RU2415143C2 - Производные спирооксиндола и их применение в качестве терапевтических агентов - Google Patents

Info

Publication number

RU2415143C2

RU2415143C2 RU2007141632/04A RU2007141632A RU2415143C2 RU 2415143 C2 RU2415143 C2 RU 2415143C2 RU 2007141632/04 A RU2007141632/04 A RU 2007141632/04A RU 2007141632 A RU2007141632 A RU 2007141632A RU 2415143 C2 RU2415143 C2 RU 2415143C2

Authority

RU

Russia

Prior art keywords

indole

benzodioxol

furo

alkyl

oxospiro

Prior art date

2005-04-11

Links

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• 239000003814 drug Substances 0.000 title abstract 2
• 229940124597 therapeutic agent Drugs 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract 64
• 208000002193 Pain Diseases 0.000 claims abstract 15
• 238000000034 method Methods 0.000 claims abstract 9
• 239000000203 mixture Substances 0.000 claims abstract 7
• 150000003839 salts Chemical class 0.000 claims abstract 7
• 201000010099 disease Diseases 0.000 claims abstract 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 6
• 108010052164 Sodium Channels Proteins 0.000 claims abstract 3
• 102000018674 Sodium Channels Human genes 0.000 claims abstract 3
• 230000001404 mediated effect Effects 0.000 claims abstract 3
• 125000000217 alkyl group Chemical group 0.000 claims 1250
• 125000005842 heteroatom Chemical group 0.000 claims 760
• 229910052760 oxygen Inorganic materials 0.000 claims 694
• 229910052717 sulfur Inorganic materials 0.000 claims 666
• 125000000623 heterocyclic group Chemical group 0.000 claims 441
• 125000003118 aryl group Chemical group 0.000 claims 352
• 125000001072 heteroaryl group Chemical group 0.000 claims 317
• 229910052736 halogen Inorganic materials 0.000 claims 313
• 150000002367 halogens Chemical class 0.000 claims 291
• 229910052757 nitrogen Inorganic materials 0.000 claims 251
• -1 aralkenyl Chemical group 0.000 claims 241
• 229910052739 hydrogen Inorganic materials 0.000 claims 191
• 239000001257 hydrogen Substances 0.000 claims 191
• 125000004093 cyano group Chemical group *C#N 0.000 claims 167
• 125000001424 substituent group Chemical group 0.000 claims 152
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 144
• 125000003342 alkenyl group Chemical group 0.000 claims 144
• 150000002431 hydrogen Chemical class 0.000 claims 141
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 137
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 113
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 102
• 125000004432 carbon atom Chemical group C* 0.000 claims 91
• 125000003545 alkoxy group Chemical group 0.000 claims 88
• 229910052799 carbon Inorganic materials 0.000 claims 88
• 125000000304 alkynyl group Chemical group 0.000 claims 81
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 81
• 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 76
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims 72
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 72
• KICNGTSGLUFGHH-UHFFFAOYSA-N spiro[1h-indole-3,7'-6h-furo[2,3-f][1,3]benzodioxole]-2-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1NC2=O KICNGTSGLUFGHH-UHFFFAOYSA-N 0.000 claims 66
• 125000003710 aryl alkyl group Chemical group 0.000 claims 65
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 63
• 125000004450 alkenylene group Chemical group 0.000 claims 62
• 125000002947 alkylene group Chemical group 0.000 claims 62
• 125000004419 alkynylene group Chemical group 0.000 claims 62
• 125000000753 cycloalkyl group Chemical group 0.000 claims 59
• 125000005843 halogen group Chemical group 0.000 claims 53
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 52
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 42
• 125000005605 benzo group Chemical group 0.000 claims 41
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 40
• 239000004202 carbamide Substances 0.000 claims 40
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 37
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 33
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 32
• 239000010802 sludge Substances 0.000 claims 31
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 30
• 125000002950 monocyclic group Chemical group 0.000 claims 28
• 239000007789 gas Substances 0.000 claims 25
• 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 19
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 19
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 18
• 125000004043 oxo group Chemical group O=* 0.000 claims 18
• 125000003003 spiro group Chemical group 0.000 claims 18
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 16
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 12
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 10
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 10
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 9
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 8
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 7
• 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 7
• 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims 6
• 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 6
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 6
• 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 6
• 125000000301 2-(3-chlorophenyl)ethyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])* 0.000 claims 5
• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 5
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 5
• 125000006284 3-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(F)=C1[H])C([H])([H])* 0.000 claims 5
• 241000124008 Mammalia Species 0.000 claims 5
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 5
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 5
• PHMRUZIIERITEP-UHFFFAOYSA-N 1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 PHMRUZIIERITEP-UHFFFAOYSA-N 0.000 claims 4
• 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims 4
• 125000002927 2-methoxybenzyl group Chemical group [H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])* 0.000 claims 4
• 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 4
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 4
• 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims 4
• 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 4
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 4
• 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 4
• 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
• 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 4
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 4
• ZMANZCXQSJIPKH-UHFFFAOYSA-N triethylamine Natural products CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 4
• 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims 3
• 125000000579 2,2-diphenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims 3
• 125000006507 2,4-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(F)C(=C1[H])C([H])([H])* 0.000 claims 3
• 125000006282 2-chlorobenzyl group Chemical group [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
• 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims 3
• 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 3
• 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 claims 3
• 101100004031 Mus musculus Aven gene Proteins 0.000 claims 3
• JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 3
• 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 3
• 208000011580 syndromic disease Diseases 0.000 claims 3
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
• GGZDPBXUIMTXCX-UHFFFAOYSA-N 1'-(3-cyclopropylpropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCC1CC1 GGZDPBXUIMTXCX-UHFFFAOYSA-N 0.000 claims 2
• MFQUWJBHQNNTCU-UHFFFAOYSA-N 1'-[(2-methylcyclopropyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CC1CC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O MFQUWJBHQNNTCU-UHFFFAOYSA-N 0.000 claims 2
• LBBWFOKTMLDAQY-UHFFFAOYSA-N 1'-[(6-chloropyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=NC(Cl)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O LBBWFOKTMLDAQY-UHFFFAOYSA-N 0.000 claims 2
• ASYZQJHAJLSZAD-UHFFFAOYSA-N 1'-[(6-methylpyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1=NC(C)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O ASYZQJHAJLSZAD-UHFFFAOYSA-N 0.000 claims 2
• VHZAENHYWWAFBA-UHFFFAOYSA-N 1'-benzhydrylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 VHZAENHYWWAFBA-UHFFFAOYSA-N 0.000 claims 2
• 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 2
• 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 2
• 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 2
• 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 125000006179 2-methyl benzyl group Chemical group [H]C1=C([H])C(=C(C([H])=C1[H])C([H])([H])*)C([H])([H])[H] 0.000 claims 2
• 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 2
• 125000006288 3,5-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(C([H])=C1F)C([H])([H])* 0.000 claims 2
• 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 2
• 125000003852 3-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])* 0.000 claims 2
• 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
• CQMDIWLOIGECLF-UHFFFAOYSA-N 4'-[(4-methyl-1,3-thiazol-2-yl)amino]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=NC(C)=CS1 CQMDIWLOIGECLF-UHFFFAOYSA-N 0.000 claims 2
• HVFUAXCTAFMIBJ-UHFFFAOYSA-N 4'-bromo-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C(Br)C2=C1N(CCCCC)C(=O)C21C2=CC(OCO3)=C3C=C2OC1 HVFUAXCTAFMIBJ-UHFFFAOYSA-N 0.000 claims 2
