HUP0002056A2 - Gombaellenes hatóanyaggal és polimerrel bevont magrészt tartalmazó pelletek - Google Patents

Gombaellenes hatóanyaggal és polimerrel bevont magrészt tartalmazó pelletek

Info

Publication number
HUP0002056A2
HUP0002056A2 HU0002056A HUP0002056A HUP0002056A2 HU P0002056 A2 HUP0002056 A2 HU P0002056A2 HU 0002056 A HU0002056 A HU 0002056A HU P0002056 A HUP0002056 A HU P0002056A HU P0002056 A2 HUP0002056 A2 HU P0002056A2
Authority
HU
Hungary
Prior art keywords
pellets
itraconazole
antifungal
polymer
day
Prior art date
Application number
HU0002056A
Other languages
English (en)
Inventor
Paul Marie Victor Gilis
Jozef Peeters
Roger Petrus Gerebern Vandecruys
Valentin Florent Victor de Condé
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HUP0002056A2 publication Critical patent/HUP0002056A2/hu
Publication of HUP0002056A3 publication Critical patent/HUP0002056A3/hu
Publication of HU224217B1 publication Critical patent/HU224217B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A találmány itrakonazolt tartalmazó új, kisméretű pelletekre, ezekneka pelleteknek az előállítási eljárására, továbbá olyan orálisadagolási formákra vonatkozik, amelyek e pelletek gyógyászatiszempontból hatásos mennyiségét tartalmazzák. A találmány előnye, hogy lehetővé teszi itrakonazolt tartalmazó,olyan adagolási formák megvalósítását, amelyek útján egy gombaellenesfertőzésben szenvedő beteg számára az itrakonazol naponta egyszeradagolható. Ennek alapján a találmány tárgyát képezi egy olyan pellet,amely (a) központi, lekerekített vagy gömb alakú magrészt, (b) vízbenoldható polimerből és gombaellenes hatóanyagból álló filmbevonatot és(c) polimer záróbevonat-réteget tartalmaz, ahol a magrész átmérőjekörülbelül 250 mm-től körülbelül 600 mm-ig terjed. A találmány előnyeabban áll, hogy a beteg számára akár kapszulában, akár tablettábannaponta egyszer adható az itrakonazol hatásos mennyisége; kétszeriadagolás nem szükséges. Ó
HU0002056A 1997-03-26 1998-03-18 Gombaellenes hatóanyaggal és polimerrel bevont magrészt tartalmazó pelletek HU224217B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200914 1997-03-26
PCT/EP1998/001773 WO1998042318A1 (en) 1997-03-26 1998-03-18 Pellets having a core coated with an antifungal and a polymer

Publications (3)

Publication Number Publication Date
HUP0002056A2 true HUP0002056A2 (hu) 2000-12-28
HUP0002056A3 HUP0002056A3 (en) 2001-01-29
HU224217B1 HU224217B1 (hu) 2005-06-28

Family

ID=8228147

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002056A HU224217B1 (hu) 1997-03-26 1998-03-18 Gombaellenes hatóanyaggal és polimerrel bevont magrészt tartalmazó pelletek

Country Status (31)

Country Link
EP (1) EP0969821B1 (hu)
JP (1) JP3608800B2 (hu)
KR (1) KR100520936B1 (hu)
CN (1) CN1206984C (hu)
AP (1) AP1227A (hu)
AT (1) ATE241969T1 (hu)
AU (1) AU734248B2 (hu)
BG (1) BG64434B1 (hu)
BR (1) BR9806174A (hu)
CA (1) CA2269501C (hu)
CY (1) CY2384B1 (hu)
CZ (1) CZ295502B6 (hu)
DE (1) DE69815316T2 (hu)
DK (1) DK0969821T3 (hu)
EE (1) EE03904B1 (hu)
ES (1) ES2201485T3 (hu)
HK (1) HK1022840A1 (hu)
HU (1) HU224217B1 (hu)
ID (1) ID21477A (hu)
IL (1) IL129575A (hu)
NO (1) NO325102B1 (hu)
NZ (1) NZ335364A (hu)
OA (1) OA11162A (hu)
PL (1) PL190566B1 (hu)
PT (1) PT969821E (hu)
RU (1) RU2218153C2 (hu)
SI (1) SI0969821T1 (hu)
SK (1) SK284813B6 (hu)
TR (1) TR199900990T2 (hu)
UA (1) UA60318C2 (hu)
WO (1) WO1998042318A1 (hu)

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DE60023465T2 (de) 1999-03-24 2006-07-20 R.P. Scherer Technologies, Inc., Las Vegas Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser
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US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
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CA2566340C (en) 2004-05-07 2014-05-06 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
WO2005111047A1 (en) 2004-05-17 2005-11-24 Tibotec Pharmaceuticals Ltd. 1-heterocyclyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones
TW200613307A (en) 2004-05-17 2006-05-01 Tibotec Pharm Ltd 4-substituted-1,5-dihydro-pyrido[3,2-b]indol-2-ones
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Also Published As

Publication number Publication date
PL190566B1 (pl) 2005-12-30
EP0969821B1 (en) 2003-06-04
BG103356A (en) 2000-03-31
NO992114D0 (no) 1999-04-30
SI0969821T1 (en) 2003-10-31
AP9901516A0 (en) 1999-06-30
JP3608800B2 (ja) 2005-01-12
AP1227A (en) 2003-11-24
RU2218153C2 (ru) 2003-12-10
CZ139899A3 (cs) 1999-10-13
NZ335364A (en) 2000-08-25
HK1022840A1 (en) 2000-08-25
TR199900990T2 (xx) 1999-10-21
EE9900453A (et) 2000-04-17
IL129575A (en) 2004-06-20
PL335542A1 (en) 2000-04-25
DE69815316T2 (de) 2004-04-29
JP2001520663A (ja) 2001-10-30
BR9806174A (pt) 1999-10-19
ATE241969T1 (de) 2003-06-15
OA11162A (en) 2003-04-16
AU7210798A (en) 1998-10-20
KR100520936B1 (ko) 2005-10-17
AU734248B2 (en) 2001-06-07
EE03904B1 (et) 2002-12-16
HU224217B1 (hu) 2005-06-28
CN1206984C (zh) 2005-06-22
UA60318C2 (uk) 2003-10-15
CN1244796A (zh) 2000-02-16
CZ295502B6 (cs) 2005-08-17
KR20000052971A (ko) 2000-08-25
NO992114L (no) 1999-08-26
DE69815316D1 (de) 2003-07-10
HUP0002056A3 (en) 2001-01-29
SK54499A3 (en) 2000-01-18
ID21477A (id) 1999-06-17
CY2384B1 (en) 2004-06-04
DK0969821T3 (da) 2003-09-15
SK284813B6 (sk) 2005-12-01
BG64434B1 (en) 2005-02-28
NO325102B1 (no) 2008-02-04
CA2269501A1 (en) 1998-10-01
WO1998042318A1 (en) 1998-10-01
CA2269501C (en) 2005-11-08
PT969821E (pt) 2003-10-31
IL129575A0 (en) 2000-02-29
ES2201485T3 (es) 2004-03-16
EP0969821A1 (en) 2000-01-12

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Effective date: 20050503