NZ515351A - Thio-oxindole derivatives - Google Patents
Thio-oxindole derivativesInfo
- Publication number
- NZ515351A NZ515351A NZ515351A NZ51535100A NZ515351A NZ 515351 A NZ515351 A NZ 515351A NZ 515351 A NZ515351 A NZ 515351A NZ 51535100 A NZ51535100 A NZ 51535100A NZ 515351 A NZ515351 A NZ 515351A
- Authority
- NZ
- New Zealand
- Prior art keywords
- optionally substituted
- substituted alkyl
- alkyl
- thio
- propynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A thio-oxindole derivative has the formula (I) wherein: R1 and R2 are independently H, optionally substituted alkyl, OH, O-(optionally substituted alkyl), O-Ac or optionally substituted aryl or heteroaryl, alkylaryl, alkylheteroaryl, 1-propynyl, or 3-propynyl or together R1 and R2 form a ring comprising -CH2(CH2)nCH2-, -O(CH2)mCH2-, O(CH2)pO-, -CH2CH2OCH2CH2- or -CH2CH2N(A)CH2CH2- or R1 and R2 together comprise a double bond to C(Me)2, C(cycloalkyl), O or C(cycloether); A is H or alkyl; m is 1 to 4; n is 1 to 5 and p is 1 to 4; R3 is H, OH, NH2, optionally substituted alkyl, alkenyl, optionally substituted alkynyl, or CORA, R4 is H, halogen, CN, NH2 or optionally substituted alkyl, alkoxy or aminoalkyl; R5 is substituted benzene or five or six membered heterocyclic ring with 1, 2, or 3 heteroatoms selected from O, S(O)t or NR6 or an optionally substituted indol-4-yl, indol-7-yl or benzo-2-thiophene moiety; t is 0 to 2; Q1 is S, NR7, or CR8R9 and RA and R6 to R8 are as defined in the specification. The compounds are useful for inducing contraception, for treating dysfunctional bleeding or carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, or prostate.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17225999P | 1999-05-04 | 1999-05-04 | |
| US09/552,033 US6355648B1 (en) | 1999-05-04 | 2000-04-19 | Thio-oxindole derivatives |
| PCT/US2000/011630 WO2000066555A1 (en) | 1999-05-04 | 2000-05-01 | Thio-oxindole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ515351A true NZ515351A (en) | 2004-01-30 |
Family
ID=26867898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ515351A NZ515351A (en) | 1999-05-04 | 2000-05-01 | Thio-oxindole derivatives |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1181275A1 (en) |
| JP (1) | JP2002543182A (en) |
| KR (1) | KR20020000636A (en) |
| CN (1) | CN1143847C (en) |
| AU (1) | AU767762B2 (en) |
| BG (1) | BG106078A (en) |
| BR (1) | BR0010216A (en) |
| CA (1) | CA2371633A1 (en) |
| CZ (1) | CZ20013950A3 (en) |
| EA (1) | EA005034B1 (en) |
| GE (1) | GEP20043266B (en) |
| HU (1) | HUP0200993A3 (en) |
| MX (1) | MXPA01011285A (en) |
| NO (1) | NO320912B1 (en) |
| NZ (1) | NZ515351A (en) |
| PL (1) | PL351407A1 (en) |
| SK (1) | SK15902001A3 (en) |
| TR (1) | TR200103288T2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2313334T3 (en) * | 2004-04-08 | 2009-03-01 | Wyeth | PROCEDURES FOR MIMIMIZING TIOMIDE IMPURITIES. |
| CN100522960C (en) * | 2004-04-08 | 2009-08-05 | 惠氏公司 | Thioamide derivatives as progesterone receptor modulators |
| GB201113538D0 (en) * | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| CN104995194B (en) * | 2012-10-12 | 2017-08-29 | 学校法人冲绳科学技术大学院大学学园 | Spiro indole derivative and preparation method thereof |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| AU2017336074A1 (en) * | 2016-09-30 | 2019-03-28 | Epizyme, Inc. | Substituted fused bi- or tri- heterocyclic compounds as ehmt2 inhibitors |
-
2000
- 2000-05-01 NZ NZ515351A patent/NZ515351A/en unknown
- 2000-05-01 HU HU0200993A patent/HUP0200993A3/en unknown
- 2000-05-01 KR KR1020017014076A patent/KR20020000636A/en not_active Application Discontinuation
- 2000-05-01 CA CA002371633A patent/CA2371633A1/en not_active Abandoned
- 2000-05-01 PL PL00351407A patent/PL351407A1/en not_active Application Discontinuation
- 2000-05-01 BR BR0010216-4A patent/BR0010216A/en not_active IP Right Cessation
- 2000-05-01 AU AU46814/00A patent/AU767762B2/en not_active Ceased
- 2000-05-01 EA EA200101180A patent/EA005034B1/en not_active IP Right Cessation
- 2000-05-01 TR TR2001/03288T patent/TR200103288T2/en unknown
- 2000-05-01 MX MXPA01011285A patent/MXPA01011285A/en unknown
- 2000-05-01 JP JP2000615386A patent/JP2002543182A/en active Pending
- 2000-05-01 EP EP00928603A patent/EP1181275A1/en not_active Withdrawn
- 2000-05-01 SK SK1590-2001A patent/SK15902001A3/en unknown
- 2000-05-01 CN CNB008071330A patent/CN1143847C/en not_active Expired - Fee Related
- 2000-05-01 CZ CZ20013950A patent/CZ20013950A3/en unknown
- 2000-05-01 GE GEAP20006121A patent/GEP20043266B/en unknown
-
2001
- 2001-11-02 NO NO20015380A patent/NO320912B1/en not_active Application Discontinuation
- 2001-11-02 BG BG106078A patent/BG106078A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20013950A3 (en) | 2002-06-12 |
| EP1181275A1 (en) | 2002-02-27 |
| HUP0200993A2 (en) | 2002-07-29 |
| MXPA01011285A (en) | 2003-09-04 |
| BG106078A (en) | 2002-05-31 |
| NO20015380L (en) | 2002-01-03 |
| EA200101180A1 (en) | 2002-04-25 |
| NO320912B1 (en) | 2006-02-13 |
| HUP0200993A3 (en) | 2003-05-28 |
| NO20015380D0 (en) | 2001-11-02 |
| KR20020000636A (en) | 2002-01-05 |
| TR200103288T2 (en) | 2002-04-22 |
| PL351407A1 (en) | 2003-04-22 |
| AU4681400A (en) | 2000-11-17 |
| EA005034B1 (en) | 2004-10-28 |
| SK15902001A3 (en) | 2002-11-06 |
| CN1349499A (en) | 2002-05-15 |
| CA2371633A1 (en) | 2000-11-09 |
| JP2002543182A (en) | 2002-12-17 |
| GEP20043266B (en) | 2004-06-25 |
| AU767762B2 (en) | 2003-11-20 |
| BR0010216A (en) | 2002-03-19 |
| CN1143847C (en) | 2004-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| ASS | Change of ownership |
Owner name: WYETH, US Free format text: OLD OWNER(S): WYETH; LIGAND PHARMACEUTICALS, INC. |