EA201590724A1 - Prdm14 и fam19a4, молекулярные диагностические маркеры для выявления впч-индуцируемых инвазивных раковых заболеваний и предшествующих им поражений высокой степени - Google Patents

Prdm14 и fam19a4, молекулярные диагностические маркеры для выявления впч-индуцируемых инвазивных раковых заболеваний и предшествующих им поражений высокой степени

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Publication number
EA201590724A1
EA201590724A1 EA201590724A EA201590724A EA201590724A1 EA 201590724 A1 EA201590724 A1 EA 201590724A1 EA 201590724 A EA201590724 A EA 201590724A EA 201590724 A EA201590724 A EA 201590724A EA 201590724 A1 EA201590724 A1 EA 201590724A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hpv
fam19a4
prdm14
identification
induced
Prior art date
Application number
EA201590724A
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English (en)
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EA032860B1 (ru
Inventor
Христофорус Йоаннес Ламбертус Мария Мейер
Петрус Йозефус Фердинандус Снейдерс
Ренске Даниэла Мария Стенберген
Original Assignee
Селф-Скрин Б.В.
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Publication date
Application filed by Селф-Скрин Б.В. filed Critical Селф-Скрин Б.В.
Publication of EA201590724A1 publication Critical patent/EA201590724A1/ru
Publication of EA032860B1 publication Critical patent/EA032860B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Изобретение относится к способу выявления ВПЧ-индуцируемых предраковых поражений высокой степени и ВПЧ-индуцируемых инвазивных раковых заболеваний, причем указанный способ включает определение гиперметилирования PRDM14 и/или FAM19A4 гена в клетках, такое гиперметилирование указывает на присутствие ВПЧ-индуцируемых предраковых поражений с инвазивным потенциалом и ВПЧ-индуцируемых инвазивных раковых заболеваний. Кроме того, изобретение включает применение гена PRDM14 и/или FAM19A4 в таком способе и тест-набора для определения метилирования PRDM14 и/или FAM19A4.
EA201590724A 2012-10-12 2013-10-14 СПОСОБ ВЫЯВЛЕНИЯ ВПЧ-ИНДУЦИРОВАННЫХ ИНВАЗИВНЫХ РАКОВЫХ ЗАБОЛЕВАНИЙ И ПРЕДШЕСТВУЮЩИХ ПОРАЖЕНИЙ ВЫСОКОЙ СТЕПЕНИ С ИСПОЛЬЗОВАНИЕМ FAM19A4 И hsa-miR124-2 В КАЧЕСТВЕ МАРКЁРОВ EA032860B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12188377 2012-10-12
PCT/NL2013/050729 WO2014058321A1 (en) 2012-10-12 2013-10-14 Prdm14 and fam19a4, molecular diagnostic markers for hpv-induced invasive cancers and their high-grade precursor lesions

Publications (2)

Publication Number Publication Date
EA201590724A1 true EA201590724A1 (ru) 2015-09-30
EA032860B1 EA032860B1 (ru) 2019-07-31

Family

ID=47049031

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590724A EA032860B1 (ru) 2012-10-12 2013-10-14 СПОСОБ ВЫЯВЛЕНИЯ ВПЧ-ИНДУЦИРОВАННЫХ ИНВАЗИВНЫХ РАКОВЫХ ЗАБОЛЕВАНИЙ И ПРЕДШЕСТВУЮЩИХ ПОРАЖЕНИЙ ВЫСОКОЙ СТЕПЕНИ С ИСПОЛЬЗОВАНИЕМ FAM19A4 И hsa-miR124-2 В КАЧЕСТВЕ МАРКЁРОВ

Country Status (21)

