HRP20130780T1 - Mal-promotor i cadm1-promotor metilacije, molekularni dijagnostiäśki marker za invazivne cervikalne karcinome inducirane hpv-om te njihove predmaligne lezije visokog stupnja - Google Patents

Mal-promotor i cadm1-promotor metilacije, molekularni dijagnostiäśki marker za invazivne cervikalne karcinome inducirane hpv-om te njihove predmaligne lezije visokog stupnja Download PDF

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HRP20130780T1
HRP20130780T1 HRP20130780AT HRP20130780T HRP20130780T1 HR P20130780 T1 HRP20130780 T1 HR P20130780T1 HR P20130780A T HRP20130780A T HR P20130780AT HR P20130780 T HRP20130780 T HR P20130780T HR P20130780 T1 HRP20130780 T1 HR P20130780T1
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hpv
mal
detecting
methylation
cadm1
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HRP20130780AT
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Christophorus Joannes Lambertus Maria Meijer
Petrus Josephus Ferdinandus Snijders
Renske Daniëla Maria Steenbergen
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Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg
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Publication of HRP20130780T1 publication Critical patent/HRP20130780T1/hr

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (4)

1. Postupak za otkrivanje predmaligne cervikalne lezije inducirane HPV-om, koja ima cervikalnu intraepitelijalnu neoplaziju (CIN) stupnja ≥ 2, kod pacijenta kojemu je to potrebno, naznačen time, da se vrši putem otkrivanja povećane metilacije CADM1-promotora i otkrivanja povećane metilacije MAL-promotora u stanicama cerviksa.
2. Postupak prema zahtjevu 1, naznačen time, da spomenuta predmaligna cervikalna lezija inducirana HPV-om je visokorizična predmaligna cervikalna lezija inducirana HPV-om.
3. Postupak prema bilo kojem prethodnom zahtjevu, naznačen time, da se povećana metilacija otkriva uporabom restrikcijske endonukleaze, poželjno restrikcijske endonukleaze osjetljive na metilaciju.
4. Garnitura od dijelova, naznačena time, da se upotrebljava u postupku otkrivanja cervikalne predmaligne lezije inducirane HPV-om, koja ima cervikalnu intraepitelijalnu neoplaziju (CIN) stupnja ≥ 2, u ispitnim stanicama kod pacijenta, pri čemu ta garnitura obuhvaća: - sredstvo za otkrivanje metilacije MAL-promotora, gdje spomenuto sredstvo sadrži sonde i/ili testne kapisle specifične za MAL-nukleotidnu sekvencu na slici 1; i - sredstvo za otkrivanje metilacije CADM1-promotora, gdje spomenuto sredstvo sadrži sonde i/ili testne kapisle specifične za CADM1; i - po želji sredstvo za otkrivanje HPV-infekcije, gdje spomenuto sredstvo sadrži sonde i/ili testne kapisle specifične za HPV.
HRP20130780AT 2008-04-14 2013-08-19 Mal-promotor i cadm1-promotor metilacije, molekularni dijagnostiäśki marker za invazivne cervikalne karcinome inducirane hpv-om te njihove predmaligne lezije visokog stupnja HRP20130780T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08154496 2008-04-14
PCT/NL2009/050194 WO2009128714A1 (en) 2008-04-14 2009-04-14 Mal, a molecular diagnostic marker for hpv-induced invasive cancers and their high-grade precursor lesions

Publications (1)

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HRP20130780T1 true HRP20130780T1 (hr) 2013-11-08

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HRP20130780AT HRP20130780T1 (hr) 2008-04-14 2013-08-19 Mal-promotor i cadm1-promotor metilacije, molekularni dijagnostiäśki marker za invazivne cervikalne karcinome inducirane hpv-om te njihove predmaligne lezije visokog stupnja

Country Status (12)

