AU2006235593B2 - Spiro-oxindole compounds and their uses as therapeutic agents - Google Patents

Spiro-oxindole compounds and their uses as therapeutic agents Download PDF

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Publication number
AU2006235593B2
AU2006235593B2 AU2006235593A AU2006235593A AU2006235593B2 AU 2006235593 B2 AU2006235593 B2 AU 2006235593B2 AU 2006235593 A AU2006235593 A AU 2006235593A AU 2006235593 A AU2006235593 A AU 2006235593A AU 2006235593 B2 AU2006235593 B2 AU 2006235593B2
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AU
Australia
Prior art keywords
indol
furo
benzodioxole
oxospiro
methyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006235593A
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AU2006235593A1 (en
Inventor
Mehran Seid Bagherzadeh
Mikhail Chafeev
Nagasree Chakka
Sultan Chowdhury
Robert Fraser
Jianmin Fu
Duanjie Hou
Tom Hsieh
Rajender Kamboj
Shifeng Liu
Vandna Raina
Jianyu Sun
Shaoyi Sun
Serguei Sviridov
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Xenon Pharmaceuticals Inc
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Xenon Pharmaceuticals Inc
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Publication of AU2006235593A1 publication Critical patent/AU2006235593A1/en
Application granted granted Critical
Publication of AU2006235593B2 publication Critical patent/AU2006235593B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems

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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2006235593A 2005-04-11 2006-04-11 Spiro-oxindole compounds and their uses as therapeutic agents Ceased AU2006235593B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67089605P 2005-04-11 2005-04-11
US60/670,896 2005-04-11
PCT/US2006/014352 WO2006110917A2 (en) 2005-04-11 2006-04-11 Spiro-oxindole compounds and their uses as therapeutic agents

Publications (2)

Publication Number Publication Date
AU2006235593A1 AU2006235593A1 (en) 2006-10-19
AU2006235593B2 true AU2006235593B2 (en) 2012-07-05

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AU2006235593A Ceased AU2006235593B2 (en) 2005-04-11 2006-04-11 Spiro-oxindole compounds and their uses as therapeutic agents

Country Status (30)

Country Link
US (4) US7700641B2 (enExample)
EP (4) EP2752417B1 (enExample)
JP (4) JP5118627B2 (enExample)
KR (5) KR20140063803A (enExample)
CN (2) CN102153562B (enExample)
AR (1) AR056968A1 (enExample)
AT (1) ATE543825T1 (enExample)
AU (1) AU2006235593B2 (enExample)
BR (1) BRPI0607926A2 (enExample)
CA (3) CA2853635C (enExample)
DK (1) DK1888595T3 (enExample)
EC (1) ECSP077852A (enExample)
ES (2) ES2381683T3 (enExample)
HK (1) HK1199874A1 (enExample)
HR (1) HRP20070505B1 (enExample)
IL (1) IL186616A (enExample)
MA (1) MA29684B1 (enExample)
MX (1) MX2007012636A (enExample)
MY (2) MY158766A (enExample)
NO (1) NO20074619L (enExample)
NZ (1) NZ561210A (enExample)
PL (1) PL1888595T3 (enExample)
PT (1) PT1888595E (enExample)
RS (1) RS52295B (enExample)
RU (1) RU2415143C2 (enExample)
SG (1) SG161262A1 (enExample)
SI (1) SI1888595T1 (enExample)
TN (1) TNSN07382A1 (enExample)
TW (1) TWI374141B (enExample)
WO (1) WO2006110917A2 (enExample)

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TW200833698A (en) * 2006-10-12 2008-08-16 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
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MX2010002938A (es) 2007-09-24 2010-04-01 Comentis Inc Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.
JP2010540628A (ja) * 2007-10-04 2010-12-24 メルク・シャープ・エンド・ドーム・コーポレイション カルシウムチャネル遮断薬としてのｎ−置換されたオキシインドリン誘導体
US8273749B2 (en) * 2007-10-04 2012-09-25 Merck Sharp & Dohme Corp. N-substituted oxindoline derivatives as calcium channel blockers
HRP20150882T1 (hr) 2008-10-17 2015-09-25 Xenon Pharmaceuticals Inc. Spirooksindolski spojevi i njihova upotreba kao terapijska sredstva
AU2014265116B2 (en) * 2008-10-17 2017-02-02 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
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WO2012049555A1 (en) 2010-10-13 2012-04-19 Lupin Limited Spirocyclic compounds as voltage-gated sodium channel modulators
ES2583061T3 (es) 2010-12-21 2016-09-16 Bayer Intellectual Property Gmbh Método para la producción de oxindoles sustituidos en el N con sulfonilo
HRP20161412T1 (hr) 2011-06-27 2016-12-02 Newron Pharmaceuticals S.P.A. Fluorirani derivati arilalkilaminokarboksamida
EP2753317B1 (en) * 2011-09-06 2020-02-26 CuRNA, Inc. TREATMENT OF DISEASES RELATED TO ALPHA SUBUNITS OF SODIUM CHANNELS, VOLTAGE-GATED (SCNxA) WITH SMALL MOLECULES
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HK1205113A1 (en) 2012-04-12 2015-12-11 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
KR101719893B1 (ko) * 2012-05-22 2017-03-24 제넨테크, 인크. Ｎ-치환된 벤즈아미드 및 통증의 치료에서 이들의 용도
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CN103554119B (zh) * 2013-10-15 2015-09-16 华东师范大学 四氢呋喃并苯并二氢吡喃多环化合物的制备方法
CN103554118B (zh) * 2013-10-15 2015-08-19 华东师范大学 四氢呋喃并苯并二氢吡喃多环化合物及其应用
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