EA201390370A1 - Молекулярно-диагностический тест для определения онкологического заболевания - Google Patents

Молекулярно-диагностический тест для определения онкологического заболевания

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EA201390370A1
EA201390370A1 EA201390370A EA201390370A EA201390370A1 EA 201390370 A1 EA201390370 A1 EA 201390370A1 EA 201390370 A EA201390370 A EA 201390370A EA 201390370 A EA201390370 A EA 201390370A EA 201390370 A1 EA201390370 A1 EA 201390370A1
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cancer
therapeutic regimen
test
diagnostic test
molecular diagnostic
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EA201390370A
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English (en)
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Тимоти Дэвисон
Джуд О'Доннелл
Макс Бюлешо
Фионнуала Макдайер
Стив Деаро
Лаура А. Хилл
Кэтрин Э. Китинг
Виталий Прутский
Денис Пол Харкин
Ричард Кеннеди
Николя Гоффар
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Олмак Дайэгностикс Лимитед
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Publication of EA201390370A1 publication Critical patent/EA201390370A1/ru

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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Abstract

Предложены способы и композиции для идентификации молекулярно-диагностического теста на онкологическое заболевание. Тест определяет новый молекулярный подтип дефицита системы репарации повреждений ДНК и проводит классификацию пациента в пределах этого подтипа. Изобретение можно применять для определения того, способен ли пациент с онкологическим заболеванием дать клинический ответ на терапевтический режим или же он не способен дать клинический ответ на терапевтический режим, перед введением какой-либо химиотерапии. Данный тест можно применять при различных типах рака и в отношении различных лекарственных препаратов, которые напрямую или опосредованно воздействуют на повреждение или систему репарации ДНК, таких как многие стандартные цитотоксические химиотерапевтические лекарства, применяемые в настоящее время. В частности, изобретение относится к применению определенных комбинаций прогностических маркеров, при этом экспрессия прогностических маркеров коррелирует со способностью или неспособностью ответить на терапевтический режим.
EA201390370A 2010-09-15 2011-09-15 Молекулярно-диагностический тест для определения онкологического заболевания EA201390370A1 (ru)

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Application Number Priority Date Filing Date Title
US38320110P 2010-09-15 2010-09-15
US201161490039P 2011-05-25 2011-05-25
PCT/US2011/051803 WO2012037378A2 (en) 2010-09-15 2011-09-15 Molecular diagnostic test for cancer

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EA201390370A1 true EA201390370A1 (ru) 2013-07-30

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US (4) US9670547B2 (ru)
EP (2) EP2619574B1 (ru)
JP (2) JP2013537045A (ru)
KR (1) KR20130115250A (ru)
CN (2) CN103299188B (ru)
AU (2) AU2011302004B2 (ru)
BR (1) BR112013006207A2 (ru)
CA (1) CA2811015A1 (ru)
EA (1) EA201390370A1 (ru)
HK (1) HK1216665A1 (ru)
MX (1) MX344636B (ru)
MY (1) MY166040A (ru)
NZ (3) NZ712823A (ru)
SG (2) SG10201610027VA (ru)
WO (1) WO2012037378A2 (ru)
ZA (2) ZA201301567B (ru)

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