JP5118627B2 - スピロオキシインドール化合物および治療剤としてのその使用 - Google Patents

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Publication number

JP5118627B2

JP5118627B2 JP2008506802A JP2008506802A JP5118627B2 JP 5118627 B2 JP5118627 B2 JP 5118627B2 JP 2008506802 A JP2008506802 A JP 2008506802A JP 2008506802 A JP2008506802 A JP 2008506802A JP 5118627 B2 JP5118627 B2 JP 5118627B2

Authority

JP

Japan

Prior art keywords

indole

furo

oxospiro

benzodioxol

methyl

Prior art date

2005-04-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 150000001875 compounds Chemical class 0.000 title claims description 138
• 239000003814 drug Substances 0.000 title description 15
• 229940124597 therapeutic agent Drugs 0.000 title description 2
• 125000001072 heteroaryl group Chemical group 0.000 claims description 416
• 125000000623 heterocyclic group Chemical group 0.000 claims description 393
• -1 aralkenyl Chemical group 0.000 claims description 391
• 125000003118 aryl group Chemical group 0.000 claims description 377
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 332
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 292
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 291
• 125000000217 alkyl group Chemical group 0.000 claims description 278
• 229910052739 hydrogen Inorganic materials 0.000 claims description 232
• 239000001257 hydrogen Substances 0.000 claims description 232
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 212
• 125000001188 haloalkyl group Chemical group 0.000 claims description 204
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 201
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 187
• 150000002431 hydrogen Chemical class 0.000 claims description 177
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 165
• 125000003342 alkenyl group Chemical group 0.000 claims description 143
• 125000005843 halogen group Chemical group 0.000 claims description 131
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 127
• 125000000304 alkynyl group Chemical group 0.000 claims description 122
• 229910052757 nitrogen Inorganic materials 0.000 claims description 104
• 125000004450 alkenylene group Chemical group 0.000 claims description 88
• 125000002947 alkylene group Chemical group 0.000 claims description 88
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 85
• 125000004419 alkynylene group Chemical group 0.000 claims description 84
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 79
• 125000001424 substituent group Chemical group 0.000 claims description 76
• 125000000262 haloalkenyl group Chemical group 0.000 claims description 68
• 125000003545 alkoxy group Chemical group 0.000 claims description 57
• 125000004438 haloalkoxy group Chemical group 0.000 claims description 56
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 55
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 48
• 125000005605 benzo group Chemical group 0.000 claims description 42
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 41
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 28
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 18
• 125000004043 oxo group Chemical group O=* 0.000 claims description 17
• 150000003839 salts Chemical class 0.000 claims description 17
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 15
• 125000002346 iodo group Chemical group I* 0.000 claims description 13
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 13
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 12
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 9
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 7
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 7
• 125000003229 2-methylhexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 6
• 125000003469 3-methylhexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims description 6
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 6
• ZMANZCXQSJIPKH-UHFFFAOYSA-N triethylamine Natural products CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 6
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
• 229910052717 sulfur Inorganic materials 0.000 claims description 5
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 3
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
• 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 496
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 60
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 44
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 38
• 239000004202 carbamide Substances 0.000 claims 38
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 13
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 9
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 9
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 6
• 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 6
• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 5
• 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 5
• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 5
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 5
• 125000003003 spiro group Chemical group 0.000 claims 5
• 125000000301 2-(3-chlorophenyl)ethyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])* 0.000 claims 4
• 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims 4
• 125000002927 2-methoxybenzyl group Chemical group [H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])* 0.000 claims 4
• 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 4
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 4
• 125000006284 3-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(F)=C1[H])C([H])([H])* 0.000 claims 4
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 4
• 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims 4
• 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 4
• 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims 4
• DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 4
• 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 4
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 4
• 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 4
• DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims 4
• KICNGTSGLUFGHH-UHFFFAOYSA-N spiro[1h-indole-3,7'-6h-furo[2,3-f][1,3]benzodioxole]-2-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1NC2=O KICNGTSGLUFGHH-UHFFFAOYSA-N 0.000 claims 4
• 125000000579 2,2-diphenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims 3
• 125000006282 2-chlorobenzyl group Chemical group [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
• 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims 3
• 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 3
• YDTGEQZIOFPADD-UHFFFAOYSA-N 4'-[(6-methoxypyridin-3-yl)amino]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC=C(OC)N=C1 YDTGEQZIOFPADD-UHFFFAOYSA-N 0.000 claims 3
• 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 claims 3
• 150000001408 amides Chemical class 0.000 claims 3
• 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 3
• QMEKTTCBVOOSHJ-UHFFFAOYSA-N 1'-(3-aminopropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QMEKTTCBVOOSHJ-UHFFFAOYSA-N 0.000 claims 2
• GGZDPBXUIMTXCX-UHFFFAOYSA-N 1'-(3-cyclopropylpropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCC1CC1 GGZDPBXUIMTXCX-UHFFFAOYSA-N 0.000 claims 2
• MFQUWJBHQNNTCU-UHFFFAOYSA-N 1'-[(2-methylcyclopropyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CC1CC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O MFQUWJBHQNNTCU-UHFFFAOYSA-N 0.000 claims 2
• ASYZQJHAJLSZAD-UHFFFAOYSA-N 1'-[(6-methylpyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1=NC(C)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O ASYZQJHAJLSZAD-UHFFFAOYSA-N 0.000 claims 2
• CKJHZRHELGEWBS-UHFFFAOYSA-N 1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O CKJHZRHELGEWBS-UHFFFAOYSA-N 0.000 claims 2
• VHZAENHYWWAFBA-UHFFFAOYSA-N 1'-benzhydrylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 VHZAENHYWWAFBA-UHFFFAOYSA-N 0.000 claims 2
• DQUNBDRRYSBCBV-UHFFFAOYSA-N 1'-pentyl-6-phenoxyspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=CC=2)COC1=CC=2OC1=CC=CC=C1 DQUNBDRRYSBCBV-UHFFFAOYSA-N 0.000 claims 2
• PHMRUZIIERITEP-UHFFFAOYSA-N 1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 PHMRUZIIERITEP-UHFFFAOYSA-N 0.000 claims 2
• GETLKOJLHYPMAK-UHFFFAOYSA-N 1-[(6-chloropyridin-3-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound ClC1=CC=C(C=N1)CN1CC2(C3=CC=CC=C13)COC=1C2=CC2=C(OCO2)C=1 GETLKOJLHYPMAK-UHFFFAOYSA-N 0.000 claims 2
• PLWSNXOCEIBKNG-UHFFFAOYSA-N 1-[(6-methoxypyridin-3-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound COC1=CC=C(C=N1)CN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 PLWSNXOCEIBKNG-UHFFFAOYSA-N 0.000 claims 2
• 125000006507 2,4-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(F)C(=C1[H])C([H])([H])* 0.000 claims 2
• 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 2
• 125000006508 2,6-difluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C(F)=C1[H])C([H])([H])* 0.000 claims 2
• 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 125000006179 2-methyl benzyl group Chemical group [H]C1=C([H])C(=C(C([H])=C1[H])C([H])([H])*)C([H])([H])[H] 0.000 claims 2
• 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 2
• 125000003852 3-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])* 0.000 claims 2
• DYQNWBBSVZGJLO-UHFFFAOYSA-N 4'-(3,5-difluoroanilino)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC(F)=CC(F)=C1 DYQNWBBSVZGJLO-UHFFFAOYSA-N 0.000 claims 2
• CZACZWJTBBVSNR-UHFFFAOYSA-N 4'-[(4,6-dimethylpyridin-2-yl)amino]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC(C)=CC(C)=N1 CZACZWJTBBVSNR-UHFFFAOYSA-N 0.000 claims 2
• CQMDIWLOIGECLF-UHFFFAOYSA-N 4'-[(4-methyl-1,3-thiazol-2-yl)amino]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=NC(C)=CS1 CQMDIWLOIGECLF-UHFFFAOYSA-N 0.000 claims 2
• HVFUAXCTAFMIBJ-UHFFFAOYSA-N 4'-bromo-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C(Br)C2=C1N(CCCCC)C(=O)C21C2=CC(OCO3)=C3C=C2OC1 HVFUAXCTAFMIBJ-UHFFFAOYSA-N 0.000 claims 2
• AHFINSWGYAZBOZ-UHFFFAOYSA-N 4-chloro-2-(trifluoromethyl)benzaldehyde Chemical group FC(F)(F)C1=CC(Cl)=CC=C1C=O AHFINSWGYAZBOZ-UHFFFAOYSA-N 0.000 claims 2
• RNOVGJWJVRESAA-UHFFFAOYSA-N 4-fluoro-2-(trifluoromethyl)phenol Chemical group OC1=CC=C(F)C=C1C(F)(F)F RNOVGJWJVRESAA-UHFFFAOYSA-N 0.000 claims 2
• 125000004861 4-isopropyl phenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• YYVUSJOJYZSQKC-UHFFFAOYSA-N 5'-methyl-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC(C)=CC=C2N1CC1=CC=C(C(F)(F)F)O1 YYVUSJOJYZSQKC-UHFFFAOYSA-N 0.000 claims 2
• DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 2
• 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 2
• 229960003966 nicotinamide Drugs 0.000 claims 2
• 235000005152 nicotinamide Nutrition 0.000 claims 2
• 239000011570 nicotinamide Substances 0.000 claims 2
• DENPQNAWGQXKCU-UHFFFAOYSA-N thiophene-2-carboxamide Chemical compound NC(=O)C1=CC=CS1 DENPQNAWGQXKCU-UHFFFAOYSA-N 0.000 claims 2
• BKMXPNAWGWSRIY-UHFFFAOYSA-N (3,4,5-trimethoxyphenyl)methylurea Chemical compound COC1=CC(CNC(N)=O)=CC(OC)=C1OC BKMXPNAWGWSRIY-UHFFFAOYSA-N 0.000 claims 1
• RPEULPUEYFQGPF-UHFFFAOYSA-N 1'-(1,2,4-oxadiazol-3-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC=1N=CON=1 RPEULPUEYFQGPF-UHFFFAOYSA-N 0.000 claims 1
• VTPRPQDBWWGAFL-UHFFFAOYSA-N 1'-(1,3-benzodioxol-5-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC=1C=C3OCOC3=CC=1)C2=O VTPRPQDBWWGAFL-UHFFFAOYSA-N 0.000 claims 1
• JRESYUYCWHYDCY-UHFFFAOYSA-N 1'-(1,3-thiazol-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CSC=N1 JRESYUYCWHYDCY-UHFFFAOYSA-N 0.000 claims 1
• ARATTZXFWCIHQP-UHFFFAOYSA-N 1'-(2,1,3-benzothiadiazol-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC=1C3=NSN=C3C=CC=1)C2=O ARATTZXFWCIHQP-UHFFFAOYSA-N 0.000 claims 1
• VSYDOYJZDIOHIN-UHFFFAOYSA-N 1'-(2,1,3-benzothiadiazol-5-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC1=CC3=NSN=C3C=C1)C2=O VSYDOYJZDIOHIN-UHFFFAOYSA-N 0.000 claims 1
• NKFPSNRHRZXGDX-UHFFFAOYSA-N 1'-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC1OC3=CC=CC=C3OC1)C2=O NKFPSNRHRZXGDX-UHFFFAOYSA-N 0.000 claims 1
• QVYXLZNJHVDOPG-UHFFFAOYSA-N 1'-(2-aminoethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCN)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QVYXLZNJHVDOPG-UHFFFAOYSA-N 0.000 claims 1
• QBBPVYOZLZVPEK-UHFFFAOYSA-N 1'-(2-bromoethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCBr)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QBBPVYOZLZVPEK-UHFFFAOYSA-N 0.000 claims 1
• CAWCKOZFWXJYGT-UHFFFAOYSA-N 1'-(2-cyclopropylethyl)-4'-quinolin-3-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC(C=3C=C4C=CC=CC4=NC=3)=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCC1CC1 CAWCKOZFWXJYGT-UHFFFAOYSA-N 0.000 claims 1
• ZQCFXLVLNULFCD-UHFFFAOYSA-N 1'-(2-cyclopropylethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCC1CC1 ZQCFXLVLNULFCD-UHFFFAOYSA-N 0.000 claims 1
• SSAAEWBZOTUPNX-UHFFFAOYSA-N 1'-(2-ethoxyethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCOCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 SSAAEWBZOTUPNX-UHFFFAOYSA-N 0.000 claims 1
• NZEOITLIMNITRZ-UHFFFAOYSA-N 1'-(2-ethylbutyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CC(CC)CC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 NZEOITLIMNITRZ-UHFFFAOYSA-N 0.000 claims 1
• FVDMZRBAWQAOOZ-UHFFFAOYSA-N 1'-(2-morpholin-4-yl-2-oxoethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC(=O)N1CCOCC1 FVDMZRBAWQAOOZ-UHFFFAOYSA-N 0.000 claims 1
• BPDQMSDNTVPVIC-UHFFFAOYSA-N 1'-(2-oxo-2-piperidin-1-ylethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC(=O)N1CCCCC1 BPDQMSDNTVPVIC-UHFFFAOYSA-N 0.000 claims 1
• SNEVEBJNSPVPGQ-UHFFFAOYSA-N 1'-(2-piperidin-1-ylethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCN1CCCCC1 SNEVEBJNSPVPGQ-UHFFFAOYSA-N 0.000 claims 1
• XKYWYNOBQLFJHB-UHFFFAOYSA-N 1'-(2-piperidin-4-ylethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCC1CCNCC1 XKYWYNOBQLFJHB-UHFFFAOYSA-N 0.000 claims 1
• JGNOTIUPVSMKRP-UHFFFAOYSA-N 1'-(2-pyrrol-1-ylethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCN1C=CC=C1 JGNOTIUPVSMKRP-UHFFFAOYSA-N 0.000 claims 1
• REIUZAXANRBWIO-UHFFFAOYSA-N 1'-(2h-triazol-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CNN=N1 REIUZAXANRBWIO-UHFFFAOYSA-N 0.000 claims 1
• NPUKYFDTBUQMSC-UHFFFAOYSA-N 1'-(3,4-dihydro-2h-1,5-benzodioxepin-7-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1CCCOC2=CC(CN3C(C4(C5=CC=6OCOC=6C=C5OC4)C4=CC=CC=C43)=O)=CC=C21 NPUKYFDTBUQMSC-UHFFFAOYSA-N 0.000 claims 1
• QRTMSVZHEMRJFE-UHFFFAOYSA-N 1'-(3-chloropropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCl)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QRTMSVZHEMRJFE-UHFFFAOYSA-N 0.000 claims 1
• GQAMGYNINYASHU-UHFFFAOYSA-N 1'-(3-hydroxypropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCO)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 GQAMGYNINYASHU-UHFFFAOYSA-N 0.000 claims 1
• WEPGWUYYPMCUDT-UHFFFAOYSA-N 1'-(3-methylbut-2-enyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CC=C(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 WEPGWUYYPMCUDT-UHFFFAOYSA-N 0.000 claims 1
• SQXXJGJKOCQFBH-UHFFFAOYSA-N 1'-(3-phenylmethoxypropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCOCC1=CC=CC=C1 SQXXJGJKOCQFBH-UHFFFAOYSA-N 0.000 claims 1
• CJBQJCRGRVFUOT-UHFFFAOYSA-N 1'-(3-piperidin-1-ylpropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCN1CCCCC1 CJBQJCRGRVFUOT-UHFFFAOYSA-N 0.000 claims 1
• LKOVUXHBNGSKFW-UHFFFAOYSA-N 1'-(3-pyrrol-1-ylpropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCN1C=CC=C1 LKOVUXHBNGSKFW-UHFFFAOYSA-N 0.000 claims 1
• BOUAZUSMAPCRKM-UHFFFAOYSA-N 1'-(3-pyrrolidin-1-ylpropyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCN1CCCC1 BOUAZUSMAPCRKM-UHFFFAOYSA-N 0.000 claims 1
• SCELVKQCHNUOOH-UHFFFAOYSA-N 1'-(4,4,4-trifluorobutyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCC(F)(F)F)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 SCELVKQCHNUOOH-UHFFFAOYSA-N 0.000 claims 1
• XYEIWIUZVAEGJE-UHFFFAOYSA-N 1'-(4-methylpentyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 XYEIWIUZVAEGJE-UHFFFAOYSA-N 0.000 claims 1
• NTPSMBDHZVNDHS-UHFFFAOYSA-N 1'-(5-chloropentyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCCCl)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 NTPSMBDHZVNDHS-UHFFFAOYSA-N 0.000 claims 1
• SIOYIEGGMNRCOQ-UHFFFAOYSA-N 1'-(5-methylhexyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 SIOYIEGGMNRCOQ-UHFFFAOYSA-N 0.000 claims 1
• LMYIODPHDKTUIO-UHFFFAOYSA-N 1'-(cyclobutylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCC1 LMYIODPHDKTUIO-UHFFFAOYSA-N 0.000 claims 1
• OGKXJSLVDCYBIQ-UHFFFAOYSA-N 1'-(cyclohexylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCCCC1 OGKXJSLVDCYBIQ-UHFFFAOYSA-N 0.000 claims 1
• YHERPHNXNWNVOO-UHFFFAOYSA-N 1'-(cyclopropylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CC1 YHERPHNXNWNVOO-UHFFFAOYSA-N 0.000 claims 1
• MCQZHODKEUGHMD-UHFFFAOYSA-N 1'-(furan-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CO1 MCQZHODKEUGHMD-UHFFFAOYSA-N 0.000 claims 1
• YISYALOZMMIVDE-UHFFFAOYSA-N 1'-(naphthalen-1-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC=1C3=CC=CC=C3C=CC=1)C2=O YISYALOZMMIVDE-UHFFFAOYSA-N 0.000 claims 1
• IRTXUHFNKHSVMV-UHFFFAOYSA-N 1'-(oxan-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCCCO1 IRTXUHFNKHSVMV-UHFFFAOYSA-N 0.000 claims 1
• BFVPTTJCADYNAJ-UHFFFAOYSA-N 1'-(oxan-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCOCC1 BFVPTTJCADYNAJ-UHFFFAOYSA-N 0.000 claims 1
• XGZKLUXHCVAMQO-UHFFFAOYSA-N 1'-(oxolan-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCCO1 XGZKLUXHCVAMQO-UHFFFAOYSA-N 0.000 claims 1
• LHJYTPHTRANOAL-UHFFFAOYSA-N 1'-(phenylmethoxymethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1COCC1=CC=CC=C1 LHJYTPHTRANOAL-UHFFFAOYSA-N 0.000 claims 1
• JZKHDHFPODDKMV-UHFFFAOYSA-N 1'-(piperidin-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1CCNCC1 JZKHDHFPODDKMV-UHFFFAOYSA-N 0.000 claims 1
• FTOGYMPSUFBHJN-UHFFFAOYSA-N 1'-(pyridin-2-ylmethyl)-6-(trifluoromethoxy)spiro[2h-1-benzofuran-3,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C=1C(OC(F)(F)F)=CC=C2C=1OCC2(C1=CC=CC=C11)C(=O)N1CC1=CC=CC=N1 FTOGYMPSUFBHJN-UHFFFAOYSA-N 0.000 claims 1
• SQICVPOVJXBQIN-UHFFFAOYSA-N 1'-(pyridin-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CC=N1 SQICVPOVJXBQIN-UHFFFAOYSA-N 0.000 claims 1
• SWKJUHBCOLARHI-UHFFFAOYSA-N 1'-(pyridin-3-ylmethyl)-6-(trifluoromethoxy)spiro[2h-1-benzofuran-3,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C=1C(OC(F)(F)F)=CC=C2C=1OCC2(C1=CC=CC=C11)C(=O)N1CC1=CC=CN=C1 SWKJUHBCOLARHI-UHFFFAOYSA-N 0.000 claims 1
• AJTGUERLIJOXRF-UHFFFAOYSA-N 1'-(pyridin-3-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CN=C1 AJTGUERLIJOXRF-UHFFFAOYSA-N 0.000 claims 1
• BCCYMGKEQKJKOZ-UHFFFAOYSA-N 1'-(pyridin-4-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=NC=C1 BCCYMGKEQKJKOZ-UHFFFAOYSA-N 0.000 claims 1
• IOUPBOXMRKTMGK-UHFFFAOYSA-N 1'-(thiophen-2-ylmethyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CS1 IOUPBOXMRKTMGK-UHFFFAOYSA-N 0.000 claims 1
• ZQEIEXQGFYYNMT-UHFFFAOYSA-N 1'-[(1-cyclobutylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(CC1)CCN1C1CCC1 ZQEIEXQGFYYNMT-UHFFFAOYSA-N 0.000 claims 1
• PHSAKMNVWAMSSQ-UHFFFAOYSA-N 1'-[(1-cyclohexylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(CC1)CCN1C1CCCCC1 PHSAKMNVWAMSSQ-UHFFFAOYSA-N 0.000 claims 1
• WMXCRRYCMGUVCZ-UHFFFAOYSA-N 1'-[(1-cyclopentylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(CC1)CCN1C1CCCC1 WMXCRRYCMGUVCZ-UHFFFAOYSA-N 0.000 claims 1
• IIQACCGKWWUQSE-UHFFFAOYSA-N 1'-[(1-ethylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(CC)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O IIQACCGKWWUQSE-UHFFFAOYSA-N 0.000 claims 1
• SLROUEVGEJXQDO-UHFFFAOYSA-N 1'-[(1-methyl-6-oxopyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(=O)N(C)C=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O SLROUEVGEJXQDO-UHFFFAOYSA-N 0.000 claims 1
• BBRGYFGKJNYOSI-UHFFFAOYSA-N 1'-[(1-methylbenzimidazol-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C2N(C)C(CN3C4=CC=CC=C4C4(C5=CC=6OCOC=6C=C5OC4)C3=O)=NC2=C1 BBRGYFGKJNYOSI-UHFFFAOYSA-N 0.000 claims 1
• VMOJFBHVOGHJRQ-UHFFFAOYSA-N 1'-[(1-methylbenzotriazol-5-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=CC=C2N(C)N=NC2=C1 VMOJFBHVOGHJRQ-UHFFFAOYSA-N 0.000 claims 1
• DYUITQZLECTEEV-UHFFFAOYSA-N 1'-[(1-methylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(C)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O DYUITQZLECTEEV-UHFFFAOYSA-N 0.000 claims 1
• RTLYWNQXZGLIJD-UHFFFAOYSA-N 1'-[(1-pentan-3-ylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(C(CC)CC)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O RTLYWNQXZGLIJD-UHFFFAOYSA-N 0.000 claims 1
• BSRPLSYDPSGQDG-UHFFFAOYSA-N 1'-[(1-propan-2-ylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(C(C)C)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O BSRPLSYDPSGQDG-UHFFFAOYSA-N 0.000 claims 1
• TXWQLKXQMHGURO-UHFFFAOYSA-N 1'-[(1-pyridin-2-ylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(CC1)CCN1C1=CC=CC=N1 TXWQLKXQMHGURO-UHFFFAOYSA-N 0.000 claims 1
• PSSJGPYANIPXDQ-UHFFFAOYSA-N 1'-[(2,2,3,3-tetrafluorocyclobutyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1(F)C(F)(F)CC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O PSSJGPYANIPXDQ-UHFFFAOYSA-N 0.000 claims 1
• WVOJCMQIONWQQK-UHFFFAOYSA-N 1'-[(2,3-difluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1F WVOJCMQIONWQQK-UHFFFAOYSA-N 0.000 claims 1
• ARQRUISTPWKFSJ-UHFFFAOYSA-N 1'-[(2,4-difluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC(F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O ARQRUISTPWKFSJ-UHFFFAOYSA-N 0.000 claims 1
• CNIISRVZSVZYRD-UHFFFAOYSA-N 1'-[(2,5-difluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=C(F)C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 CNIISRVZSVZYRD-UHFFFAOYSA-N 0.000 claims 1
