RU2164520C2 - Производное инсулина, растворимая пролонгированная фармацевтическая композиция, способ пролонгирования гипогликемического действия при лечении диабета - Google Patents
Производное инсулина, растворимая пролонгированная фармацевтическая композиция, способ пролонгирования гипогликемического действия при лечении диабета Download PDFInfo
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- RU2164520C2 RU2164520C2 RU96108249/04A RU96108249A RU2164520C2 RU 2164520 C2 RU2164520 C2 RU 2164520C2 RU 96108249/04 A RU96108249/04 A RU 96108249/04A RU 96108249 A RU96108249 A RU 96108249A RU 2164520 C2 RU2164520 C2 RU 2164520C2
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- human insulin
- insulin
- des
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK104493A DK104493D0 (da) | 1993-09-17 | 1993-09-17 | Hidtil ukendte peptider |
| DK1044/93 | 1993-09-17 | ||
| US19082994A | 1994-02-02 | 1994-02-02 | |
| US08/190,829 | 1994-02-02 | ||
| US08/190.829 | 1994-02-02 |
Publications (2)
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| RU96108249A RU96108249A (ru) | 1998-07-20 |
| RU2164520C2 true RU2164520C2 (ru) | 2001-03-27 |
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| RU96108249/04A RU2164520C2 (ru) | 1993-09-17 | 1994-09-16 | Производное инсулина, растворимая пролонгированная фармацевтическая композиция, способ пролонгирования гипогликемического действия при лечении диабета |
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| EP (2) | EP0792290B1 (enExample) |
| JP (3) | JP3014764B2 (enExample) |
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| CN (1) | CN1056618C (enExample) |
| AT (1) | ATE204882T1 (enExample) |
| AU (2) | AU682061B2 (enExample) |
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| BR (1) | BR9407508A (enExample) |
| CA (1) | CA2171424C (enExample) |
| CZ (1) | CZ287945B6 (enExample) |
| DE (2) | DE69428134T2 (enExample) |
| DK (1) | DK0792290T3 (enExample) |
| ES (1) | ES2163451T3 (enExample) |
| FI (1) | FI117055B (enExample) |
| FR (1) | FR04C0020I2 (enExample) |
| HU (1) | HU217684B (enExample) |
| IL (1) | IL110977A (enExample) |
| LU (1) | LU91101I2 (enExample) |
| NL (1) | NL300160I2 (enExample) |
| NO (3) | NO316944B1 (enExample) |
| NZ (1) | NZ273285A (enExample) |
| PL (1) | PL178466B1 (enExample) |
| PT (1) | PT792290E (enExample) |
| RO (1) | RO112873B1 (enExample) |
| RU (1) | RU2164520C2 (enExample) |
| SI (1) | SI0792290T1 (enExample) |
| SK (1) | SK282495B6 (enExample) |
| UA (1) | UA45321C2 (enExample) |
| WO (1) | WO1995007931A1 (enExample) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2299743C2 (ru) * | 2001-07-05 | 2007-05-27 | Транслэйшнл Рисерч Лтд. | Композиции инсулина для носового введения |
| RU2345062C2 (ru) * | 2002-09-25 | 2009-01-27 | Ново Нордиск А/С | Способ ацилирования пептидов |
| RU2352581C2 (ru) * | 2003-08-05 | 2009-04-20 | Ново Нордиск А/С | Производные инсулина |
| US8691759B2 (en) | 2008-03-18 | 2014-04-08 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| RU2518460C2 (ru) * | 2003-08-05 | 2014-06-10 | Ново Нордиск А/С | Производные инсулина |
| US9034818B2 (en) | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
| US9481721B2 (en) | 2012-04-11 | 2016-11-01 | Novo Nordisk A/S | Insulin formulations |
| US9603904B2 (en) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| RU2673185C2 (ru) * | 2013-10-07 | 2018-11-22 | Ново Нордиск А/С | Новое производное аналога инсулина |
| US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
| US10265385B2 (en) | 2016-12-16 | 2019-04-23 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| US10596229B2 (en) | 2010-10-27 | 2020-03-24 | Novo Nordisk A/S | Method of treating diabetes mellitus by administration, at specifically defined intervals, of a derivative of a naturally occurring insulin or insulin analogue, the derivative having a prolonged profile of action |
| US11167035B2 (en) | 2005-12-28 | 2021-11-09 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
Families Citing this family (178)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9316895D0 (en) * | 1993-08-13 | 1993-09-29 | Guy S And St Thomas Hospitals | Hepatoselective insulin analogues |
| US6342225B1 (en) | 1993-08-13 | 2002-01-29 | Deutshces Wollforschungsinstitut | Pharmaceutical active conjugates |
| US6869930B1 (en) * | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
| US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| DE4437604A1 (de) * | 1994-10-21 | 1996-04-25 | Basf Ag | Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung |
| US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US5646242A (en) | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| CN1196061A (zh) * | 1995-03-17 | 1998-10-14 | 诺沃挪第克公司 | 胰岛素衍生物 |
| US6251856B1 (en) | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
| US20010041786A1 (en) * | 1995-06-07 | 2001-11-15 | Mark L. Brader | Stabilized acylated insulin formulations |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| BR9709845B1 (pt) * | 1996-06-20 | 2008-11-18 | preparaÇço aquosa de insulina, formulaÇço farmacÊutica parenteral, e, processso para aumentar a estabilidade quÍmica de uma preparaÇço de insulina. | |
| US5905140A (en) * | 1996-07-11 | 1999-05-18 | Novo Nordisk A/S, Novo Alle | Selective acylation method |
| WO1998002460A1 (en) * | 1996-07-11 | 1998-01-22 | Novo Nordisk A/S | Selective acylation method |
| EP0821006B1 (de) * | 1996-07-26 | 2004-04-21 | Aventis Pharma Deutschland GmbH | Insulinderivate mit erhöhter Zinkbindung |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US20020025933A1 (en) * | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
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| SU1554766A3 (ru) * | 1980-07-24 | 1990-03-30 | Карлсберг Биотекнолоджи, Лтд, А/С (Фирма) | Способ получени человеческого инсулина формулы I @ -Т @ -ОН или его производных |
| WO1991012817A1 (en) * | 1990-02-21 | 1991-09-05 | Novo Nordisk A/S | Novel insulin compositions |
| WO1992000321A1 (en) * | 1990-06-28 | 1992-01-09 | Novo Nordisk A/S | Novel, protracted insulin analogues |
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|---|---|---|---|---|
| US3823125A (en) * | 1969-10-14 | 1974-07-09 | American Home Prod | N-aminoacyl-substituted insulins |
| US3950517A (en) * | 1970-05-08 | 1976-04-13 | National Research Development Corporation | Insulin derivatives |
| GB1381274A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| GB1381273A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| US3907763A (en) * | 1972-03-01 | 1975-09-23 | Bayer Ag | Insulin derivatives crosslinked by a dicarboxylic acid moiety |
| IL68769A (en) * | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| JPH01254699A (ja) * | 1988-04-05 | 1989-10-11 | Kodama Kk | インスリン誘導体及びその用途 |
| AU8091091A (en) * | 1990-07-26 | 1992-02-18 | University Of Iowa Research Foundation, The | Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule |
| US5336782A (en) * | 1991-04-24 | 1994-08-09 | Kuraray Co., Ltd. | Long chain carboxylic acid imide ester |
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1994
- 1994-09-16 PT PT94926816T patent/PT792290E/pt unknown
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| SU1554766A3 (ru) * | 1980-07-24 | 1990-03-30 | Карлсберг Биотекнолоджи, Лтд, А/С (Фирма) | Способ получени человеческого инсулина формулы I @ -Т @ -ОН или его производных |
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| WO1991012817A1 (en) * | 1990-02-21 | 1991-09-05 | Novo Nordisk A/S | Novel insulin compositions |
| WO1992000321A1 (en) * | 1990-06-28 | 1992-01-09 | Novo Nordisk A/S | Novel, protracted insulin analogues |
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| RU2299743C2 (ru) * | 2001-07-05 | 2007-05-27 | Транслэйшнл Рисерч Лтд. | Композиции инсулина для носового введения |
| RU2345062C2 (ru) * | 2002-09-25 | 2009-01-27 | Ново Нордиск А/С | Способ ацилирования пептидов |
| RU2352581C2 (ru) * | 2003-08-05 | 2009-04-20 | Ново Нордиск А/С | Производные инсулина |
| RU2518460C2 (ru) * | 2003-08-05 | 2014-06-10 | Ново Нордиск А/С | Производные инсулина |
| US8828923B2 (en) | 2003-08-05 | 2014-09-09 | Novo Nordisk A/S | Insulin derivatives |
| US11167035B2 (en) | 2005-12-28 | 2021-11-09 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
| US9034818B2 (en) | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
| US10259856B2 (en) | 2008-03-18 | 2019-04-16 | Novo Nordisk A/S | Protease stabilized acylated insulin analogues |
| US8691759B2 (en) | 2008-03-18 | 2014-04-08 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| US9045560B2 (en) | 2008-03-18 | 2015-06-02 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| RU2571857C2 (ru) * | 2008-03-18 | 2015-12-20 | Ново Нордиск А/С | Стабилизированные по отношению к протеазам ацилированные аналоги инсулина |
| US9688737B2 (en) | 2008-03-18 | 2017-06-27 | Novo Nordisk A/S | Protease stabilized acylated insulin analogues |
| US9603904B2 (en) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| US10596229B2 (en) | 2010-10-27 | 2020-03-24 | Novo Nordisk A/S | Method of treating diabetes mellitus by administration, at specifically defined intervals, of a derivative of a naturally occurring insulin or insulin analogue, the derivative having a prolonged profile of action |
| US9481721B2 (en) | 2012-04-11 | 2016-11-01 | Novo Nordisk A/S | Insulin formulations |
| US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
| RU2673185C2 (ru) * | 2013-10-07 | 2018-11-22 | Ново Нордиск А/С | Новое производное аналога инсулина |
| US10265385B2 (en) | 2016-12-16 | 2019-04-23 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
| US10596231B2 (en) | 2016-12-16 | 2020-03-24 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| US12226458B2 (en) | 2018-06-26 | 2025-02-18 | Novo Nordisk A/S | System for providing an up-to-date and long-acting or ultra-long-acting insulin dose guidance recommendation to treat diabetes mellitus |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
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