• MYQYTYFBFKRCPA-UHFFFAOYSA-N 4-(3h-thiadiazol-2-yl)benzamide Chemical compound C1=CC(C(=O)N)=CC=C1N1SC=CN1 MYQYTYFBFKRCPA-UHFFFAOYSA-N 0.000 claims 2
• AHFINSWGYAZBOZ-UHFFFAOYSA-N 4-chloro-2-(trifluoromethyl)benzaldehyde Chemical group FC(F)(F)C1=CC(Cl)=CC=C1C=O AHFINSWGYAZBOZ-UHFFFAOYSA-N 0.000 claims 2
• RNOVGJWJVRESAA-UHFFFAOYSA-N 4-fluoro-2-(trifluoromethyl)phenol Chemical group OC1=CC=C(F)C=C1C(F)(F)F RNOVGJWJVRESAA-UHFFFAOYSA-N 0.000 claims 2
• 125000004861 4-isopropyl phenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• YYVUSJOJYZSQKC-UHFFFAOYSA-N 5'-methyl-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC(C)=CC=C2N1CC1=CC=C(C(F)(F)F)O1 YYVUSJOJYZSQKC-UHFFFAOYSA-N 0.000 claims 2
• 206010015150 Erythema Diseases 0.000 claims 2
• 208000031886 HIV Infections Diseases 0.000 claims 2
• 206010019233 Headaches Diseases 0.000 claims 2
• 208000007914 Labor Pain Diseases 0.000 claims 2
• 208000035945 Labour pain Diseases 0.000 claims 2
• WTCWGULWSBELGJ-UHFFFAOYSA-N N-(6-methoxypyridin-3-yl)-1-pentylspiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole]-4-amine Chemical compound COC1=CC=C(C=N1)NC1=C2C3(CN(C2=CC=C1)CCCCC)COC1=CC2=C(OCO2)C=C13 WTCWGULWSBELGJ-UHFFFAOYSA-N 0.000 claims 2
• HVDBZFLTCGVQTG-UHFFFAOYSA-N N-[(2'-oxospiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]benzamide Chemical compound C(C1=CC=CC=C1)(=O)NCN1C(C2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12)=O HVDBZFLTCGVQTG-UHFFFAOYSA-N 0.000 claims 2
• LIYAJABVPAMACB-UHFFFAOYSA-N N1=CC2(COC=3C2=CC2=C(OCO2)C3)C3=CC=CC=C13 Chemical compound N1=CC2(COC=3C2=CC2=C(OCO2)C3)C3=CC=CC=C13 LIYAJABVPAMACB-UHFFFAOYSA-N 0.000 claims 2
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
• 206010003119 arrhythmia Diseases 0.000 claims 2
• 230000006793 arrhythmia Effects 0.000 claims 2
• METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 claims 2
• 230000001419 dependent effect Effects 0.000 claims 2
• 231100000321 erythema Toxicity 0.000 claims 2
• 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 2
• 150000002500 ions Chemical class 0.000 claims 2
• 201000006417 multiple sclerosis Diseases 0.000 claims 2
• HWVFMWDZJQLZHS-UHFFFAOYSA-N n,n-bis(trifluoromethyl)benzamide Chemical compound FC(F)(F)N(C(F)(F)F)C(=O)C1=CC=CC=C1 HWVFMWDZJQLZHS-UHFFFAOYSA-N 0.000 claims 2
• 208000004296 neuralgia Diseases 0.000 claims 2
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 2
• 208000033808 peripheral neuropathy Diseases 0.000 claims 2
• 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 2
• DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims 2
• OTRJYIUNPJCQFU-UHFFFAOYSA-N (2-oxospiro[1h-indole-3,3'-2h-1-benzofuran]-5'-yl) trifluoromethanesulfonate Chemical compound O=C1NC2=CC=CC=C2C21COC1=CC=C(OS(=O)(=O)C(F)(F)F)C=C12 OTRJYIUNPJCQFU-UHFFFAOYSA-N 0.000 claims 1
• BKMXPNAWGWSRIY-UHFFFAOYSA-N (3,4,5-trimethoxyphenyl)methylurea Chemical compound COC1=CC(CNC(N)=O)=CC(OC)=C1OC BKMXPNAWGWSRIY-UHFFFAOYSA-N 0.000 claims 1
• 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
• RPEULPUEYFQGPF-UHFFFAOYSA-N 1'-(1,2,4-oxadiazol-3-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC=1N=CON=1 RPEULPUEYFQGPF-UHFFFAOYSA-N 0.000 claims 1
• VTPRPQDBWWGAFL-UHFFFAOYSA-N 1'-(1,3-benzodioxol-5-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC=1C=C3OCOC3=CC=1)C2=O VTPRPQDBWWGAFL-UHFFFAOYSA-N 0.000 claims 1
• JRESYUYCWHYDCY-UHFFFAOYSA-N 1'-(1,3-thiazol-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CSC=N1 JRESYUYCWHYDCY-UHFFFAOYSA-N 0.000 claims 1
• ARATTZXFWCIHQP-UHFFFAOYSA-N 1'-(2,1,3-benzothiadiazol-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC=1C3=NSN=C3C=CC=1)C2=O ARATTZXFWCIHQP-UHFFFAOYSA-N 0.000 claims 1
• VSYDOYJZDIOHIN-UHFFFAOYSA-N 1'-(2,1,3-benzothiadiazol-5-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC1=CC3=NSN=C3C=C1)C2=O VSYDOYJZDIOHIN-UHFFFAOYSA-N 0.000 claims 1
• OBXXDQDEVYLRRA-UHFFFAOYSA-N 1'-(2,1,3-benzoxadiazol-5-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC1=CC3=NON=C3C=C1)C2=O OBXXDQDEVYLRRA-UHFFFAOYSA-N 0.000 claims 1
• NKFPSNRHRZXGDX-UHFFFAOYSA-N 1'-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC1OC3=CC=CC=C3OC1)C2=O NKFPSNRHRZXGDX-UHFFFAOYSA-N 0.000 claims 1
• QVYXLZNJHVDOPG-UHFFFAOYSA-N 1'-(2-aminoethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCN)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QVYXLZNJHVDOPG-UHFFFAOYSA-N 0.000 claims 1
• QBBPVYOZLZVPEK-UHFFFAOYSA-N 1'-(2-bromoethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCBr)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QBBPVYOZLZVPEK-UHFFFAOYSA-N 0.000 claims 1
• CAWCKOZFWXJYGT-UHFFFAOYSA-N 1'-(2-cyclopropylethyl)-4'-quinolin-3-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC(C=3C=C4C=CC=CC4=NC=3)=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCC1CC1 CAWCKOZFWXJYGT-UHFFFAOYSA-N 0.000 claims 1
• ZQCFXLVLNULFCD-UHFFFAOYSA-N 1'-(2-cyclopropylethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCC1CC1 ZQCFXLVLNULFCD-UHFFFAOYSA-N 0.000 claims 1
• SSAAEWBZOTUPNX-UHFFFAOYSA-N 1'-(2-ethoxyethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCOCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 SSAAEWBZOTUPNX-UHFFFAOYSA-N 0.000 claims 1
• NZEOITLIMNITRZ-UHFFFAOYSA-N 1'-(2-ethylbutyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CC(CC)CC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 NZEOITLIMNITRZ-UHFFFAOYSA-N 0.000 claims 1
• FVDMZRBAWQAOOZ-UHFFFAOYSA-N 1'-(2-morpholin-4-yl-2-oxoethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC(=O)N1CCOCC1 FVDMZRBAWQAOOZ-UHFFFAOYSA-N 0.000 claims 1
• BPDQMSDNTVPVIC-UHFFFAOYSA-N 1'-(2-oxo-2-piperidin-1-ylethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC(=O)N1CCCCC1 BPDQMSDNTVPVIC-UHFFFAOYSA-N 0.000 claims 1
• NPUKYFDTBUQMSC-UHFFFAOYSA-N 1'-(3,4-dihydro-2h-1,5-benzodioxepin-7-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1CCCOC2=CC(CN3C(C4(C5=CC=6OCOC=6C=C5OC4)C4=CC=CC=C43)=O)=CC=C21 NPUKYFDTBUQMSC-UHFFFAOYSA-N 0.000 claims 1
• QMEKTTCBVOOSHJ-UHFFFAOYSA-N 1'-(3-aminopropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QMEKTTCBVOOSHJ-UHFFFAOYSA-N 0.000 claims 1
• QRTMSVZHEMRJFE-UHFFFAOYSA-N 1'-(3-chloropropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCl)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QRTMSVZHEMRJFE-UHFFFAOYSA-N 0.000 claims 1
• GQAMGYNINYASHU-UHFFFAOYSA-N 1'-(3-hydroxypropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCO)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 GQAMGYNINYASHU-UHFFFAOYSA-N 0.000 claims 1
• WEPGWUYYPMCUDT-UHFFFAOYSA-N 1'-(3-methylbut-2-enyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CC=C(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 WEPGWUYYPMCUDT-UHFFFAOYSA-N 0.000 claims 1
• SQXXJGJKOCQFBH-UHFFFAOYSA-N 1'-(3-phenylmethoxypropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCOCC1=CC=CC=C1 SQXXJGJKOCQFBH-UHFFFAOYSA-N 0.000 claims 1
• CJBQJCRGRVFUOT-UHFFFAOYSA-N 1'-(3-piperidin-1-ylpropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCN1CCCCC1 CJBQJCRGRVFUOT-UHFFFAOYSA-N 0.000 claims 1
• BOUAZUSMAPCRKM-UHFFFAOYSA-N 1'-(3-pyrrolidin-1-ylpropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCN1CCCC1 BOUAZUSMAPCRKM-UHFFFAOYSA-N 0.000 claims 1
• SCELVKQCHNUOOH-UHFFFAOYSA-N 1'-(4,4,4-trifluorobutyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCC(F)(F)F)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 SCELVKQCHNUOOH-UHFFFAOYSA-N 0.000 claims 1
• GOFZKOOXCCSCFO-UHFFFAOYSA-N 1'-(4-fluorobutyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCF)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 GOFZKOOXCCSCFO-UHFFFAOYSA-N 0.000 claims 1
• XYEIWIUZVAEGJE-UHFFFAOYSA-N 1'-(4-methylpentyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 XYEIWIUZVAEGJE-UHFFFAOYSA-N 0.000 claims 1
• NTPSMBDHZVNDHS-UHFFFAOYSA-N 1'-(5-chloropentyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCCCl)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 NTPSMBDHZVNDHS-UHFFFAOYSA-N 0.000 claims 1
• SIOYIEGGMNRCOQ-UHFFFAOYSA-N 1'-(5-methylhexyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 SIOYIEGGMNRCOQ-UHFFFAOYSA-N 0.000 claims 1
• LMYIODPHDKTUIO-UHFFFAOYSA-N 1'-(cyclobutylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCC1 LMYIODPHDKTUIO-UHFFFAOYSA-N 0.000 claims 1
• OGKXJSLVDCYBIQ-UHFFFAOYSA-N 1'-(cyclohexylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCCCC1 OGKXJSLVDCYBIQ-UHFFFAOYSA-N 0.000 claims 1
• YHERPHNXNWNVOO-UHFFFAOYSA-N 1'-(cyclopropylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CC1 YHERPHNXNWNVOO-UHFFFAOYSA-N 0.000 claims 1
• MCQZHODKEUGHMD-UHFFFAOYSA-N 1'-(furan-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CO1 MCQZHODKEUGHMD-UHFFFAOYSA-N 0.000 claims 1
• YISYALOZMMIVDE-UHFFFAOYSA-N 1'-(naphthalen-1-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC=1C3=CC=CC=C3C=CC=1)C2=O YISYALOZMMIVDE-UHFFFAOYSA-N 0.000 claims 1
• IRTXUHFNKHSVMV-UHFFFAOYSA-N 1'-(oxan-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCCCO1 IRTXUHFNKHSVMV-UHFFFAOYSA-N 0.000 claims 1
• BFVPTTJCADYNAJ-UHFFFAOYSA-N 1'-(oxan-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCOCC1 BFVPTTJCADYNAJ-UHFFFAOYSA-N 0.000 claims 1
• XGZKLUXHCVAMQO-UHFFFAOYSA-N 1'-(oxolan-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCCO1 XGZKLUXHCVAMQO-UHFFFAOYSA-N 0.000 claims 1
• LHJYTPHTRANOAL-UHFFFAOYSA-N 1'-(phenylmethoxymethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1COCC1=CC=CC=C1 LHJYTPHTRANOAL-UHFFFAOYSA-N 0.000 claims 1
• JZKHDHFPODDKMV-UHFFFAOYSA-N 1'-(piperidin-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCNCC1 JZKHDHFPODDKMV-UHFFFAOYSA-N 0.000 claims 1
• FTOGYMPSUFBHJN-UHFFFAOYSA-N 1'-(pyridin-2-ylmethyl)-6-(trifluoromethoxy)spiro[2h-1-benzofuran-3,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C=1C(OC(F)(F)F)=CC=C2C=1OCC2(C1=CC=CC=C11)C(=O)N1CC1=CC=CC=N1 FTOGYMPSUFBHJN-UHFFFAOYSA-N 0.000 claims 1
• SQICVPOVJXBQIN-UHFFFAOYSA-N 1'-(pyridin-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CC=N1 SQICVPOVJXBQIN-UHFFFAOYSA-N 0.000 claims 1
• SWKJUHBCOLARHI-UHFFFAOYSA-N 1'-(pyridin-3-ylmethyl)-6-(trifluoromethoxy)spiro[2h-1-benzofuran-3,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C=1C(OC(F)(F)F)=CC=C2C=1OCC2(C1=CC=CC=C11)C(=O)N1CC1=CC=CN=C1 SWKJUHBCOLARHI-UHFFFAOYSA-N 0.000 claims 1
• AJTGUERLIJOXRF-UHFFFAOYSA-N 1'-(pyridin-3-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CN=C1 AJTGUERLIJOXRF-UHFFFAOYSA-N 0.000 claims 1
• BCCYMGKEQKJKOZ-UHFFFAOYSA-N 1'-(pyridin-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=NC=C1 BCCYMGKEQKJKOZ-UHFFFAOYSA-N 0.000 claims 1
• IOUPBOXMRKTMGK-UHFFFAOYSA-N 1'-(thiophen-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CS1 IOUPBOXMRKTMGK-UHFFFAOYSA-N 0.000 claims 1
• IIQACCGKWWUQSE-UHFFFAOYSA-N 1'-[(1-ethylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(CC)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O IIQACCGKWWUQSE-UHFFFAOYSA-N 0.000 claims 1
• SLROUEVGEJXQDO-UHFFFAOYSA-N 1'-[(1-methyl-6-oxopyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(=O)N(C)C=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O SLROUEVGEJXQDO-UHFFFAOYSA-N 0.000 claims 1
• VMOJFBHVOGHJRQ-UHFFFAOYSA-N 1'-[(1-methylbenzotriazol-5-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=CC=C2N(C)N=NC2=C1 VMOJFBHVOGHJRQ-UHFFFAOYSA-N 0.000 claims 1
• DYUITQZLECTEEV-UHFFFAOYSA-N 1'-[(1-methylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(C)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O DYUITQZLECTEEV-UHFFFAOYSA-N 0.000 claims 1
• WVOJCMQIONWQQK-UHFFFAOYSA-N 1'-[(2,3-difluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1F WVOJCMQIONWQQK-UHFFFAOYSA-N 0.000 claims 1
• CNIISRVZSVZYRD-UHFFFAOYSA-N 1'-[(2,5-difluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=C(F)C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 CNIISRVZSVZYRD-UHFFFAOYSA-N 0.000 claims 1
• QVNNBLFAIHQNGV-UHFFFAOYSA-N 1'-[(2,6-difluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(F)=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O QVNNBLFAIHQNGV-UHFFFAOYSA-N 0.000 claims 1
• NZSGJTDQUFOQEI-UHFFFAOYSA-N 1'-[(2-chloro-1,3-thiazol-5-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C(Cl)=NC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O NZSGJTDQUFOQEI-UHFFFAOYSA-N 0.000 claims 1
• YUJBKOVXXMEPFL-UHFFFAOYSA-N 1'-[(2-chloro-4-fluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound ClC1=CC(F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O YUJBKOVXXMEPFL-UHFFFAOYSA-N 0.000 claims 1
• XKZZFRZGGCDJTK-UHFFFAOYSA-N 1'-[(2-methyl-1,3-thiazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C(C)=NC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 XKZZFRZGGCDJTK-UHFFFAOYSA-N 0.000 claims 1
• YIXYHDKIFLPTNX-UHFFFAOYSA-N 1'-[(2-phenylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CC=C1C1=CC=CC=C1 YIXYHDKIFLPTNX-UHFFFAOYSA-N 0.000 claims 1
• KEYCNSBXRZCERC-UHFFFAOYSA-N 1'-[(2-propan-2-yl-1,3-oxazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(C(C)C)=NC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 KEYCNSBXRZCERC-UHFFFAOYSA-N 0.000 claims 1
• VDNNGROEBXRVQB-UHFFFAOYSA-N 1'-[(3-fluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 VDNNGROEBXRVQB-UHFFFAOYSA-N 0.000 claims 1
• CKTUKNOPGUZTPA-UHFFFAOYSA-N 1'-[(3-methoxyphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound COC1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 CKTUKNOPGUZTPA-UHFFFAOYSA-N 0.000 claims 1
• QHIBPTVXLHQTMD-UHFFFAOYSA-N 1'-[(3-nitrophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound [O-][N+](=O)C1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 QHIBPTVXLHQTMD-UHFFFAOYSA-N 0.000 claims 1
• VBHPJGRHUZKUJA-UHFFFAOYSA-N 1'-[(4-chlorophenoxy)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(Cl)=CC=C1OCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O VBHPJGRHUZKUJA-UHFFFAOYSA-N 0.000 claims 1
• CBZDSRKPCQBACL-UHFFFAOYSA-N 1'-[(4-fluoro-3-methylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(F)C(C)=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 CBZDSRKPCQBACL-UHFFFAOYSA-N 0.000 claims 1
• DTVRNKGYGSHILK-UHFFFAOYSA-N 1'-[(4-fluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O DTVRNKGYGSHILK-UHFFFAOYSA-N 0.000 claims 1
• CNPOLAKRFUNSKM-UHFFFAOYSA-N 1'-[(4-hydroxy-1,2,2,6,6-pentamethylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1C(C)(C)N(C)C(C)(C)CC1(O)CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O CNPOLAKRFUNSKM-UHFFFAOYSA-N 0.000 claims 1
• ZLYVJSRDNJIKGH-UHFFFAOYSA-N 1'-[(4-methoxyphenyl)methyl]-6-(trifluoromethoxy)spiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C1=CC(OC)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=C(OC(F)(F)F)C=C3OC2)C1=O ZLYVJSRDNJIKGH-UHFFFAOYSA-N 0.000 claims 1
• SRIOKKJYFBEZSD-UHFFFAOYSA-N 1'-[(5-bromofuran-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(Br)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O SRIOKKJYFBEZSD-UHFFFAOYSA-N 0.000 claims 1
• RDOOPPPVWNCVGI-UHFFFAOYSA-N 1'-[(5-chloro-1,3,4-thiadiazol-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C(Cl)=NN=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O RDOOPPPVWNCVGI-UHFFFAOYSA-N 0.000 claims 1
• PXNLGQYRAQQLRL-UHFFFAOYSA-N 1'-[(5-chlorofuran-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(Cl)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O PXNLGQYRAQQLRL-UHFFFAOYSA-N 0.000 claims 1
• JNBPICRKECPDTB-UHFFFAOYSA-N 1'-[(5-chlorothiophen-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C(Cl)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O JNBPICRKECPDTB-UHFFFAOYSA-N 0.000 claims 1
• QDZCRRSOTKOOEY-UHFFFAOYSA-N 1'-[(5-fluoro-2-methylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CC1=CC=C(F)C=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O QDZCRRSOTKOOEY-UHFFFAOYSA-N 0.000 claims 1
• VQCYDVYLHDWDNZ-UHFFFAOYSA-N 1'-[(5-methyl-1,2-oxazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1N=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1C VQCYDVYLHDWDNZ-UHFFFAOYSA-N 0.000 claims 1
• IIALACDSVNRKDV-UHFFFAOYSA-N 1'-[(5-methyl-2-phenyltriazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound N1=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C(C)=NN1C1=CC=CC=C1 IIALACDSVNRKDV-UHFFFAOYSA-N 0.000 claims 1
• WJDNFTGYDVTHDN-UHFFFAOYSA-N 1'-[(5-phenyl-1,3-oxazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC=1N=COC=1C1=CC=CC=C1 WJDNFTGYDVTHDN-UHFFFAOYSA-N 0.000 claims 1
• NHFVLUQQMNIGQA-UHFFFAOYSA-N 1'-[(6-fluoro-4h-1,3-benzodioxin-8-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1COCC2=CC(F)=CC(CN3C4=CC=CC=C4C4(C5=CC=6OCOC=6C=C5OC4)C3=O)=C21 NHFVLUQQMNIGQA-UHFFFAOYSA-N 0.000 claims 1
• QCAQXSVYHMLDNO-UHFFFAOYSA-N 1'-[(6-methoxypyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=NC(OC)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O QCAQXSVYHMLDNO-UHFFFAOYSA-N 0.000 claims 1
• KTEJABWLSIDCJF-UHFFFAOYSA-N 1'-[(6-morpholin-4-ylpyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=N1)=CC=C1N1CCOCC1 KTEJABWLSIDCJF-UHFFFAOYSA-N 0.000 claims 1
• YJOUTZMMEUJKFB-UHFFFAOYSA-N 1'-[(6-oxo-1h-pyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC=1C=CC(=O)NC=1 YJOUTZMMEUJKFB-UHFFFAOYSA-N 0.000 claims 1
• YJQSCPRMCHUZAL-UHFFFAOYSA-N 1'-[(6-pyrrolidin-1-ylpyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=N1)=CC=C1N1CCCC1 YJQSCPRMCHUZAL-UHFFFAOYSA-N 0.000 claims 1
• NMLFFWKYAICRGF-UHFFFAOYSA-N 1'-[(7-methoxy-2-oxo-1,4-benzoxazin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=NC2=CC=C(OC)C=C2OC1=O NMLFFWKYAICRGF-UHFFFAOYSA-N 0.000 claims 1
• UVLKIDCBVFNEOG-UHFFFAOYSA-N 1'-[(7-methoxy-2-oxochromen-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=CC(=O)OC2=CC(OC)=CC=C21 UVLKIDCBVFNEOG-UHFFFAOYSA-N 0.000 claims 1
• GUOJXISRQSLSJW-UHFFFAOYSA-N 1'-[2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1CC(C)(C)COC1(C)CCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O GUOJXISRQSLSJW-UHFFFAOYSA-N 0.000 claims 1
• GWFFQXNKIDYQPZ-UHFFFAOYSA-N 1'-[2-(2-methoxyethoxy)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCOCCOC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 GWFFQXNKIDYQPZ-UHFFFAOYSA-N 0.000 claims 1
• DMETYASETWMKDX-UHFFFAOYSA-N 1'-[2-(diethylamino)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCN(CC)CC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 DMETYASETWMKDX-UHFFFAOYSA-N 0.000 claims 1
• FTKFBEZKJKDETG-UHFFFAOYSA-N 1'-[2-(dipyridin-2-ylamino)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCN(C=1N=CC=CC=1)C1=CC=CC=N1 FTKFBEZKJKDETG-UHFFFAOYSA-N 0.000 claims 1
• IYGPXKMZGBDZBB-UHFFFAOYSA-N 1'-[2-(pyridin-2-ylamino)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCNC1=CC=CC=N1 IYGPXKMZGBDZBB-UHFFFAOYSA-N 0.000 claims 1
• ZJCQRDCZAJGIAZ-UHFFFAOYSA-N 1'-[3-(1-phenylpropan-2-ylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCCNC(C)CC1=CC=CC=C1 ZJCQRDCZAJGIAZ-UHFFFAOYSA-N 0.000 claims 1
• XHAYGGWAINLZBA-UHFFFAOYSA-N 1'-[3-(2,2,2-trifluoroethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCC(F)(F)F)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 XHAYGGWAINLZBA-UHFFFAOYSA-N 0.000 claims 1