• QVNNBLFAIHQNGV-UHFFFAOYSA-N 1'-[(2,6-difluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(F)=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O QVNNBLFAIHQNGV-UHFFFAOYSA-N 0.000 claims 1
• NZSGJTDQUFOQEI-UHFFFAOYSA-N 1'-[(2-chloro-1,3-thiazol-5-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C(Cl)=NC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O NZSGJTDQUFOQEI-UHFFFAOYSA-N 0.000 claims 1
• YUJBKOVXXMEPFL-UHFFFAOYSA-N 1'-[(2-chloro-4-fluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound ClC1=CC(F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O YUJBKOVXXMEPFL-UHFFFAOYSA-N 0.000 claims 1
• ADXDXRGHOAKFNW-UHFFFAOYSA-N 1'-[(2-cyclopropyl-4-oxo-1h-pyrimidin-6-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound N=1C(O)=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=NC=1C1CC1 ADXDXRGHOAKFNW-UHFFFAOYSA-N 0.000 claims 1
• XKZZFRZGGCDJTK-UHFFFAOYSA-N 1'-[(2-methyl-1,3-thiazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C(C)=NC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 XKZZFRZGGCDJTK-UHFFFAOYSA-N 0.000 claims 1
• PUEWHVPXTGDJHM-UHFFFAOYSA-N 1'-[(2-oxo-1,3-benzothiazol-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CN1C(SC3=CC=CC=C31)=O)C2=O PUEWHVPXTGDJHM-UHFFFAOYSA-N 0.000 claims 1
• YIXYHDKIFLPTNX-UHFFFAOYSA-N 1'-[(2-phenylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CC=C1C1=CC=CC=C1 YIXYHDKIFLPTNX-UHFFFAOYSA-N 0.000 claims 1
• KEYCNSBXRZCERC-UHFFFAOYSA-N 1'-[(2-propan-2-yl-1,3-oxazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(C(C)C)=NC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 KEYCNSBXRZCERC-UHFFFAOYSA-N 0.000 claims 1
• DKLRWVFHELFKGI-UHFFFAOYSA-N 1'-[(3,5-difluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC(F)=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 DKLRWVFHELFKGI-UHFFFAOYSA-N 0.000 claims 1
• MUGICCIBIFQXME-UHFFFAOYSA-N 1'-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CC1=NOC(C)=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O MUGICCIBIFQXME-UHFFFAOYSA-N 0.000 claims 1
• VDNNGROEBXRVQB-UHFFFAOYSA-N 1'-[(3-fluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 VDNNGROEBXRVQB-UHFFFAOYSA-N 0.000 claims 1
• CKTUKNOPGUZTPA-UHFFFAOYSA-N 1'-[(3-methoxyphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound COC1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 CKTUKNOPGUZTPA-UHFFFAOYSA-N 0.000 claims 1
• MOMXDTHBGFNVJQ-UHFFFAOYSA-N 1'-[(3-methyl-5-phenyl-1,2-oxazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC=1C(C)=NOC=1C1=CC=CC=C1 MOMXDTHBGFNVJQ-UHFFFAOYSA-N 0.000 claims 1
• QHIBPTVXLHQTMD-UHFFFAOYSA-N 1'-[(3-nitrophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound [O-][N+](=O)C1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 QHIBPTVXLHQTMD-UHFFFAOYSA-N 0.000 claims 1
• RVISZLWDGRHVJI-UHFFFAOYSA-N 1'-[(3-pyrrol-1-ylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=1)=CC=CC=1N1C=CC=C1 RVISZLWDGRHVJI-UHFFFAOYSA-N 0.000 claims 1
• VBHPJGRHUZKUJA-UHFFFAOYSA-N 1'-[(4-chlorophenoxy)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(Cl)=CC=C1OCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O VBHPJGRHUZKUJA-UHFFFAOYSA-N 0.000 claims 1
• CBZDSRKPCQBACL-UHFFFAOYSA-N 1'-[(4-fluoro-3-methylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(F)C(C)=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 CBZDSRKPCQBACL-UHFFFAOYSA-N 0.000 claims 1
• DTVRNKGYGSHILK-UHFFFAOYSA-N 1'-[(4-fluorophenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O DTVRNKGYGSHILK-UHFFFAOYSA-N 0.000 claims 1
• CNPOLAKRFUNSKM-UHFFFAOYSA-N 1'-[(4-hydroxy-1,2,2,6,6-pentamethylpiperidin-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1C(C)(C)N(C)C(C)(C)CC1(O)CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O CNPOLAKRFUNSKM-UHFFFAOYSA-N 0.000 claims 1
• ZLYVJSRDNJIKGH-UHFFFAOYSA-N 1'-[(4-methoxyphenyl)methyl]-6-(trifluoromethoxy)spiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C1=CC(OC)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=C(OC(F)(F)F)C=C3OC2)C1=O ZLYVJSRDNJIKGH-UHFFFAOYSA-N 0.000 claims 1
• RGHIDJBRMWASIV-UHFFFAOYSA-N 1'-[(4-phenylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1 RGHIDJBRMWASIV-UHFFFAOYSA-N 0.000 claims 1
• XEHUHFDAEQGOCP-UHFFFAOYSA-N 1'-[(4-pyrazol-1-ylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=C1)=CC=C1N1C=CC=N1 XEHUHFDAEQGOCP-UHFFFAOYSA-N 0.000 claims 1
• HCWRHFDIYSCUJH-UHFFFAOYSA-N 1'-[(4-pyrrol-1-ylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=C1)=CC=C1N1C=CC=C1 HCWRHFDIYSCUJH-UHFFFAOYSA-N 0.000 claims 1
• SRIOKKJYFBEZSD-UHFFFAOYSA-N 1'-[(5-bromofuran-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(Br)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O SRIOKKJYFBEZSD-UHFFFAOYSA-N 0.000 claims 1
• RDOOPPPVWNCVGI-UHFFFAOYSA-N 1'-[(5-chloro-1,3,4-thiadiazol-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C(Cl)=NN=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O RDOOPPPVWNCVGI-UHFFFAOYSA-N 0.000 claims 1
• QFWRYOMLYKFIMQ-UHFFFAOYSA-N 1'-[(5-chloro-1-benzothiophen-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=CSC2=CC=C(Cl)C=C21 QFWRYOMLYKFIMQ-UHFFFAOYSA-N 0.000 claims 1
• PXNLGQYRAQQLRL-UHFFFAOYSA-N 1'-[(5-chlorofuran-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(Cl)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O PXNLGQYRAQQLRL-UHFFFAOYSA-N 0.000 claims 1
• OTRJFXKTNUJFGM-UHFFFAOYSA-N 1'-[(5-chlorothiophen-2-yl)methyl]-5'-fluorospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC(F)=CC=C2N1CC1=CC=C(Cl)S1 OTRJFXKTNUJFGM-UHFFFAOYSA-N 0.000 claims 1
• JNBPICRKECPDTB-UHFFFAOYSA-N 1'-[(5-chlorothiophen-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C(Cl)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O JNBPICRKECPDTB-UHFFFAOYSA-N 0.000 claims 1
• QDZCRRSOTKOOEY-UHFFFAOYSA-N 1'-[(5-fluoro-2-methylphenyl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CC1=CC=C(F)C=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O QDZCRRSOTKOOEY-UHFFFAOYSA-N 0.000 claims 1
• VQCYDVYLHDWDNZ-UHFFFAOYSA-N 1'-[(5-methyl-1,2-oxazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1N=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1C VQCYDVYLHDWDNZ-UHFFFAOYSA-N 0.000 claims 1
• IIALACDSVNRKDV-UHFFFAOYSA-N 1'-[(5-methyl-2-phenyltriazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound N1=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C(C)=NN1C1=CC=CC=C1 IIALACDSVNRKDV-UHFFFAOYSA-N 0.000 claims 1
• LQAXLOXMGYGMPF-UHFFFAOYSA-N 1'-[(5-methylfuran-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(C)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O LQAXLOXMGYGMPF-UHFFFAOYSA-N 0.000 claims 1
• NKLQZJKICGIATF-UHFFFAOYSA-N 1'-[(5-methylsulfonylfuran-2-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(S(=O)(=O)C)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O NKLQZJKICGIATF-UHFFFAOYSA-N 0.000 claims 1
• WJDNFTGYDVTHDN-UHFFFAOYSA-N 1'-[(5-phenyl-1,3-oxazol-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC=1N=COC=1C1=CC=CC=C1 WJDNFTGYDVTHDN-UHFFFAOYSA-N 0.000 claims 1
• NHFVLUQQMNIGQA-UHFFFAOYSA-N 1'-[(6-fluoro-4h-1,3-benzodioxin-8-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1COCC2=CC(F)=CC(CN3C4=CC=CC=C4C4(C5=CC=6OCOC=6C=C5OC4)C3=O)=C21 NHFVLUQQMNIGQA-UHFFFAOYSA-N 0.000 claims 1
• KTEJABWLSIDCJF-UHFFFAOYSA-N 1'-[(6-morpholin-4-ylpyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=N1)=CC=C1N1CCOCC1 KTEJABWLSIDCJF-UHFFFAOYSA-N 0.000 claims 1
• YJOUTZMMEUJKFB-UHFFFAOYSA-N 1'-[(6-oxo-1h-pyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC=1C=CC(=O)NC=1 YJOUTZMMEUJKFB-UHFFFAOYSA-N 0.000 claims 1
• YJQSCPRMCHUZAL-UHFFFAOYSA-N 1'-[(6-pyrrolidin-1-ylpyridin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=N1)=CC=C1N1CCCC1 YJQSCPRMCHUZAL-UHFFFAOYSA-N 0.000 claims 1
• NMLFFWKYAICRGF-UHFFFAOYSA-N 1'-[(7-methoxy-2-oxo-1,4-benzoxazin-3-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=NC2=CC=C(OC)C=C2OC1=O NMLFFWKYAICRGF-UHFFFAOYSA-N 0.000 claims 1
• UVLKIDCBVFNEOG-UHFFFAOYSA-N 1'-[(7-methoxy-2-oxochromen-4-yl)methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=CC(=O)OC2=CC(OC)=CC=C21 UVLKIDCBVFNEOG-UHFFFAOYSA-N 0.000 claims 1
• FTCOYNFKHUACGY-ZZXKWVIFSA-N 1'-[(e)-pent-2-enyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(C/C=C/CC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 FTCOYNFKHUACGY-ZZXKWVIFSA-N 0.000 claims 1
• QVKIZNJCPQBHHA-CHHVJCJISA-N 1'-[(z)-4-methylhex-3-enyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CC\C=C(C)/CC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QVKIZNJCPQBHHA-CHHVJCJISA-N 0.000 claims 1
• FOZKSYFLKKYSAS-UHFFFAOYSA-N 1'-[2-(1-cyclopentylpiperidin-4-yl)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCC(CC1)CCN1C1CCCC1 FOZKSYFLKKYSAS-UHFFFAOYSA-N 0.000 claims 1
• QJTUHCOYYIGOQP-UHFFFAOYSA-N 1'-[2-(1-propan-2-ylpiperidin-4-yl)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(C(C)C)CCC1CCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O QJTUHCOYYIGOQP-UHFFFAOYSA-N 0.000 claims 1
• GUOJXISRQSLSJW-UHFFFAOYSA-N 1'-[2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1CC(C)(C)COC1(C)CCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O GUOJXISRQSLSJW-UHFFFAOYSA-N 0.000 claims 1
• GWFFQXNKIDYQPZ-UHFFFAOYSA-N 1'-[2-(2-methoxyethoxy)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCOCCOC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 GWFFQXNKIDYQPZ-UHFFFAOYSA-N 0.000 claims 1
• DMETYASETWMKDX-UHFFFAOYSA-N 1'-[2-(diethylamino)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCN(CC)CC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 DMETYASETWMKDX-UHFFFAOYSA-N 0.000 claims 1
• FTKFBEZKJKDETG-UHFFFAOYSA-N 1'-[2-(dipyridin-2-ylamino)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCN(C=1N=CC=CC=1)C1=CC=CC=N1 FTKFBEZKJKDETG-UHFFFAOYSA-N 0.000 claims 1
• IYGPXKMZGBDZBB-UHFFFAOYSA-N 1'-[2-(pyridin-2-ylamino)ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCNC1=CC=CC=N1 IYGPXKMZGBDZBB-UHFFFAOYSA-N 0.000 claims 1
• GRJHVJVJZHRSCH-UHFFFAOYSA-N 1'-[2-[1-(oxan-4-yl)piperidin-4-yl]ethyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCC(CC1)CCN1C1CCOCC1 GRJHVJVJZHRSCH-UHFFFAOYSA-N 0.000 claims 1
• ZJCQRDCZAJGIAZ-UHFFFAOYSA-N 1'-[3-(1-phenylpropan-2-ylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCCNC(C)CC1=CC=CC=C1 ZJCQRDCZAJGIAZ-UHFFFAOYSA-N 0.000 claims 1
• XHAYGGWAINLZBA-UHFFFAOYSA-N 1'-[3-(2,2,2-trifluoroethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCC(F)(F)F)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 XHAYGGWAINLZBA-UHFFFAOYSA-N 0.000 claims 1
• IHYUJNPXNWGBFA-UHFFFAOYSA-N 1'-[3-(2,2-dimethylpropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCC(C)(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 IHYUJNPXNWGBFA-UHFFFAOYSA-N 0.000 claims 1
• UJAKRJUYBSQLLH-UHFFFAOYSA-N 1'-[3-(2,2-diphenylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC(C=1C=CC=CC=1)C1=CC=CC=C1 UJAKRJUYBSQLLH-UHFFFAOYSA-N 0.000 claims 1
