RU2218153C2 - Драже, имеющее ядро, покрытое противогрибковым средством и полимером - Google Patents

Драже, имеющее ядро, покрытое противогрибковым средством и полимером Download PDF

Info

Publication number
RU2218153C2
RU2218153C2 RU99112123/15A RU99112123A RU2218153C2 RU 2218153 C2 RU2218153 C2 RU 2218153C2 RU 99112123/15 A RU99112123/15 A RU 99112123/15A RU 99112123 A RU99112123 A RU 99112123A RU 2218153 C2 RU2218153 C2 RU 2218153C2
Authority
RU
Russia
Prior art keywords
polymer
dragee
itraconazole
water
soluble polymer
Prior art date
Application number
RU99112123/15A
Other languages
English (en)
Russian (ru)
Other versions
RU99112123A (ru
Inventor
Роже Петрус Гереберн ВАНДЕКРУЙС
КОНДЕ Валентэн Флоран Виктор ДЕ
Поль Мари Виктор Жили
Йозеф Петерс
Original Assignee
Жансен Фармасетика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Жансен Фармасетика Н.В. filed Critical Жансен Фармасетика Н.В.
Publication of RU99112123A publication Critical patent/RU99112123A/ru
Application granted granted Critical
Publication of RU2218153C2 publication Critical patent/RU2218153C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
RU99112123/15A 1997-03-26 1998-03-18 Драже, имеющее ядро, покрытое противогрибковым средством и полимером RU2218153C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200914 1997-03-26
EP97200914.6 1997-03-26

Publications (2)

Publication Number Publication Date
RU99112123A RU99112123A (ru) 2001-04-20
RU2218153C2 true RU2218153C2 (ru) 2003-12-10

Family

ID=8228147

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99112123/15A RU2218153C2 (ru) 1997-03-26 1998-03-18 Драже, имеющее ядро, покрытое противогрибковым средством и полимером

Country Status (31)

Country Link
EP (1) EP0969821B1 (xx)
JP (1) JP3608800B2 (xx)
KR (1) KR100520936B1 (xx)
CN (1) CN1206984C (xx)
AP (1) AP1227A (xx)
AT (1) ATE241969T1 (xx)
AU (1) AU734248B2 (xx)
BG (1) BG64434B1 (xx)
BR (1) BR9806174A (xx)
CA (1) CA2269501C (xx)
CY (1) CY2384B1 (xx)
CZ (1) CZ295502B6 (xx)
DE (1) DE69815316T2 (xx)
DK (1) DK0969821T3 (xx)
EE (1) EE03904B1 (xx)
ES (1) ES2201485T3 (xx)
HK (1) HK1022840A1 (xx)
HU (1) HU224217B1 (xx)
ID (1) ID21477A (xx)
IL (1) IL129575A (xx)
NO (1) NO325102B1 (xx)
NZ (1) NZ335364A (xx)
OA (1) OA11162A (xx)
PL (1) PL190566B1 (xx)
PT (1) PT969821E (xx)
RU (1) RU2218153C2 (xx)
SI (1) SI0969821T1 (xx)
SK (1) SK284813B6 (xx)
TR (1) TR199900990T2 (xx)
UA (1) UA60318C2 (xx)
WO (1) WO1998042318A1 (xx)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002520351A (ja) * 1998-07-17 2002-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗菌・カビ剤及びポリマーを被覆したコアを有するペレット
ES2157731B1 (es) 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
DE60023465T2 (de) 1999-03-24 2006-07-20 R.P. Scherer Technologies, Inc., Las Vegas Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser
KR100432949B1 (ko) * 2000-06-13 2004-05-31 코오롱제약주식회사 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
CN101230067B (zh) 2001-02-14 2011-06-15 泰博特克药品有限公司 广谱的2-(取代-氨基)-苯并噻唑磺酰胺hiv蛋白酶抑制剂
AU2002257774B2 (en) 2001-04-09 2007-08-30 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
EP1387842B1 (en) 2001-05-11 2009-04-22 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors
AU2002317063A (en) * 2001-06-12 2002-12-23 Smartrix Technologies Inc Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
EP1463502B1 (en) 2001-12-21 2011-07-13 Tibotec Pharmaceuticals Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
KR20100130234A (ko) 2002-05-17 2010-12-10 티보텍 파마슈티컬즈 광범위 스펙트럼의 치환된 벤즈이속사졸 설폰아미드 ｈｉｖ 프로테아제 저해제
JP4681296B2 (ja) 2002-08-14 2011-05-11 テイボテク・フアーマシユーチカルズ・リミテツド スペクトルの広い置換オキシインドールスルホンアミドｈｉｖプロテアーゼ阻害剤
KR100557680B1 (ko) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
DE60312635T3 (de) * 2003-01-14 2013-05-08 Cimex Pharma Ag Zusammensetzung in Form eines festen Dispersion enthaltend Itraconazol und ein hydrophilisches Polymer mit einer verbesserten Bioverfügbarkeit
ATE357235T1 (de) * 2003-01-14 2007-04-15 Cimex Pharma Ag Bioaequivalente zusammensetzung in der form einer festen dispersion enthaltend itraconazol und ein hydrophiles polymer
CN1845725A (zh) * 2003-08-06 2006-10-11 尼马尔·穆利耶 包含水溶性药物的药物组合物
US8268885B2 (en) 2003-09-11 2012-09-18 Janssen R&D Ireland Entry inhibitors of the HIV virus
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
CN1997363B (zh) 2004-05-07 2012-03-28 塞阔伊亚药品公司 抗耐药性反转录病毒蛋白酶抑制剂
EA012330B1 (ru) 2004-05-17 2009-08-28 Тиботек Фармасьютикалз Лтд. 1-ГЕТЕРОЦИКЛИЛ-1,5-ДИГИДРОПИРИДО[3,2-b]ИНДОЛ-2-ОНЫ
BRPI0511267A (pt) 2004-05-17 2007-11-27 Tibotec Pharm Ltd 1,5-diidropirido[3,2-b]indol-2-onas 4-substituìdas
BRPI0511173A (pt) 2004-05-17 2007-12-04 Tibotec Pharm Ltd 1-fenil-1,5-diidro-pirido-(3,2b)indol-2-onas substituìdas nas posições 6,7,8,9, de utilidade como agentes farmacêuticos antiinfecciosos
JP2009534311A (ja) 2006-04-03 2009-09-24 テイボテク・フアーマシユーチカルズ・リミテツド ＨＩＶ阻害性３，４−ジヒドロ−イミダゾ［４，５−ｂ］ピリジン−５−オン
US8277843B2 (en) * 2006-09-04 2012-10-02 Panacea Biotec Limited Programmable buoyant delivery technology
KR100809903B1 (ko) * 2006-09-05 2008-03-06 주식회사유한양행 안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
JP2008280254A (ja) * 2007-05-08 2008-11-20 Everest Pharm Industrial Co Ltd 生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
US8313527B2 (en) 2007-11-05 2012-11-20 Allergan, Inc. Soft prosthesis shell texturing method
JP5745855B2 (ja) 2007-11-28 2015-07-08 セコイア、ファーマシューティカルズ、インコーポレイテッドＳｅｑｕｏｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． シトクロムｐ４５０ ２ｄ６を阻害するための組成物および方法
WO2009105776A1 (en) 2008-02-21 2009-08-27 Sequoia Pharmaceuticals, Inc. Diamide inhibitors of cytochrome p450
US9050184B2 (en) 2008-08-13 2015-06-09 Allergan, Inc. Dual plane breast implant
US8877822B2 (en) 2010-09-28 2014-11-04 Allergan, Inc. Porogen compositions, methods of making and uses
US9205577B2 (en) 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
GB2479213B (en) 2010-04-01 2013-07-10 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
US11202853B2 (en) 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
HUE031363T2 (hu) * 2010-05-11 2017-07-28 Allergan Inc Porogén készítmények, az elõállításukra szolgáló eljárások és felhasználásuk
US8679279B2 (en) 2010-11-16 2014-03-25 Allergan, Inc. Methods for creating foam-like texture
CN102100678B (zh) * 2011-02-18 2012-10-17 天津力生制药股份有限公司 伊曲康唑硫酸盐微丸及其制备方法
WO2014093669A1 (en) 2012-12-13 2014-06-19 Allergan, Inc. Device and method for making a variable surface breast implant
US10092392B2 (en) 2014-05-16 2018-10-09 Allergan, Inc. Textured breast implant and methods of making same
WO2017127073A1 (en) 2016-01-20 2017-07-27 Theravida, Inc. Methods and compositions for treating hyperhidrosis
EP3781132B1 (en) * 2018-04-16 2024-03-20 Bristol-Myers Squibb Company Apixaban formulations
CN114767636B (zh) * 2022-04-11 2023-11-07 苏州中化药品工业有限公司 伊曲康唑微丸、制备方法及伊曲康唑微丸胶囊

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
TR199802718T2 (xx) * 1996-06-28 1999-03-22 Schering Corporation Bir triazol mantara kar�� bile�i�ini i�eren a��zdan al�nan bile�im.

