RU2708068C2 - Лечение судорог с использованием рекомбинантной щелочной фосфатазы - Google Patents
Лечение судорог с использованием рекомбинантной щелочной фосфатазы Download PDFInfo
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- RU2708068C2 RU2708068C2 RU2017123540A RU2017123540A RU2708068C2 RU 2708068 C2 RU2708068 C2 RU 2708068C2 RU 2017123540 A RU2017123540 A RU 2017123540A RU 2017123540 A RU2017123540 A RU 2017123540A RU 2708068 C2 RU2708068 C2 RU 2708068C2
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| RU2842282C1 (ru) * | 2019-12-09 | 2025-06-24 | Алексион Фармасьютикалз, Инк. | Полипептиды, представляющие собой щелочную фосфатазу, и способы их применения |
| US12433938B2 (en) | 2019-12-09 | 2025-10-07 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
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| ES2887039T3 (es) | 2004-04-21 | 2021-12-21 | Alexion Pharma Inc | Conjugados para administración ósea y procedimiento de uso de estos para dirigir proteínas al hueso |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| ES3038086T3 (en) | 2014-12-05 | 2025-10-09 | Alexion Pharma Inc | Treating seizure with recombinant alkaline phosphatase |
| EP3250227A2 (en) | 2015-01-28 | 2017-12-06 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| RU2745528C2 (ru) | 2015-08-17 | 2021-03-26 | Алексион Фармасьютикалз, Инк. | Производство щелочных фосфатаз |
| JP6868617B2 (ja) | 2015-09-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 低ホスファターゼ血症の組織非特異的アルカリホスファターゼ（ｔｎｓａｌｐ）酵素補充療法に有効な投薬計画の特定 |
| JP2018533571A (ja) | 2015-10-30 | 2018-11-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者の頭蓋縫合早期癒合症を治療するための方法 |
| US11065306B2 (en) | 2016-03-08 | 2021-07-20 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| US11186832B2 (en) | 2016-04-01 | 2021-11-30 | Alexion Pharmaceuticals, Inc. | Treating muscle weakness with alkaline phosphatases |
| US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| US10988744B2 (en) | 2016-06-06 | 2021-04-27 | Alexion Pharmaceuticals, Inc. | Method of producing alkaline phosphatase |
| WO2018035420A1 (en) * | 2016-08-18 | 2018-02-22 | Alexion Pharmaceuticals, Inc. | Methods for treating tracheobronchomalacia |
| CN106591255B (zh) * | 2017-01-13 | 2019-07-02 | 山东省医药生物技术研究中心 | 人碱性磷酸酶糖蛋白的癌细胞高效表达系统及其应用 |
| WO2018164995A1 (en) * | 2017-03-09 | 2018-09-13 | Alexion Pharmaceuticals, Inc . | Glycoprotein manufacturing process |
| WO2018183720A1 (en) * | 2017-03-31 | 2018-10-04 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia (hpp) in adults and adolescents |
| US11338020B2 (en) | 2018-01-09 | 2022-05-24 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| EP3768302B1 (en) | 2018-03-20 | 2025-05-07 | Theriva Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| EP4275761A3 (en) | 2018-03-20 | 2024-02-28 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| JP2021519590A (ja) | 2018-03-30 | 2021-08-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 糖タンパク質の製造 |
| CN110499284A (zh) * | 2018-05-17 | 2019-11-26 | 西安组织工程与再生医学研究所 | Wnt信号通路激活剂在制备治疗基因ALPL敲除小鼠牙硬组织矿化异常产品中的应用 |
| US12268733B2 (en) | 2018-08-10 | 2025-04-08 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| WO2020227263A1 (en) | 2019-05-06 | 2020-11-12 | Synthetic Biologics, Inc. | Alkaline phosphate-based oncology treatments |
| KR20230117327A (ko) * | 2020-09-03 | 2023-08-08 | 어빈 에스.와이. 첸 | 가용성 알칼리성 포스파타제 작제물 및 가용성 알칼리성 포스파타제 작제물을 인코딩하는 폴리뉴클레오티드를 포함하는 발현 벡터 |
| MX2023009463A (es) | 2021-02-12 | 2023-09-21 | Alexion Pharma Inc | Polipeptidos de fosfatasa alcalina y metodos para su uso. |
| JP7720105B2 (ja) * | 2021-03-23 | 2025-08-07 | 学校法人日本医科大学 | 組織非特異型アルカリホスファターゼの送達のための遺伝子療法構築物およびその使用方法 |
| CN115575646B (zh) * | 2022-11-21 | 2023-04-28 | 四川大学华西医院 | 一种代谢标志物组在制备预测癫痫发作的试剂盒中的用途 |
| WO2025097067A2 (en) * | 2023-11-02 | 2025-05-08 | Be Biopharma, Inc. | Engineered cell preparations for treatment of hypophosphatasia |
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| WO2008138131A1 (en) * | 2007-05-11 | 2008-11-20 | Enobia Pharma Inc. | Bone targeted alkaline phosphatase, kits and methods of use thereof |
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| WO2011134084A1 (en) * | 2010-04-30 | 2011-11-03 | Enobia Pharma Inc. | Methods, compositions, and kits for the treatment of matrix mineralization disorders |
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| RU2842282C1 (ru) * | 2019-12-09 | 2025-06-24 | Алексион Фармасьютикалз, Инк. | Полипептиды, представляющие собой щелочную фосфатазу, и способы их применения |
| US12433938B2 (en) | 2019-12-09 | 2025-10-07 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
Also Published As
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| US20170360899A1 (en) | 2017-12-21 |
| RU2017123540A (ru) | 2019-01-10 |
| AU2015357551B2 (en) | 2021-02-25 |
| AU2015357551A1 (en) | 2017-05-25 |
| CN107405390A (zh) | 2017-11-28 |
| ES3038086T3 (en) | 2025-10-09 |
| MX2017007392A (es) | 2019-01-24 |
| US10449236B2 (en) | 2019-10-22 |
| CA2967851A1 (en) | 2016-06-09 |
| MX389350B (es) | 2025-03-19 |
| EP3226891B1 (en) | 2025-06-25 |
| RU2017123540A3 (enExample) | 2019-07-17 |
| JP2018502836A (ja) | 2018-02-01 |
| KR20240045379A (ko) | 2024-04-05 |
| CO2017005034A2 (es) | 2017-08-31 |
| BR112017011900A2 (pt) | 2018-02-27 |
| EP3226891A1 (en) | 2017-10-11 |
| US11224638B2 (en) | 2022-01-18 |
| CA2967851C (en) | 2024-02-27 |
| KR20170095278A (ko) | 2017-08-22 |
| US20200093898A1 (en) | 2020-03-26 |
| WO2016090251A1 (en) | 2016-06-09 |
| JP6787894B2 (ja) | 2020-11-18 |
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