• BGEVEDJWJVANIK-UHFFFAOYSA-N 1'-[3-(2-cyclohexylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1CCCCC1 BGEVEDJWJVANIK-UHFFFAOYSA-N 0.000 claims 1
• ZWVBSNRCANQYBC-UHFFFAOYSA-N 1'-[3-(2-cyclopropylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1CC1 ZWVBSNRCANQYBC-UHFFFAOYSA-N 0.000 claims 1
• GKPLEGSELZQOTP-UHFFFAOYSA-N 1'-[3-(2-ethoxyethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCOCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 GKPLEGSELZQOTP-UHFFFAOYSA-N 0.000 claims 1
• LJRMJCNWSHKGEP-UHFFFAOYSA-N 1'-[3-(2-methylpropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 LJRMJCNWSHKGEP-UHFFFAOYSA-N 0.000 claims 1
• CMWJKTXLFOEZEZ-UHFFFAOYSA-N 1'-[3-(2-morpholin-4-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCN1CCOCC1 CMWJKTXLFOEZEZ-UHFFFAOYSA-N 0.000 claims 1
• YOTXLZNPGJPHMA-UHFFFAOYSA-N 1'-[3-(2-phenylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1=CC=CC=C1 YOTXLZNPGJPHMA-UHFFFAOYSA-N 0.000 claims 1
• IDPKQUVBWCGWLS-UHFFFAOYSA-N 1'-[3-(2-piperidin-1-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCN1CCCCC1 IDPKQUVBWCGWLS-UHFFFAOYSA-N 0.000 claims 1
• OFKYTAQWJRVYFL-UHFFFAOYSA-N 1'-[3-(2-propan-2-yloxyethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCOC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 OFKYTAQWJRVYFL-UHFFFAOYSA-N 0.000 claims 1
• GIVMUMRKJJGCBV-UHFFFAOYSA-N 1'-[3-(2-pyridin-2-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1=CC=CC=N1 GIVMUMRKJJGCBV-UHFFFAOYSA-N 0.000 claims 1
• NQRKQWACFYEZHR-UHFFFAOYSA-N 1'-[3-(2-pyridin-3-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC1=CC=CN=C1 NQRKQWACFYEZHR-UHFFFAOYSA-N 0.000 claims 1
• KTPWASWOTPXWSH-UHFFFAOYSA-N 1'-[3-(2-pyrrolidin-1-ylethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCN1CCCC1 KTPWASWOTPXWSH-UHFFFAOYSA-N 0.000 claims 1
• ZKGULDRBOBFADQ-UHFFFAOYSA-N 1'-[3-(3,3-dimethylbutylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCC(C)(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 ZKGULDRBOBFADQ-UHFFFAOYSA-N 0.000 claims 1
• IERASTOZDZPGKT-UHFFFAOYSA-N 1'-[3-(3-ethoxypropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCOCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 IERASTOZDZPGKT-UHFFFAOYSA-N 0.000 claims 1
• WCFWUULSAZRTMZ-UHFFFAOYSA-N 1'-[3-(3-methoxypropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCOC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 WCFWUULSAZRTMZ-UHFFFAOYSA-N 0.000 claims 1
• KAQLIWUBQOKVDS-UHFFFAOYSA-N 1'-[3-(3-methylbutan-2-ylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNC(C)C(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 KAQLIWUBQOKVDS-UHFFFAOYSA-N 0.000 claims 1
• LZSIEVQKLPECOI-UHFFFAOYSA-N 1'-[3-(3-morpholin-4-ylpropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCCN1CCOCC1 LZSIEVQKLPECOI-UHFFFAOYSA-N 0.000 claims 1
• HNCNQTHOSBIPGC-UHFFFAOYSA-N 1'-[3-(3-phenylpropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCCC1=CC=CC=C1 HNCNQTHOSBIPGC-UHFFFAOYSA-N 0.000 claims 1
• ZNYVZFDSYHHZAE-UHFFFAOYSA-N 1'-[3-(3-propan-2-yloxypropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCOC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 ZNYVZFDSYHHZAE-UHFFFAOYSA-N 0.000 claims 1
• KHUOVTZHBOHNIQ-UHFFFAOYSA-N 1'-[3-(benzylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1=CC=CC=C1 KHUOVTZHBOHNIQ-UHFFFAOYSA-N 0.000 claims 1
• ZZOXELOTQICWBO-UHFFFAOYSA-N 1'-[3-(cyclobutylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNC1CCC1 ZZOXELOTQICWBO-UHFFFAOYSA-N 0.000 claims 1
• LUYOBNDESCLUEH-UHFFFAOYSA-N 1'-[3-(cyclohexylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNC1CCCCC1 LUYOBNDESCLUEH-UHFFFAOYSA-N 0.000 claims 1
• UOUKWMJAQFNKGK-UHFFFAOYSA-N 1'-[3-(cyclohexylmethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1CCCCC1 UOUKWMJAQFNKGK-UHFFFAOYSA-N 0.000 claims 1
• UPDLYRDYEYEHOW-UHFFFAOYSA-N 1'-[3-(cyclopentylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNC1CCCC1 UPDLYRDYEYEHOW-UHFFFAOYSA-N 0.000 claims 1
• UISDRWUXULANES-UHFFFAOYSA-N 1'-[3-(cyclopropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNC1CC1 UISDRWUXULANES-UHFFFAOYSA-N 0.000 claims 1
• PXVJDDCCIYXSPR-UHFFFAOYSA-N 1'-[3-(dibenzylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCN(CC=1C=CC=CC=1)CC1=CC=CC=C1 PXVJDDCCIYXSPR-UHFFFAOYSA-N 0.000 claims 1
• JCMJXQVYLSVERX-UHFFFAOYSA-N 1'-[3-(dibutylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(CCCC)CCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 JCMJXQVYLSVERX-UHFFFAOYSA-N 0.000 claims 1
• RDWJRFRCVQZACW-UHFFFAOYSA-N 1'-[3-(dipropylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(CCC)CCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 RDWJRFRCVQZACW-UHFFFAOYSA-N 0.000 claims 1
• VNYQRQRGWZFLDX-UHFFFAOYSA-N 1'-[3-(ethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 VNYQRQRGWZFLDX-UHFFFAOYSA-N 0.000 claims 1
• BPYFAQKNQFVZIZ-UHFFFAOYSA-N 1'-[3-(furan-2-ylmethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1=CC=CO1 BPYFAQKNQFVZIZ-UHFFFAOYSA-N 0.000 claims 1
• WJLAJIVERFTSGL-UHFFFAOYSA-N 1'-[3-(heptylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 WJLAJIVERFTSGL-UHFFFAOYSA-N 0.000 claims 1
• DROIEEGOLIMRBU-UHFFFAOYSA-N 1'-[3-(hexylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 DROIEEGOLIMRBU-UHFFFAOYSA-N 0.000 claims 1
• FBNNHEWWOKNJJJ-UHFFFAOYSA-N 1'-[3-(methylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 FBNNHEWWOKNJJJ-UHFFFAOYSA-N 0.000 claims 1
• FUAKYDPHCKZGBA-UHFFFAOYSA-N 1'-[3-(octylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 FUAKYDPHCKZGBA-UHFFFAOYSA-N 0.000 claims 1
• OXXPBPLYKYQPSU-UHFFFAOYSA-N 1'-[3-(oxolan-2-ylmethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1CCCO1 OXXPBPLYKYQPSU-UHFFFAOYSA-N 0.000 claims 1
• ISJQJNRXVQAQLY-UHFFFAOYSA-N 1'-[3-(pentylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 ISJQJNRXVQAQLY-UHFFFAOYSA-N 0.000 claims 1
• PLOCDOPROXMVQK-UHFFFAOYSA-N 1'-[3-(propan-2-ylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNC(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 PLOCDOPROXMVQK-UHFFFAOYSA-N 0.000 claims 1
• XFELXRGXQMNWJP-UHFFFAOYSA-N 1'-[3-(propylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 XFELXRGXQMNWJP-UHFFFAOYSA-N 0.000 claims 1
• DEAVQKWZOCWTSM-UHFFFAOYSA-N 1'-[3-(pyridin-2-ylmethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1=CC=CC=N1 DEAVQKWZOCWTSM-UHFFFAOYSA-N 0.000 claims 1
• VXIGMEVBCJZINU-UHFFFAOYSA-N 1'-[3-(pyridin-4-ylmethylamino)propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCC1=CC=NC=C1 VXIGMEVBCJZINU-UHFFFAOYSA-N 0.000 claims 1
• JMUAEBKYOCTRHF-UHFFFAOYSA-N 1'-[3-[(2,4-difluorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC(F)=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O JMUAEBKYOCTRHF-UHFFFAOYSA-N 0.000 claims 1
• FICRZITUFLCJFS-UHFFFAOYSA-N 1'-[3-[(2,6-difluorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(F)=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O FICRZITUFLCJFS-UHFFFAOYSA-N 0.000 claims 1
• DILASYFAVLTISK-UHFFFAOYSA-N 1'-[3-[(2-chlorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound ClC1=CC=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O DILASYFAVLTISK-UHFFFAOYSA-N 0.000 claims 1
• ZODZMHGOSAKWPY-UHFFFAOYSA-N 1'-[3-[(2-fluorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O ZODZMHGOSAKWPY-UHFFFAOYSA-N 0.000 claims 1
• MEEMDZHVQBAUDY-UHFFFAOYSA-N 1'-[3-[(2-methylphenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CC1=CC=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O MEEMDZHVQBAUDY-UHFFFAOYSA-N 0.000 claims 1
• LQEUTMOCWBMSOO-UHFFFAOYSA-N 1'-[3-[(3,5-difluorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC(F)=CC(CNCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 LQEUTMOCWBMSOO-UHFFFAOYSA-N 0.000 claims 1
• KLPVJDRSPLQDDW-UHFFFAOYSA-N 1'-[3-[(3-fluorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(CNCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 KLPVJDRSPLQDDW-UHFFFAOYSA-N 0.000 claims 1
• BYZBJKQJIRMDJL-UHFFFAOYSA-N 1'-[3-[(3-methylphenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CC1=CC=CC(CNCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 BYZBJKQJIRMDJL-UHFFFAOYSA-N 0.000 claims 1
• AOGOECHLLUJSEE-UHFFFAOYSA-N 1'-[3-[(4-chlorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(Cl)=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O AOGOECHLLUJSEE-UHFFFAOYSA-N 0.000 claims 1
• NFAVDEHOSBHAGE-UHFFFAOYSA-N 1'-[3-[(4-fluorophenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(F)=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O NFAVDEHOSBHAGE-UHFFFAOYSA-N 0.000 claims 1
• IXJAPWUOUCVUBD-UHFFFAOYSA-N 1'-[3-[(4-methoxyphenyl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(OC)=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O IXJAPWUOUCVUBD-UHFFFAOYSA-N 0.000 claims 1
• UDCGWFCIYMWQPU-UHFFFAOYSA-N 1'-[3-[(5-methylfuran-2-yl)methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(C)=CC=C1CNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UDCGWFCIYMWQPU-UHFFFAOYSA-N 0.000 claims 1
• BHGKHGRGPYLBFJ-UHFFFAOYSA-N 1'-[3-[2-(1-methylpyrrolidin-2-yl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CN1CCCC1CCNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O BHGKHGRGPYLBFJ-UHFFFAOYSA-N 0.000 claims 1
• CNLNTOSWWGLRBL-UHFFFAOYSA-N 1'-[3-[2-(2-chlorophenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound ClC1=CC=CC=C1CCNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O CNLNTOSWWGLRBL-UHFFFAOYSA-N 0.000 claims 1
• UZVFBTOFGNRWJE-UHFFFAOYSA-N 1'-[3-[2-(2-fluorophenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC=C1CCNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UZVFBTOFGNRWJE-UHFFFAOYSA-N 0.000 claims 1
• CEYASFAHFWOXGT-UHFFFAOYSA-N 1'-[3-[2-(3-chlorophenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound ClC1=CC=CC(CCNCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 CEYASFAHFWOXGT-UHFFFAOYSA-N 0.000 claims 1
• WLMWLYMCMQDYFT-UHFFFAOYSA-N 1'-[3-[2-(3-fluorophenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(CCNCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 WLMWLYMCMQDYFT-UHFFFAOYSA-N 0.000 claims 1
• KYVMDVPKCQYOHG-UHFFFAOYSA-N 1'-[3-[2-(4-fluorophenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(F)=CC=C1CCNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O KYVMDVPKCQYOHG-UHFFFAOYSA-N 0.000 claims 1
• ZMNCNZXODMGMKV-UHFFFAOYSA-N 1'-[3-[2-(4-methylphenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(C)=CC=C1CCNCCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O ZMNCNZXODMGMKV-UHFFFAOYSA-N 0.000 claims 1
• LSKIODHJZLRCHT-UHFFFAOYSA-N 1'-[3-[2-(4-phenylphenyl)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CCCNCCC(C=C1)=CC=C1C1=CC=CC=C1 LSKIODHJZLRCHT-UHFFFAOYSA-N 0.000 claims 1
• WSRQVRHAOPWHNZ-UHFFFAOYSA-N 1'-[3-[2-(diethylamino)ethyl-methylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(C)CCN(CC)CC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 WSRQVRHAOPWHNZ-UHFFFAOYSA-N 0.000 claims 1
• DZTRFTAZBLJISJ-UHFFFAOYSA-N 1'-[3-[2-(dimethylamino)ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCN(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 DZTRFTAZBLJISJ-UHFFFAOYSA-N 0.000 claims 1
• KXULAJWWUJTZPU-UHFFFAOYSA-N 1'-[3-[2-[di(propan-2-yl)amino]ethylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCN(C(C)C)C(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 KXULAJWWUJTZPU-UHFFFAOYSA-N 0.000 claims 1
• IUASKJBQAMDKMU-UHFFFAOYSA-N 1'-[3-[3-(dimethylamino)propylamino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCNCCCN(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 IUASKJBQAMDKMU-UHFFFAOYSA-N 0.000 claims 1
• MQYFFEWXYLIVQO-XZATXCMXSA-N 1'-[3-[[(1r)-1-cyclohexylethyl]amino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1([C@H](NCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C)CCCCC1 MQYFFEWXYLIVQO-XZATXCMXSA-N 0.000 claims 1
• MQYFFEWXYLIVQO-HSYKDVHTSA-N 1'-[3-[[(1s)-1-cyclohexylethyl]amino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1([C@@H](NCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C)CCCCC1 MQYFFEWXYLIVQO-HSYKDVHTSA-N 0.000 claims 1
• DMRGBBZJIXZGBU-UHFFFAOYSA-N 1'-[3-[bis(2-methoxyethyl)amino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(CCOC)CCOC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 DMRGBBZJIXZGBU-UHFFFAOYSA-N 0.000 claims 1
• IQYCAXRMNVCNOF-UHFFFAOYSA-N 1'-[3-[butyl(methyl)amino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(C)CCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 IQYCAXRMNVCNOF-UHFFFAOYSA-N 0.000 claims 1
• ALVULQJOJUSPIX-UHFFFAOYSA-N 1'-[3-[di(propan-2-yl)amino]propyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCN(C(C)C)C(C)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 ALVULQJOJUSPIX-UHFFFAOYSA-N 0.000 claims 1
• VYWBCISEJJHPLO-UHFFFAOYSA-N 1'-[4,4-bis(4-fluorophenyl)butyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O VYWBCISEJJHPLO-UHFFFAOYSA-N 0.000 claims 1
• XWIPCPSWCFODHH-UHFFFAOYSA-N 1'-[[1-(3,3-dimethylbutyl)piperidin-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(CCC(C)(C)C)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O XWIPCPSWCFODHH-UHFFFAOYSA-N 0.000 claims 1
• GIDNRYZABBHQMA-UHFFFAOYSA-N 1'-[[1-(3-methylbutyl)piperidin-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(CCC(C)C)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O GIDNRYZABBHQMA-UHFFFAOYSA-N 0.000 claims 1
• LYKUAZYGPFZFKK-UHFFFAOYSA-N 1'-[[1-(3-methylsulfanylpropyl)piperidin-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1CN(CCCSC)CCC1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O LYKUAZYGPFZFKK-UHFFFAOYSA-N 0.000 claims 1
• FJRYXOZWRWZSEY-UHFFFAOYSA-N 1'-[[1-(oxan-4-yl)piperidin-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(CC1)CCN1C1CCOCC1 FJRYXOZWRWZSEY-UHFFFAOYSA-N 0.000 claims 1
• RVRNPEPDGYUWQV-UHFFFAOYSA-N 1'-[[1-(pyridin-2-ylmethyl)piperidin-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(CC1)CCN1CC1=CC=CC=N1 RVRNPEPDGYUWQV-UHFFFAOYSA-N 0.000 claims 1
• FWLCYWBAWQWLBM-UHFFFAOYSA-N 1'-[[1-(pyridin-3-ylmethyl)piperidin-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(CC1)CCN1CC1=CC=CN=C1 FWLCYWBAWQWLBM-UHFFFAOYSA-N 0.000 claims 1
• LCMYJUQZARTJDT-UHFFFAOYSA-N 1'-[[1-(thiophen-2-ylmethyl)piperidin-4-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(CC1)CCN1CC1=CC=CS1 LCMYJUQZARTJDT-UHFFFAOYSA-N 0.000 claims 1
• QERDOWSUOLIWGH-UHFFFAOYSA-N 1'-[[2-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=CC=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=1C(=O)N(CC1)CCN1C1=NC=CC=N1 QERDOWSUOLIWGH-UHFFFAOYSA-N 0.000 claims 1
• VPVFWHQUYJDNOS-UHFFFAOYSA-N 1'-[[2-(trifluoromethoxy)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC(F)(F)OC1=CC=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O VPVFWHQUYJDNOS-UHFFFAOYSA-N 0.000 claims 1
• AVFVDDSXMJXONJ-UHFFFAOYSA-N 1'-[[2-[4-(1,3-benzodioxol-5-ylmethyl)piperazine-1-carbonyl]phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=CC=CC=C1C(=O)N1CCN(CC=2C=C3OCOC3=CC=2)CC1 AVFVDDSXMJXONJ-UHFFFAOYSA-N 0.000 claims 1
• RKKXQUMZFNJUPV-UHFFFAOYSA-N 1'-[[2-fluoro-3-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C(C(F)(F)F)C(F)=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O RKKXQUMZFNJUPV-UHFFFAOYSA-N 0.000 claims 1
• KICHXJFSHZIQSA-UHFFFAOYSA-N 1'-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC(C(F)(F)F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O KICHXJFSHZIQSA-UHFFFAOYSA-N 0.000 claims 1
• NUXBCNBOWPVIIA-UHFFFAOYSA-N 1'-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=C(C(F)(F)F)C=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O NUXBCNBOWPVIIA-UHFFFAOYSA-N 0.000 claims 1
• HDRYXQCJOGBONA-UHFFFAOYSA-N 1'-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=CC(C(F)(F)F)=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O HDRYXQCJOGBONA-UHFFFAOYSA-N 0.000 claims 1
• SEAKXUNSPYBGCJ-UHFFFAOYSA-N 1'-[[3-(4-methylpiperazine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1CN(C)CCN1C(=O)C1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 SEAKXUNSPYBGCJ-UHFFFAOYSA-N 0.000 claims 1
• RTCCXWATAANXDR-UHFFFAOYSA-N 1'-[[3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=CC=1C(=O)N(CC1)CCN1C1=NC=CC=N1 RTCCXWATAANXDR-UHFFFAOYSA-N 0.000 claims 1
• WWYHBAYMQOVCPI-UHFFFAOYSA-N 1'-[[3-(trifluoromethoxy)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC(F)(F)OC1=CC=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 WWYHBAYMQOVCPI-UHFFFAOYSA-N 0.000 claims 1
• TVQUIPUFUDUAHL-UHFFFAOYSA-N 1'-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(C(F)(F)F)C(F)=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 TVQUIPUFUDUAHL-UHFFFAOYSA-N 0.000 claims 1
• VPSLUNFHHRCRBG-UHFFFAOYSA-N 1'-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC(F)(F)C1=CC(F)=CC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 VPSLUNFHHRCRBG-UHFFFAOYSA-N 0.000 claims 1
• HZCJPQPBMYEGLM-UHFFFAOYSA-N 1'-[[3-hydroxy-5-(trifluoromethyl)thiophen-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(C(F)(F)F)SC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1O HZCJPQPBMYEGLM-UHFFFAOYSA-N 0.000 claims 1
• ANMKGVMPNMUIEO-UHFFFAOYSA-N 1'-[[3-methoxy-5-(trifluoromethyl)thiophen-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(C(F)(F)F)SC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1OC ANMKGVMPNMUIEO-UHFFFAOYSA-N 0.000 claims 1
• AWUJFVQKIGWIAV-UHFFFAOYSA-N 1'-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC(C=C1)=CC=C1N1C=NC=N1 AWUJFVQKIGWIAV-UHFFFAOYSA-N 0.000 claims 1
• YGCQMVZDPGIAJX-UHFFFAOYSA-N 1'-[[4-(4-methylpiperazine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1CN(C)CCN1C(=O)C(C=C1)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O YGCQMVZDPGIAJX-UHFFFAOYSA-N 0.000 claims 1
• WOAIECMTJKOJAI-UHFFFAOYSA-N 1'-[[4-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=CC=1C(=O)N(CC1)CCN1C1=NC=CC=N1 WOAIECMTJKOJAI-UHFFFAOYSA-N 0.000 claims 1
• LLDBZKSLZMAMTM-UHFFFAOYSA-N 1'-[[4-(morpholine-4-carbonyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C=1C=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=CC=1C(=O)N1CCOCC1 LLDBZKSLZMAMTM-UHFFFAOYSA-N 0.000 claims 1
• QCNPSUOAZCQXQS-UHFFFAOYSA-N 1'-[[4-[4-(1,3-benzodioxol-5-ylmethyl)piperazine-1-carbonyl]phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC(C=C1)=CC=C1C(=O)N1CCN(CC=2C=C3OCOC3=CC=2)CC1 QCNPSUOAZCQXQS-UHFFFAOYSA-N 0.000 claims 1
• LIBIIKAPKCSHPM-UHFFFAOYSA-N 1'-[[4-chloro-2-(trifluoromethyl)quinolin-6-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC1=CC2=C(Cl)C=C(C(F)(F)F)N=C2C=C1 LIBIIKAPKCSHPM-UHFFFAOYSA-N 0.000 claims 1
• VSCWZDNSXJIDGV-UHFFFAOYSA-N 1'-[[4-fluoro-2-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC(F)(F)C1=CC(F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O VSCWZDNSXJIDGV-UHFFFAOYSA-N 0.000 claims 1
• FGVDFTPPQSSQBH-UHFFFAOYSA-N 1'-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=C(C(F)(F)F)C(F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O FGVDFTPPQSSQBH-UHFFFAOYSA-N 0.000 claims 1
• KYNSEJGURMILEZ-UHFFFAOYSA-N 1'-[[5-(2-chlorophenyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound ClC1=CC=CC=C1C(O1)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O KYNSEJGURMILEZ-UHFFFAOYSA-N 0.000 claims 1
• FGQPEIVOXDMRHE-UHFFFAOYSA-N 1'-[[5-(3-chlorophenyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound ClC1=CC=CC(C=2OC(CN3C4=CC=CC=C4C4(C5=CC=6OCOC=6C=C5OC4)C3=O)=CC=2)=C1 FGQPEIVOXDMRHE-UHFFFAOYSA-N 0.000 claims 1
• NEBUOXBYNAHKFV-UHFFFAOYSA-N 1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(C(F)(F)F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O NEBUOXBYNAHKFV-UHFFFAOYSA-N 0.000 claims 1
• NKPNBAVPEGIBQR-UHFFFAOYSA-N 1'-[[5-[2-(trifluoromethyl)phenyl]furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC(F)(F)C1=CC=CC=C1C(O1)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O NKPNBAVPEGIBQR-UHFFFAOYSA-N 0.000 claims 1
• KEVWQCIPSZIPNY-UHFFFAOYSA-N 1'-[[5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=NC(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=NO1 KEVWQCIPSZIPNY-UHFFFAOYSA-N 0.000 claims 1
• ZEDAATHDOBXZEF-UHFFFAOYSA-N 1'-[[5-fluoro-2-(trifluoromethyl)phenyl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound FC1=CC=C(C(F)(F)F)C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 ZEDAATHDOBXZEF-UHFFFAOYSA-N 0.000 claims 1
• OSOPODHEDLQRPG-UHFFFAOYSA-N 1'-[[6-(dimethylamino)pyridin-3-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one;hydrochloride Chemical compound Cl.C1=NC(N(C)C)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O OSOPODHEDLQRPG-UHFFFAOYSA-N 0.000 claims 1
• JPBUNTYPRHZZCS-UHFFFAOYSA-N 1'-[[6-(trifluoromethyl)pyridin-3-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=NC(C(F)(F)F)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O JPBUNTYPRHZZCS-UHFFFAOYSA-N 0.000 claims 1
• HDHXDUNPHNLDOC-UHFFFAOYSA-N 1'-benzhydryl-5'-methylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC(C)=CC=C2N1C(C=1C=CC=CC=1)C1=CC=CC=C1 HDHXDUNPHNLDOC-UHFFFAOYSA-N 0.000 claims 1
• LRNWOJDFRXDNHS-UHFFFAOYSA-N 1'-benzhydryl-5-bromospiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC(Br)=CC=C2OCC1(C1=CC=CC=C11)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 LRNWOJDFRXDNHS-UHFFFAOYSA-N 0.000 claims 1
• PTDDUYJLOQGZPK-UHFFFAOYSA-N 1'-benzhydryl-5-hydroxyspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC(O)=CC=C2OCC1(C1=CC=CC=C11)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 PTDDUYJLOQGZPK-UHFFFAOYSA-N 0.000 claims 1
• SFOTULKPJMTGPR-UHFFFAOYSA-N 1'-benzhydryl-5-pyridin-3-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC(=CC=C3OC2)C=2C=NC=CC=2)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 SFOTULKPJMTGPR-UHFFFAOYSA-N 0.000 claims 1
• FEHMEKPMEKIRNG-UHFFFAOYSA-N 1'-benzhydryl-6-(trifluoromethoxy)spiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C=1C(OC(F)(F)F)=CC=C2C=1OCC2(C1=CC=CC=C11)C(=O)N1C(C=1C=CC=CC=1)C1=CC=CC=C1 FEHMEKPMEKIRNG-UHFFFAOYSA-N 0.000 claims 1
• PUNHNDNPPHVDTC-UHFFFAOYSA-N 1'-benzylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C(=O)N1CC1=CC=CC=C1 PUNHNDNPPHVDTC-UHFFFAOYSA-N 0.000 claims 1