• BGEVEDJWJVANIK-UHFFFAOYSA-N 1'-[3-(2-cyclohexylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1CCCCC1 BGEVEDJWJVANIK-UHFFFAOYSA-N 0.000 claims 1
• ZWVBSNRCANQYBC-UHFFFAOYSA-N 1'-[3-(2-cyclopropylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1CC1 ZWVBSNRCANQYBC-UHFFFAOYSA-N 0.000 claims 1
• GKPLEGSELZQOTP-UHFFFAOYSA-N 1'-[3-(2-ethoxyethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCOCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 GKPLEGSELZQOTP-UHFFFAOYSA-N 0.000 claims 1
• LJRMJCNWSHKGEP-UHFFFAOYSA-N 1'-[3-(2-methylpropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 LJRMJCNWSHKGEP-UHFFFAOYSA-N 0.000 claims 1
• CMWJKTXLFOEZEZ-UHFFFAOYSA-N 1'-[3-(2-morpholin-4-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCN1CCOCC1 CMWJKTXLFOEZEZ-UHFFFAOYSA-N 0.000 claims 1
• YOTXLZNPGJPHMA-UHFFFAOYSA-N 1'-[3-(2-phenylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1=CC=CC=C1 YOTXLZNPGJPHMA-UHFFFAOYSA-N 0.000 claims 1
• IDPKQUVBWCGWLS-UHFFFAOYSA-N 1'-[3-(2-piperidin-1-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCN1CCCCC1 IDPKQUVBWCGWLS-UHFFFAOYSA-N 0.000 claims 1
• OFKYTAQWJRVYFL-UHFFFAOYSA-N 1'-[3-(2-propan-2-yloxyethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCOC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 OFKYTAQWJRVYFL-UHFFFAOYSA-N 0.000 claims 1
• GIVMUMRKJJGCBV-UHFFFAOYSA-N 1'-[3-(2-pyridin-2-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1=CC=CC=N1 GIVMUMRKJJGCBV-UHFFFAOYSA-N 0.000 claims 1
• NQRKQWACFYEZHR-UHFFFAOYSA-N 1'-[3-(2-pyridin-3-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1=CC=CN=C1 NQRKQWACFYEZHR-UHFFFAOYSA-N 0.000 claims 1
• KTPWASWOTPXWSH-UHFFFAOYSA-N 1'-[3-(2-pyrrolidin-1-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCN1CCCC1 KTPWASWOTPXWSH-UHFFFAOYSA-N 0.000 claims 1
• IERASTOZDZPGKT-UHFFFAOYSA-N 1'-[3-(3-ethoxypropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCOCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 IERASTOZDZPGKT-UHFFFAOYSA-N 0.000 claims 1
• WCFWUULSAZRTMZ-UHFFFAOYSA-N 1'-[3-(3-methoxypropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCOC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 WCFWUULSAZRTMZ-UHFFFAOYSA-N 0.000 claims 1
• WGESBNGESRFZSI-UHFFFAOYSA-N 1'-[3-(3-methylbutylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 WGESBNGESRFZSI-UHFFFAOYSA-N 0.000 claims 1
• LZSIEVQKLPECOI-UHFFFAOYSA-N 1'-[3-(3-morpholin-4-ylpropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCCN1CCOCC1 LZSIEVQKLPECOI-UHFFFAOYSA-N 0.000 claims 1
• HNCNQTHOSBIPGC-UHFFFAOYSA-N 1'-[3-(3-phenylpropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCCC1=CC=CC=C1 HNCNQTHOSBIPGC-UHFFFAOYSA-N 0.000 claims 1
• ZNYVZFDSYHHZAE-UHFFFAOYSA-N 1'-[3-(3-propan-2-yloxypropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCOC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 ZNYVZFDSYHHZAE-UHFFFAOYSA-N 0.000 claims 1
• OPEYMDGMAZOWLV-UHFFFAOYSA-N 1'-[3-(4-chloroanilino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(Cl)=CC=C1NCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O OPEYMDGMAZOWLV-UHFFFAOYSA-N 0.000 claims 1
• KHUOVTZHBOHNIQ-UHFFFAOYSA-N 1'-[3-(benzylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1=CC=CC=C1 KHUOVTZHBOHNIQ-UHFFFAOYSA-N 0.000 claims 1
• ZZOXELOTQICWBO-UHFFFAOYSA-N 1'-[3-(cyclobutylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNC1CCC1 ZZOXELOTQICWBO-UHFFFAOYSA-N 0.000 claims 1
• LUYOBNDESCLUEH-UHFFFAOYSA-N 1'-[3-(cyclohexylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNC1CCCCC1 LUYOBNDESCLUEH-UHFFFAOYSA-N 0.000 claims 1
• UOUKWMJAQFNKGK-UHFFFAOYSA-N 1'-[3-(cyclohexylmethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1CCCCC1 UOUKWMJAQFNKGK-UHFFFAOYSA-N 0.000 claims 1
• UPDLYRDYEYEHOW-UHFFFAOYSA-N 1'-[3-(cyclopentylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNC1CCCC1 UPDLYRDYEYEHOW-UHFFFAOYSA-N 0.000 claims 1
• UISDRWUXULANES-UHFFFAOYSA-N 1'-[3-(cyclopropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNC1CC1 UISDRWUXULANES-UHFFFAOYSA-N 0.000 claims 1
• BEEMRHMMNBBFKU-UHFFFAOYSA-N 1'-[3-(cyclopropylmethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1CC1 BEEMRHMMNBBFKU-UHFFFAOYSA-N 0.000 claims 1
• PXVJDDCCIYXSPR-UHFFFAOYSA-N 1'-[3-(dibenzylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCN(CC=1C=CC=CC=1)CC1=CC=CC=C1 PXVJDDCCIYXSPR-UHFFFAOYSA-N 0.000 claims 1
• JCMJXQVYLSVERX-UHFFFAOYSA-N 1'-[3-(dibutylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(CCCC)CCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 JCMJXQVYLSVERX-UHFFFAOYSA-N 0.000 claims 1
• YFAQUCZKCHFRNE-UHFFFAOYSA-N 1'-[3-(diethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(CC)CC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 YFAQUCZKCHFRNE-UHFFFAOYSA-N 0.000 claims 1
• RDWJRFRCVQZACW-UHFFFAOYSA-N 1'-[3-(dipropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(CCC)CCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 RDWJRFRCVQZACW-UHFFFAOYSA-N 0.000 claims 1
• VNYQRQRGWZFLDX-UHFFFAOYSA-N 1'-[3-(ethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 VNYQRQRGWZFLDX-UHFFFAOYSA-N 0.000 claims 1
• BPYFAQKNQFVZIZ-UHFFFAOYSA-N 1'-[3-(furan-2-ylmethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1=CC=CO1 BPYFAQKNQFVZIZ-UHFFFAOYSA-N 0.000 claims 1
• WJLAJIVERFTSGL-UHFFFAOYSA-N 1'-[3-(heptylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 WJLAJIVERFTSGL-UHFFFAOYSA-N 0.000 claims 1
• DROIEEGOLIMRBU-UHFFFAOYSA-N 1'-[3-(hexylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 DROIEEGOLIMRBU-UHFFFAOYSA-N 0.000 claims 1
• FBNNHEWWOKNJJJ-UHFFFAOYSA-N 1'-[3-(methylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 FBNNHEWWOKNJJJ-UHFFFAOYSA-N 0.000 claims 1
• FUAKYDPHCKZGBA-UHFFFAOYSA-N 1'-[3-(octylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 FUAKYDPHCKZGBA-UHFFFAOYSA-N 0.000 claims 1
• VUEZNLMJVVUHJB-UHFFFAOYSA-N 1'-[3-(pentan-2-ylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNC(C)CCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 VUEZNLMJVVUHJB-UHFFFAOYSA-N 0.000 claims 1
• ISJQJNRXVQAQLY-UHFFFAOYSA-N 1'-[3-(pentylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 ISJQJNRXVQAQLY-UHFFFAOYSA-N 0.000 claims 1
• PLOCDOPROXMVQK-UHFFFAOYSA-N 1'-[3-(propan-2-ylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 PLOCDOPROXMVQK-UHFFFAOYSA-N 0.000 claims 1
• XFELXRGXQMNWJP-UHFFFAOYSA-N 1'-[3-(propylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 XFELXRGXQMNWJP-UHFFFAOYSA-N 0.000 claims 1
• DILASYFAVLTISK-UHFFFAOYSA-N 1'-[3-[(2-chlorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound ClC1=CC=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O DILASYFAVLTISK-UHFFFAOYSA-N 0.000 claims 1
• ZODZMHGOSAKWPY-UHFFFAOYSA-N 1'-[3-[(2-fluorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O ZODZMHGOSAKWPY-UHFFFAOYSA-N 0.000 claims 1
• MEEMDZHVQBAUDY-UHFFFAOYSA-N 1'-[3-[(2-methylphenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CC1=CC=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O MEEMDZHVQBAUDY-UHFFFAOYSA-N 0.000 claims 1
• KLPVJDRSPLQDDW-UHFFFAOYSA-N 1'-[3-[(3-fluorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(CNCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 KLPVJDRSPLQDDW-UHFFFAOYSA-N 0.000 claims 1
• BYZBJKQJIRMDJL-UHFFFAOYSA-N 1'-[3-[(3-methylphenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CC1=CC=CC(CNCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 BYZBJKQJIRMDJL-UHFFFAOYSA-N 0.000 claims 1
• AOGOECHLLUJSEE-UHFFFAOYSA-N 1'-[3-[(4-chlorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(Cl)=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O AOGOECHLLUJSEE-UHFFFAOYSA-N 0.000 claims 1
• NFAVDEHOSBHAGE-UHFFFAOYSA-N 1'-[3-[(4-fluorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(F)=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O NFAVDEHOSBHAGE-UHFFFAOYSA-N 0.000 claims 1
• IXJAPWUOUCVUBD-UHFFFAOYSA-N 1'-[3-[(4-methoxyphenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(OC)=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O IXJAPWUOUCVUBD-UHFFFAOYSA-N 0.000 claims 1
• BHGKHGRGPYLBFJ-UHFFFAOYSA-N 1'-[3-[2-(1-methylpyrrolidin-2-yl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CN1CCCC1CCNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O BHGKHGRGPYLBFJ-UHFFFAOYSA-N 0.000 claims 1
• CNLNTOSWWGLRBL-UHFFFAOYSA-N 1'-[3-[2-(2-chlorophenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound ClC1=CC=CC=C1CCNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O CNLNTOSWWGLRBL-UHFFFAOYSA-N 0.000 claims 1
• WLMWLYMCMQDYFT-UHFFFAOYSA-N 1'-[3-[2-(3-fluorophenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(CCNCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 WLMWLYMCMQDYFT-UHFFFAOYSA-N 0.000 claims 1
• KYVMDVPKCQYOHG-UHFFFAOYSA-N 1'-[3-[2-(4-fluorophenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(F)=CC=C1CCNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O KYVMDVPKCQYOHG-UHFFFAOYSA-N 0.000 claims 1
• ZMNCNZXODMGMKV-UHFFFAOYSA-N 1'-[3-[2-(4-methylphenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(C)=CC=C1CCNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O ZMNCNZXODMGMKV-UHFFFAOYSA-N 0.000 claims 1
• LSKIODHJZLRCHT-UHFFFAOYSA-N 1'-[3-[2-(4-phenylphenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC(C=C1)=CC=C1C1=CC=CC=C1 LSKIODHJZLRCHT-UHFFFAOYSA-N 0.000 claims 1
