RU2562263C9 - Способ и рабочий узел для приготовления микрочастиц с использованием эмульсии - Google Patents

Способ и рабочий узел для приготовления микрочастиц с использованием эмульсии Download PDF

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Publication number
RU2562263C9
RU2562263C9 RU2012130937/05A RU2012130937A RU2562263C9 RU 2562263 C9 RU2562263 C9 RU 2562263C9 RU 2012130937/05 A RU2012130937/05 A RU 2012130937/05A RU 2012130937 A RU2012130937 A RU 2012130937A RU 2562263 C9 RU2562263 C9 RU 2562263C9
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RU
Russia
Prior art keywords
solvent
filter
microparticles
phase
substance
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RU2012130937/05A
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English (en)
Russian (ru)
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RU2562263C2 (ru
RU2012130937A (ru
Inventor
Гэри ВИНЧЕСТЕР
Питер Марклэнд
Original Assignee
Евоник Корпорейшн
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Publication of RU2012130937A publication Critical patent/RU2012130937A/ru
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4523—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through sieves, screens or meshes which obstruct the whole diameter of the tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/60—Pump mixers, i.e. mixing within a pump
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/111—Centrifugal stirrers, i.e. stirrers with radial outlets; Stirrers of the turbine type, e.g. with means to guide the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/82—Combinations of dissimilar mixers
    • B01F33/822—Combinations of dissimilar mixers with moving and non-moving stirring devices in the same receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Colloid Chemistry (AREA)
  • Accessories For Mixers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
RU2012130937/05A 2009-12-22 2010-12-15 Способ и рабочий узел для приготовления микрочастиц с использованием эмульсии RU2562263C9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28897309P 2009-12-22 2009-12-22
US61/288,973 2009-12-22
PCT/US2010/060473 WO2011087689A2 (en) 2009-12-22 2010-12-15 Emulsion-based process for preparing microparticles and workhead assembly for use with same

Publications (3)

Publication Number Publication Date
RU2012130937A RU2012130937A (ru) 2014-01-27
RU2562263C2 RU2562263C2 (ru) 2015-09-10
RU2562263C9 true RU2562263C9 (ru) 2016-04-27

Family

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RU2012130937/05A RU2562263C9 (ru) 2009-12-22 2010-12-15 Способ и рабочий узел для приготовления микрочастиц с использованием эмульсии

Country Status (10)

Country Link
US (1) US9486416B2 (ko)
EP (1) EP2516053B1 (ko)
JP (2) JP5791629B2 (ko)
KR (1) KR101862416B1 (ko)
CN (1) CN102985175B (ko)
BR (1) BR112012015200B1 (ko)
CA (1) CA2784287C (ko)
ES (1) ES2764971T3 (ko)
RU (1) RU2562263C9 (ko)
WO (1) WO2011087689A2 (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2737742C1 (ru) * 2016-12-13 2020-12-02 Самьянг Байофармасьютикалз Корпорейшн Пористые микрочастицы биоразлагаемого полимера и полимерный наполнитель, их содержащий
RU2784855C2 (ru) * 2017-09-11 2022-11-30 Президент Энд Феллоус Оф Харвард Колледж Пористые микросферы оксида металла

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
RU2110991C1 (ru) * 1990-05-18 1998-05-20 Бракко Интернэшнл Б.В. Микрошарики микронного или субмикронного размера с полимерной оболочкой и способ их изготовления

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2737742C1 (ru) * 2016-12-13 2020-12-02 Самьянг Байофармасьютикалз Корпорейшн Пористые микрочастицы биоразлагаемого полимера и полимерный наполнитель, их содержащий
RU2784855C2 (ru) * 2017-09-11 2022-11-30 Президент Энд Феллоус Оф Харвард Колледж Пористые микросферы оксида металла

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Publication number Publication date
US9486416B2 (en) 2016-11-08
JP5984903B2 (ja) 2016-09-06
WO2011087689A2 (en) 2011-07-21
EP2516053B1 (en) 2019-11-20
CN102985175B (zh) 2016-03-09
US20110204533A1 (en) 2011-08-25
EP2516053A2 (en) 2012-10-31
BR112012015200A8 (pt) 2018-06-26
KR20120115302A (ko) 2012-10-17
JP2015037792A (ja) 2015-02-26
JP2013515059A (ja) 2013-05-02
CA2784287A1 (en) 2011-07-21
ES2764971T3 (es) 2020-06-05
KR101862416B1 (ko) 2018-05-29
RU2562263C2 (ru) 2015-09-10
CN102985175A (zh) 2013-03-20
BR112012015200B1 (pt) 2021-07-20
CA2784287C (en) 2017-07-18
BR112012015200A2 (pt) 2018-05-22
RU2012130937A (ru) 2014-01-27
EP2516053A4 (en) 2013-08-21
JP5791629B2 (ja) 2015-10-07
WO2011087689A3 (en) 2011-11-17

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