EE03904B1 - Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid - Google Patents

Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid

Info

Publication number
EE03904B1
EE03904B1 EEP199900453A EEP9900453A EE03904B1 EE 03904 B1 EE03904 B1 EE 03904B1 EE P199900453 A EEP199900453 A EE P199900453A EE P9900453 A EEP9900453 A EE P9900453A EE 03904 B1 EE03904 B1 EE 03904B1
Authority
EE
Estonia
Prior art keywords
granules
granule
drug
preparation
dosage form
Prior art date
Application number
EEP199900453A
Other languages
English (en)
Inventor
Florent Victor De Cond Valentin
Petrus Gerebern Vandecruys Roger
Marie Victor Gilis Paul
Peeters Jozef
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE9900453A publication Critical patent/EE9900453A/et
Publication of EE03904B1 publication Critical patent/EE03904B1/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
EEP199900453A 1997-03-26 1998-03-18 Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid EE03904B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200914 1997-03-26
PCT/EP1998/001773 WO1998042318A1 (en) 1997-03-26 1998-03-18 Pellets having a core coated with an antifungal and a polymer

Publications (2)

Publication Number Publication Date
EE9900453A EE9900453A (et) 2000-04-17
EE03904B1 true EE03904B1 (et) 2002-12-16

Family

ID=8228147

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900453A EE03904B1 (et) 1997-03-26 1998-03-18 Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid

Country Status (31)

Country Link
EP (1) EP0969821B1 (et)
JP (1) JP3608800B2 (et)
KR (1) KR100520936B1 (et)
CN (1) CN1206984C (et)
AP (1) AP1227A (et)
AT (1) ATE241969T1 (et)
AU (1) AU734248B2 (et)
BG (1) BG64434B1 (et)
BR (1) BR9806174A (et)
CA (1) CA2269501C (et)
CY (1) CY2384B1 (et)
CZ (1) CZ295502B6 (et)
DE (1) DE69815316T2 (et)
DK (1) DK0969821T3 (et)
EE (1) EE03904B1 (et)
ES (1) ES2201485T3 (et)
HK (1) HK1022840A1 (et)
HU (1) HU224217B1 (et)
ID (1) ID21477A (et)
IL (1) IL129575A (et)
NO (1) NO325102B1 (et)
NZ (1) NZ335364A (et)
OA (1) OA11162A (et)
PL (1) PL190566B1 (et)
PT (1) PT969821E (et)
RU (1) RU2218153C2 (et)
SI (1) SI0969821T1 (et)
SK (1) SK284813B6 (et)
TR (1) TR199900990T2 (et)
UA (1) UA60318C2 (et)
WO (1) WO1998042318A1 (et)

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TR200002217T2 (tr) 1998-07-17 2001-02-21 Janssen Pharmaceutica N.V. Bir mantar ilacı ve bir polimer ile kaplanmış bir çekirdeğe sahip taneler.
ES2157731B1 (es) * 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
JP2003531099A (ja) 1999-03-24 2003-10-21 エフ エム シー コーポレーション 改良された水溶解度をもつ医薬製剤
KR100432949B1 (ko) * 2000-06-13 2004-05-31 코오롱제약주식회사 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
ES2275866T3 (es) 2001-02-14 2007-06-16 Tibotec Pharmaceuticals Ltd. 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih.
PL367084A1 (en) 2001-04-09 2005-02-21 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
CN100549007C (zh) 2001-05-11 2009-10-14 泰博特克药品有限公司 广谱2-氨基-苯并唑磺酰胺hiv蛋白酶抑制剂
WO2002100407A1 (en) * 2001-06-12 2002-12-19 Smartrix Technologies Inc. Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
MY138657A (en) 2001-12-21 2009-07-31 Tibotec Pharm Ltd broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
WO2003097616A1 (en) 2002-05-17 2003-11-27 Tibotec Pharmaceuticals Ltd Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
AU2003262574B2 (en) 2002-08-14 2009-07-09 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors
KR100557680B1 (ko) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
DK1438960T4 (da) * 2003-01-14 2013-03-25 Cimex Pharma Ag Sammensætning af itraconazol dispergeret i en hydrofil polymer med forhøjet biotilgængelighed
DE60312636T3 (de) * 2003-01-14 2014-12-24 Acino Pharma Ag Bioaequivalente Zusammensetzung in der Form einer festen Dispersion enthaltend Itraconazol und ein hydrophiles Polymer
CN1845725A (zh) * 2003-08-06 2006-10-11 尼马尔·穆利耶 包含水溶性药物的药物组合物
NZ544980A (en) 2003-09-11 2009-02-28 Tibotec Pharm Ltd Entry inhibitors of the HIV virus
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
US7378441B2 (en) 2004-05-07 2008-05-27 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
TW200613307A (en) 2004-05-17 2006-05-01 Tibotec Pharm Ltd 4-substituted-1,5-dihydro-pyrido[3,2-b]indol-2-ones
AR049340A1 (es) 2004-05-17 2006-07-19 Tibotec Pharm Ltd 1- heterociclil - l, 5- dihidro- pirido (3,2-b) indol - 2- onas
ES2351702T3 (es) 2004-05-17 2011-02-09 Tibotec Pharmaceuticals 1-fenil-1,5-dihidro-pirido[3,2-b]indol-2-onas 6,7,8,9-sustituidas útiles como agentes farmacéuticos antiinfecciosos.
RU2008143342A (ru) 2006-04-03 2010-05-10 Тиботек Фармасьютикалз Лтд. (Ie) 3, 4-дигидроимидазо(4, 5-b)пиридин-5-оны, ингибирующие вич(hiv)
WO2008062440A2 (en) * 2006-09-04 2008-05-29 Panacea Biotec Limited Programmable buoyant delivery technology
KR100809903B1 (ko) * 2006-09-05 2008-03-06 주식회사유한양행 안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
JP2008280254A (ja) * 2007-05-08 2008-11-20 Everest Pharm Industrial Co Ltd 生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
US8313527B2 (en) 2007-11-05 2012-11-20 Allergan, Inc. Soft prosthesis shell texturing method
AU2008329677B2 (en) 2007-11-28 2015-02-19 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome P450 2D6
CA2716348C (en) 2008-02-21 2017-04-04 Sequoia Pharmaceuticals, Inc. Diamide inhibitors of cytochrome p450
US9050184B2 (en) 2008-08-13 2015-06-09 Allergan, Inc. Dual plane breast implant
US8877822B2 (en) 2010-09-28 2014-11-04 Allergan, Inc. Porogen compositions, methods of making and uses
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
US9205577B2 (en) 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
SG174658A1 (en) 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
ES2623475T3 (es) * 2010-05-11 2017-07-11 Allergan, Inc. Composiciones de porógenos, métodos para hacerlas y usos
US11202853B2 (en) 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
US8679279B2 (en) 2010-11-16 2014-03-25 Allergan, Inc. Methods for creating foam-like texture
CN102100678B (zh) * 2011-02-18 2012-10-17 天津力生制药股份有限公司 伊曲康唑硫酸盐微丸及其制备方法
AU2013359158B2 (en) 2012-12-13 2018-08-02 Allergan, Inc. Device and method for making a variable surface breast implant
US10092392B2 (en) 2014-05-16 2018-10-09 Allergan, Inc. Textured breast implant and methods of making same
JP6841834B2 (ja) 2016-01-20 2021-03-10 テラヴィダ, インコーポレイテッドTheraVida, Inc. 多汗症の処置のための方法および組成物
AU2019255599B2 (en) * 2018-04-16 2024-02-29 Bristol-Myers Squibb Holdings Ireland Unlimited Company Apixaban formulations
CN114767636B (zh) * 2022-04-11 2023-11-07 苏州中化药品工业有限公司 伊曲康唑微丸、制备方法及伊曲康唑微丸胶囊

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DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
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PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
CN1228693A (zh) * 1996-06-28 1999-09-15 先灵公司 含有三唑类抗真菌化合物的口服组合物

Also Published As

Publication number Publication date
JP2001520663A (ja) 2001-10-30
JP3608800B2 (ja) 2005-01-12
SK54499A3 (en) 2000-01-18
SI0969821T1 (en) 2003-10-31
DE69815316T2 (de) 2004-04-29
TR199900990T2 (xx) 1999-10-21
EE9900453A (et) 2000-04-17
KR20000052971A (ko) 2000-08-25
CZ295502B6 (cs) 2005-08-17
HUP0002056A2 (hu) 2000-12-28
PL190566B1 (pl) 2005-12-30
CY2384B1 (en) 2004-06-04
AU7210798A (en) 1998-10-20
SK284813B6 (sk) 2005-12-01
CN1206984C (zh) 2005-06-22
BG103356A (en) 2000-03-31
IL129575A (en) 2004-06-20
BR9806174A (pt) 1999-10-19
ES2201485T3 (es) 2004-03-16
AP9901516A0 (en) 1999-06-30
AU734248B2 (en) 2001-06-07
HU224217B1 (hu) 2005-06-28
AP1227A (en) 2003-11-24
OA11162A (en) 2003-04-16
EP0969821A1 (en) 2000-01-12
CZ139899A3 (cs) 1999-10-13
RU2218153C2 (ru) 2003-12-10
UA60318C2 (uk) 2003-10-15
NZ335364A (en) 2000-08-25
NO992114L (no) 1999-08-26
PT969821E (pt) 2003-10-31
CA2269501A1 (en) 1998-10-01
ATE241969T1 (de) 2003-06-15
BG64434B1 (en) 2005-02-28
WO1998042318A1 (en) 1998-10-01
IL129575A0 (en) 2000-02-29
CN1244796A (zh) 2000-02-16
HK1022840A1 (en) 2000-08-25
DE69815316D1 (de) 2003-07-10
KR100520936B1 (ko) 2005-10-17
ID21477A (id) 1999-06-17
CA2269501C (en) 2005-11-08
EP0969821B1 (en) 2003-06-04
HUP0002056A3 (en) 2001-01-29
NO992114D0 (no) 1999-04-30
PL335542A1 (en) 2000-04-25
NO325102B1 (no) 2008-02-04
DK0969821T3 (da) 2003-09-15

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