BR112015008257A2 - marcadores para diagnóstico molecular prdm14 e fam19a4 para cânceres invasivos induzidos por hpv e suas lesões precursoras de alto grau - Google Patents

marcadores para diagnóstico molecular prdm14 e fam19a4 para cânceres invasivos induzidos por hpv e suas lesões precursoras de alto grau

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Publication number
BR112015008257A2
BR112015008257A2 BR112015008257A BR112015008257A BR112015008257A2 BR 112015008257 A2 BR112015008257 A2 BR 112015008257A2 BR 112015008257 A BR112015008257 A BR 112015008257A BR 112015008257 A BR112015008257 A BR 112015008257A BR 112015008257 A2 BR112015008257 A2 BR 112015008257A2
Authority
BR
Brazil
Prior art keywords
hpv
prdm14
fam19a4
induced
invasive cancers
Prior art date
Application number
BR112015008257A
Other languages
English (en)
Other versions
BR112015008257B1 (pt
Inventor
Joannes Lambertus Maria Meijer Christophorus
Josephus Ferdinandus Snijders Petrus
Daniëla Maria Steenbergen Renske
Original Assignee
Self Screen Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Self Screen Bv filed Critical Self Screen Bv
Publication of BR112015008257A2 publication Critical patent/BR112015008257A2/pt
Publication of BR112015008257B1 publication Critical patent/BR112015008257B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

“marcadores para diagnóstico molecular prdm14 e fam19a4 para cânceres invasivos induzidos por hpv e suas lesões precursoras de alto grau” a invenção refere-se a um método para a detecção de lesões pré-cancerosas de alto grau induzidas por hpv e cânceres invasivos induzidos por hpv, o dito método compreendendo a detecção de hipermetilação no gene prdm14 e/ou fam19a4 em uma célula em que tal hipermetilação indica a presença de lesões precursoras induzidas por hpv com potencial invasivo e cânceres invasivos induzidos por hpv. a invenção compreende ainda o uso do gene prdm14 e/ou fam19a4 em tal método e um kit de teste para a detecção da metilação de prdm14 e/ou fam19a4.
BR112015008257-2A 2012-10-12 2013-10-14 Métodos in vitro para a detecção de lesões pré-cancerosas de alto grau induzidas por hpv ou cânceres invasivos induzidos por hpv, uso de uma combinação de fam19a4 e hsa-mir124-2 para a detecção das ditas lesões ou carcinomas e kit de partes compreendendo meios para a detecção de metilação de fam19a4 e metilação de hsa-mir124-2 BR112015008257B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12188377 2012-10-12
EP12188377.1 2012-10-12
PCT/NL2013/050729 WO2014058321A1 (en) 2012-10-12 2013-10-14 Prdm14 and fam19a4, molecular diagnostic markers for hpv-induced invasive cancers and their high-grade precursor lesions

Publications (2)

Publication Number Publication Date
BR112015008257A2 true BR112015008257A2 (pt) 2017-11-28
BR112015008257B1 BR112015008257B1 (pt) 2022-05-24

Family

ID=47049031

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015008257-2A BR112015008257B1 (pt) 2012-10-12 2013-10-14 Métodos in vitro para a detecção de lesões pré-cancerosas de alto grau induzidas por hpv ou cânceres invasivos induzidos por hpv, uso de uma combinação de fam19a4 e hsa-mir124-2 para a detecção das ditas lesões ou carcinomas e kit de partes compreendendo meios para a detecção de metilação de fam19a4 e metilação de hsa-mir124-2

Country Status (21)

Country Link
US (1) US9890432B2 (pt)
EP (2) EP2906716B1 (pt)
JP (1) JP6703400B2 (pt)
KR (1) KR102143241B1 (pt)
CN (2) CN104870653A (pt)
AU (1) AU2013330509B2 (pt)
BR (1) BR112015008257B1 (pt)
CA (1) CA2887544C (pt)
DK (1) DK2906716T5 (pt)
EA (1) EA032860B1 (pt)
ES (1) ES2664923T3 (pt)
HK (1) HK1209460A1 (pt)
MX (1) MX361211B (pt)
MY (1) MY183325A (pt)
NO (1) NO2906716T3 (pt)
NZ (1) NZ708027A (pt)
PH (1) PH12015500808A1 (pt)
PT (1) PT2906716T (pt)
SG (1) SG11201502897VA (pt)
WO (1) WO2014058321A1 (pt)
ZA (1) ZA201503276B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107148476B (zh) * 2014-10-17 2021-06-08 科罗拉多大学董事会法人团体 头颈部癌症的生物标志物及其使用方法
EP3135768A1 (en) * 2015-08-26 2017-03-01 Self-screen B.V. Zic1 and ghsr, molecular diagnostic markers for hpv-induced invasive cancers, nonhpv-induced gynaecological and anogenital cancers and their high-grade precursor lesions
PT3592867T (pt) * 2017-03-10 2022-10-13 Self Screen Bv Um classificador de metilação para deteção de cancros invasivos induzidos por hpv, cancros ginecológicos e anogenitais não induzidos por hpv e suas lesões precursoras de elevado grau
US20190112673A1 (en) 2017-05-10 2019-04-18 Genomic Vision Association between integration of high-risk hpv genomes detected by molecular combing and the severity and/or clinical outcome of cervical lesions
US20200282042A1 (en) * 2017-05-11 2020-09-10 Inovio Pharmaceuticals, Inc. Clinical and immunologic biomarkers for regression of high grade cervical dysplasia and clearance of hpv16 and hpv18 infection after immunotherapy
CN107287294A (zh) * 2017-06-14 2017-10-24 广州中心法则生物科技有限公司 一种宫颈癌相关基因甲基化程度的检测引物、探针、试剂盒及其应用
WO2019022605A1 (en) 2017-07-25 2019-01-31 Stichting Vumc RNA-MICRO-BASED METHODS AND COMPOSITIONS FOR DETECTING HPV-INDUCED INVASIVE CANCER AND HIGH-LEVEL PRECURSOR INJURIES
WO2019069229A1 (en) * 2017-10-02 2019-04-11 Neuracle Science Co., Ltd. USE OF ANTIBODIES DIRECTED AGAINST A SIMILARITY FAMILY OF SEQUENCE 19, ELEMENT A5, FOR THE TREATMENT AND DIAGNOSIS OF MOOD DISORDERS
CN108060231A (zh) * 2018-02-24 2018-05-22 韩林志 用于宫颈癌基因FAM19A4、miR-124-2甲基化检测的引物对、试剂盒及方法
EP3887552A1 (en) 2018-11-30 2021-10-06 Genomic Vision Association between integration of viral as hpv or hiv genomes and the severity and/or clinical outcome of disorders as hpv associated cervical lesions or aids pathology
CN114214415A (zh) * 2021-12-29 2022-03-22 广州安必平医药科技股份有限公司 一种用于宫颈癌相关基因甲基化检测的引物探针组合及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2283154T3 (da) * 2008-04-14 2013-08-26 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg MAL- og CADM1-promotormethylering, molekylær diagnostisk markør for HPV-inducerede invasive livmoderhalscancere samt deres forstadielæsioner med høj malignitet
WO2013033627A2 (en) * 2011-09-01 2013-03-07 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
SI2756099T1 (sl) 2011-09-15 2017-11-30 Self-Screen B.V. Postopek za detekcijo HPV-induciranega raka materničnega vratu

Also Published As

Publication number Publication date
BR112015008257B1 (pt) 2022-05-24
JP6703400B2 (ja) 2020-06-03
AU2013330509B2 (en) 2019-01-17
ES2664923T3 (es) 2018-04-24
CN106282342A (zh) 2017-01-04
DK2906716T3 (en) 2018-04-23
PH12015500808B1 (en) 2015-06-08
MX361211B (es) 2018-11-30
MX2015004556A (es) 2015-10-22
US20150284815A1 (en) 2015-10-08
KR102143241B1 (ko) 2020-08-11
NO2906716T3 (pt) 2018-06-30
EA201590724A1 (ru) 2015-09-30
PT2906716T (pt) 2018-04-13
WO2014058321A1 (en) 2014-04-17
JP2015532108A (ja) 2015-11-09
PH12015500808A1 (en) 2015-06-08
US9890432B2 (en) 2018-02-13
CN104870653A (zh) 2015-08-26
AU2013330509A1 (en) 2015-05-28
HK1209460A1 (en) 2016-04-01
CA2887544C (en) 2021-03-16
EP2906716B1 (en) 2018-01-31
KR20150084868A (ko) 2015-07-22
EP3106524A1 (en) 2016-12-21
ZA201503276B (en) 2016-10-26
DK2906716T5 (en) 2018-05-07
EP2906716A1 (en) 2015-08-19
EA032860B1 (ru) 2019-07-31
CA2887544A1 (en) 2014-04-17
MY183325A (en) 2021-02-18
SG11201502897VA (en) 2015-05-28
NZ708027A (en) 2019-01-25

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/10/2013, OBSERVADAS AS CONDICOES LEGAIS