• IQYCAXRMNVCNOF-UHFFFAOYSA-N 1'-[3-[butyl(methyl)amino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(C)CCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 IQYCAXRMNVCNOF-UHFFFAOYSA-N 0.000 claims 1
• ALVULQJOJUSPIX-UHFFFAOYSA-N 1'-[3-[di(propan-2-yl)amino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(C(C)C)C(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 ALVULQJOJUSPIX-UHFFFAOYSA-N 0.000 claims 1
• VYWBCISEJJHPLO-UHFFFAOYSA-N 1'-[4,4-bis(4-fluorophenyl)butyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O VYWBCISEJJHPLO-UHFFFAOYSA-N 0.000 claims 1
• XWIPCPSWCFODHH-UHFFFAOYSA-N 1'-[[1-(3,3-dimethylbutyl)piperidin-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(CCC(C)(C)C)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O XWIPCPSWCFODHH-UHFFFAOYSA-N 0.000 claims 1
• LCMYJUQZARTJDT-UHFFFAOYSA-N 1'-[[1-(thiophen-2-ylmethyl)piperidin-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(CC1)CCN1CC1=CC=CS1 LCMYJUQZARTJDT-UHFFFAOYSA-N 0.000 claims 1
• TYZBBAXGNKGMNQ-UHFFFAOYSA-N 1'-[[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(F)=C1CN1N=NC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 TYZBBAXGNKGMNQ-UHFFFAOYSA-N 0.000 claims 1
• QERDOWSUOLIWGH-UHFFFAOYSA-N 1'-[[2-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=CC=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=1C(=O)N(CC1)CCN1C1=NC=CC=N1 QERDOWSUOLIWGH-UHFFFAOYSA-N 0.000 claims 1
• YZAHGFMEHSSKIA-UHFFFAOYSA-N 1'-[[2-(morpholine-4-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=CC=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=1C(=O)N1CCOCC1 YZAHGFMEHSSKIA-UHFFFAOYSA-N 0.000 claims 1
• AIVPHMZRHAXRHH-UHFFFAOYSA-N 1'-[[2-(piperidine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=CC=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=1C(=O)N1CCCCC1 AIVPHMZRHAXRHH-UHFFFAOYSA-N 0.000 claims 1
• AVFVDDSXMJXONJ-UHFFFAOYSA-N 1'-[[2-[4-(1,3-benzodioxol-5-ylmethyl)piperazine-1-carbonyl]phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=CC=CC=C1C(=O)N1CCN(CC=2C=C3OCOC3=CC=2)CC1 AVFVDDSXMJXONJ-UHFFFAOYSA-N 0.000 claims 1
• NUXBCNBOWPVIIA-UHFFFAOYSA-N 1'-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=C(C(F)(F)F)C=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O NUXBCNBOWPVIIA-UHFFFAOYSA-N 0.000 claims 1
• HDRYXQCJOGBONA-UHFFFAOYSA-N 1'-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(C(F)(F)F)=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O HDRYXQCJOGBONA-UHFFFAOYSA-N 0.000 claims 1
• SEAKXUNSPYBGCJ-UHFFFAOYSA-N 1'-[[3-(4-methylpiperazine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1CN(C)CCN1C(=O)C1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 SEAKXUNSPYBGCJ-UHFFFAOYSA-N 0.000 claims 1
• RTCCXWATAANXDR-UHFFFAOYSA-N 1'-[[3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=CC=1C(=O)N(CC1)CCN1C1=NC=CC=N1 RTCCXWATAANXDR-UHFFFAOYSA-N 0.000 claims 1
• JRWLPCXSMARLHX-UHFFFAOYSA-N 1'-[[3-(morpholine-4-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=CC=1C(=O)N1CCOCC1 JRWLPCXSMARLHX-UHFFFAOYSA-N 0.000 claims 1
• LJEDAVATEIRHHF-UHFFFAOYSA-N 1'-[[3-(piperidine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=CC=1C(=O)N1CCCCC1 LJEDAVATEIRHHF-UHFFFAOYSA-N 0.000 claims 1
• TVQUIPUFUDUAHL-UHFFFAOYSA-N 1'-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(C(F)(F)F)C(F)=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 TVQUIPUFUDUAHL-UHFFFAOYSA-N 0.000 claims 1
• HZCJPQPBMYEGLM-UHFFFAOYSA-N 1'-[[3-hydroxy-5-(trifluoromethyl)thiophen-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(C(F)(F)F)SC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1O HZCJPQPBMYEGLM-UHFFFAOYSA-N 0.000 claims 1
• ANMKGVMPNMUIEO-UHFFFAOYSA-N 1'-[[3-methoxy-5-(trifluoromethyl)thiophen-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(C(F)(F)F)SC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1OC ANMKGVMPNMUIEO-UHFFFAOYSA-N 0.000 claims 1
• AWUJFVQKIGWIAV-UHFFFAOYSA-N 1'-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=C1)=CC=C1N1C=NC=N1 AWUJFVQKIGWIAV-UHFFFAOYSA-N 0.000 claims 1
• WOAIECMTJKOJAI-UHFFFAOYSA-N 1'-[[4-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=CC=1C(=O)N(CC1)CCN1C1=NC=CC=N1 WOAIECMTJKOJAI-UHFFFAOYSA-N 0.000 claims 1
• LLDBZKSLZMAMTM-UHFFFAOYSA-N 1'-[[4-(morpholine-4-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=CC=1C(=O)N1CCOCC1 LLDBZKSLZMAMTM-UHFFFAOYSA-N 0.000 claims 1
• KRJYYGQYBSLSIU-UHFFFAOYSA-N 1'-[[4-(piperidine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=CC=1C(=O)N1CCCCC1 KRJYYGQYBSLSIU-UHFFFAOYSA-N 0.000 claims 1
• CKJHZRHELGEWBS-UHFFFAOYSA-N 1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O CKJHZRHELGEWBS-UHFFFAOYSA-N 0.000 claims 1
• QCNPSUOAZCQXQS-UHFFFAOYSA-N 1'-[[4-[4-(1,3-benzodioxol-5-ylmethyl)piperazine-1-carbonyl]phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC(C=C1)=CC=C1C(=O)N1CCN(CC=2C=C3OCOC3=CC=2)CC1 QCNPSUOAZCQXQS-UHFFFAOYSA-N 0.000 claims 1
• LIBIIKAPKCSHPM-UHFFFAOYSA-N 1'-[[4-chloro-2-(trifluoromethyl)quinolin-6-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=CC2=C(Cl)C=C(C(F)(F)F)N=C2C=C1 LIBIIKAPKCSHPM-UHFFFAOYSA-N 0.000 claims 1
• FGVDFTPPQSSQBH-UHFFFAOYSA-N 1'-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(C(F)(F)F)C(F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O FGVDFTPPQSSQBH-UHFFFAOYSA-N 0.000 claims 1
• KEVWQCIPSZIPNY-UHFFFAOYSA-N 1'-[[5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=NC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=NO1 KEVWQCIPSZIPNY-UHFFFAOYSA-N 0.000 claims 1
• LRNWOJDFRXDNHS-UHFFFAOYSA-N 1'-benzhydryl-5-bromospiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC(Br)=CC=C2OCC1(C1=CC=CC=C11)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 LRNWOJDFRXDNHS-UHFFFAOYSA-N 0.000 claims 1
• PTDDUYJLOQGZPK-UHFFFAOYSA-N 1'-benzhydryl-5-hydroxyspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC(O)=CC=C2OCC1(C1=CC=CC=C11)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 PTDDUYJLOQGZPK-UHFFFAOYSA-N 0.000 claims 1
• SFOTULKPJMTGPR-UHFFFAOYSA-N 1'-benzhydryl-5-pyridin-3-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC(=CC=C3OC2)C=2C=NC=CC=2)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 SFOTULKPJMTGPR-UHFFFAOYSA-N 0.000 claims 1
• FEHMEKPMEKIRNG-UHFFFAOYSA-N 1'-benzhydryl-6-(trifluoromethoxy)spiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C=1C(OC(F)(F)F)=CC=C2C=1OCC2(C1=CC=CC=C11)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 FEHMEKPMEKIRNG-UHFFFAOYSA-N 0.000 claims 1
• PUNHNDNPPHVDTC-UHFFFAOYSA-N 1'-benzylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CC=C1 PUNHNDNPPHVDTC-UHFFFAOYSA-N 0.000 claims 1
• UUGJZINLZDDYEU-UHFFFAOYSA-N 1'-butylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 UUGJZINLZDDYEU-UHFFFAOYSA-N 0.000 claims 1
• RTCUMTHXKKBDRN-UHFFFAOYSA-N 1'-hex-5-enylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC=C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 RTCUMTHXKKBDRN-UHFFFAOYSA-N 0.000 claims 1
• QQGPXTPTXKAHHT-UHFFFAOYSA-N 1'-hexylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QQGPXTPTXKAHHT-UHFFFAOYSA-N 0.000 claims 1
• QJIYSHJUWGIZHU-UHFFFAOYSA-N 1'-hexylspiro[7h-[1,3]dioxolo[4,5-g]chromene-8,3'-indole]-2',6-dione Chemical compound C12=CC=CC=C2N(CCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC(=O)C1 QJIYSHJUWGIZHU-UHFFFAOYSA-N 0.000 claims 1
• VZPBXHHDMVMWQY-UHFFFAOYSA-N 1'-methylsulfonylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(S(=O)(=O)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 VZPBXHHDMVMWQY-UHFFFAOYSA-N 0.000 claims 1
• QCSJADXRVNKALO-UHFFFAOYSA-N 1'-pent-4-enylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCC=C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QCSJADXRVNKALO-UHFFFAOYSA-N 0.000 claims 1
• YHNAOVOHARDENS-UHFFFAOYSA-N 1'-pentyl-4'-(2-phenoxyphenyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC=C1OC1=CC=CC=C1 YHNAOVOHARDENS-UHFFFAOYSA-N 0.000 claims 1
• YTFIOOPOULFLLX-UHFFFAOYSA-N 1'-pentyl-4'-(4-phenoxyphenyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(C=C1)=CC=C1OC1=CC=CC=C1 YTFIOOPOULFLLX-UHFFFAOYSA-N 0.000 claims 1
• AGKSAGXYEIVRRV-UHFFFAOYSA-N 1'-pentyl-4'-(4-propan-2-yloxyphenyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC(C)C)C=C1 AGKSAGXYEIVRRV-UHFFFAOYSA-N 0.000 claims 1
• KBGBXHKBNVMIOL-UHFFFAOYSA-N 1'-pentyl-4'-(pyridin-3-ylamino)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC=CN=C1 KBGBXHKBNVMIOL-UHFFFAOYSA-N 0.000 claims 1
• AYVCZCFPMLPQMM-UHFFFAOYSA-N 1'-pentyl-4'-(pyrimidin-2-ylamino)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=NC=CC=N1 AYVCZCFPMLPQMM-UHFFFAOYSA-N 0.000 claims 1
• VXDMCAUPRGKVLQ-UHFFFAOYSA-N 1'-pentyl-4'-(pyrimidin-4-ylamino)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC=NC=N1 VXDMCAUPRGKVLQ-UHFFFAOYSA-N 0.000 claims 1
• IMPGGPQZOYKVGV-UHFFFAOYSA-N 1'-pentyl-4'-[2-(trifluoromethoxy)phenyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC=C1OC(F)(F)F IMPGGPQZOYKVGV-UHFFFAOYSA-N 0.000 claims 1
• BYHBVEQRAMDHAJ-UHFFFAOYSA-N 1'-pentyl-4'-[3-(trifluoromethoxy)phenyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(OC(F)(F)F)=C1 BYHBVEQRAMDHAJ-UHFFFAOYSA-N 0.000 claims 1
• YLISUWSIFGUMKZ-UHFFFAOYSA-N 1'-pentyl-4'-[4-(trifluoromethoxy)phenyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC(F)(F)F)C=C1 YLISUWSIFGUMKZ-UHFFFAOYSA-N 0.000 claims 1
• QWHRENGUGIZBON-UHFFFAOYSA-N 1'-pentyl-4'-[4-(trifluoromethyl)pyridin-3-yl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CN=CC=C1C(F)(F)F QWHRENGUGIZBON-UHFFFAOYSA-N 0.000 claims 1