Country Link
US (1) US9890432B2 (ru)
EP (2) EP2906716B1 (ru)
JP (1) JP6703400B2 (ru)
KR (1) KR102143241B1 (ru)
CN (2) CN104870653A (ru)
AU (1) AU2013330509B2 (ru)
BR (1) BR112015008257B1 (ru)
CA (1) CA2887544C (ru)
DK (1) DK2906716T5 (ru)
EA (1) EA032860B1 (ru)
ES (1) ES2664923T3 (ru)
HK (1) HK1209460A1 (ru)
MX (1) MX361211B (ru)
MY (1) MY183325A (ru)
NO (1) NO2906716T3 (ru)
NZ (1) NZ708027A (ru)
PH (1) PH12015500808A1 (ru)
PT (1) PT2906716T (ru)
SG (1) SG11201502897VA (ru)
WO (1) WO2014058321A1 (ru)
ZA (1) ZA201503276B (ru)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
CN107148476B (zh) * 2014-10-17 2021-06-08 科罗拉多大学董事会法人团体 头颈部癌症的生物标志物及其使用方法
EP3135768A1 (en) * 2015-08-26 2017-03-01 Self-screen B.V. Zic1 and ghsr, molecular diagnostic markers for hpv-induced invasive cancers, nonhpv-induced gynaecological and anogenital cancers and their high-grade precursor lesions
PT3592867T (pt) * 2017-03-10 2022-10-13 Self Screen Bv Um classificador de metilação para deteção de cancros invasivos induzidos por hpv, cancros ginecológicos e anogenitais não induzidos por hpv e suas lesões precursoras de elevado grau
US20190112673A1 (en) 2017-05-10 2019-04-18 Genomic Vision Association between integration of high-risk hpv genomes detected by molecular combing and the severity and/or clinical outcome of cervical lesions
US20200282042A1 (en) * 2017-05-11 2020-09-10 Inovio Pharmaceuticals, Inc. Clinical and immunologic biomarkers for regression of high grade cervical dysplasia and clearance of hpv16 and hpv18 infection after immunotherapy
CN107287294A (zh) * 2017-06-14 2017-10-24 广州中心法则生物科技有限公司 一种宫颈癌相关基因甲基化程度的检测引物、探针、试剂盒及其应用
WO2019022605A1 (en) 2017-07-25 2019-01-31 Stichting Vumc RNA-MICRO-BASED METHODS AND COMPOSITIONS FOR DETECTING HPV-INDUCED INVASIVE CANCER AND HIGH-LEVEL PRECURSOR INJURIES
WO2019069229A1 (en) * 2017-10-02 2019-04-11 Neuracle Science Co., Ltd. USE OF ANTIBODIES DIRECTED AGAINST A SIMILARITY FAMILY OF SEQUENCE 19, ELEMENT A5, FOR THE TREATMENT AND DIAGNOSIS OF MOOD DISORDERS
CN108060231A (zh) * 2018-02-24 2018-05-22 韩林志 用于宫颈癌基因FAM19A4、miR-124-2甲基化检测的引物对、试剂盒及方法
EP3887552A1 (en) 2018-11-30 2021-10-06 Genomic Vision Association between integration of viral as hpv or hiv genomes and the severity and/or clinical outcome of disorders as hpv associated cervical lesions or aids pathology
CN114214415A (zh) * 2021-12-29 2022-03-22 广州安必平医药科技股份有限公司 一种用于宫颈癌相关基因甲基化检测的引物探针组合及其应用

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DK2283154T3 (da) * 2008-04-14 2013-08-26 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg MAL- og CADM1-promotormethylering, molekylær diagnostisk markør for HPV-inducerede invasive livmoderhalscancere samt deres forstadielæsioner med høj malignitet
WO2013033627A2 (en) * 2011-09-01 2013-03-07 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
SI2756099T1 (sl) 2011-09-15 2017-11-30 Self-Screen B.V. Postopek za detekcijo HPV-induciranega raka materničnega vratu

Also Published As

Publication number Publication date
BR112015008257B1 (pt) 2022-05-24
JP6703400B2 (ja) 2020-06-03
AU2013330509B2 (en) 2019-01-17
ES2664923T3 (es) 2018-04-24
CN106282342A (zh) 2017-01-04
DK2906716T3 (en) 2018-04-23
PH12015500808B1 (en) 2015-06-08
BR112015008257A2 (pt) 2017-11-28
MX361211B (es) 2018-11-30
MX2015004556A (es) 2015-10-22
US20150284815A1 (en) 2015-10-08
KR102143241B1 (ko) 2020-08-11
NO2906716T3 (ru) 2018-06-30
PT2906716T (pt) 2018-04-13
WO2014058321A1 (en) 2014-04-17
JP2015532108A (ja) 2015-11-09
PH12015500808A1 (en) 2015-06-08
US9890432B2 (en) 2018-02-13
CN104870653A (zh) 2015-08-26
AU2013330509A1 (en) 2015-05-28
HK1209460A1 (en) 2016-04-01
CA2887544C (en) 2021-03-16
EP2906716B1 (en) 2018-01-31
KR20150084868A (ko) 2015-07-22
EP3106524A1 (en) 2016-12-21
ZA201503276B (en) 2016-10-26
DK2906716T5 (en) 2018-05-07
EP2906716A1 (en) 2015-08-19
EA032860B1 (ru) 2019-07-31
CA2887544A1 (en) 2014-04-17
MY183325A (en) 2021-02-18
SG11201502897VA (en) 2015-05-28
NZ708027A (en) 2019-01-25

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