Also Published As

Publication number Publication date
SI0969821T1 (en) 2003-10-31
TR199900990T2 (xx) 1999-10-21
EP0969821B1 (en) 2003-06-04
CZ295502B6 (cs) 2005-08-17
BG103356A (en) 2000-03-31
DE69815316D1 (de) 2003-07-10
NZ335364A (en) 2000-08-25
PL335542A1 (en) 2000-04-25
JP3608800B2 (ja) 2005-01-12
AU7210798A (en) 1998-10-20
CA2269501C (en) 2005-11-08
ES2201485T3 (es) 2004-03-16
PL190566B1 (pl) 2005-12-30
HUP0002056A2 (hu) 2000-12-28
DE69815316T2 (de) 2004-04-29
AU734248B2 (en) 2001-06-07
PT969821E (pt) 2003-10-31
NO992114D0 (no) 1999-04-30
CN1244796A (zh) 2000-02-16
CN1206984C (zh) 2005-06-22
BG64434B1 (en) 2005-02-28
IL129575A0 (en) 2000-02-29
KR20000052971A (ko) 2000-08-25
ATE241969T1 (de) 2003-06-15
WO1998042318A1 (en) 1998-10-01
ID21477A (id) 1999-06-17
JP2001520663A (ja) 2001-10-30
SK54499A3 (en) 2000-01-18
HU224217B1 (hu) 2005-06-28
UA60318C2 (uk) 2003-10-15
EP0969821A1 (en) 2000-01-12
NO325102B1 (no) 2008-02-04
HK1022840A1 (en) 2000-08-25
CZ139899A3 (cs) 1999-10-13
IL129575A (en) 2004-06-20
CA2269501A1 (en) 1998-10-01
AP1227A (en) 2003-11-24
OA11162A (en) 2003-04-16
KR100520936B1 (ko) 2005-10-17
HUP0002056A3 (en) 2001-01-29
EE03904B1 (et) 2002-12-16
CY2384B1 (en) 2004-06-04
BR9806174A (pt) 1999-10-19
DK0969821T3 (da) 2003-09-15
EE9900453A (et) 2000-04-17
AP9901516A0 (en) 1999-06-30
SK284813B6 (sk) 2005-12-01
NO992114L (no) 1999-08-26

Similar Documents

Publication Publication Date Title
RU2218153C2 (ru) Драже, имеющее ядро, покрытое противогрибковым средством и полимером
RU99112123A (ru) Драже, имеющее ядро, покрытое противогрибковым средством и полимером
SI9300461B (en) Beads having a core coated with an antifugal and a polymer
US5260068A (en) Multiparticulate pulsatile drug delivery system
RU95108537A (ru) Гранула, способ ее получения и фармацевтическая композиция
US3490454A (en) Catamenial products having a coating of rupturable microcapsules containing medicants
Dey et al. Multiparticulate drug delivery systems for controlled release
ES2226886T3 (es) Forma de administracion de accion retardada que contiene sacarinato de tramadol.
US4891223A (en) Controlled release delivery coating formulation for bioactive substances
IE64084B1 (en) Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat
JP2007511510A (ja) 持続放出性ベンラファキシン製剤
US7022342B2 (en) Controlled release oral dosage form of beta-adrenergic blocking agents
US4975284A (en) Controlled release means
US9078830B2 (en) Multi-layered, multiple unit pharmaceutical compositions
JPH08506802A (ja) 波状粒薬配給システム
CN101647789B (zh) 左乙拉西坦缓释微丸胶囊制剂
CZ18599A3 (cs) Formulace s násobnou jednotkou tramadolu
CZ20014639A3 (cs) Potaľená jádra s opoľděným uvolňováním účinné látky a farmaceutické dávkovací formy je obsahující
RU2000120913A (ru) Гранулы, имеющие ядро, покрытое противогрибковым препаратом и полимером
CN100362996C (zh) 一种度洛西汀肠溶微丸胶囊及其制备方法
CA1333996C (en) Dhp delayed release preparation
WO2004110410A1 (en) Extended release composition containing tramadol
WO2000074656A1 (en) Microencapsulated and controlled-release herbal formulations
CA2448927A1 (en) Pharmaceutical composition
HUP0102052A2 (hu) Pelletek, amelyek magja lipidszintcsökkentő hatóanyaggal és egy polimerrel van bevonva és eljárás az előállításukra