EA200101180A1 - TIO-OXINDOL DERIVATIVES - Google Patents

TIO-OXINDOL DERIVATIVES

Info

Publication number
EA200101180A1
EA200101180A1 EA200101180A EA200101180A EA200101180A1 EA 200101180 A1 EA200101180 A1 EA 200101180A1 EA 200101180 A EA200101180 A EA 200101180A EA 200101180 A EA200101180 A EA 200101180A EA 200101180 A1 EA200101180 A1 EA 200101180A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tio
progesterone
oxindol derivatives
oxindol
derivatives
Prior art date
Application number
EA200101180A
Other languages
Russian (ru)
Other versions
EA005034B1 (en
Inventor
Эндрю Фенсам
Пувен Жанг
Марси С. Коко
Джей Э. Вроубел
Джеймс П. Эдвардс
Тодд К. Джоунс
Кристофер М. Тегли
Лин Жи
Эвард Дж. Меленски
Original Assignee
Америкэн Хоум Продактс Корпорейшн
Лиганд Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,033 external-priority patent/US6355648B1/en
Application filed by Америкэн Хоум Продактс Корпорейшн, Лиганд Фармасьютикалз, Инк. filed Critical Америкэн Хоум Продактс Корпорейшн
Publication of EA200101180A1 publication Critical patent/EA200101180A1/en
Publication of EA005034B1 publication Critical patent/EA005034B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Настоящее изобретение включает соединения общей формулы (1) или (2), имеющие указанные заместители, или их фармацевтически приемлемую соль, которые являются агонистами рецептора прогестерона, а также способ их получения и их применение для проведения контрацепции или лечения прогестеронзависимых карцином и аденокарцином.Международная заявка была опубликована вместе с отчетом о международном поиске.The present invention includes compounds of the general formula (1) or (2) having the indicated substituents, or a pharmaceutically acceptable salt thereof, which are progesterone receptor agonists, as well as a method for their preparation and their use for contraception or treatment of progesterone dependent carcinomas and adenocarcinomas. International application was published with the international search report.

EA200101180A 1999-05-04 2000-05-01 Thio-oxindole derivatives EA005034B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17225999P 1999-05-04 1999-05-04
US09/552,033 US6355648B1 (en) 1999-05-04 2000-04-19 Thio-oxindole derivatives
PCT/US2000/011630 WO2000066555A1 (en) 1999-05-04 2000-05-01 Thio-oxindole derivatives

Publications (2)

Publication Number Publication Date
EA200101180A1 true EA200101180A1 (en) 2002-04-25
EA005034B1 EA005034B1 (en) 2004-10-28

Family

ID=26867898

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200101180A EA005034B1 (en) 1999-05-04 2000-05-01 Thio-oxindole derivatives

Country Status (18)

Country Link
EP (1) EP1181275A1 (en)
JP (1) JP2002543182A (en)
KR (1) KR20020000636A (en)
CN (1) CN1143847C (en)
AU (1) AU767762B2 (en)
BG (1) BG106078A (en)
BR (1) BR0010216A (en)
CA (1) CA2371633A1 (en)
CZ (1) CZ20013950A3 (en)
EA (1) EA005034B1 (en)
GE (1) GEP20043266B (en)
HU (1) HUP0200993A3 (en)
MX (1) MXPA01011285A (en)
NO (1) NO320912B1 (en)
NZ (1) NZ515351A (en)
PL (1) PL351407A1 (en)
SK (1) SK15902001A3 (en)
TR (1) TR200103288T2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2313334T3 (en) * 2004-04-08 2009-03-01 Wyeth PROCEDURES FOR MIMIMIZING TIOMIDE IMPURITIES.
CN100522960C (en) * 2004-04-08 2009-08-05 惠氏公司 Thioamide derivatives as progesterone receptor modulators
GB201113538D0 (en) * 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN104995194B (en) * 2012-10-12 2017-08-29 学校法人冲绳科学技术大学院大学学园 Spiro indole derivative and preparation method thereof
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
AU2017336074A1 (en) * 2016-09-30 2019-03-28 Epizyme, Inc. Substituted fused bi- or tri- heterocyclic compounds as ehmt2 inhibitors

Also Published As

Publication number Publication date
CZ20013950A3 (en) 2002-06-12
EP1181275A1 (en) 2002-02-27
HUP0200993A2 (en) 2002-07-29
MXPA01011285A (en) 2003-09-04
BG106078A (en) 2002-05-31
NO20015380L (en) 2002-01-03
NO320912B1 (en) 2006-02-13
HUP0200993A3 (en) 2003-05-28
NO20015380D0 (en) 2001-11-02
KR20020000636A (en) 2002-01-05
TR200103288T2 (en) 2002-04-22
PL351407A1 (en) 2003-04-22
AU4681400A (en) 2000-11-17
EA005034B1 (en) 2004-10-28
SK15902001A3 (en) 2002-11-06
CN1349499A (en) 2002-05-15
NZ515351A (en) 2004-01-30
CA2371633A1 (en) 2000-11-09
JP2002543182A (en) 2002-12-17
GEP20043266B (en) 2004-06-25
AU767762B2 (en) 2003-11-20
BR0010216A (en) 2002-03-19
CN1143847C (en) 2004-03-31

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU