maxwell Barrett | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| HK1245095A1 (zh) | 2015-05-20 | 2018-08-24 | Novartis Ag | 依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合 |
| EP4043556B1 (en) | 2015-06-30 | 2024-02-07 | Cellectis | Methods for improving functionality in nk cell by gene inactivation using specific endonuclease |
| AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| EP3331913A1 (en) | 2015-08-07 | 2018-06-13 | Novartis AG | Treatment of cancer using chimeric cd3 receptor proteins |
| JP6905163B2 (ja) | 2015-09-03 | 2021-07-21 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | サイトカイン放出症候群を予測するバイオマーカー |
| EA201891338A1 (ru) | 2015-12-04 | 2018-12-28 | Новартис Аг | Композиции и способы для иммуноонкологии |
| EP3393504B1 (en) | 2015-12-22 | 2025-09-24 | Novartis AG | Mesothelin chimeric antigen receptor (car) and antibody against pd-l1 inhibitor for combined use in anticancer therapy |
| SG11201805449PA (en) | 2015-12-28 | 2018-07-30 | Novartis Ag | Methods of making chimeric antigen receptor -expressing cells |
| AU2016382512A1 (en) | 2015-12-30 | 2018-07-12 | Novartis Ag | Immune effector cell therapies with enhanced efficacy |
| WO2017125897A1 (en) * | 2016-01-21 | 2017-07-27 | Novartis Ag | Multispecific molecules targeting cll-1 |
| AU2017225733A1 (en) | 2016-03-04 | 2018-09-27 | Novartis Ag | Cells expressing multiple chimeric antigen receptor (CAR) molecules and uses therefore |
| US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
| WO2017172981A2 (en) * | 2016-03-29 | 2017-10-05 | University Of Southern California | Chimeric antigen receptors targeting cancer |
| PT3436079T (pt) | 2016-04-01 | 2021-10-06 | Kite Pharma Inc | Recetores de antigénios quiméricos e de células t e métodos de uso |
| CN109414455B (zh) | 2016-04-01 | 2023-01-20 | 凯德药业股份有限公司 | Bcma结合分子及其使用方法 |
| KR20200068750A (ko) * | 2016-04-01 | 2020-06-15 | 카이트 파마 인코포레이티드 | 키메라 수용체 및 그의 사용 방법 |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| MY209117A (en) | 2016-04-15 | 2025-06-23 | Novartis Ag | Compositions and methods for selective protein expression |
| SG10202012157QA (en) | 2016-06-07 | 2021-01-28 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Chimeric antigen receptor and car-t cells that bind bcma |
| US20190336504A1 (en) | 2016-07-15 | 2019-11-07 | Novartis Ag | Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor |
| BR112019001570A2 (pt) | 2016-07-28 | 2019-07-09 | Novartis Ag | terapias de combinação de receptores de antígeno quiméricos e inibidores de pd-1 |
| US20190161542A1 (en) | 2016-08-01 | 2019-05-30 | Novartis Ag | Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule |
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2015
- 2015-07-21 KR KR1020177004392A patent/KR20170037625A/ko not_active Ceased
- 2015-07-21 CA CA2955465A patent/CA2955465A1/en not_active Abandoned
- 2015-07-21 WO PCT/US2015/041337 patent/WO2016014535A1/en not_active Ceased
- 2015-07-21 SG SG11201700418VA patent/SG11201700418VA/en unknown
- 2015-07-21 US US14/805,075 patent/US10568947B2/en active Active
- 2015-07-21 MX MX2017001013A patent/MX2017001013A/es unknown
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- 2015-07-21 JP JP2017503488A patent/JP6736540B2/ja not_active Expired - Fee Related
- 2015-07-21 RU RU2017105161A patent/RU2741120C2/ru active
- 2015-07-21 TW TW104123638A patent/TWI718992B/zh not_active IP Right Cessation
- 2015-07-21 SG SG10201913782UA patent/SG10201913782UA/en unknown
- 2015-07-21 EP EP15744448.0A patent/EP3171882A1/en not_active Withdrawn
- 2015-07-21 CN CN201580050589.9A patent/CN107109420A/zh active Pending
- 2015-07-21 BR BR112017000939A patent/BR112017000939A2/pt not_active IP Right Cessation
- 2015-07-21 AU AU2015292811A patent/AU2015292811B2/en not_active Ceased
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2017
- 2017-01-15 IL IL250116A patent/IL250116B/en active IP Right Grant
- 2017-01-20 CO CONC2017/0000506A patent/CO2017000506A2/es unknown
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2019
- 2019-12-27 US US16/728,557 patent/US20200215171A1/en not_active Abandoned
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2020
- 2020-03-18 AU AU2020201939A patent/AU2020201939A1/en not_active Abandoned
- 2020-07-15 JP JP2020121501A patent/JP2020185001A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EA201390847A1 (ru) * | 2010-12-09 | 2013-12-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Применение модифицированных t-клеток с химерными антигенными рецепторами для лечения злокачественных новообразований |
| WO2013169625A1 (en) * | 2012-05-07 | 2013-11-14 | Cellerant Therapeutics, Inc. | Antibodies specific for cll-1 |
Non-Patent Citations (3)
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| KANAZAWA NOBUO, "Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells." Journal of dermatological science, 2007, 45 (2): 77-86. * |
| ZHAO XIAOXIAN et al., "Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia." Haematologica, 2010, 95(1): 71-78. * |
| ZHAO XIAOXIAN et al., "Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia." Haematologica, 2010, 95(1): 71-78. KANAZAWA NOBUO, "Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells." Journal of dermatological science, 2007, 45(2): 77-86. * |
Also Published As
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| WO2016014535A1 (en) | 2016-01-28 |
| TW201619380A (zh) | 2016-06-01 |
| IL250116A0 (en) | 2017-03-30 |
| JP6736540B2 (ja) | 2020-08-05 |
| JP2020185001A (ja) | 2020-11-19 |
| SG11201700418VA (en) | 2017-02-27 |
| AR101829A1 (es) | 2017-01-18 |
| US20200215171A1 (en) | 2020-07-09 |
| EP3171882A1 (en) | 2017-05-31 |
| IL250116B (en) | 2021-06-30 |
| US20160051651A1 (en) | 2016-02-25 |
| US10568947B2 (en) | 2020-02-25 |
| CO2017000506A2 (es) | 2017-06-30 |
| RU2017105161A (ru) | 2018-08-21 |
| BR112017000939A2 (pt) | 2017-11-14 |
| CA2955465A1 (en) | 2016-01-28 |
| AU2020201939A1 (en) | 2020-04-09 |
| KR20170037625A (ko) | 2017-04-04 |
| SG10201913782UA (en) | 2020-03-30 |
| CN107109420A (zh) | 2017-08-29 |
| TWI718992B (zh) | 2021-02-21 |
| MX2017001013A (es) | 2018-02-21 |
| AU2015292811B2 (en) | 2019-12-19 |
| AU2015292811A1 (en) | 2017-02-02 |
| RU2017105161A3 (https=) | 2019-04-01 |
| JP2017522879A (ja) | 2017-08-17 |
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