• UUGJZINLZDDYEU-UHFFFAOYSA-N 1'-butylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 UUGJZINLZDDYEU-UHFFFAOYSA-N 0.000 claims 1
• RTCUMTHXKKBDRN-UHFFFAOYSA-N 1'-hex-5-enylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC=C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 RTCUMTHXKKBDRN-UHFFFAOYSA-N 0.000 claims 1
• QQGPXTPTXKAHHT-UHFFFAOYSA-N 1'-hexylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QQGPXTPTXKAHHT-UHFFFAOYSA-N 0.000 claims 1
• QJIYSHJUWGIZHU-UHFFFAOYSA-N 1'-hexylspiro[7h-[1,3]dioxolo[4,5-g]chromene-8,3'-indole]-2',6-dione Chemical compound C12=CC=CC=C2N(CCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC(=O)C1 QJIYSHJUWGIZHU-UHFFFAOYSA-N 0.000 claims 1
• AHLOWWNBTATPDG-UHFFFAOYSA-N 1'-methyl-4'-pyrimidin-5-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CN=CN=C1 AHLOWWNBTATPDG-UHFFFAOYSA-N 0.000 claims 1
• VZPBXHHDMVMWQY-UHFFFAOYSA-N 1'-methylsulfonylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(S(=O)(=O)C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 VZPBXHHDMVMWQY-UHFFFAOYSA-N 0.000 claims 1
• CRSVENVZHKQEKA-UHFFFAOYSA-N 1'-pent-2-ynylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CC#CCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 CRSVENVZHKQEKA-UHFFFAOYSA-N 0.000 claims 1
• QCSJADXRVNKALO-UHFFFAOYSA-N 1'-pent-4-enylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCC=C)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 QCSJADXRVNKALO-UHFFFAOYSA-N 0.000 claims 1
• YHNAOVOHARDENS-UHFFFAOYSA-N 1'-pentyl-4'-(2-phenoxyphenyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC=C1OC1=CC=CC=C1 YHNAOVOHARDENS-UHFFFAOYSA-N 0.000 claims 1
• KDYIFXZGHPSOGR-UHFFFAOYSA-N 1'-pentyl-4'-(3,4,5-trimethoxyphenyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(OC)=C(OC)C(OC)=C1 KDYIFXZGHPSOGR-UHFFFAOYSA-N 0.000 claims 1
• YTFIOOPOULFLLX-UHFFFAOYSA-N 1'-pentyl-4'-(4-phenoxyphenyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(C=C1)=CC=C1OC1=CC=CC=C1 YTFIOOPOULFLLX-UHFFFAOYSA-N 0.000 claims 1
• AGKSAGXYEIVRRV-UHFFFAOYSA-N 1'-pentyl-4'-(4-propan-2-yloxyphenyl)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC(C)C)C=C1 AGKSAGXYEIVRRV-UHFFFAOYSA-N 0.000 claims 1
• KBGBXHKBNVMIOL-UHFFFAOYSA-N 1'-pentyl-4'-(pyridin-3-ylamino)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC=CN=C1 KBGBXHKBNVMIOL-UHFFFAOYSA-N 0.000 claims 1
• AYVCZCFPMLPQMM-UHFFFAOYSA-N 1'-pentyl-4'-(pyrimidin-2-ylamino)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=NC=CC=N1 AYVCZCFPMLPQMM-UHFFFAOYSA-N 0.000 claims 1
• VXDMCAUPRGKVLQ-UHFFFAOYSA-N 1'-pentyl-4'-(pyrimidin-4-ylamino)spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC=NC=N1 VXDMCAUPRGKVLQ-UHFFFAOYSA-N 0.000 claims 1
• DMVQPXUEMWQVQB-BUHFOSPRSA-N 1'-pentyl-4'-[(e)-2-phenylethenyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2\C=C\C1=CC=CC=C1 DMVQPXUEMWQVQB-BUHFOSPRSA-N 0.000 claims 1
• IMPGGPQZOYKVGV-UHFFFAOYSA-N 1'-pentyl-4'-[2-(trifluoromethoxy)phenyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC=C1OC(F)(F)F IMPGGPQZOYKVGV-UHFFFAOYSA-N 0.000 claims 1
• BYHBVEQRAMDHAJ-UHFFFAOYSA-N 1'-pentyl-4'-[3-(trifluoromethoxy)phenyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(OC(F)(F)F)=C1 BYHBVEQRAMDHAJ-UHFFFAOYSA-N 0.000 claims 1
• YLISUWSIFGUMKZ-UHFFFAOYSA-N 1'-pentyl-4'-[4-(trifluoromethoxy)phenyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC(F)(F)F)C=C1 YLISUWSIFGUMKZ-UHFFFAOYSA-N 0.000 claims 1
• QWHRENGUGIZBON-UHFFFAOYSA-N 1'-pentyl-4'-[4-(trifluoromethyl)pyridin-3-yl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CN=CC=C1C(F)(F)F QWHRENGUGIZBON-UHFFFAOYSA-N 0.000 claims 1
• FYCMAEKPYZZNHL-UHFFFAOYSA-N 1'-pentyl-4'-phenoxathiin-4-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound S1C2=CC=CC=C2OC2=C1C=CC=C2C1=CC=CC2=C1C1(C3=CC=4OCOC=4C=C3OC1)C(=O)N2CCCCC FYCMAEKPYZZNHL-UHFFFAOYSA-N 0.000 claims 1
• KHCAPMSWLGDOMC-UHFFFAOYSA-N 1'-pentyl-4'-phenylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC=C1 KHCAPMSWLGDOMC-UHFFFAOYSA-N 0.000 claims 1
• PPWDAPUARFZSKG-UHFFFAOYSA-N 1'-pentyl-4'-pyridin-3-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CN=C1 PPWDAPUARFZSKG-UHFFFAOYSA-N 0.000 claims 1
• BWSQWILGIFMAOO-UHFFFAOYSA-N 1'-pentyl-4'-pyridin-4-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=NC=C1 BWSQWILGIFMAOO-UHFFFAOYSA-N 0.000 claims 1
• BDCQYOKWNQBRIJ-UHFFFAOYSA-N 1'-pentyl-4'-pyrimidin-5-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CN=CN=C1 BDCQYOKWNQBRIJ-UHFFFAOYSA-N 0.000 claims 1
• KITOPRFYIWXYAD-UHFFFAOYSA-N 1'-pentyl-4'-quinolin-3-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=CC2=CC(C3=CC=CC4=C3C3(C5=CC=6OCOC=6C=C5OC3)C(=O)N4CCCCC)=CN=C21 KITOPRFYIWXYAD-UHFFFAOYSA-N 0.000 claims 1
• QERQKYYWLMCENX-UHFFFAOYSA-N 1'-pentyl-4'-quinolin-6-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound N1=CC=CC2=CC(C3=CC=CC4=C3C3(C5=CC=6OCOC=6C=C5OC3)C(=O)N4CCCCC)=CC=C21 QERQKYYWLMCENX-UHFFFAOYSA-N 0.000 claims 1
• PYGNPLWZOWESAI-UHFFFAOYSA-N 1'-pentyl-4'-thiophen-3-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C=1C=CSC=1 PYGNPLWZOWESAI-UHFFFAOYSA-N 0.000 claims 1
• CBDIRGCFMYQOBK-UHFFFAOYSA-N 1'-pentyl-5-(trifluoromethyl)spiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(C(F)(F)F)=CC=C2OC1 CBDIRGCFMYQOBK-UHFFFAOYSA-N 0.000 claims 1
• JWUDCQZKFHWVOM-UHFFFAOYSA-N 1'-pentyl-5-phenoxyspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=C2)COC1=CC=C2OC1=CC=CC=C1 JWUDCQZKFHWVOM-UHFFFAOYSA-N 0.000 claims 1
• DDMDACHLNFOZLQ-UHFFFAOYSA-N 1'-pentyl-5-pyridin-3-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=C2)COC1=CC=C2C1=CC=CN=C1 DDMDACHLNFOZLQ-UHFFFAOYSA-N 0.000 claims 1
• BYHCUPIXPFLNOT-UHFFFAOYSA-N 1'-pentyl-5-pyridin-4-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=C2)COC1=CC=C2C1=CC=NC=C1 BYHCUPIXPFLNOT-UHFFFAOYSA-N 0.000 claims 1
• KXVTXVSJOVCSDW-UHFFFAOYSA-N 1'-pentyl-5-pyrimidin-5-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=C2)COC1=CC=C2C1=CN=CN=C1 KXVTXVSJOVCSDW-UHFFFAOYSA-N 0.000 claims 1
• MRTQCNYAQVKOGL-UHFFFAOYSA-N 1'-pentyl-6-pyridin-4-ylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C1(C1=CC=2)COC1=CC=2C1=CC=NC=C1 MRTQCNYAQVKOGL-UHFFFAOYSA-N 0.000 claims 1
• IQNHROGZDGEPQM-UHFFFAOYSA-N 1'-pentylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC=CC=C2OC1 IQNHROGZDGEPQM-UHFFFAOYSA-N 0.000 claims 1
• SKMITBUYSAXHIH-UHFFFAOYSA-N 1'-pentylspiro[5,6-dihydrocyclopenta[f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2CC1 SKMITBUYSAXHIH-UHFFFAOYSA-N 0.000 claims 1
• KTFHKMBXOMMQGS-UHFFFAOYSA-N 1'-pentylspiro[5h-furo[3,4-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2CO1 KTFHKMBXOMMQGS-UHFFFAOYSA-N 0.000 claims 1
• NAECDUFDXJDYAG-UHFFFAOYSA-N 1'-pentylspiro[6,7-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-8,3'-indole]-2',5-dione Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2C(=O)NC1 NAECDUFDXJDYAG-UHFFFAOYSA-N 0.000 claims 1
• LJJMIJUUHNZIGS-UHFFFAOYSA-N 1'-pentylspiro[6,7-dihydrobenzo[f][1,3]benzodioxole-5,3'-indole]-2',8-dione Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2C(=O)CC1 LJJMIJUUHNZIGS-UHFFFAOYSA-N 0.000 claims 1
• UGTQLKHEIQMVBY-UHFFFAOYSA-N 1'-pentylspiro[6h-cyclopenta[f][1,3]benzodioxole-7,3'-indole]-2',5-dione Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2C(=O)C1 UGTQLKHEIQMVBY-UHFFFAOYSA-N 0.000 claims 1
• PZKABQGUVWNWLA-UHFFFAOYSA-N 1'-pentylspiro[7,8-dihydro-6h-benzo[f][1,3]benzodioxole-5,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2CCC1 PZKABQGUVWNWLA-UHFFFAOYSA-N 0.000 claims 1
• ZRIBKTWBEDKUQR-UHFFFAOYSA-N 1'-prop-2-ynylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CC#C)C2=O ZRIBKTWBEDKUQR-UHFFFAOYSA-N 0.000 claims 1
• VCIWUDKYGYHPRR-UHFFFAOYSA-N 1'-propylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 VCIWUDKYGYHPRR-UHFFFAOYSA-N 0.000 claims 1
• LKYNGTHMKCTTQC-UHFFFAOYSA-N 1,2-oxazole-3-carboxamide Chemical compound NC(=O)C=1C=CON=1 LKYNGTHMKCTTQC-UHFFFAOYSA-N 0.000 claims 1
• FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims 1
• AHWCADIFIFAXIT-UHFFFAOYSA-N 1-(2,3-dichlorophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound ClC1=CC=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1Cl AHWCADIFIFAXIT-UHFFFAOYSA-N 0.000 claims 1
• CGOFMALNLDXUQU-UHFFFAOYSA-N 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O1CCOC2=CC(NC(NCCN3C4=CC=CC=C4C4(C5=CC=6OCOC=6C=C5OC4)C3=O)=O)=CC=C21 CGOFMALNLDXUQU-UHFFFAOYSA-N 0.000 claims 1
• MWSHKTVSFLYEOT-UHFFFAOYSA-N 1-(2-fluoro-5-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound CC1=CC=C(F)C(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 MWSHKTVSFLYEOT-UHFFFAOYSA-N 0.000 claims 1
• WVVMKELOHOXHDF-UHFFFAOYSA-N 1-(2-methoxy-4-nitrophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound COC1=CC([N+]([O-])=O)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O WVVMKELOHOXHDF-UHFFFAOYSA-N 0.000 claims 1
• VYDROLIPSUAPKK-UHFFFAOYSA-N 1-(2-nitrophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound [O-][N+](=O)C1=CC=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O VYDROLIPSUAPKK-UHFFFAOYSA-N 0.000 claims 1
• HBDLRQUHSIVJRO-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C(Cl)C(Cl)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O HBDLRQUHSIVJRO-UHFFFAOYSA-N 0.000 claims 1
• HFTSRXFCSZICDP-UHFFFAOYSA-N 1-(3-chloro-2-fluorophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound FC1=C(Cl)C=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O HFTSRXFCSZICDP-UHFFFAOYSA-N 0.000 claims 1
• BIBNQKDGRAGULI-UHFFFAOYSA-N 1-(3-chloro-2-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound CC1=C(Cl)C=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O BIBNQKDGRAGULI-UHFFFAOYSA-N 0.000 claims 1
• JVSRDMBKSXDDNP-UHFFFAOYSA-N 1-(3-chloro-4-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C(Cl)C(C)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O JVSRDMBKSXDDNP-UHFFFAOYSA-N 0.000 claims 1
• LFQXFEXKCKAPOK-UHFFFAOYSA-N 1-(3-fluoro-4-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C(F)C(C)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O LFQXFEXKCKAPOK-UHFFFAOYSA-N 0.000 claims 1
• MOMMCVGQIMQWQL-UHFFFAOYSA-N 1-(4-butoxyphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC(OCCCC)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O MOMMCVGQIMQWQL-UHFFFAOYSA-N 0.000 claims 1
• YGMZDRMBZIKMSQ-UHFFFAOYSA-N 1-(4-butylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC(CCCC)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O YGMZDRMBZIKMSQ-UHFFFAOYSA-N 0.000 claims 1
• UVRHWJBDPPIUCZ-UHFFFAOYSA-N 1-(4-chloro-2-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound CC1=CC(Cl)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UVRHWJBDPPIUCZ-UHFFFAOYSA-N 0.000 claims 1
• QRRKJGWWCNJWCN-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC(Cl)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O QRRKJGWWCNJWCN-UHFFFAOYSA-N 0.000 claims 1
• UWPDCHOFZVSPDL-UHFFFAOYSA-N 1-(4-ethylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC(CC)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UWPDCHOFZVSPDL-UHFFFAOYSA-N 0.000 claims 1
• HAAQIGMKFBDFRY-UHFFFAOYSA-N 1-(4-fluoro-3-methylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C(F)C(C)=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 HAAQIGMKFBDFRY-UHFFFAOYSA-N 0.000 claims 1
• FZRZHUNCWVKYFJ-UHFFFAOYSA-N 1-(4-fluorophenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC(F)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O FZRZHUNCWVKYFJ-UHFFFAOYSA-N 0.000 claims 1
• AGCQQVIZHAFAOZ-UHFFFAOYSA-N 1-(4-fluorophenyl)-5-methyl-n-[3-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)propyl]pyrazole-4-carboxamide Chemical compound CC1=C(C(=O)NCCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=NN1C1=CC=C(F)C=C1 AGCQQVIZHAFAOZ-UHFFFAOYSA-N 0.000 claims 1
• UZAGYMSEIKUSBW-UHFFFAOYSA-N 1-(4-tert-butylphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC(C(C)(C)C)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UZAGYMSEIKUSBW-UHFFFAOYSA-N 0.000 claims 1
• WJJBEFPGVBRBKI-UHFFFAOYSA-N 1-(5-tert-butyl-2-methoxyphenyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O WJJBEFPGVBRBKI-UHFFFAOYSA-N 0.000 claims 1
• CPYIFLKUVCOPNS-UHFFFAOYSA-N 1-(9h-fluoren-9-yl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O CPYIFLKUVCOPNS-UHFFFAOYSA-N 0.000 claims 1
• UWQKZQGZQQPEIN-UHFFFAOYSA-N 1-(furan-2-ylmethyl)-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NCC1=CC=CO1 UWQKZQGZQQPEIN-UHFFFAOYSA-N 0.000 claims 1
• DIYVBUSMVVITGP-UHFFFAOYSA-N 1-[(3-fluorophenyl)methyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound FC1=CC=CC(CNC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 DIYVBUSMVVITGP-UHFFFAOYSA-N 0.000 claims 1
• CBQGSVSLGCLLOS-UHFFFAOYSA-N 1-[(6-fluoro-1H-benzimidazol-2-yl)methyl]spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound FC1=CC2=C(NC(=N2)CN2CC3(C4=CC=CC=C24)COC2=CC4=C(OCO4)C=C23)C=C1 CBQGSVSLGCLLOS-UHFFFAOYSA-N 0.000 claims 1
• ARKZBHXUPOIEDE-UHFFFAOYSA-N 1-[2-(1,3-benzodioxol-5-yl)ethyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C2OCOC2=CC(CCNC(NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=O)=C1 ARKZBHXUPOIEDE-UHFFFAOYSA-N 0.000 claims 1
• KDPQUYLIKFAPGL-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-(2-phenoxyphenyl)urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NC1=CC=CC=C1OC1=CC=CC=C1 KDPQUYLIKFAPGL-UHFFFAOYSA-N 0.000 claims 1
• WCWRNPHWIAGWKG-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-(2-phenylethyl)urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NCCC1=CC=CC=C1 WCWRNPHWIAGWKG-UHFFFAOYSA-N 0.000 claims 1
• BTUCCWZCWHMMBS-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)urea Chemical compound COC1=C(OC)C(OC)=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 BTUCCWZCWHMMBS-UHFFFAOYSA-N 0.000 claims 1
• OWVULQJJEOCPFQ-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-(4-phenoxyphenyl)urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NC(C=C1)=CC=C1OC1=CC=CC=C1 OWVULQJJEOCPFQ-UHFFFAOYSA-N 0.000 claims 1
• IKPOLXKQAMPABJ-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-(5,6,7,8-tetrahydronaphthalen-1-yl)urea Chemical compound C1CCCC2=C1C=CC=C2NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O IKPOLXKQAMPABJ-UHFFFAOYSA-N 0.000 claims 1
• UUVOVJXRYDMRGW-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-[2-(trifluoromethoxy)phenyl]urea Chemical compound FC(F)(F)OC1=CC=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UUVOVJXRYDMRGW-UHFFFAOYSA-N 0.000 claims 1
• IMAOTYDCBOMBBY-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-[2-(trifluoromethyl)phenyl]urea Chemical compound FC(F)(F)C1=CC=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O IMAOTYDCBOMBBY-UHFFFAOYSA-N 0.000 claims 1
• PIVHACYCVDWCTC-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]urea Chemical compound FC(F)(F)C1=CC=CC(NC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 PIVHACYCVDWCTC-UHFFFAOYSA-N 0.000 claims 1
• LYTMPZNZYMJLMS-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-[4-(trifluoromethyl)phenyl]urea Chemical compound C1=CC(C(F)(F)F)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O LYTMPZNZYMJLMS-UHFFFAOYSA-N 0.000 claims 1
• HXBQQNNQQNJKRG-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-pentylurea Chemical compound C12=CC=CC=C2N(CCNC(=O)NCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 HXBQQNNQQNJKRG-UHFFFAOYSA-N 0.000 claims 1
• IBLSBGDGXRTTSY-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-phenylurea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NC1=CC=CC=C1 IBLSBGDGXRTTSY-UHFFFAOYSA-N 0.000 claims 1
• XIUOFELAUBTXFJ-UHFFFAOYSA-N 1-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]-3-propylurea Chemical compound C12=CC=CC=C2N(CCNC(=O)NCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 XIUOFELAUBTXFJ-UHFFFAOYSA-N 0.000 claims 1
• DOWBKXJZKCWXEQ-UHFFFAOYSA-N 1-[2-(3,5-dimethoxyphenyl)ethyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound COC1=CC(OC)=CC(CCNC(=O)NCCN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)=C1 DOWBKXJZKCWXEQ-UHFFFAOYSA-N 0.000 claims 1
• WBYFIDYNBSVRFQ-UHFFFAOYSA-N 1-[2-(4-ethylphenyl)ethyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC(CC)=CC=C1CCNC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O WBYFIDYNBSVRFQ-UHFFFAOYSA-N 0.000 claims 1
• FPLDYJFBXFGIAP-UHFFFAOYSA-N 1-[2-(difluoromethoxy)phenyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound FC(F)OC1=CC=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O FPLDYJFBXFGIAP-UHFFFAOYSA-N 0.000 claims 1
• GPJFBJKZEXXNCX-UHFFFAOYSA-N 1-[4-(cyanomethyl)phenyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NC1=CC=C(CC#N)C=C1 GPJFBJKZEXXNCX-UHFFFAOYSA-N 0.000 claims 1
• LSEBGPTVHNVHNG-UHFFFAOYSA-N 1-[4-(dimethylamino)phenyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC(N(C)C)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O LSEBGPTVHNVHNG-UHFFFAOYSA-N 0.000 claims 1
• HRFRMIVYYUONHN-UHFFFAOYSA-N 1-[4-fluoro-2-(trifluoromethyl)phenyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound FC(F)(F)C1=CC(F)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O HRFRMIVYYUONHN-UHFFFAOYSA-N 0.000 claims 1
• DLEMDIHBIGJHLG-UHFFFAOYSA-N 1-[4-methyl-3-(trifluoromethyl)phenyl]-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=C(C(F)(F)F)C(C)=CC=C1NC(=O)NCCN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O DLEMDIHBIGJHLG-UHFFFAOYSA-N 0.000 claims 1
• HFKUYFCDKWHLAU-UHFFFAOYSA-N 1-benzyl-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCNC(=O)NCC1=CC=CC=C1 HFKUYFCDKWHLAU-UHFFFAOYSA-N 0.000 claims 1
• HTCBXRZEXZCKPH-UHFFFAOYSA-N 1-methyl-n-[3-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)propyl]benzotriazole-5-carboxamide Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CCCNC(=O)C1=CC=C2N(C)N=NC2=C1 HTCBXRZEXZCKPH-UHFFFAOYSA-N 0.000 claims 1
• BZQNPRKLINDORP-UHFFFAOYSA-N 1-naphthalen-2-yl-3-[2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)ethyl]urea Chemical compound C1=CC=CC2=CC(NC(NCCN3C4=CC=CC=C4C4(C5=CC=6OCOC=6C=C5OC4)C3=O)=O)=CC=C21 BZQNPRKLINDORP-UHFFFAOYSA-N 0.000 claims 1
• WHUPSLJSMYXMCC-UHFFFAOYSA-N 2'-oxo-1'-pentyl-n-pyridin-2-ylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-4'-carboxamide Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(=O)NC1=CC=CC=N1 WHUPSLJSMYXMCC-UHFFFAOYSA-N 0.000 claims 1
• SAEPYURJYIBTBY-UHFFFAOYSA-N 2'-oxo-1'-pentylspiro[2h-1-benzofuran-3,3'-indole]-5-carbonitrile Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(C#N)=CC=C2OC1 SAEPYURJYIBTBY-UHFFFAOYSA-N 0.000 claims 1
• HUHCBRWRRQHFGK-UHFFFAOYSA-N 2,4,4-trimethylpentan-2-ylurea Chemical compound CC(C)(C)CC(C)(C)NC(N)=O HUHCBRWRRQHFGK-UHFFFAOYSA-N 0.000 claims 1
• 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 1
• UXGQGJAZEPZESS-UHFFFAOYSA-N 2-(2'-oxospiro[2,5,6,7-tetrahydrocyclopenta[f][1]benzofuran-3,3'-indole]-1'-yl)acetic acid Chemical compound C12=CC=CC=C2N(CC(=O)O)C(=O)C11C2=CC(CCC3)=C3C=C2OC1 UXGQGJAZEPZESS-UHFFFAOYSA-N 0.000 claims 1
• VEJGQIDHMBGGTG-UHFFFAOYSA-N 2-(2'-oxospiro[5,6,7,8-tetrahydro-2h-benzo[f][1]benzofuran-3,3'-indole]-1'-yl)acetic acid Chemical compound C12=CC=CC=C2N(CC(=O)O)C(=O)C11C2=CC(CCCC3)=C3C=C2OC1 VEJGQIDHMBGGTG-UHFFFAOYSA-N 0.000 claims 1
• JTNKHWOBZYYRMG-UHFFFAOYSA-N 2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)-n,n-dipropylacetamide Chemical compound C12=CC=CC=C2N(CC(=O)N(CCC)CCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 JTNKHWOBZYYRMG-UHFFFAOYSA-N 0.000 claims 1
• MUQLSXKZOUKGRD-UHFFFAOYSA-N 2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)-n-pentylacetamide Chemical compound C12=CC=CC=C2N(CC(=O)NCCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 MUQLSXKZOUKGRD-UHFFFAOYSA-N 0.000 claims 1
• XEXCCHMAJJQTIB-UHFFFAOYSA-N 2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)-n-phenylacetamide Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C2=CC=CC=C2N1CC(=O)NC1=CC=CC=C1 XEXCCHMAJJQTIB-UHFFFAOYSA-N 0.000 claims 1
• ZVYFSAYBLGVYAF-UHFFFAOYSA-N 2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)-n-propylacetamide Chemical compound C12=CC=CC=C2N(CC(=O)NCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 ZVYFSAYBLGVYAF-UHFFFAOYSA-N 0.000 claims 1
• APIBPJKXEFNJPQ-UHFFFAOYSA-N 2-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)acetic acid Chemical compound C12=CC=CC=C2N(CC(=O)O)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 APIBPJKXEFNJPQ-UHFFFAOYSA-N 0.000 claims 1
• SCPDOXDFOSSRMG-UHFFFAOYSA-N 2-[(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-n-(1,3,4-thiadiazol-2-yl)benzamide Chemical compound C=1C=CC=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=1C(=O)NC1=NN=CS1 SCPDOXDFOSSRMG-UHFFFAOYSA-N 0.000 claims 1
• XBRYZJKWZYKDBR-UHFFFAOYSA-N 2-[(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-n-(1,3-thiazol-2-yl)benzamide Chemical compound C=1C=CC=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=1C(=O)NC1=NC=CS1 XBRYZJKWZYKDBR-UHFFFAOYSA-N 0.000 claims 1
• ONISECBBIZDUPE-UHFFFAOYSA-N 2-[(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-n-pentylbenzamide Chemical compound CCCCCNC(=O)C1=CC=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O ONISECBBIZDUPE-UHFFFAOYSA-N 0.000 claims 1
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• JYARFVCXCARTSH-UHFFFAOYSA-N 4'-(2-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC=C1F JYARFVCXCARTSH-UHFFFAOYSA-N 0.000 claims 1
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• ORAPBEYNBARRKP-UHFFFAOYSA-N 4'-(3-fluoro-5-methoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(F)=CC(OC)=C1 ORAPBEYNBARRKP-UHFFFAOYSA-N 0.000 claims 1
• FYVLTICDXLWIDI-UHFFFAOYSA-N 4'-(3-fluoroanilino)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC=CC(F)=C1 FYVLTICDXLWIDI-UHFFFAOYSA-N 0.000 claims 1
• AUHMTFSWZHZAFL-UHFFFAOYSA-N 4'-(3-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(F)=C1 AUHMTFSWZHZAFL-UHFFFAOYSA-N 0.000 claims 1
• IJLJDQKHPHNDOD-UHFFFAOYSA-N 4'-(4-butoxy-3-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OCCCC)C(F)=C1 IJLJDQKHPHNDOD-UHFFFAOYSA-N 0.000 claims 1
• VJIYETPRCUISFB-UHFFFAOYSA-N 4'-(4-butoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OCCCC)C=C1 VJIYETPRCUISFB-UHFFFAOYSA-N 0.000 claims 1
• GSUJPUJDDJTHPS-UHFFFAOYSA-N 4'-(4-butylphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(CCCC)C=C1 GSUJPUJDDJTHPS-UHFFFAOYSA-N 0.000 claims 1
• DDCZMIPHISFRGA-UHFFFAOYSA-N 4'-(4-chlorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(Cl)C=C1 DDCZMIPHISFRGA-UHFFFAOYSA-N 0.000 claims 1
• BXRWNLABHQDVGT-UHFFFAOYSA-N 4'-(4-ethoxy-3-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OCC)C(F)=C1 BXRWNLABHQDVGT-UHFFFAOYSA-N 0.000 claims 1
• FEEJYOCSELUHEL-UHFFFAOYSA-N 4'-(4-fluoro-2-methylphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(F)C=C1C FEEJYOCSELUHEL-UHFFFAOYSA-N 0.000 claims 1
• WASWOQMWUQOJTH-UHFFFAOYSA-N 4'-(4-fluorophenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(F)C=C1 WASWOQMWUQOJTH-UHFFFAOYSA-N 0.000 claims 1
• DHQDPSBZKNZNEU-UHFFFAOYSA-N 4'-(4-methoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC)C=C1 DHQDPSBZKNZNEU-UHFFFAOYSA-N 0.000 claims 1
• QWZLWXIASJJIPZ-UHFFFAOYSA-N 4'-(4-methoxypyridin-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CN=CC=C1OC QWZLWXIASJJIPZ-UHFFFAOYSA-N 0.000 claims 1
• WUOGZFBSMZBTIT-UHFFFAOYSA-N 4'-(4-methylphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(C)C=C1 WUOGZFBSMZBTIT-UHFFFAOYSA-N 0.000 claims 1
• ACTSJBMXNQGVBW-UHFFFAOYSA-N 4'-(4-methylpiperazin-1-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2N1CCN(C)CC1 ACTSJBMXNQGVBW-UHFFFAOYSA-N 0.000 claims 1
• WOXGHQZVJPELCV-UHFFFAOYSA-N 4'-(4-morpholin-4-ylphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(C=C1)=CC=C1N1CCOCC1 WOXGHQZVJPELCV-UHFFFAOYSA-N 0.000 claims 1
• FPIGVUQJSXLNNK-UHFFFAOYSA-N 4'-(5-chloro-2-methoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(Cl)=CC=C1OC FPIGVUQJSXLNNK-UHFFFAOYSA-N 0.000 claims 1
• YQQUHSBVEAUINQ-UHFFFAOYSA-N 4'-(5-fluoro-2-methoxyphenyl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(F)=CC=C1OC YQQUHSBVEAUINQ-UHFFFAOYSA-N 0.000 claims 1
• XPRDNLJUDMYHMP-UHFFFAOYSA-N 4'-(5-methoxypyridin-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CN=CC(OC)=C1 XPRDNLJUDMYHMP-UHFFFAOYSA-N 0.000 claims 1
• XLZGSZXUBNMYLG-UHFFFAOYSA-N 4'-(6-fluoropyridin-2-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(F)=N1 XLZGSZXUBNMYLG-UHFFFAOYSA-N 0.000 claims 1
• YPPPOVHTMHPNDF-UHFFFAOYSA-N 4'-(6-fluoropyridin-3-yl)-1'-methylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(F)N=C1 YPPPOVHTMHPNDF-UHFFFAOYSA-N 0.000 claims 1
• YDBINQWWEREMMT-UHFFFAOYSA-N 4'-(6-fluoropyridin-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(F)N=C1 YDBINQWWEREMMT-UHFFFAOYSA-N 0.000 claims 1
• SORQKETUXLKGLM-UHFFFAOYSA-N 4'-(6-methoxypyridin-2-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC(OC)=N1 SORQKETUXLKGLM-UHFFFAOYSA-N 0.000 claims 1
• QXTBUNZUJNFXDK-UHFFFAOYSA-N 4'-(6-methoxypyridin-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OC)N=C1 QXTBUNZUJNFXDK-UHFFFAOYSA-N 0.000 claims 1
• ASXPQVXBXBBQEB-UHFFFAOYSA-N 4'-(furan-3-yl)-1'-methylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C=1C=COC=1 ASXPQVXBXBBQEB-UHFFFAOYSA-N 0.000 claims 1
• IMAMQKYHXYPHBZ-UHFFFAOYSA-N 4'-(furan-3-yl)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C=1C=COC=1 IMAMQKYHXYPHBZ-UHFFFAOYSA-N 0.000 claims 1
• XJDFRDSMQIPLBP-UHFFFAOYSA-N 4'-(naphthalen-2-ylamino)-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=CC2=CC(NC3=CC=CC4=C3C3(C5=CC=6OCOC=6C=C5OC3)C(=O)N4CCCCC)=CC=C21 XJDFRDSMQIPLBP-UHFFFAOYSA-N 0.000 claims 1
• HYJSXMVKPXUMEX-DHZHZOJOSA-N 4'-[(e)-2-(4-fluorophenyl)ethenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2\C=C\C1=CC=C(F)C=C1 HYJSXMVKPXUMEX-DHZHZOJOSA-N 0.000 claims 1
• HEMNUZOUELHOQY-VURMDHGXSA-N 4'-[(z)-3-chloroprop-1-enyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C(\C=C/CCl)C2=C1N(CCCCC)C(=O)C21C2=CC(OCO3)=C3C=C2OC1 HEMNUZOUELHOQY-VURMDHGXSA-N 0.000 claims 1
• GWEMUKFLKOVMPM-UHFFFAOYSA-N 4'-[1-(benzenesulfonyl)indol-3-yl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(C1=CC=CC=C11)=CN1S(=O)(=O)C1=CC=CC=C1 GWEMUKFLKOVMPM-UHFFFAOYSA-N 0.000 claims 1
• LXZUYELEDLMUON-UHFFFAOYSA-N 4'-[2-chloro-4-[(3,5-dimethoxyphenyl)methoxy]phenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C(C(=C1)Cl)=CC=C1OCC1=CC(OC)=CC(OC)=C1 LXZUYELEDLMUON-UHFFFAOYSA-N 0.000 claims 1
• QJXSPFKYAYUCTH-UHFFFAOYSA-N 4'-[3,5-bis(trifluoromethyl)phenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 QJXSPFKYAYUCTH-UHFFFAOYSA-N 0.000 claims 1
• ZPJYLQPMKLHZCA-UHFFFAOYSA-N 4'-[4-(2-methylpropoxy)phenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(OCC(C)C)C=C1 ZPJYLQPMKLHZCA-UHFFFAOYSA-N 0.000 claims 1
• ZNFRCVNTHCOYIE-UHFFFAOYSA-N 4'-[4-(dimethylamino)phenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(N(C)C)C=C1 ZNFRCVNTHCOYIE-UHFFFAOYSA-N 0.000 claims 1
• IKWDFZABMCCIBN-UHFFFAOYSA-N 4'-[4-[(dimethylamino)methyl]phenyl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(CN(C)C)C=C1 IKWDFZABMCCIBN-UHFFFAOYSA-N 0.000 claims 1
• RUCBIOIGMVIWPA-UHFFFAOYSA-N 4'-[4-chloro-2-(trifluoromethyl)anilino]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2NC1=CC=C(Cl)C=C1C(F)(F)F RUCBIOIGMVIWPA-UHFFFAOYSA-N 0.000 claims 1
• OVJJOSKIKHLSBC-UHFFFAOYSA-N 4'-[6-(dimethylamino)pyridin-3-yl]-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(N(C)C)N=C1 OVJJOSKIKHLSBC-UHFFFAOYSA-N 0.000 claims 1
• MKYJMAOGIRCWID-UHFFFAOYSA-N 4'-bromo-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(C(F)(F)F)=CC=C1CN1C(C=CC=C2Br)=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O MKYJMAOGIRCWID-UHFFFAOYSA-N 0.000 claims 1
• KLHLFKUVNLZXBN-UHFFFAOYSA-N 4'-bromo-1'-methylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C(Br)C2=C1N(C)C(=O)C21C2=CC(OCO3)=C3C=C2OC1 KLHLFKUVNLZXBN-UHFFFAOYSA-N 0.000 claims 1
• KGLLFHTUYDZIHB-UHFFFAOYSA-N 4'-dibenzofuran-4-yl-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C12=CC=CC=C2OC2=C1C=CC=C2C1=CC=CC2=C1C1(C3=CC=4OCOC=4C=C3OC1)C(=O)N2CCCCC KGLLFHTUYDZIHB-UHFFFAOYSA-N 0.000 claims 1
• SQTJOXDCPGUIBT-UHFFFAOYSA-N 4'-isoquinolin-4-yl-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound C1=CC=C2C(C3=CC=CC4=C3C3(C5=CC=6OCOC=6C=C5OC3)C(=O)N4CCCCC)=CN=CC2=C1 SQTJOXDCPGUIBT-UHFFFAOYSA-N 0.000 claims 1
• QJJLYNOLBHHGGY-UHFFFAOYSA-N 4'-methoxy-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C=2C(OC)=CC=CC=2N1CC1=CC=C(C(F)(F)F)O1 QJJLYNOLBHHGGY-UHFFFAOYSA-N 0.000 claims 1
• LJUVRLVOYKOIEO-UHFFFAOYSA-N 4'-methyl-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O=C1C2(C3=CC=4OCOC=4C=C3OC2)C=2C(C)=CC=CC=2N1CC1=CC=C(C(F)(F)F)O1 LJUVRLVOYKOIEO-UHFFFAOYSA-N 0.000 claims 1
• NPTMSMOKDRFNJW-UHFFFAOYSA-N 4'-morpholin-4-yl-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2N1CCOCC1 NPTMSMOKDRFNJW-UHFFFAOYSA-N 0.000 claims 1
• VMXCZTIPLYHBSN-UHFFFAOYSA-N 4'-quinolin-3-yl-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one Chemical compound O1C(C(F)(F)F)=CC=C1CN1C(C=CC=C2C=3C=C4C=CC=CC4=NC=3)=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O VMXCZTIPLYHBSN-UHFFFAOYSA-N 0.000 claims 1
• LOMZFLOALBNXHI-UHFFFAOYSA-N 4-(2'-oxo-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-4'-yl)benzonitrile Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=C(C#N)C=C1 LOMZFLOALBNXHI-UHFFFAOYSA-N 0.000 claims 1
• KHKFHZFSMGPMIR-UHFFFAOYSA-N 4-(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)butanenitrile Chemical compound C1OC2=CC=3OCOC=3C=C2C21C1=CC=CC=C1N(CCCC#N)C2=O KHKFHZFSMGPMIR-UHFFFAOYSA-N 0.000 claims 1
• WMRRCVGZZXWDGO-UHFFFAOYSA-N 4-(3,5-dimethoxyphenyl)-1-pentylspiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole] Chemical compound COC=1C=C(C=C(C=1)OC)C1=C2C3(CN(C2=CC=C1)CCCCC)COC1=CC2=C(OCO2)C=C13 WMRRCVGZZXWDGO-UHFFFAOYSA-N 0.000 claims 1
• MCLDQIWDLILQOP-UHFFFAOYSA-N 4-(furan-3-yl)spiro[1h-indole-3,7'-6h-furo[2,3-f][1,3]benzodioxole]-2-one Chemical compound C=12C3(C4=CC=5OCOC=5C=C4OC3)C(=O)NC2=CC=CC=1C=1C=COC=1 MCLDQIWDLILQOP-UHFFFAOYSA-N 0.000 claims 1
• KWRWHBSNLGDQMK-UHFFFAOYSA-N 4-[(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-n-(1,3-thiazol-2-yl)benzamide Chemical compound C=1C=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=CC=1C(=O)NC1=NC=CS1 KWRWHBSNLGDQMK-UHFFFAOYSA-N 0.000 claims 1
• UIAAQLGIZMUFDE-UHFFFAOYSA-N 4-[(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-n-pentylbenzamide Chemical compound C1=CC(C(=O)NCCCCC)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O UIAAQLGIZMUFDE-UHFFFAOYSA-N 0.000 claims 1
• SLKLPUHAYWJPIK-UHFFFAOYSA-N 4-[(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-n-phenylbenzamide Chemical compound C=1C=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=CC=1C(=O)NC1=CC=CC=C1 SLKLPUHAYWJPIK-UHFFFAOYSA-N 0.000 claims 1
• ARBYMAKVZADERA-UHFFFAOYSA-N 4-[(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-n-propylbenzamide Chemical compound C1=CC(C(=O)NCCC)=CC=C1CN1C2=CC=CC=C2C2(C3=CC=4OCOC=4C=C3OC2)C1=O ARBYMAKVZADERA-UHFFFAOYSA-N 0.000 claims 1
• NPTLPAYAUCDUEH-UHFFFAOYSA-N 4-[(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-n-pyridin-3-ylbenzamide Chemical compound C=1C=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=CC=1C(=O)NC1=CC=CN=C1 NPTLPAYAUCDUEH-UHFFFAOYSA-N 0.000 claims 1
• QWJVVSLYLHDKOF-UHFFFAOYSA-N 4-[(2'-oxospiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-n-pyrimidin-4-ylbenzamide Chemical compound C=1C=C(CN2C3=CC=CC=C3C3(C4=CC=5OCOC=5C=C4OC3)C2=O)C=CC=1C(=O)NC1=CC=NC=N1 QWJVVSLYLHDKOF-UHFFFAOYSA-N 0.000 claims 1
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• ZZKVOPMTRYYKPY-UHFFFAOYSA-N 5-bromo-1'-pentylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC(Br)=CC=C2OC1 ZZKVOPMTRYYKPY-UHFFFAOYSA-N 0.000 claims 1
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• NRDWJIYWPFNLSQ-UHFFFAOYSA-N 6-methylsulfonyl-1'-pentylspiro[2h-1-benzofuran-3,3'-indole]-2'-one Chemical compound C12=CC=CC=C2N(CCCCC)C(=O)C11C2=CC=C(S(C)(=O)=O)C=C2OC1 NRDWJIYWPFNLSQ-UHFFFAOYSA-N 0.000 claims 1
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• ITQZSEIQROAGQG-UHFFFAOYSA-N FC=1C=C(C=C(C1)F)C1=C2C3(CN(C2=CC=C1)CCCCC)COC1=CC2=C(OCO2)C=C13 Chemical compound FC=1C=C(C=C(C1)F)C1=C2C3(CN(C2=CC=C1)CCCCC)COC1=CC2=C(OCO2)C=C13 ITQZSEIQROAGQG-UHFFFAOYSA-N 0.000 claims 1
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• KVFUJPMZXDDBMM-UHFFFAOYSA-N N-(cyclopropylmethyl)-3-spiro[2H-indole-3,7'-6H-furo[2,3-f][1,3]benzodioxole]-1-ylpropan-1-amine Chemical compound C1(CC1)CNCCCN1CC2(C3=CC=CC=C13)COC1=CC3=C(OCO3)C=C12 KVFUJPMZXDDBMM-UHFFFAOYSA-N 0.000 claims 1
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
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• 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 claims 1
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• HDPZTEKBHYBHGQ-UHFFFAOYSA-N n-[2-(2'-oxo-1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-4'-yl)phenyl]acetamide Chemical compound CCCCCN1C(=O)C2(C3=CC=4OCOC=4C=C3OC2)C2=C1C=CC=C2C1=CC=CC=C1NC(C)=O HDPZTEKBHYBHGQ-UHFFFAOYSA-N 0.000 claims 1
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