Country Link
US (1) US9315866B2 (hr)
EP (1) EP2283154B1 (hr)
JP (1) JP5584197B2 (hr)
CN (1) CN102105595A (hr)
AU (1) AU2009236789B2 (hr)
CA (1) CA2721356C (hr)
DK (1) DK2283154T3 (hr)
ES (1) ES2425617T3 (hr)
HR (1) HRP20130780T1 (hr)
NZ (1) NZ588618A (hr)
PT (1) PT2283154E (hr)
WO (1) WO2009128714A1 (hr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102822672B (zh) * 2010-01-08 2015-12-09 安科健康公司 用于诊断和筛选与hpv有关的癌症的高通量细胞基hpv免疫测定
AU2012309226B2 (en) * 2011-09-15 2017-12-14 Self-Screen B.V. Methylation analysis on self-samples as triage tool for HPV-positive women
KR101906254B1 (ko) 2011-12-08 2018-10-10 파이브3 제노믹스, 엘엘씨 Mdm2-포함 이중 소염색체들 및 그의 방법들
US20150051100A1 (en) * 2012-02-27 2015-02-19 The Johns Hopkins University Dna hypermethylation of promoters of target genes and clinical diagnosis and treatment of hpv related disease
WO2013144344A2 (en) * 2012-03-30 2013-10-03 Istituto Europeo Di Oncologia S.R.L. Biomarkers for hpv infections, related diagnostic methods and kits
SG11201502897VA (en) * 2012-10-12 2015-05-28 Self Screen Bv Prdm14 and fam19a4, molecular diagnostic markers for hpv-induced invasive cancers and their high-grade precursor lesions
KR20160133293A (ko) * 2015-05-12 2016-11-22 에이비온 주식회사 Hpv 바이러스의 발암 유전자 발현 저해물질을 유효성분으로 포함하는 암세포 감작용 조성물
EP3135768A1 (en) * 2015-08-26 2017-03-01 Self-screen B.V. Zic1 and ghsr, molecular diagnostic markers for hpv-induced invasive cancers, nonhpv-induced gynaecological and anogenital cancers and their high-grade precursor lesions
WO2017040491A1 (en) 2015-08-31 2017-03-09 The United States Of America As Represented By The Secretary Of The Army Methods for molecularly characterizing cervical cell samples
CN107328620B (zh) * 2017-06-23 2020-06-05 浙江普罗亭健康科技有限公司 用于流式细胞技术的封闭缓冲液及试剂盒
KR102179381B1 (ko) * 2018-12-28 2020-11-16 주식회사 네오젠티씨 Mal이 발현된 줄기세포 유사 기억 t 세포를 유효성분으로 포함하는 면역증강 또는 항암활성 증진용 조성물
WO2024129928A2 (en) * 2022-12-13 2024-06-20 The Johns Hopkins University Methylation markers for cervical cancer detection and surveillance

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60318294T2 (de) * 2003-03-31 2008-12-11 Stichting Researchfonds Pathologie Nachweis von invasivem Krebs induziert von HPV und dessen Vorläufer Läsionen mit Invasionspotential
US20060211009A1 (en) * 2005-03-18 2006-09-21 Sungwhan An System for biomarker discovery
EP2265956A1 (en) * 2008-03-13 2010-12-29 Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg Cervical screening algorithms
EP2626435B1 (en) * 2008-03-21 2016-06-01 MDxHealth S.A. Detection and prognosis of cervical cancer

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Publication number Publication date
US20110104660A1 (en) 2011-05-05
AU2009236789A1 (en) 2009-10-22
JP2011519272A (ja) 2011-07-07
NZ588618A (en) 2012-10-26
AU2009236789B2 (en) 2014-10-09
CA2721356A1 (en) 2009-10-22
DK2283154T3 (da) 2013-08-26
CN102105595A (zh) 2011-06-22
JP5584197B2 (ja) 2014-09-03
PT2283154E (pt) 2013-08-29
EP2283154A1 (en) 2011-02-16
EP2283154B1 (en) 2013-05-22
CA2721356C (en) 2019-11-12
ES2425617T3 (es) 2013-10-16
WO2009128714A1 (en) 2009-10-22
US9315866B2 (en) 2016-04-19

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