RU2715038C2 - Антитела анти-pd-l1 и способы их диагностического применения - Google Patents

Антитела анти-pd-l1 и способы их диагностического применения Download PDF

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RU2715038C2
RU2715038C2 RU2017103495A RU2017103495A RU2715038C2 RU 2715038 C2 RU2715038 C2 RU 2715038C2 RU 2017103495 A RU2017103495 A RU 2017103495A RU 2017103495 A RU2017103495 A RU 2017103495A RU 2715038 C2 RU2715038 C2 RU 2715038C2
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antibody
cancer
sample
tumor
binding
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RU2017103495A
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RU2017103495A3 (OSRAM
RU2017103495A (ru
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Чжимин ЛЯО
Марчин КОВАНЕЦ
Закари БОЙД
Хартмут КЁППЕН
Патрик К. РОШ
Ифэй ЧЖУ
Бхаратхи ВЕННАПУСА
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Дженентек, Инк.
Спринг Байосайенс Корпорейшн
Вентана Медикал Системз, Инк.
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
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    • A61N2005/1021Radioactive fluid
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07K2317/00Immunoglobulins specific features
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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RU2017103495A 2014-07-11 2015-05-29 Антитела анти-pd-l1 и способы их диагностического применения RU2715038C2 (ru)

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Application Number Priority Date Filing Date Title
US201462023741P 2014-07-11 2014-07-11
US62/023,741 2014-07-11
PCT/US2015/033395 WO2016007235A1 (en) 2014-07-11 2015-05-29 Anti-pd-l1 antibodies and diagnostic uses thereof

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RU2017103495A RU2017103495A (ru) 2018-08-14
RU2017103495A3 RU2017103495A3 (OSRAM) 2019-01-15
RU2715038C2 true RU2715038C2 (ru) 2020-02-21

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US (4) US20160009805A1 (OSRAM)
EP (2) EP3166974A1 (OSRAM)
JP (2) JP7032929B2 (OSRAM)
KR (1) KR102360693B1 (OSRAM)
CN (1) CN106604933B (OSRAM)
AU (1) AU2015288232B2 (OSRAM)
BR (1) BR112017000497B1 (OSRAM)
CA (1) CA2954868C (OSRAM)
DK (1) DK3309174T3 (OSRAM)
ES (1) ES2916923T3 (OSRAM)
IL (1) IL250032B (OSRAM)
MX (1) MX384364B (OSRAM)
MY (1) MY188940A (OSRAM)
RU (1) RU2715038C2 (OSRAM)
SG (1) SG11201700207WA (OSRAM)
WO (1) WO2016007235A1 (OSRAM)
ZA (1) ZA201700832B (OSRAM)

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