BR9406993A - Microesferas de gases insolúveis encapsulados com proteína e sua preparação e uso como agentes de imagem ultrassônica - Google Patents

Microesferas de gases insolúveis encapsulados com proteína e sua preparação e uso como agentes de imagem ultrassônica

Info

Publication number
BR9406993A
BR9406993A BR9406993A BR9406993A BR9406993A BR 9406993 A BR9406993 A BR 9406993A BR 9406993 A BR9406993 A BR 9406993A BR 9406993 A BR9406993 A BR 9406993A BR 9406993 A BR9406993 A BR 9406993A
Authority
BR
Brazil
Prior art keywords
microspheres
protein
preparation
ultrasonic imaging
imaging agents
Prior art date
Application number
BR9406993A
Other languages
English (en)
Inventor
Karel J Lambert
Sheila Benay Podell
Edward J Jablonski
Carl Hulle
Kenneth Hamilton
Rolf Lohrmann
Original Assignee
Molecular Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26775071&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9406993(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Molecular Biosystems Inc filed Critical Molecular Biosystems Inc
Publication of BR9406993A publication Critical patent/BR9406993A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/04Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
BR9406993A 1993-07-02 1994-07-01 Microesferas de gases insolúveis encapsulados com proteína e sua preparação e uso como agentes de imagem ultrassônica BR9406993A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8671793A 1993-07-02 1993-07-02
US18765694A 1994-01-26 1994-01-26
PCT/US1994/007533 WO1995001187A1 (en) 1993-07-02 1994-07-01 Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents

Publications (1)

Publication Number Publication Date
BR9406993A true BR9406993A (pt) 1996-09-10

Family

ID=26775071

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9406993A BR9406993A (pt) 1993-07-02 1994-07-01 Microesferas de gases insolúveis encapsulados com proteína e sua preparação e uso como agentes de imagem ultrassônica

Country Status (20)

Country Link
US (1) US5552133A (pt)
EP (2) EP0885615B1 (pt)
JP (3) JP2905598B2 (pt)
KR (1) KR100218642B1 (pt)
CN (1) CN1129910A (pt)
AT (1) ATE179334T1 (pt)
AU (1) AU683485B2 (pt)
BR (1) BR9406993A (pt)
CA (1) CA2166459C (pt)
CZ (1) CZ350895A3 (pt)
DE (2) DE69418101T2 (pt)
ES (2) ES2195247T3 (pt)
FI (1) FI956312A (pt)
HU (1) HUT74827A (pt)
IL (1) IL110185A (pt)
NO (1) NO955351L (pt)
NZ (1) NZ268826A (pt)
PL (1) PL312387A1 (pt)
TW (1) TW283646B (pt)
WO (1) WO1995001187A1 (pt)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (pt) 1990-04-02 1993-05-01 Sint Sa
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
SG52198A1 (en) * 1993-01-25 1998-09-28 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5701899A (en) * 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5695740A (en) * 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
EP1550464A1 (en) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
PL182223B1 (pl) * 1993-12-15 2001-11-30 Bracco Research Sa Biokompatybilna faza rozproszona do otrzymywania srodka kontrastowego do badan ultradzwiekowych, srodek kontrastowy do badan ultradzwiekowych, suchy preparat srodka kontrastowego oraz dwuskladnikowy zestaw do otrzymywania srodka kontrastowego do badan ultradzwiekowych PL PL PL
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US5965109A (en) * 1994-08-02 1999-10-12 Molecular Biosystems, Inc. Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US5674469A (en) * 1995-06-07 1997-10-07 Molecular Biosystems, Inc. Gas-exchange method of making gas-filled microspheres
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
AU736301B2 (en) 1996-05-01 2001-07-26 Imarx Therapeutics, Inc. Methods for delivering compounds into a cell
US5976501A (en) * 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
CN1042700C (zh) * 1996-06-25 1999-03-31 谢峰 含有全氟化碳或六氟化硫的右旋糖酐白蛋白声学造影剂及其制作方法
US5849727A (en) 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
ES2189974T3 (es) 1996-09-11 2003-07-16 Imarx Pharmaceutical Corp Procedimientos mejorados para la obtencion de imagenes de diagnostico usando un agente de contraste y un vasodilatador.
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6083484A (en) * 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
AU7702798A (en) 1997-05-30 1998-12-30 Alliance Pharmaceutical Corporation Methods and apparatus for monitoring and quantifying the movement of fluid
AU8231098A (en) 1997-07-04 1999-02-10 Nycomed Imaging As Process for the selection of particles of a preselected size from a particulate pharmaceutical product
GB9717476D0 (en) * 1997-08-18 1997-10-22 Nycomed Imaging As Process
JP4808842B2 (ja) * 1997-08-18 2011-11-02 ジーイー・ヘルスケア・アクスイェ・セルスカプ 小胞の調製方法
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6386751B1 (en) 1997-10-24 2002-05-14 Diffusion Dynamics, Inc. Diffuser/emulsifier
US20110075507A1 (en) * 1997-10-24 2011-03-31 Revalesio Corporation Diffuser/emulsifier
US7128278B2 (en) 1997-10-24 2006-10-31 Microdiffusion, Inc. System and method for irritating with aerated water
US7654728B2 (en) * 1997-10-24 2010-02-02 Revalesio Corporation System and method for therapeutic application of dissolved oxygen
US6702949B2 (en) 1997-10-24 2004-03-09 Microdiffusion, Inc. Diffuser/emulsifier for aquaculture applications
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US20010021372A1 (en) * 1998-08-18 2001-09-13 Tore Omtveit Apparatus having partially gold-plated surface
CA2353869A1 (en) * 1998-12-23 2000-07-06 Unilever Plc Pourable water and oil containing emulsions comprising gas bubbles
US6444192B1 (en) 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
US6627784B2 (en) * 2000-05-17 2003-09-30 Hydro Dynamics, Inc. Highly efficient method of mixing dissimilar fluids using mechanically induced cavitation
US20050150618A1 (en) * 2000-05-17 2005-07-14 Bijan Kazem Methods of processing lignocellulosic pulp with cavitation
AU2001266696A1 (en) 2000-06-02 2001-12-11 Bracco Research Usa Compounds for targeting endothelial cells
DE60223239T2 (de) 2001-04-06 2008-08-14 Bracco Research S.A. Vorrichtung zur Messung lokaler physikalischer Parameter in einem flüssigkeitsgefüllten Hohlraum
US7087212B2 (en) * 2001-08-17 2006-08-08 Mallinckrodt, Inc Multicomponent assemblies having enhanced binding properties for diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
CA2477836A1 (en) 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
CA2513044A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US20040126400A1 (en) * 2002-05-03 2004-07-01 Iversen Patrick L. Delivery of therapeutic compounds via microparticles or microbubbles