• FYCMAEKPYZZNHL-UHFFFAOYSA-N 1'-pentyl-4'-phenoxathiin-4-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C2=CC=CC=C2OC2=C1C=CC=C2C1=CC=CC2=C1C1(C3=CC=4OCOC=4C=C3OC1)C(=O)N2CCCCC FYCMAEKPYZZNHL-UHFFFAOYSA-N 0.000 claims 1
• KHCAPMSWLGDOMC-UHFFFAOYSA-N 1'-pentyl-4'-phenylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC=C1 KHCAPMSWLGDOMC-UHFFFAOYSA-N 0.000 claims 1
• PPWDAPUARFZSKG-UHFFFAOYSA-N 1'-pentyl-4'-pyridin-3-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CN=C1 PPWDAPUARFZSKG-UHFFFAOYSA-N 0.000 claims 1
• BWSQWILGIFMAOO-UHFFFAOYSA-N 1'-pentyl-4'-pyridin-4-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=NC=C1 BWSQWILGIFMAOO-UHFFFAOYSA-N 0.000 claims 1
• BDCQYOKWNQBRIJ-UHFFFAOYSA-N 1'-pentyl-4'-pyrimidin-5-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CN=CN=C1 BDCQYOKWNQBRIJ-UHFFFAOYSA-N 0.000 claims 1
• KITOPRFYIWXYAD-UHFFFAOYSA-N 1'-pentyl-4'-quinolin-3-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=CC2=CC(C3=CC=CC4=C3C3(C5=CC=6OCOC=6C=C5OC3)C(=O)N4CCCCC)=CN=C21 KITOPRFYIWXYAD-UHFFFAOYSA-N 0.000 claims 1
• QERQKYYWLMCENX-UHFFFAOYSA-N 1'-pentyl-4'-quinolin-6-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound N1=CC=CC2=CC(C3=CC=CC4=C3C3(C5=CC=6OCOC=6C=C5OC3)C(=O)N4CCCCC)=CC=C21 QERQKYYWLMCENX-UHFFFAOYSA-N 0.000 claims 1
• PYGNPLWZOWESAI-UHFFFAOYSA-N 1'-pentyl-4'-thiophen-3-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C=1C=CSC=1 PYGNPLWZOWESAI-UHFFFAOYSA-N 0.000 claims 1
• CBDIRGCFMYQOBK-UHFFFAOYSA-N 1'-pentyl-5-(trifluoromethyl)spiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(C(F)(F)F)=CC=C2OC1 CBDIRGCFMYQOBK-UHFFFAOYSA-N 0.000 claims 1
• JWUDCQZKFHWVOM-UHFFFAOYSA-N 1'-pentyl-5-phenoxyspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=C2)COC1=CC=C2OC1=CC=CC=C1 JWUDCQZKFHWVOM-UHFFFAOYSA-N 0.000 claims 1
• DDMDACHLNFOZLQ-UHFFFAOYSA-N 1'-pentyl-5-pyridin-3-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=C2)COC1=CC=C2C1=CC=CN=C1 DDMDACHLNFOZLQ-UHFFFAOYSA-N 0.000 claims 1
• BYHCUPIXPFLNOT-UHFFFAOYSA-N 1'-pentyl-5-pyridin-4-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=C2)COC1=CC=C2C1=CC=NC=C1 BYHCUPIXPFLNOT-UHFFFAOYSA-N 0.000 claims 1
• KXVTXVSJOVCSDW-UHFFFAOYSA-N 1'-pentyl-5-pyrimidin-5-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=C2)COC1=CC=C2C1=CN=CN=C1 KXVTXVSJOVCSDW-UHFFFAOYSA-N 0.000 claims 1
• DQUNBDRRYSBCBV-UHFFFAOYSA-N 1'-pentyl-6-phenoxyspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=CC=2)COC1=CC=2OC1=CC=CC=C1 DQUNBDRRYSBCBV-UHFFFAOYSA-N 0.000 claims 1
• MRTQCNYAQVKOGL-UHFFFAOYSA-N 1'-pentyl-6-pyridin-4-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=CC=2)COC1=CC=2C1=CC=NC=C1 MRTQCNYAQVKOGL-UHFFFAOYSA-N 0.000 claims 1
• IQNHROGZDGEPQM-UHFFFAOYSA-N 1'-pentylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC=CC=C2OC1 IQNHROGZDGEPQM-UHFFFAOYSA-N 0.000 claims 1
• SKMITBUYSAXHIH-UHFFFAOYSA-N 1'-pentylspiro[5,6-dihydrocyclopenta[f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2CC1 SKMITBUYSAXHIH-UHFFFAOYSA-N 0.000 claims 1
• KTFHKMBXOMMQGS-UHFFFAOYSA-N 1'-pentylspiro[5h-furo[3,4-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2CO1 KTFHKMBXOMMQGS-UHFFFAOYSA-N 0.000 claims 1
• NAECDUFDXJDYAG-UHFFFAOYSA-N 1'-pentylspiro[6,7-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-8,3'-indole]-2',5-dione Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2C(=O)NC1 NAECDUFDXJDYAG-UHFFFAOYSA-N 0.000 claims 1
• LJJMIJUUHNZIGS-UHFFFAOYSA-N 1'-pentylspiro[6,7-dihydrobenzo[f][1,3]benzodioxole-5,3'-indole]-2',8-dione Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2C(=O)CC1 LJJMIJUUHNZIGS-UHFFFAOYSA-N 0.000 claims 1
• UGTQLKHEIQMVBY-UHFFFAOYSA-N 1'-pentylspiro[6h-cyclopenta[f][1,3]benzodioxole-7,3'-indole]-2',5-dione Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2C(=O)C1 UGTQLKHEIQMVBY-UHFFFAOYSA-N 0.000 claims 1
• PZKABQGUVWNWLA-UHFFFAOYSA-N 1'-pentylspiro[7,8-dihydro-6h-benzo[f][1,3]benzodioxole-5,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2CCC1 PZKABQGUVWNWLA-UHFFFAOYSA-N 0.000 claims 1
• ZRIBKTWBEDKUQR-UHFFFAOYSA-N 1'-prop-2-ynylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC#C)C2=O ZRIBKTWBEDKUQR-UHFFFAOYSA-N 0.000 claims 1
• VCIWUDKYGYHPRR-UHFFFAOYSA-N 1'-propylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 VCIWUDKYGYHPRR-UHFFFAOYSA-N 0.000 claims 1
• FBEBRFBVNGSIAZ-UHFFFAOYSA-N 1,7,7-trimethyl-2-oxo-n-[3-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)propyl]-3-oxabicyclo[2.2.1]heptane-4-carboxamide Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCCNC(=O)C1(OC2=O)CCC2(C)C1(C)C FBEBRFBVNGSIAZ-UHFFFAOYSA-N 0.000 claims 1
• HLHHIDUUMDICFM-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C2OCOC2=CC(NC(NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=O)=C1 HLHHIDUUMDICFM-UHFFFAOYSA-N 0.000 claims 1
• AHWCADIFIFAXIT-UHFFFAOYSA-N 1-(2,3-dichlorophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound ClC1=CC=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1Cl AHWCADIFIFAXIT-UHFFFAOYSA-N 0.000 claims 1
• CGOFMALNLDXUQU-UHFFFAOYSA-N 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O1CCOC2=CC(NC(NCCN3C4=CC=CC=C4C4(C5=CC=6OCOC=6C=C5OC4)C3=O)=O)=CC=C21 CGOFMALNLDXUQU-UHFFFAOYSA-N 0.000 claims 1
• RNKRACSPEZEGJL-UHFFFAOYSA-N 1-(2,3-dihydro-1h-inden-5-yl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C2CCCC2=CC(NC(NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=O)=C1 RNKRACSPEZEGJL-UHFFFAOYSA-N 0.000 claims 1
• HLFCLXQKONRZJV-UHFFFAOYSA-N 1-(2-pyrrol-1-ylethyl)spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound N1(C=CC=C1)CCN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 HLFCLXQKONRZJV-UHFFFAOYSA-N 0.000 claims 1
• LEJGHJQYPYXVGI-UHFFFAOYSA-N 1-(2H-triazol-4-ylmethyl)spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound N1N=NC(=C1)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 LEJGHJQYPYXVGI-UHFFFAOYSA-N 0.000 claims 1
• SQEQVFZYCIOPCR-UHFFFAOYSA-N 1-(3,4-dimethoxyphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C(OC)C(OC)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O SQEQVFZYCIOPCR-UHFFFAOYSA-N 0.000 claims 1
• NSEUPIWJHPBZRJ-UHFFFAOYSA-N 1-(3,5-dichlorophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound ClC1=CC(Cl)=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 NSEUPIWJHPBZRJ-UHFFFAOYSA-N 0.000 claims 1
• DUGMQSLOWPNBFS-UHFFFAOYSA-N 1-(3,5-dimethoxyphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound COC1=CC(OC)=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 DUGMQSLOWPNBFS-UHFFFAOYSA-N 0.000 claims 1
• HFTSRXFCSZICDP-UHFFFAOYSA-N 1-(3-chloro-2-fluorophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound FC1=C(Cl)C=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O HFTSRXFCSZICDP-UHFFFAOYSA-N 0.000 claims 1
• BIBNQKDGRAGULI-UHFFFAOYSA-N 1-(3-chloro-2-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound CC1=C(Cl)C=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O BIBNQKDGRAGULI-UHFFFAOYSA-N 0.000 claims 1
• RNLURKOIKKWROR-UHFFFAOYSA-N 1-(3-pyrrol-1-ylpropyl)spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound N1(C=CC=C1)CCCN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 RNLURKOIKKWROR-UHFFFAOYSA-N 0.000 claims 1
• UVRHWJBDPPIUCZ-UHFFFAOYSA-N 1-(4-chloro-2-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound CC1=CC(Cl)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UVRHWJBDPPIUCZ-UHFFFAOYSA-N 0.000 claims 1
• HAAQIGMKFBDFRY-UHFFFAOYSA-N 1-(4-fluoro-3-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C(F)C(C)=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 HAAQIGMKFBDFRY-UHFFFAOYSA-N 0.000 claims 1
• AGCQQVIZHAFAOZ-UHFFFAOYSA-N 1-(4-fluorophenyl)-5-methyl-n-[3-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)propyl]pyrazole-4-carboxamide Chemical compound CC1=C(C(=O)NCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=NN1C1=CC=C(F)C=C1 AGCQQVIZHAFAOZ-UHFFFAOYSA-N 0.000 claims 1
• YHIQJJHXLMXYQX-UHFFFAOYSA-N 1-(4-methoxy-2-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound CC1=CC(OC)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O YHIQJJHXLMXYQX-UHFFFAOYSA-N 0.000 claims 1
• UZAGYMSEIKUSBW-UHFFFAOYSA-N 1-(4-tert-butylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC(C(C)(C)C)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UZAGYMSEIKUSBW-UHFFFAOYSA-N 0.000 claims 1
• SITIYJDKBYPQQQ-UHFFFAOYSA-N 1-(5-chloro-2-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound CC1=CC=C(Cl)C=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O SITIYJDKBYPQQQ-UHFFFAOYSA-N 0.000 claims 1
• WHOJXYPVEIXLLP-UHFFFAOYSA-N 1-(9h-fluoren-2-yl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C2CC3=CC=CC=C3C2=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O WHOJXYPVEIXLLP-UHFFFAOYSA-N 0.000 claims 1
• WUMFJKHZWSGZBM-UHFFFAOYSA-N 1-(cyclohexylmethyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NCC1CCCCC1 WUMFJKHZWSGZBM-UHFFFAOYSA-N 0.000 claims 1
• SHWFMHPBKUUKGZ-UHFFFAOYSA-N 1-[(1-cyclobutylpiperidin-4-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound C1(CCC1)N1CCC(CC1)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 SHWFMHPBKUUKGZ-UHFFFAOYSA-N 0.000 claims 1
• CXGWSTOQXCUOMA-UHFFFAOYSA-N 1-[(1-cyclohexylpiperidin-4-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound C1(CCCCC1)N1CCC(CC1)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 CXGWSTOQXCUOMA-UHFFFAOYSA-N 0.000 claims 1
• FHRPTJXVAZPALE-UHFFFAOYSA-N 1-[(1-cyclopentylpiperidin-4-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound C1(CCCC1)N1CCC(CC1)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 FHRPTJXVAZPALE-UHFFFAOYSA-N 0.000 claims 1
• ZUXQJFURQHVCAO-UHFFFAOYSA-N 1-[(1-methylbenzimidazol-2-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound CN1C(=NC2=C1C=CC=C2)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 ZUXQJFURQHVCAO-UHFFFAOYSA-N 0.000 claims 1
• DADVSKADUJTGSJ-UHFFFAOYSA-N 1-[(1-propan-2-ylpiperidin-4-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound C(C)(C)N1CCC(CC1)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 DADVSKADUJTGSJ-UHFFFAOYSA-N 0.000 claims 1
• DJIBCFDIQYLTAG-UHFFFAOYSA-N 1-[(1-pyridin-2-ylpiperidin-4-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound N1=C(C=CC=C1)N1CCC(CC1)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 DJIBCFDIQYLTAG-UHFFFAOYSA-N 0.000 claims 1
• NQBPKDWRIXJINS-UHFFFAOYSA-N 1-[(2,2,3,3-tetrafluorocyclobutyl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound FC1(C(CC1(F)F)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12)F NQBPKDWRIXJINS-UHFFFAOYSA-N 0.000 claims 1
• UNJHASKMWGLVFE-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound ClC1=CC(Cl)=CC=C1CNC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UNJHASKMWGLVFE-UHFFFAOYSA-N 0.000 claims 1
• GKGNASJZCIIQEK-UHFFFAOYSA-N 1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]spiro[2h-indole-3,7'-6h-furo[2,3-f][1,3]benzodioxole] Chemical compound CC1=NOC(C)=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1 GKGNASJZCIIQEK-UHFFFAOYSA-N 0.000 claims 1
• WEXZWVBUBDLTGL-UHFFFAOYSA-N 1-[(3-methyl-5-phenyl-1,2-oxazol-4-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound CC1=NOC(=C1CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12)C1=CC=CC=C1 WEXZWVBUBDLTGL-UHFFFAOYSA-N 0.000 claims 1
• TXAYXMBGFPCDLS-UHFFFAOYSA-N 1-[(3-methylbenzotriazol-5-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound CN1N=NC2=C1C=C(C=C2)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 TXAYXMBGFPCDLS-UHFFFAOYSA-N 0.000 claims 1
• VDKRRUBUYYIOSO-UHFFFAOYSA-N 1-[(4-pyrazol-1-ylphenyl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound N1(N=CC=C1)C1=CC=C(CN2CC3(C4=CC=CC=C24)COC2=CC4=C(OCO4)C=C23)C=C1 VDKRRUBUYYIOSO-UHFFFAOYSA-N 0.000 claims 1
• SROJRCAERSOQFQ-UHFFFAOYSA-N 1-[(5-chloro-1-benzothiophen-3-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound ClC=1C=CC2=C(C(=CS2)CN2CC3(C4=CC=CC=C24)COC=2C3=CC3=C(OCO3)C=2)C=1 SROJRCAERSOQFQ-UHFFFAOYSA-N 0.000 claims 1
• DFMKRFZPRCANHP-UHFFFAOYSA-N 1-[(5-chlorothiophen-2-yl)methyl]-5-fluorospiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound ClC1=CC=C(S1)CN1CC2(C3=CC(=CC=C13)F)COC1=CC3=C(OCO3)C=C12 DFMKRFZPRCANHP-UHFFFAOYSA-N 0.000 claims 1
• WTENTVHZASVSPT-UHFFFAOYSA-N 1-[(5-methylfuran-2-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound CC1=CC=C(O1)CN1CC2(C3=CC=CC=C13)COC=1C2=CC2=C(OCO2)C=1 WTENTVHZASVSPT-UHFFFAOYSA-N 0.000 claims 1
• WJWXMQNQOVVCHL-UHFFFAOYSA-N 1-[(5-methylsulfonylfuran-2-yl)methyl]spiro[2h-indole-3,7'-6h-furo[2,3-f][1,3]benzodioxole] Chemical compound O1C(S(=O)(=O)C)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1 WJWXMQNQOVVCHL-UHFFFAOYSA-N 0.000 claims 1
• CBQGSVSLGCLLOS-UHFFFAOYSA-N 1-[(6-fluoro-1H-benzimidazol-2-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound FC1=CC2=C(NC(=N2)CN2CC3(C4=CC=CC=C24)COC2=CC4=C(OCO4)C=C23)C=C1 CBQGSVSLGCLLOS-UHFFFAOYSA-N 0.000 claims 1
• ARKZBHXUPOIEDE-UHFFFAOYSA-N 1-[2-(1,3-benzodioxol-5-yl)ethyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C2OCOC2=CC(CCNC(NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=O)=C1 ARKZBHXUPOIEDE-UHFFFAOYSA-N 0.000 claims 1
• QYAADSJLGLEYFI-UHFFFAOYSA-N 1-[2-(1-propan-2-ylpiperidin-4-yl)ethyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound C(C)(C)N1CCC(CC1)CCN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 QYAADSJLGLEYFI-UHFFFAOYSA-N 0.000 claims 1
• WCWRNPHWIAGWKG-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-(2-phenylethyl)urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NCCC1=CC=CC=C1 WCWRNPHWIAGWKG-UHFFFAOYSA-N 0.000 claims 1
• BTUCCWZCWHMMBS-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)urea Chemical compound COC1=C(OC)C(OC)=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 BTUCCWZCWHMMBS-UHFFFAOYSA-N 0.000 claims 1
• OWVULQJJEOCPFQ-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-(4-phenoxyphenyl)urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NC(C=C1)=CC=C1OC1=CC=CC=C1 OWVULQJJEOCPFQ-UHFFFAOYSA-N 0.000 claims 1
• IKPOLXKQAMPABJ-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-(5,6,7,8-tetrahydronaphthalen-1-yl)urea Chemical compound C1CCCC2=C1C=CC=C2NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O IKPOLXKQAMPABJ-UHFFFAOYSA-N 0.000 claims 1
• MNMGUSBNZUMIBC-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-[2-(4-phenylphenyl)ethyl]urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NCCC(C=C1)=CC=C1C1=CC=CC=C1 MNMGUSBNZUMIBC-UHFFFAOYSA-N 0.000 claims 1
• PIVHACYCVDWCTC-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]urea Chemical compound FC(F)(F)C1=CC=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 PIVHACYCVDWCTC-UHFFFAOYSA-N 0.000 claims 1
• LYTMPZNZYMJLMS-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-[4-(trifluoromethyl)phenyl]urea Chemical compound C1=CC(C(F)(F)F)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O LYTMPZNZYMJLMS-UHFFFAOYSA-N 0.000 claims 1
• IBLSBGDGXRTTSY-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-phenylurea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NC1=CC=CC=C1 IBLSBGDGXRTTSY-UHFFFAOYSA-N 0.000 claims 1
• FPLDYJFBXFGIAP-UHFFFAOYSA-N 1-[2-(difluoromethoxy)phenyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound FC(F)OC1=CC=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O FPLDYJFBXFGIAP-UHFFFAOYSA-N 0.000 claims 1
• SBZHYBRGCXHPDH-UHFFFAOYSA-N 1-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NC(C=C1)=CC=C1C1=NC2=CC=C(C)C=C2S1 SBZHYBRGCXHPDH-UHFFFAOYSA-N 0.000 claims 1
• HRFRMIVYYUONHN-UHFFFAOYSA-N 1-[4-fluoro-2-(trifluoromethyl)phenyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound FC(F)(F)C1=CC(F)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O HRFRMIVYYUONHN-UHFFFAOYSA-N 0.000 claims 1
• DLEMDIHBIGJHLG-UHFFFAOYSA-N 1-[4-methyl-3-(trifluoromethyl)phenyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C(C(F)(F)F)C(C)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O DLEMDIHBIGJHLG-UHFFFAOYSA-N 0.000 claims 1
• RAOIUHQTOVTFIJ-UHFFFAOYSA-N 1-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[2h-indole-3,7'-6h-furo[2,3-f][1,3]benzodioxole] Chemical compound O1C(C(F)(F)F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1 RAOIUHQTOVTFIJ-UHFFFAOYSA-N 0.000 claims 1
• PFKAOQCLYHFNQV-UHFFFAOYSA-N 1-[[5-(trifluoromethyl)thiophen-2-yl]methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound FC(C1=CC=C(S1)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12)(F)F PFKAOQCLYHFNQV-UHFFFAOYSA-N 0.000 claims 1
• CJHROMGXRHPIDK-UHFFFAOYSA-N 1-[[6-(trifluoromethyl)pyridin-3-yl]methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound FC(C1=CC=C(C=N1)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12)(F)F CJHROMGXRHPIDK-UHFFFAOYSA-N 0.000 claims 1
• GGZCYBTXYPUOBK-UHFFFAOYSA-N 1-benzhydryl-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NC(C=1C=CC=CC=1)C1=CC=CC=C1 GGZCYBTXYPUOBK-UHFFFAOYSA-N 0.000 claims 1
• HFKUYFCDKWHLAU-UHFFFAOYSA-N 1-benzyl-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NCC1=CC=CC=C1 HFKUYFCDKWHLAU-UHFFFAOYSA-N 0.000 claims 1
• KFTOMYSBGYZJBF-UHFFFAOYSA-N 1-butyl-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C12=CC=CC=C2N(CCNC(=O)NCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 KFTOMYSBGYZJBF-UHFFFAOYSA-N 0.000 claims 1
• UVCZPDNHYBWURD-UHFFFAOYSA-N 1-cyclohexyl-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NC1CCCCC1 UVCZPDNHYBWURD-UHFFFAOYSA-N 0.000 claims 1
• OXRNFZAAGGIGAG-UHFFFAOYSA-N 1-ethyl-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C12=CC=CC=C2N(CCNC(=O)NCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 OXRNFZAAGGIGAG-UHFFFAOYSA-N 0.000 claims 1
• LQPDSKLPCTXPPI-UHFFFAOYSA-N 1-hexyl-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C12=CC=CC=C2N(CCNC(=O)NCCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 LQPDSKLPCTXPPI-UHFFFAOYSA-N 0.000 claims 1
• HTCBXRZEXZCKPH-UHFFFAOYSA-N 1-methyl-n-[3-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)propyl]benzotriazole-5-carboxamide Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCCNC(=O)C1=CC=C2N(C)N=NC2=C1 HTCBXRZEXZCKPH-UHFFFAOYSA-N 0.000 claims 1
• VUUYFNUNDXILJL-UHFFFAOYSA-N 1-pentyl-4-(3,4,5-trimethoxyphenyl)spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound C(CCCC)N1CC2(C3=C(C=CC=C13)C1=CC(=C(C(=C1)OC)OC)OC)COC1=CC3=C(OCO3)C=C12 VUUYFNUNDXILJL-UHFFFAOYSA-N 0.000 claims 1
• KPULZUZZPUCJII-BUHFOSPRSA-N 1-pentyl-4-[(E)-2-phenylethenyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound C(CCCC)N1CC2(C3=C(C=CC=C13)\C=C\C1=CC=CC=C1)COC1=CC3=C(OCO3)C=C12 KPULZUZZPUCJII-BUHFOSPRSA-N 0.000 claims 1
• IDQDPSLVOKKOBU-UHFFFAOYSA-N 1-tert-butyl-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C12=CC=CC=C2N(CCNC(=O)NC(C)(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 IDQDPSLVOKKOBU-UHFFFAOYSA-N 0.000 claims 1
• WHUPSLJSMYXMCC-UHFFFAOYSA-N 2'-oxo-1'-pentyl-n-pyridin-2-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-4'-carboxamide Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(=O)NC1=CC=CC=N1 WHUPSLJSMYXMCC-UHFFFAOYSA-N 0.000 claims 1
• SAEPYURJYIBTBY-UHFFFAOYSA-N 2'-oxo-1'-pentylspiro[2h-1-benzofuran-3,3'-indole]-5-carbonitrile Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(C#N)=CC=C2OC1 SAEPYURJYIBTBY-UHFFFAOYSA-N 0.000 claims 1
