GEP20043266B - Thio-Oxindole Derivatives - Google Patents

Thio-Oxindole Derivatives

Info

Publication number
GEP20043266B
GEP20043266B GEAP20006121A GEAP2000006121A GEP20043266B GE P20043266 B GEP20043266 B GE P20043266B GE AP20006121 A GEAP20006121 A GE AP20006121A GE AP2000006121 A GEAP2000006121 A GE AP2000006121A GE P20043266 B GEP20043266 B GE P20043266B
Authority
GE
Georgia
Prior art keywords
thio
oxindole derivatives
treatment
hormonotherapy
haemorrhage
Prior art date
Application number
GEAP20006121A
Inventor
Edward G Melenski
Christopher M Tegley
Lin Zhi
Andrew Fensome
Marci C Koko
James P Edwards
Todd K Jones
Jay E Wrobel
Puwen Zhang
Original Assignee
Ligand Pharmaceuticals Inc Us
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,033 external-priority patent/US6355648B1/en
Application filed by Ligand Pharmaceuticals Inc Us, American Home Prod filed Critical Ligand Pharmaceuticals Inc Us
Publication of GEP20043266B publication Critical patent/GEP20043266B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1. Technical Result Improvement of medicinal properties and increase in treatment efficiency. 2. Essence A compound of the formula (1) wherein R1-R5 and Q have the values indicated in the description or a pharmaceutically acceptable salt thereof and their use for mammals to obtain the medicament for treatment carcinomas and adenocarcinomas of endometrium, ovary, mammary gland, colon or prostatitis, dysfunctional haemorrhage and menopause after substitution hormonotherapy 3. Field of Application Medicine.
GEAP20006121A 1999-05-04 2000-05-01 Thio-Oxindole Derivatives GEP20043266B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17225999P 1999-05-04 1999-05-04
US09/552,033 US6355648B1 (en) 1999-05-04 2000-04-19 Thio-oxindole derivatives

Publications (1)

Publication Number Publication Date
GEP20043266B true GEP20043266B (en) 2004-06-25

Family

ID=26867898

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP20006121A GEP20043266B (en) 1999-05-04 2000-05-01 Thio-Oxindole Derivatives

Country Status (18)

Country Link
EP (1) EP1181275A1 (en)
JP (1) JP2002543182A (en)
KR (1) KR20020000636A (en)
CN (1) CN1143847C (en)
AU (1) AU767762B2 (en)
BG (1) BG106078A (en)
BR (1) BR0010216A (en)
CA (1) CA2371633A1 (en)
CZ (1) CZ20013950A3 (en)
EA (1) EA005034B1 (en)
GE (1) GEP20043266B (en)
HU (1) HUP0200993A3 (en)
MX (1) MXPA01011285A (en)
NO (1) NO320912B1 (en)
NZ (1) NZ515351A (en)
PL (1) PL351407A1 (en)
SK (1) SK15902001A3 (en)
TR (1) TR200103288T2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2313334T3 (en) * 2004-04-08 2009-03-01 Wyeth PROCEDURES FOR MIMIMIZING TIOMIDE IMPURITIES.
CN100522960C (en) * 2004-04-08 2009-08-05 惠氏公司 Thioamide derivatives as progesterone receptor modulators
GB201113538D0 (en) * 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN104995194B (en) * 2012-10-12 2017-08-29 学校法人冲绳科学技术大学院大学学园 Spiro indole derivative and preparation method thereof
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
AU2017336074A1 (en) * 2016-09-30 2019-03-28 Epizyme, Inc. Substituted fused bi- or tri- heterocyclic compounds as ehmt2 inhibitors

Also Published As

Publication number Publication date
CZ20013950A3 (en) 2002-06-12
EP1181275A1 (en) 2002-02-27
HUP0200993A2 (en) 2002-07-29
MXPA01011285A (en) 2003-09-04
BG106078A (en) 2002-05-31
NO20015380L (en) 2002-01-03
EA200101180A1 (en) 2002-04-25
NO320912B1 (en) 2006-02-13
HUP0200993A3 (en) 2003-05-28
NO20015380D0 (en) 2001-11-02
KR20020000636A (en) 2002-01-05
TR200103288T2 (en) 2002-04-22
PL351407A1 (en) 2003-04-22
AU4681400A (en) 2000-11-17
EA005034B1 (en) 2004-10-28
SK15902001A3 (en) 2002-11-06
CN1349499A (en) 2002-05-15
NZ515351A (en) 2004-01-30
CA2371633A1 (en) 2000-11-09
JP2002543182A (en) 2002-12-17
AU767762B2 (en) 2003-11-20
BR0010216A (en) 2002-03-19
CN1143847C (en) 2004-03-31

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