US6823820B2 (en) 2002-12-03 2004-11-30 Christian Helmut Thoma Apparatus for heating fluids
PL1944312T3 (pl) 2003-03-03 2012-12-31 Dyax Corp Peptydy, które specyficznie wiążą receptor HGF (CMET) i ich zastosowanie
CA2526333C (en) * 2003-05-19 2011-12-06 Hydro Dynamics, Inc. Method and apparatus for conducting a chemical reaction in the presence of cavitation and an electrical current
US6910448B2 (en) 2003-07-07 2005-06-28 Christian Thoma Apparatus and method for heating fluids
US20050042129A1 (en) * 2003-08-22 2005-02-24 Bijan Kazem Method and apparatus for irradiating fluids
US8076117B2 (en) * 2004-03-18 2011-12-13 Mayo Foundation For Medical Education And Research Microbial biofilm removal methods and systems
US7316501B2 (en) * 2004-05-20 2008-01-08 Christian Thoma Apparatus and method for mixing dissimilar fluids
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US10435639B2 (en) 2006-09-05 2019-10-08 Cerion, Llc Fuel additive containing lattice engineered cerium dioxide nanoparticles
US8883865B2 (en) 2006-09-05 2014-11-11 Cerion Technology, Inc. Cerium-containing nanoparticles
WO2008030813A1 (en) * 2006-09-05 2008-03-13 Cerion Technology, Inc. Method of conditioning an internal combustion engine
EP2086668B1 (en) 2006-10-25 2016-11-16 Revalesio Corporation Mixing device and method
US8784897B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of therapeutic treatment of eyes
WO2008052145A2 (en) 2006-10-25 2008-05-02 Revalesio Corporation Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution
US8784898B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
US8609148B2 (en) 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
CA2667614A1 (en) 2006-10-25 2008-09-25 Revalesio Corporation Method of wound care and treatment
US8445546B2 (en) 2006-10-25 2013-05-21 Revalesio Corporation Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures
US8465642B2 (en) * 2007-05-04 2013-06-18 Hydro Dynamics, Inc. Method and apparatus for separating impurities from a liquid stream by electrically generated gas bubbles
US20090036856A1 (en) * 2007-07-31 2009-02-05 Kimberly-Clark Worldwide, Inc. Triggerable self-generating liquid foam barrier/interceptor
US9745567B2 (en) 2008-04-28 2017-08-29 Revalesio Corporation Compositions and methods for treating multiple sclerosis
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
US10125359B2 (en) 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation
US8430968B2 (en) 2008-01-22 2013-04-30 Hydro Dynamics, Inc. Method of extracting starches and sugar from biological material using controlled cavitation
JP5901291B2 (ja) 2008-05-01 2016-04-06 リバルシオ コーポレイション 消化器障害を治療するための組成物および方法
EP2365758B2 (en) 2008-12-12 2016-08-03 The University of Birmingham Low fat food containing gas bubbles
US8846063B2 (en) * 2008-12-16 2014-09-30 Kimberly-Clark Worldwide, Inc. Personal care composition containing a volatile and a terpene alcohol
US8815292B2 (en) 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
EP2516053B1 (en) 2009-12-22 2019-11-20 Evonik Corporation Emulsion-based process for preparing microparticles and workhead assembly for use with same
AU2011249856B2 (en) 2010-05-07 2015-11-26 Revalesio Corporation Compositions and methods for enhancing physiological performance and recovery time
CN102302507B (zh) * 2010-07-12 2014-02-05 四川大学华西医院 定向控释微量元素的药物组合物及制备方法和应用
CN101926821B (zh) * 2010-07-12 2012-01-25 四川大学华西医院 一种靶向释放微量元素的药物组合物及制备方法和应用
EP2603202A4 (en) 2010-08-12 2016-06-01 Revalesio Corp COMPOSITIONS AND METHOD FOR THE TREATMENT OF TAUOPATHIES
CZ303992B6 (cs) * 2010-11-04 2013-08-07 Student Science, S.R.O. Nanovlákenné nosice s fotoafinne vázanými mikrosférami a zpusob jejich výroby
CN103534014B (zh) * 2011-05-27 2016-04-13 M技术株式会社 微小气泡发生装置、微小气泡发生方法及使用了其的气液反应方法
KR20120140290A (ko) * 2011-06-21 2012-12-31 주식회사 퍼시픽시스템 기능성 물질의 전달을 촉진하는 기포 제조 방법 및 이를 이용하는 기능성 물질 전달 장치
JP6594772B2 (ja) * 2012-04-30 2019-10-23 ジーイー・ヘルスケア・アクスイェ・セルスカプ 発泡性組成物を容器に充填する方法
BR112014032254B1 (pt) 2012-06-26 2022-11-01 Ge Healthcare As Processo para a preparação de uma composição, aparelho, e, uso de um aparelho
WO2015058037A1 (en) 2013-10-17 2015-04-23 Cerion, Llc Malic acid stabilized nanoceria particles
CN105233308B (zh) * 2015-11-02 2018-10-30 中国科学院深圳先进技术研究院 一种用于hifu的超声造影剂及其制备方法与应用
WO2017145118A1 (en) * 2016-02-25 2017-08-31 King Abdullah University Of Science And Technology Acoustically excited encapsulated microbubbles and mitigation of biofouling
WO2018071551A1 (en) 2016-10-11 2018-04-19 Thomas Jefferson University Non-invasive method for pressure measurement
CN107519502B (zh) * 2017-08-20 2019-01-15 湖南康润药业有限公司 超声造影微泡的制备方法及超声造影微泡

