ATE251899T1 - Pharmazeutische dosierungsform zur freisetzung im colon - Google Patents
Pharmazeutische dosierungsform zur freisetzung im colonInfo
- Publication number
- ATE251899T1 ATE251899T1 AT96920227T AT96920227T ATE251899T1 AT E251899 T1 ATE251899 T1 AT E251899T1 AT 96920227 T AT96920227 T AT 96920227T AT 96920227 T AT96920227 T AT 96920227T AT E251899 T1 ATE251899 T1 AT E251899T1
- Authority
- AT
- Austria
- Prior art keywords
- dosage form
- colon
- coating material
- enteric polymer
- polymer coating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/442,921 US5686106A (en) | 1995-05-17 | 1995-05-17 | Pharmaceutical dosage form for colonic delivery |
PCT/US1996/006986 WO1996036319A1 (en) | 1995-05-17 | 1996-05-16 | Pharmaceutical dosage form for colonic delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE251899T1 true ATE251899T1 (de) | 2003-11-15 |
Family
ID=23758702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96920227T ATE251899T1 (de) | 1995-05-17 | 1996-05-16 | Pharmazeutische dosierungsform zur freisetzung im colon |
Country Status (6)
Country | Link |
---|---|
US (2) | US5686106A (de) |
EP (1) | EP0827398B1 (de) |
JP (1) | JP3902228B2 (de) |
AT (1) | ATE251899T1 (de) |
DE (1) | DE69630375D1 (de) |
WO (1) | WO1996036319A1 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6028190A (en) | 1994-02-01 | 2000-02-22 | The Regents Of The University Of California | Probes labeled with energy transfer coupled dyes |
US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
US6190691B1 (en) * | 1994-04-12 | 2001-02-20 | Adolor Corporation | Methods for treating inflammatory conditions |
GB9412394D0 (en) | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
US6166024A (en) | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
US5686106A (en) * | 1995-05-17 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form for colonic delivery |
US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
US5849761A (en) * | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
US6231888B1 (en) | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
CA2271560C (en) * | 1996-11-15 | 2003-09-23 | Mayo Foundation For Medical Education And Research | Pharmaceutical dosage form for colonic delivery |
US5788987A (en) * | 1997-01-29 | 1998-08-04 | Poli Industria Chimica Spa | Methods for treating early morning pathologies |
DK1067910T3 (da) * | 1998-04-03 | 2004-10-04 | Egalet As | Komposition med styret afgivelse |
UA69413C2 (uk) | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
US7122207B2 (en) | 1998-05-22 | 2006-10-17 | Bristol-Myers Squibb Company | High drug load acid labile pharmaceutical composition |
UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
DK1105141T3 (da) * | 1998-08-06 | 2004-03-08 | Wolfgang Stremmel | Phosphatidylcholin som et medikament med slimhindebeskyttende virkning |
US6531152B1 (en) | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
US6884792B2 (en) * | 1999-01-08 | 2005-04-26 | Marvin B. Bacaner | Bretylium compositions and kits and their use in preventing and treating cardiovascular conditions |
CA2358459C (en) | 1999-01-08 | 2011-05-24 | Marvin B. Bacaner | Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions |
US6270807B1 (en) | 1999-03-02 | 2001-08-07 | L. Perrigo Company | Taste-masked pharmaceutical composition |
US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
US20020054903A1 (en) * | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
IT1318376B1 (it) * | 2000-03-07 | 2003-08-25 | Pharmatec Internat S R L | Forme solide orali a rilascio controllato contenenti mesalazina comeprincipio attivo. |
US6365181B1 (en) | 2000-04-20 | 2002-04-02 | Gattefosse Corporation | Thixatropic gelatin carrier composition |
CA2359812C (en) * | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
EP1390032A4 (de) * | 2001-05-11 | 2004-12-29 | Marvin B Bacaner | Neue, mit erleichternden anionen gekuppelte quaternäre ammoniumzusammensetzungen und ihre verwendung in kits sowie ihre verwendung bei der prävention und behandlung bestimmter erkrankungen |
US20030070584A1 (en) | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
US20030083286A1 (en) * | 2001-08-22 | 2003-05-01 | Ching-Leou Teng | Bioadhesive compositions and methods for enhanced intestinal drug absorption |
US20030124196A1 (en) * | 2001-08-22 | 2003-07-03 | Susan Weinbach | Pulsatile release compositions and methods for enhanced intestinal drug absorption |
US8309118B2 (en) | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
US6837696B2 (en) * | 2001-09-28 | 2005-01-04 | Mcneil-Ppc, Inc. | Apparatus for manufacturing dosage forms |
GB0124953D0 (en) * | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
DE602004020187D1 (de) * | 2003-02-20 | 2009-05-07 | Constant Res & Dev Ltd | Prozess zur Herstellung einer Dexamethason enthaltenden Formulierung zur oralen Anwendung |
US20080286359A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
US7645460B2 (en) * | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of risedronate |
US7645459B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
US20080287400A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
JP4880591B2 (ja) | 2004-06-04 | 2012-02-22 | テバ ファーマシューティカル インダストリーズ リミティド | イルベサルタンを含む医薬組成物 |
US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
US20060177415A1 (en) * | 2004-11-01 | 2006-08-10 | Burke Steven K | Once a day formulation for phosphate binders |
CA2620406A1 (en) | 2005-09-02 | 2007-03-08 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
EP1924246B1 (de) | 2005-09-15 | 2015-10-21 | Genzyme Corporation | Beutelformulierung für aminpolymere |
BRPI0717545A2 (pt) | 2006-09-29 | 2013-10-22 | Gezyme Corp | Composição farmacêutica, método para tratar uma doença, polímero de amida, rede de polímero, e, método para preparar um polímero de amida |
JP2010513271A (ja) | 2006-12-14 | 2010-04-30 | ゲンズイメ コーポレーション | アミド−アミンポリマー組成物 |
US20090028944A1 (en) * | 2007-07-16 | 2009-01-29 | Balaji Sathurappan | Pharmaceutical compositions comprising mesalamine |
US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
US8753677B2 (en) | 2008-09-16 | 2014-06-17 | The Invention Science Fund I, Llc | Ex vivo modifiable multiple medicament final dosage form |
US20100069887A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Multiple chamber ex vivo adjustable-release final dosage form |
CA2746767A1 (en) * | 2008-12-17 | 2010-07-08 | Altheus Therapeutics, Inc. | Oral formulations |
IT1395143B1 (it) | 2009-08-06 | 2012-09-05 | Sofar Spa | Composizioni granulari a rilascio controllato di mesalazina e processo per il loro ottenimento. |
WO2011160062A2 (en) | 2010-06-17 | 2011-12-22 | The Usa As Represented By The Secretary, National Institutes Of Health | Compositions and methods for treating inflammatory conditions |
PL2826467T3 (pl) | 2010-12-22 | 2018-01-31 | Purdue Pharma Lp | Zamknięte, zabezpieczone przed manipulowaniem formy dozowania o kontrolowanym uwalnianiu |
ES2581323T3 (es) | 2010-12-23 | 2016-09-05 | Purdue Pharma Lp | Formas de dosificación oral sólida resistentes a alteraciones |
GB201202433D0 (en) | 2012-02-13 | 2012-03-28 | Diurnal Ltd | Controlled drug release |
AP2015008579A0 (en) | 2013-02-05 | 2015-07-31 | Purdue Pharma Lp | Tamper resistant pharmaceutical formulations |
US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
WO2014152450A1 (en) | 2013-03-15 | 2014-09-25 | Warner Chilcott Company, Llc | Mesalamine pharmaceutical composition with multiple dosage elements for reduced delivery variability |
US10570169B2 (en) | 2014-05-22 | 2020-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
WO2016065279A1 (en) * | 2014-10-23 | 2016-04-28 | Symbiotic Health Inc. | A capsule for the oral administration of biopharmaceuticals |
MA41611A (fr) * | 2015-02-23 | 2018-01-02 | Omthera Pharmaceuticals Inc | Préparations en milli-capsules comprenant des acides gras polyinsaturés libres |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1204363B (de) * | 1963-09-10 | 1965-11-04 | Hoffmann La Roche | Verfahren zur Herstellung einer oralen Arzneizubereitung, die ihren Wirkstoff erst im Ileum abgibt |
LU72439A1 (de) * | 1975-05-09 | 1977-02-09 | ||
JPS53133625A (en) * | 1977-04-25 | 1978-11-21 | Shin Etsu Chem Co Ltd | Manufacturing of pharmaceutical coated with enteric film |
JPS5535031A (en) * | 1978-09-04 | 1980-03-11 | Shin Etsu Chem Co Ltd | Enteric coating composition |
FR2471186A1 (fr) * | 1979-12-10 | 1981-06-19 | Roussel Uclaf | Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation |
ZA825384B (en) * | 1981-07-31 | 1983-05-25 | Tillott J B Ltd | Orally administrable pharmaceutical compositions |
JPS59139317A (ja) * | 1983-01-31 | 1984-08-10 | Teisan Seiyaku Kk | 持続性のニフエジピン製剤 |
JPS59193816A (ja) * | 1983-04-19 | 1984-11-02 | Morishita Jintan Kk | 腸溶性軟カプセルの製造法 |
FR2556965B1 (fr) * | 1983-12-21 | 1986-08-22 | Rhone Poulenc Sante | Nouvelle forme galenique du ketoprofene a liberation controlee |
JPS61221117A (ja) * | 1985-03-26 | 1986-10-01 | Fujisawa Pharmaceut Co Ltd | 腸溶性硬カプセル剤 |
IL77186A0 (en) * | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
US4822629A (en) * | 1986-12-12 | 1989-04-18 | Norwich Eaton Pharmaceuticals, Inc. | Azumolene dosage form |
US4816259A (en) * | 1987-02-12 | 1989-03-28 | Chase Chemical Company, L.P. | Process for coating gelatin capsules |
US5068110A (en) * | 1987-09-29 | 1991-11-26 | Warner-Lambert Company | Stabilization of enteric coated dosage form |
JP2782691B2 (ja) * | 1987-09-29 | 1998-08-06 | ワーナー−ランバート・コンパニー | 腸溶製剤の安定化 |
JPH089536B2 (ja) * | 1987-10-30 | 1996-01-31 | 日清製粉株式会社 | 腸溶性カプセルの製造方法 |
IT1230576B (it) * | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
SE8903914D0 (sv) * | 1989-11-22 | 1989-11-22 | Draco Ab | Oral composition for the treatment of inflammatory bowel diseases |
IT1246382B (it) * | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
JPH064531B2 (ja) * | 1990-06-04 | 1994-01-19 | アイセロ化学株式会社 | 大腸崩壊性硬質カプセル |
JP2773959B2 (ja) * | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
US5229135A (en) * | 1991-11-22 | 1993-07-20 | Prographarm Laboratories | Sustained release diltiazem formulation |
IT1260505B (it) * | 1992-06-01 | 1996-04-09 | Poli Ind Chimica Spa | Sistemi farmaceutici orali a cessione ritardata per il rilascio specifico nel colon |
US5330759A (en) * | 1992-08-26 | 1994-07-19 | Sterling Winthrop Inc. | Enteric coated soft capsules and method of preparation thereof |
US5651983A (en) * | 1993-02-26 | 1997-07-29 | The Procter & Gamble Company | Bisacodyl dosage form for colonic delivery |
GB9412394D0 (en) * | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
US5686106A (en) * | 1995-05-17 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form for colonic delivery |
-
1995
- 1995-05-17 US US08/442,921 patent/US5686106A/en not_active Expired - Lifetime
-
1996
- 1996-05-16 EP EP96920227A patent/EP0827398B1/de not_active Expired - Lifetime
- 1996-05-16 WO PCT/US1996/006986 patent/WO1996036319A1/en active IP Right Grant
- 1996-05-16 JP JP53502596A patent/JP3902228B2/ja not_active Expired - Fee Related
- 1996-05-16 AT AT96920227T patent/ATE251899T1/de not_active IP Right Cessation
- 1996-05-16 DE DE69630375T patent/DE69630375D1/de not_active Expired - Lifetime
- 1996-09-24 US US08/719,108 patent/US5814336A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0827398B1 (de) | 2003-10-15 |
EP0827398A1 (de) | 1998-03-11 |
JP3902228B2 (ja) | 2007-04-04 |
US5814336A (en) | 1998-09-29 |
JPH11505253A (ja) | 1999-05-18 |
DE69630375D1 (de) | 2003-11-20 |
US5686106A (en) | 1997-11-11 |
WO1996036319A1 (en) | 1996-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |