DK2283154T3 - MAL- og CADM1-promotormethylering, molekylær diagnostisk markør for HPV-inducerede invasive livmoderhalscancere samt deres forstadielæsioner med høj malignitet - Google Patents

MAL- og CADM1-promotormethylering, molekylær diagnostisk markør for HPV-inducerede invasive livmoderhalscancere samt deres forstadielæsioner med høj malignitet

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Publication number
DK2283154T3
DK2283154T3 DK09732836.3T DK09732836T DK2283154T3 DK 2283154 T3 DK2283154 T3 DK 2283154T3 DK 09732836 T DK09732836 T DK 09732836T DK 2283154 T3 DK2283154 T3 DK 2283154T3
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DK
Denmark
Prior art keywords
hpv
mal
well
diagnostic marker
molecular diagnostic
Prior art date
Application number
DK09732836.3T
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English (en)
Inventor
Petrus Josephus Ferdinandus Snijders
Christophorus Joannes Lambertus Maria Meijer
Renske Daniela Maria Steenbergen
Original Assignee
Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg
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Application granted granted Critical
Publication of DK2283154T3 publication Critical patent/DK2283154T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK09732836.3T 2008-04-14 2009-04-14 MAL- og CADM1-promotormethylering, molekylær diagnostisk markør for HPV-inducerede invasive livmoderhalscancere samt deres forstadielæsioner med høj malignitet DK2283154T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08154496 2008-04-14
PCT/NL2009/050194 WO2009128714A1 (en) 2008-04-14 2009-04-14 Mal, a molecular diagnostic marker for hpv-induced invasive cancers and their high-grade precursor lesions

Publications (1)

Publication Number Publication Date
DK2283154T3 true DK2283154T3 (da) 2013-08-26

Family

ID=39718999

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09732836.3T DK2283154T3 (da) 2008-04-14 2009-04-14 MAL- og CADM1-promotormethylering, molekylær diagnostisk markør for HPV-inducerede invasive livmoderhalscancere samt deres forstadielæsioner med høj malignitet

Country Status (12)

Country Link
US (1) US9315866B2 (da)
EP (1) EP2283154B1 (da)
JP (1) JP5584197B2 (da)
CN (1) CN102105595A (da)
AU (1) AU2009236789B2 (da)
CA (1) CA2721356C (da)
DK (1) DK2283154T3 (da)
ES (1) ES2425617T3 (da)
HR (1) HRP20130780T1 (da)
NZ (1) NZ588618A (da)
PT (1) PT2283154E (da)
WO (1) WO2009128714A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2521914A4 (en) * 2010-01-08 2013-07-10 Oncohealth Corp CELL-BASED HPV IMMUNOTESTS HAVE A HIGH PERFORMANCE FOR DIAGNOSIS AND SCANNING OF HPV ASSOCIATED CANCER
CA2848654C (en) * 2011-09-15 2021-07-20 Self-Screen B.V. Methylation analysis on self-samples as triage tool for hpv-positive women
AU2012347522B2 (en) * 2011-12-08 2015-07-30 Five3 Genomics, Llc MDM2-containing double minute chromosomes and methods therefore
WO2013130517A1 (en) * 2012-02-27 2013-09-06 The Johns Hopkins University Dna hypermethylation of promoters of target genes and clinical diagnosis and treatment of hpv related disease
WO2013144344A2 (en) * 2012-03-30 2013-10-03 Istituto Europeo Di Oncologia S.R.L. Biomarkers for hpv infections, related diagnostic methods and kits
PT2906716T (pt) * 2012-10-12 2018-04-13 Self Screen Bv Hsa-mir124 e fam19a4, marcadores moleculares de diagnóstico para cancros invasivos induzidos por hpv e suas lesões precursoras de alto grau
KR20160133293A (ko) * 2015-05-12 2016-11-22 에이비온 주식회사 Hpv 바이러스의 발암 유전자 발현 저해물질을 유효성분으로 포함하는 암세포 감작용 조성물
EP3135768A1 (en) * 2015-08-26 2017-03-01 Self-screen B.V. Zic1 and ghsr, molecular diagnostic markers for hpv-induced invasive cancers, nonhpv-induced gynaecological and anogenital cancers and their high-grade precursor lesions
WO2017040491A1 (en) 2015-08-31 2017-03-09 The United States Of America As Represented By The Secretary Of The Army Methods for molecularly characterizing cervical cell samples
CN107328620B (zh) * 2017-06-23 2020-06-05 浙江普罗亭健康科技有限公司 用于流式细胞技术的封闭缓冲液及试剂盒
CN113677361A (zh) * 2018-12-28 2021-11-19 株式会社Neogentc 包含表达mal的干细胞样记忆t细胞作为活性成分的免疫增强或抗癌活性增强的组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE382099T1 (de) * 2003-03-31 2008-01-15 Stichting Res Fonds Pathologie Nachweis von invasivem krebs induziert von hpv und dessen vorläufer läsionen mit invasionspotential
KR100943525B1 (ko) * 2005-03-18 2010-02-22 (주)지노믹트리 바이오마커 스크리닝 시스템
AU2009224093A1 (en) * 2008-03-13 2009-09-17 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Cervical screening algorithms
CA2718092C (en) * 2008-03-21 2019-03-19 Oncomethylome Sciences S.A. Detection and prognosis of cervical cancer

Also Published As

Publication number Publication date
NZ588618A (en) 2012-10-26
JP2011519272A (ja) 2011-07-07
US9315866B2 (en) 2016-04-19
CA2721356A1 (en) 2009-10-22
HRP20130780T1 (hr) 2013-11-08
ES2425617T3 (es) 2013-10-16
CA2721356C (en) 2019-11-12
EP2283154B1 (en) 2013-05-22
PT2283154E (pt) 2013-08-29
JP5584197B2 (ja) 2014-09-03
AU2009236789A1 (en) 2009-10-22
US20110104660A1 (en) 2011-05-05
CN102105595A (zh) 2011-06-22
EP2283154A1 (en) 2011-02-16
WO2009128714A1 (en) 2009-10-22
AU2009236789B2 (en) 2014-10-09

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