AU2002234134A1 - 3-substituted oxindole beta 3 agonists - Google Patents

3-substituted oxindole beta 3 agonists

Info

Publication number
AU2002234134A1
AU2002234134A1 AU2002234134A AU3413402A AU2002234134A1 AU 2002234134 A1 AU2002234134 A1 AU 2002234134A1 AU 2002234134 A AU2002234134 A AU 2002234134A AU 3413402 A AU3413402 A AU 3413402A AU 2002234134 A1 AU2002234134 A1 AU 2002234134A1
Authority
AU
Australia
Prior art keywords
beta
agonists
substituted oxindole
sub
oxindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002234134A
Inventor
Cynthia Darshini Jesudason
Daniel Jon Sall
Freddie Craig Stevens
John Arnold Werner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2002234134A1 publication Critical patent/AU2002234134A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to a beta<SUB>3 </SUB>adrenergic receptor agonist of formula I: or a pharmaceutical salt thereof; which is useful for treating Type II diabetes and/or obesity.
AU2002234134A 2000-11-10 2001-10-26 3-substituted oxindole beta 3 agonists Abandoned AU2002234134A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24730400P 2000-11-10 2000-11-10
US60/247,304 2000-11-10
US30679301P 2001-07-20 2001-07-20
US60/306,793 2001-07-20
PCT/US2001/050666 WO2002038544A2 (en) 2000-11-10 2001-10-26 3-substituted oxindole beta 3 agonists

Publications (1)

Publication Number Publication Date
AU2002234134A1 true AU2002234134A1 (en) 2002-05-21

Family

ID=26938590

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002234134A Abandoned AU2002234134A1 (en) 2000-11-10 2001-10-26 3-substituted oxindole beta 3 agonists
AU2432002A Pending AU2432002A (en) 2000-11-10 2001-11-02 3-substituted oxindole beta 3 agonists

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2432002A Pending AU2432002A (en) 2000-11-10 2001-11-02 3-substituted oxindole beta 3 agonists

Country Status (10)

Country Link
US (2) US6825220B2 (en)
EP (1) EP1341759B1 (en)
JP (1) JP2004513164A (en)
AT (1) ATE329901T1 (en)
AU (2) AU2002234134A1 (en)
CA (1) CA2421594A1 (en)
DE (1) DE60120748T2 (en)
ES (1) ES2265447T3 (en)
IL (1) IL154928A0 (en)
WO (2) WO2002038544A2 (en)

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Also Published As

Publication number Publication date
WO2002038544A2 (en) 2002-05-16
US7122680B2 (en) 2006-10-17
DE60120748T2 (en) 2007-05-16
WO2002038543A2 (en) 2002-05-16
JP2004513164A (en) 2004-04-30
ATE329901T1 (en) 2006-07-15
WO2002038543A3 (en) 2002-07-04
EP1341759A2 (en) 2003-09-10
EP1341759B1 (en) 2006-06-14
AU2432002A (en) 2002-05-21
WO2002038544A3 (en) 2002-09-26
US6825220B2 (en) 2004-11-30
DE60120748D1 (en) 2006-07-27
IL154928A0 (en) 2003-10-31
ES2265447T3 (en) 2007-02-16
CA2421594A1 (en) 2002-05-16
US20040097532A1 (en) 2004-05-20
US20050054713A1 (en) 2005-03-10

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