• 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 1
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• IZLWGKPVXRNXSI-UHFFFAOYSA-N 4'-(3,4-dimethoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC)C(OC)=C1 IZLWGKPVXRNXSI-UHFFFAOYSA-N 0.000 claims 1
• HVFHFGUXINIMSO-UHFFFAOYSA-N 4'-(3,5-dichlorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(Cl)=CC(Cl)=C1 HVFHFGUXINIMSO-UHFFFAOYSA-N 0.000 claims 1
• VHKWVSXWNLKJNK-UHFFFAOYSA-N 4'-(3,5-difluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(F)=CC(F)=C1 VHKWVSXWNLKJNK-UHFFFAOYSA-N 0.000 claims 1
• GSCKPWVMLNPNJK-UHFFFAOYSA-N 4'-(3,5-dimethoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(OC)=CC(OC)=C1 GSCKPWVMLNPNJK-UHFFFAOYSA-N 0.000 claims 1
• UFSIMUVREICXHS-UHFFFAOYSA-N 4'-(3-acetylphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(C(C)=O)=C1 UFSIMUVREICXHS-UHFFFAOYSA-N 0.000 claims 1
• DAUNIGODKMYARG-UHFFFAOYSA-N 4'-(3-butoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(OCCCC)=C1 DAUNIGODKMYARG-UHFFFAOYSA-N 0.000 claims 1
• IOXFZDXPWCIOER-UHFFFAOYSA-N 4'-(3-chloro-4-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(F)C(Cl)=C1 IOXFZDXPWCIOER-UHFFFAOYSA-N 0.000 claims 1
• BOOKUIPTCVRTTH-UHFFFAOYSA-N 4'-(3-chlorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(Cl)=C1 BOOKUIPTCVRTTH-UHFFFAOYSA-N 0.000 claims 1
• GNPIODRDXGINHB-UHFFFAOYSA-N 4'-(3-fluoro-4-methoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC)C(F)=C1 GNPIODRDXGINHB-UHFFFAOYSA-N 0.000 claims 1
• ORAPBEYNBARRKP-UHFFFAOYSA-N 4'-(3-fluoro-5-methoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(F)=CC(OC)=C1 ORAPBEYNBARRKP-UHFFFAOYSA-N 0.000 claims 1
• FYVLTICDXLWIDI-UHFFFAOYSA-N 4'-(3-fluoroanilino)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC=CC(F)=C1 FYVLTICDXLWIDI-UHFFFAOYSA-N 0.000 claims 1
• AUHMTFSWZHZAFL-UHFFFAOYSA-N 4'-(3-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(F)=C1 AUHMTFSWZHZAFL-UHFFFAOYSA-N 0.000 claims 1
• IJLJDQKHPHNDOD-UHFFFAOYSA-N 4'-(4-butoxy-3-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OCCCC)C(F)=C1 IJLJDQKHPHNDOD-UHFFFAOYSA-N 0.000 claims 1
• VJIYETPRCUISFB-UHFFFAOYSA-N 4'-(4-butoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OCCCC)C=C1 VJIYETPRCUISFB-UHFFFAOYSA-N 0.000 claims 1
• GSUJPUJDDJTHPS-UHFFFAOYSA-N 4'-(4-butylphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(CCCC)C=C1 GSUJPUJDDJTHPS-UHFFFAOYSA-N 0.000 claims 1
• DDCZMIPHISFRGA-UHFFFAOYSA-N 4'-(4-chlorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(Cl)C=C1 DDCZMIPHISFRGA-UHFFFAOYSA-N 0.000 claims 1
• BXRWNLABHQDVGT-UHFFFAOYSA-N 4'-(4-ethoxy-3-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OCC)C(F)=C1 BXRWNLABHQDVGT-UHFFFAOYSA-N 0.000 claims 1
• FEEJYOCSELUHEL-UHFFFAOYSA-N 4'-(4-fluoro-2-methylphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(F)C=C1C FEEJYOCSELUHEL-UHFFFAOYSA-N 0.000 claims 1
• WASWOQMWUQOJTH-UHFFFAOYSA-N 4'-(4-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(F)C=C1 WASWOQMWUQOJTH-UHFFFAOYSA-N 0.000 claims 1
• DHQDPSBZKNZNEU-UHFFFAOYSA-N 4'-(4-methoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC)C=C1 DHQDPSBZKNZNEU-UHFFFAOYSA-N 0.000 claims 1
• QWZLWXIASJJIPZ-UHFFFAOYSA-N 4'-(4-methoxypyridin-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CN=CC=C1OC QWZLWXIASJJIPZ-UHFFFAOYSA-N 0.000 claims 1
• ACTSJBMXNQGVBW-UHFFFAOYSA-N 4'-(4-methylpiperazin-1-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2N1CCN(C)CC1 ACTSJBMXNQGVBW-UHFFFAOYSA-N 0.000 claims 1
• WOXGHQZVJPELCV-UHFFFAOYSA-N 4'-(4-morpholin-4-ylphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(C=C1)=CC=C1N1CCOCC1 WOXGHQZVJPELCV-UHFFFAOYSA-N 0.000 claims 1
• FPIGVUQJSXLNNK-UHFFFAOYSA-N 4'-(5-chloro-2-methoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(Cl)=CC=C1OC FPIGVUQJSXLNNK-UHFFFAOYSA-N 0.000 claims 1
• YQQUHSBVEAUINQ-UHFFFAOYSA-N 4'-(5-fluoro-2-methoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(F)=CC=C1OC YQQUHSBVEAUINQ-UHFFFAOYSA-N 0.000 claims 1
• XPRDNLJUDMYHMP-UHFFFAOYSA-N 4'-(5-methoxypyridin-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CN=CC(OC)=C1 XPRDNLJUDMYHMP-UHFFFAOYSA-N 0.000 claims 1
• XLZGSZXUBNMYLG-UHFFFAOYSA-N 4'-(6-fluoropyridin-2-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(F)=N1 XLZGSZXUBNMYLG-UHFFFAOYSA-N 0.000 claims 1
• YPPPOVHTMHPNDF-UHFFFAOYSA-N 4'-(6-fluoropyridin-3-yl)-1'-methylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(F)N=C1 YPPPOVHTMHPNDF-UHFFFAOYSA-N 0.000 claims 1
• YDBINQWWEREMMT-UHFFFAOYSA-N 4'-(6-fluoropyridin-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(F)N=C1 YDBINQWWEREMMT-UHFFFAOYSA-N 0.000 claims 1
• SORQKETUXLKGLM-UHFFFAOYSA-N 4'-(6-methoxypyridin-2-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(OC)=N1 SORQKETUXLKGLM-UHFFFAOYSA-N 0.000 claims 1
• KEGZAIRYUXEJLU-UHFFFAOYSA-N 4'-(6-methoxypyridin-3-yl)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=NC(OC)=CC=C1C1=CC=CC2=C1C1(C3=CC=4OCOC=4C=C3OC1)C(=O)N2CC1=CC=C(C(F)(F)F)O1 KEGZAIRYUXEJLU-UHFFFAOYSA-N 0.000 claims 1
• QXTBUNZUJNFXDK-UHFFFAOYSA-N 4'-(6-methoxypyridin-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC)N=C1 QXTBUNZUJNFXDK-UHFFFAOYSA-N 0.000 claims 1
• NEWMIENJJRMVOG-UHFFFAOYSA-N 4'-(furan-2-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CO1 NEWMIENJJRMVOG-UHFFFAOYSA-N 0.000 claims 1
• ASXPQVXBXBBQEB-UHFFFAOYSA-N 4'-(furan-3-yl)-1'-methylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C=1C=COC=1 ASXPQVXBXBBQEB-UHFFFAOYSA-N 0.000 claims 1
• IMAMQKYHXYPHBZ-UHFFFAOYSA-N 4'-(furan-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C=1C=COC=1 IMAMQKYHXYPHBZ-UHFFFAOYSA-N 0.000 claims 1
• XJDFRDSMQIPLBP-UHFFFAOYSA-N 4'-(naphthalen-2-ylamino)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=CC2=CC(NC3=CC=CC4=C3C3(C5=CC=6OCOC=6C=C5OC3)C(=O)N4CCCCC)=CC=C21 XJDFRDSMQIPLBP-UHFFFAOYSA-N 0.000 claims 1
• CZACZWJTBBVSNR-UHFFFAOYSA-N 4'-[(4,6-dimethylpyridin-2-yl)amino]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC(C)=CC(C)=N1 CZACZWJTBBVSNR-UHFFFAOYSA-N 0.000 claims 1
• YDTGEQZIOFPADD-UHFFFAOYSA-N 4'-[(6-methoxypyridin-3-yl)amino]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC=C(OC)N=C1 YDTGEQZIOFPADD-UHFFFAOYSA-N 0.000 claims 1
• HYJSXMVKPXUMEX-DHZHZOJOSA-N 4'-[(e)-2-(4-fluorophenyl)ethenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2\C=C\C1=CC=C(F)C=C1 HYJSXMVKPXUMEX-DHZHZOJOSA-N 0.000 claims 1
• HEMNUZOUELHOQY-VURMDHGXSA-N 4'-[(z)-3-chloroprop-1-enyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C(\C=C/CCl)C2=C1N(CCCCC)C(=O)C21C2=CC(OCO3)=C3C=C2OC1 HEMNUZOUELHOQY-VURMDHGXSA-N 0.000 claims 1
• GWEMUKFLKOVMPM-UHFFFAOYSA-N 4'-[1-(benzenesulfonyl)indol-3-yl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(C1=CC=CC=C11)=CN1S(=O)(=O)C1=CC=CC=C1 GWEMUKFLKOVMPM-UHFFFAOYSA-N 0.000 claims 1
• LXZUYELEDLMUON-UHFFFAOYSA-N 4'-[2-chloro-4-[(3,5-dimethoxyphenyl)methoxy]phenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(C(=C1)Cl)=CC=C1OCC1=CC(OC)=CC(OC)=C1 LXZUYELEDLMUON-UHFFFAOYSA-N 0.000 claims 1
• ZPJYLQPMKLHZCA-UHFFFAOYSA-N 4'-[4-(2-methylpropoxy)phenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OCC(C)C)C=C1 ZPJYLQPMKLHZCA-UHFFFAOYSA-N 0.000 claims 1
• ZNFRCVNTHCOYIE-UHFFFAOYSA-N 4'-[4-(dimethylamino)phenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(N(C)C)C=C1 ZNFRCVNTHCOYIE-UHFFFAOYSA-N 0.000 claims 1
• PKTVDJYMMPRRQZ-UHFFFAOYSA-N 4'-[6-(dimethylamino)pyridin-3-yl]-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=NC(N(C)C)=CC=C1C1=CC=CC2=C1C1(C3=CC=4OCOC=4C=C3OC1)C(=O)N2CC1=CC=C(C(F)(F)F)O1 PKTVDJYMMPRRQZ-UHFFFAOYSA-N 0.000 claims 1
• MKYJMAOGIRCWID-UHFFFAOYSA-N 4'-bromo-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(C(F)(F)F)=CC=C1CN1C(C=CC=C2Br)=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O MKYJMAOGIRCWID-UHFFFAOYSA-N 0.000 claims 1
• KLHLFKUVNLZXBN-UHFFFAOYSA-N 4'-bromo-1'-methylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C(Br)C2=C1N(C)C(=O)C21C2=CC(OCO3)=C3C=C2OC1 KLHLFKUVNLZXBN-UHFFFAOYSA-N 0.000 claims 1
• SQTJOXDCPGUIBT-UHFFFAOYSA-N 4'-isoquinolin-4-yl-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C2C(C3=CC=CC4=C3C3(C5=CC=6OCOC=6C=C5OC3)C(=O)N4CCCCC)=CN=CC2=C1 SQTJOXDCPGUIBT-UHFFFAOYSA-N 0.000 claims 1
• QJJLYNOLBHHGGY-UHFFFAOYSA-N 4'-methoxy-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C=2C(OC)=CC=CC=2N1CC1=CC=C(C(F)(F)F)O1 QJJLYNOLBHHGGY-UHFFFAOYSA-N 0.000 claims 1
• LJUVRLVOYKOIEO-UHFFFAOYSA-N 4'-methyl-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C=2C(C)=CC=CC=2N1CC1=CC=C(C(F)(F)F)O1 LJUVRLVOYKOIEO-UHFFFAOYSA-N 0.000 claims 1
• NPTMSMOKDRFNJW-UHFFFAOYSA-N 4'-morpholin-4-yl-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2N1CCOCC1 NPTMSMOKDRFNJW-UHFFFAOYSA-N 0.000 claims 1
• VMXCZTIPLYHBSN-UHFFFAOYSA-N 4'-quinolin-3-yl-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(C(F)(F)F)=CC=C1CN1C(C=CC=C2C=3C=C4C=CC=CC4=NC=3)=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O VMXCZTIPLYHBSN-UHFFFAOYSA-N 0.000 claims 1
• LOMZFLOALBNXHI-UHFFFAOYSA-N 4-(2'-oxo-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-4'-yl)benzonitrile Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(C#N)C=C1 LOMZFLOALBNXHI-UHFFFAOYSA-N 0.000 claims 1
• KHKFHZFSMGPMIR-UHFFFAOYSA-N 4-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)butanenitrile Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CCCC#N)C2=O KHKFHZFSMGPMIR-UHFFFAOYSA-N 0.000 claims 1
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