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
IE61591B1 (en) * 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
CA2068334C (en) * 1990-10-05 1996-09-03 Claude Giddey Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
RU2114637C1 (ru) * 1991-09-17 1998-07-10 Сонус Фармасьютикалз, Инк. Биосовместимая контрастная среда и способ получения ультразвукового изображения
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them

Also Published As

Publication number Publication date
FI956312A (fi) 1996-01-17
HUT74827A (en) 1997-02-28
EP0633030B1 (en) 1999-04-28
JPH08509002A (ja) 1996-09-24
IL110185A0 (en) 1994-10-21
CA2166459C (en) 2000-03-28
HU9503977D0 (en) 1996-03-28
AU7218494A (en) 1995-01-24
WO1995001187A1 (en) 1995-01-12
JP2002167338A (ja) 2002-06-11
DE69418101D1 (de) 1999-06-02
EP0633030A1 (en) 1995-01-11
CZ350895A3 (en) 1996-10-16
AU683485B2 (en) 1997-11-13
JP3809368B2 (ja) 2006-08-16
KR960703624A (ko) 1996-08-31
EP0885615B1 (en) 2003-03-26
CN1129910A (zh) 1996-08-28
US5552133A (en) 1996-09-03
DE69432370T2 (de) 2004-02-19
JPH11139995A (ja) 1999-05-25
CA2166459A1 (en) 1995-01-12
TW283646B (pt) 1996-08-21
NO955351D0 (no) 1995-12-29
ES2134321T3 (es) 1999-10-01
IL110185A (en) 1999-05-09
NO955351L (no) 1996-02-02
JP2905598B2 (ja) 1999-06-14
EP0885615A1 (en) 1998-12-23
ES2195247T3 (es) 2003-12-01
DE69432370D1 (de) 2003-04-30
KR100218642B1 (ko) 1999-09-01
PL312387A1 (en) 1996-04-15
DE69418101T2 (de) 1999-11-11
ATE179334T1 (de) 1999-05-15
NZ268826A (en) 1996-11-26
JP3285544B2 (ja) 2002-05-27
FI956312A0 (fi) 1995-12-29

Similar Documents

Publication Publication Date Title
BR9406993A (pt) Microesferas de gases insolúveis encapsulados com proteína e sua preparação e uso como agentes de imagem ultrassônica
NO307448B1 (no) Gassholdige kontrastmidler, fremgangsmõte til fremstilliing derav, mikrosfærer og dispersjoner inneholdende disse
DK220484A (da) Enteralt kontrastmiddel til kernespintomografi og dets fremstilling
ATE125711T1 (de) Stabile mikroblasensuspensionen zur injektion in lebewesen.
NO864203L (no) Biologiske makromolekyler.
FI950062A (fi) Proteiinien foroaktivaatio konjugaatiotarkoituksia varten
ZA881067B (en) Production of proteins in active forms
ES2022832B3 (es) Procedimiento para la obtencion de cloruros de 3 imerizados.
EP0336779A3 (en) Polypeptides stabilized by covalent hydrogen bond replacements
NO881904D0 (no) Fremgangsmaate til selektiv immunologisk bestemmelse av intakt prokollagen peptid (type iii) og prokollagen (type iii) i kroppsvaesker, og middel til dets gjennomfoering.
ES2022171B3 (es) Aminoazucares carbonatantes y su preparacion.
ATE195322T1 (de) Verwendung von oberflächenaktiven substanzen zur stabilisierung von peptiden und proteinen zur radiopharmazeutischen verwendung
DE58907746D1 (de) Verfahren zur Bestimmung von Fructosamin.
DK528386A (da) Proteinabsorptionsforoegende midler
DK0540560T3 (da) Ancrod-lignende proteiner, fremstilling og anvendelse deraf
NO952506D0 (no) Antistoffpreparater mot homogent minaktivin og anvendelse derav for påvisning av minaktivin i humane kroppsvæsker
BG51697A1 (en) Parentral formulation with extended action and method for its preparation
Vartanian et al. Edema of the paws of white mice--test for assessing the activity of E. coli enterotoxins
Maretic Health education of the population, tourists and health workers in connection with the invasion of the jellyfish Pelagia noctiluca
PUSHKIN NATURAL HYBRIDS OF WHITE BREAM AND OTHER SPECIES FROM THE FAMILY CYPRINIDAE(IN RUSSIAN)
TR199900160T2 (xx) Immunoterapötik aktif maddeler olarak kullanışlı polipeptidler.
ATE85086T1 (de) Nachweis von diaminen in biologischen fluessigkeiten.
RU94027129A (ru) Способ диагностики гельминтозов у животных
NZ243860A (en) Increasing glutathione levels in human and animal organs using whey protein concentrate
NO911278D0 (no) Hiv-proteiner og peptider som er anvendelige i diagnose, profylakse eller terapi av aids.

Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal