HUP0102052A2 - Pelletek, amelyek magja lipidszintcsökkentő hatóanyaggal és egy polimerrel van bevonva és eljárás az előállításukra - Google Patents
Pelletek, amelyek magja lipidszintcsökkentő hatóanyaggal és egy polimerrel van bevonva és eljárás az előállításukraInfo
- Publication number
- HUP0102052A2 HUP0102052A2 HU0102052A HUP0102052A HUP0102052A2 HU P0102052 A2 HUP0102052 A2 HU P0102052A2 HU 0102052 A HU0102052 A HU 0102052A HU P0102052 A HUP0102052 A HU P0102052A HU P0102052 A2 HUP0102052 A2 HU P0102052A2
- Authority
- HU
- Hungary
- Prior art keywords
- pellets
- barrier layer
- cores
- lipid
- active ingredient
- Prior art date
Links
- 239000008188 pellet Substances 0.000 title abstract 4
- 229920000642 polymer Polymers 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000003524 antilipemic agent Substances 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 6
- 230000004888 barrier function Effects 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 229920003169 water-soluble polymer Polymers 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000006199 nebulizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány pelletekre vonatkozik, amelyek 250-1180 mm (16-60mesh)méretű lekerekített vagy gömb alakú középső magot, egy vízoldhatópolimert és egy kevéssé oldódó lipidszint-csökkentő hatóanyagottartalmazó bevonófilmet és adott esetben egy polimer zárórétegettartalmaznak. A pelleteket a találmány szerint oly módon állítják elő,hogy a) 250-1180 mm (16-60 mesh) méretű magokra egy alsó porlasztóWurster betéttel felszerelt fluidágyas granulátorban egy lipidszint-csökkentő hatóanyag és egy vízoldható polimer metilénkloridot és egyalkoholt tartalmazó szerves oldószerrel készített oldatát porlasztják,b) a kapott bevont magokat megszárítják, és c) a megszárított magokatzáróréteggel látják el oly módon, hogy azokra egy alsó porlasztóWurster betéttel felszerelt fluidágyas granulátorban egy zárórétegetképező polimer metilénkloridot és egy alkoholt tartalmazó szervesoldószerrel készített oldatát porlasztják. A találmány tárgyát képezikemellett a pelletekből készíthető, előnyösen kapszula vagy tablettaalakú gyógyászati készítmények, amelyekkel hiperlipidémiás, elhízottvagy ateroszklerózisos emlősöket, különösen embert lehet egyetlendózis napi egyszeri beadásával kezelni, a gyógyszer beadását azétkezéstől függetlenítve. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98201331 | 1998-04-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0102052A2 true HUP0102052A2 (hu) | 2002-05-29 |
| HUP0102052A3 HUP0102052A3 (en) | 2002-10-28 |
Family
ID=8233644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102052A HUP0102052A3 (en) | 1998-04-27 | 1999-04-20 | Pellets having a core coated with a lipid lowering agent and a polymer and process for their preparation |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1073424A1 (hu) |
| JP (1) | JP2002544118A (hu) |
| KR (1) | KR20010041460A (hu) |
| CN (1) | CN1308523A (hu) |
| AU (1) | AU3710099A (hu) |
| BG (1) | BG104757A (hu) |
| BR (1) | BR9909963A (hu) |
| CA (1) | CA2328970A1 (hu) |
| EE (1) | EE200000796A (hu) |
| HU (1) | HUP0102052A3 (hu) |
| NO (1) | NO20005426D0 (hu) |
| PL (1) | PL358909A1 (hu) |
| SK (1) | SK15252000A3 (hu) |
| WO (1) | WO1999055313A1 (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1413624B1 (en) * | 2002-10-22 | 2006-03-08 | Rohm and Haas Company | Tablet coating |
| AU2004314693B2 (en) | 2003-09-26 | 2011-04-07 | Alza Corporation | Drug coating providing high drug loading and methods for providing the same |
| US20080234291A1 (en) * | 2004-01-21 | 2008-09-25 | Marc Karel Jozef Francois | Mitratapide Oral Solution |
| US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
| FR2897267A1 (fr) * | 2006-02-16 | 2007-08-17 | Flamel Technologies Sa | Formes pharmaceutiques multimicroparticulaires pour administration per os |
| WO2019226213A2 (en) | 2018-03-08 | 2019-11-28 | Incyte Corporation | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996013499A1 (en) * | 1994-10-27 | 1996-05-09 | Janssen Pharmaceutica N.V. | Apolipoprotein-b synthesis inhibitors |
-
1999
- 1999-04-20 KR KR1020007009614A patent/KR20010041460A/ko not_active Application Discontinuation
- 1999-04-20 JP JP2000545512A patent/JP2002544118A/ja not_active Withdrawn
- 1999-04-20 CN CN99805457A patent/CN1308523A/zh active Pending
- 1999-04-20 SK SK1525-2000A patent/SK15252000A3/sk unknown
- 1999-04-20 EE EEP200000796A patent/EE200000796A/xx unknown
- 1999-04-20 HU HU0102052A patent/HUP0102052A3/hu unknown
- 1999-04-20 AU AU37100/99A patent/AU3710099A/en not_active Abandoned
- 1999-04-20 WO PCT/EP1999/002768 patent/WO1999055313A1/en not_active Application Discontinuation
- 1999-04-20 BR BR9909963-2A patent/BR9909963A/pt not_active Application Discontinuation
- 1999-04-20 EP EP99919266A patent/EP1073424A1/en not_active Ceased
- 1999-04-20 PL PL99358909A patent/PL358909A1/xx unknown
- 1999-04-20 CA CA002328970A patent/CA2328970A1/en not_active Abandoned
-
2000
- 2000-09-12 BG BG104757A patent/BG104757A/xx unknown
- 2000-10-27 NO NO20005426A patent/NO20005426D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2328970A1 (en) | 1999-11-04 |
| PL358909A1 (en) | 2004-08-23 |
| NO20005426L (no) | 2000-10-27 |
| BG104757A (en) | 2001-05-31 |
| AU3710099A (en) | 1999-11-16 |
| EP1073424A1 (en) | 2001-02-07 |
| SK15252000A3 (sk) | 2001-10-08 |
| NO20005426D0 (no) | 2000-10-27 |
| KR20010041460A (ko) | 2001-05-25 |
| WO1999055313A1 (en) | 1999-11-04 |
| JP2002544118A (ja) | 2002-12-24 |
| CN1308523A (zh) | 2001-08-15 |
| BR9909963A (pt) | 2000-12-26 |
| EE200000796A (et) | 2002-06-17 |
| HUP0102052A3 (en) | 2002-10-28 |
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