RU2021100063A - Дифференцировка плюрипотентных стволовых клеток в клетки кишечной энтодермы средней кишки - Google Patents

Дифференцировка плюрипотентных стволовых клеток в клетки кишечной энтодермы средней кишки Download PDF

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RU2021100063A
RU2021100063A RU2021100063A RU2021100063A RU2021100063A RU 2021100063 A RU2021100063 A RU 2021100063A RU 2021100063 A RU2021100063 A RU 2021100063A RU 2021100063 A RU2021100063 A RU 2021100063A RU 2021100063 A RU2021100063 A RU 2021100063A
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cells
population
midgut
intestinal endoderm
essentially
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Себастьян РИК
Алиреза РЕЗАНИА
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Янссен Байотек, Инк.
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Claims (18)

1. Популяция по существу клеток кишечной энтодермы средней кишки, где популяция клеток является инкапсулированной.
2. Популяция по существу клеток кишечной энтодермы средней кишки по п. 1, где популяция клеток является микро-инкапсулированной.
3. Популяция по существу клеток кишечной энтодермы средней кишки по п. 1, где популяция клеток является макро-инкапсулированной.
4. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-3, где клетки кишечной энтодермы средней кишки экспрессируют CDX2 и FOXA2.
5. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-4, где клетки кишечной энтодермы средней кишки экспрессируют транскрипционные факторы, выбранные из группы, состоящей из SOX9, PDX1, KLF5 и HOXC5.
6. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-5, где клетки кишечной энтодермы средней кишки не экспрессируют транскрипционные факторы, выбранные из группы, состоящей из SOX2, ALB, PTF1A, HOXA13 и LGR5.
7. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-6, где клетки кишечной энтодермы средней кишки не экспрессируют HAND1.
8. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-7, где популяция содержит более 70% клеток кишечной энтодермы средней кишки.
9. Популяция по существу клеток кишечной энтодермы средней кишки по п. 8, где популяция содержит более 80% клеток кишечной энтодермы средней кишки.
10. Популяция по существу клеток кишечной энтодермы средней кишки по п. 8, где популяция содержит более 90% клеток кишечной энтодермы средней кишки.
11. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-10, где популяция содержит менее чем 20% мезенхимальных клеток.
12. Популяция по существу клеток кишечной энтодермы средней кишки по п. 11, где популяция содержит менее чем 10% мезенхимальных клеток.
13. Популяция по существу клеток кишечной энтодермы средней кишки по п. 11, где популяция содержит менее чем 1% мезенхимальных клеток.
14. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-10, где популяция не включает мезенхимальные клетки.
15. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-14, где популяция экспрессирует инкретиновый гормон.
16. Популяция по существу клеток кишечной энтодермы средней кишки по п. 15, где инкретиновый гормон включает глюкагонподобный пептид 1 (GLP-1), глюкозозависимый инсулинотропный полипептид (GIP) или оба из них.
17. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-16, где клетки энтодермы средней кишки представляют собой L-клетки.
18. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-16, где клетки энтодермы средней кишки представляют собой K-клетки.
RU2021100063A 2016-04-14 2017-04-04 Дифференцировка плюрипотентных стволовых клеток в клетки кишечной энтодермы средней кишки RU2021100063A (ru)

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MA45479A (fr) * 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
WO2020243666A1 (en) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. A biocompatible membrane composite
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