SG11201807915QA - Differentiation of pluripotent stem cells to intestinal midgut endoderm cells - Google Patents

Differentiation of pluripotent stem cells to intestinal midgut endoderm cells

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Publication number
SG11201807915QA
SG11201807915QA SG11201807915QA SG11201807915QA SG11201807915QA SG 11201807915Q A SG11201807915Q A SG 11201807915QA SG 11201807915Q A SG11201807915Q A SG 11201807915QA SG 11201807915Q A SG11201807915Q A SG 11201807915QA SG 11201807915Q A SG11201807915Q A SG 11201807915QA
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Singapore
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international
intestinal
cells
pct
applicant
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SG11201807915QA
Inventor
Sebastian Rieck
Alireza Rezania
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Janssen Biotech Inc
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Publication of SG11201807915QA publication Critical patent/SG11201807915QA/en

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Abstract

12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101111110111110011011011111101111011111 International Bureau 0.. .... .. ..... ..or::,„, (10) International Publication Number International Publication Date WO 2017/180361 Al 19 October 2017(19.10.2017) WIPO I PCT (51) (21) (22) (25) Filing Language: (26) Publication Language: (30) (71) Applicant: (72) (74) (81) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C12N 5/071 (2010.01) A61K 35/38 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, International Application Number: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, PCT/US2017/025847 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, International Filing Date: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 4 April 2017 (04.04.2017) TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. English (84) Designated States (unless otherwise indicated, for every English kind of regional protection available): ARIPO (BW, GH, Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/322,636 14 April 2016 (14.04.2016) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, JANSSEN BIOTECH, INC. [US/US]; DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 800/850 Ridgeview Drive, Horsham, Pennsylvania 19044 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Inventors: RIECK, Sebastian; 3210 Merryfield Row, San GW, KM, ML, MR, NE, SN, TD, TG). Diego, California 92121 (US). REZANIA, Alireza; 3550 Declarations under Rule 4.17: General Atomics Court, San Diego, California 92121 (US). — as to applicant's entitlement to apply for and be granted a Agents: SHIRTZ, Joseph F. et al.; JOHNSON & JOHN- patent (Rule 4. 1 7(ii)) SON, One Johnson & Johnson Plaza, New Brunswick, — as to the applicant's entitlement to claim the priority of the New Jersey 08933 (US). earlier application (Rule 4 . 1 7(iii)) Designated States (unless otherwise indicated, for every Published: kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, — with international search report (Art. 21(3)) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, . = = = = Title: DIFFERENTIATION OF PLURIPOTENT Human ES Cell (H1- hESC) STEM CELLS TO INTESTINAL FIG. IA MIDGUT ENDODERM CELLS the cells expressing markers charac - as diabetes are also disclosed. of generating — (54) = = Definitive endoderm Stage 1 -3d F 2 midgut endoderm cells and methods Methods of treating conditions Primitive gut tube Stage 2 - 2d FOXA2 Intestinal midgut endoderm Stage 3 - 5d FOXA2, CDX2, KLF5, SOX% PDX•fie such = = = : Cell populations of intestinal of intestinal endoderm lineage are disclosed. _ = — ,—, Il ,tD © en GC Il IN 1-1 (57) 0 teristic ei 0
SG11201807915QA 2016-04-14 2017-04-04 Differentiation of pluripotent stem cells to intestinal midgut endoderm cells SG11201807915QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662322636P 2016-04-14 2016-04-14
PCT/US2017/025847 WO2017180361A1 (en) 2016-04-14 2017-04-04 Differentiation of pluripotent stem cells to intestinal midgut endoderm cells

Publications (1)

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SG11201807915QA true SG11201807915QA (en) 2018-10-30

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US (2) US10420803B2 (en)
EP (1) EP3443073A4 (en)
JP (3) JP6705911B2 (en)
KR (4) KR102403165B1 (en)
CN (2) CN115449506A (en)
AR (1) AR108134A1 (en)
AU (1) AU2017251651B2 (en)
BR (1) BR112018070293A2 (en)
CA (1) CA3020905A1 (en)
MA (1) MA45479A (en)
MX (1) MX2018012629A (en)
PH (1) PH12018502061A1 (en)
RU (2) RU2741114C2 (en)
SG (1) SG11201807915QA (en)
TW (1) TW201803983A (en)
WO (1) WO2017180361A1 (en)

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MA45479A (en) * 2016-04-14 2019-02-20 Janssen Biotech Inc DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN ENDODERMAL CELLS OF MIDDLE INTESTINE
AU2020284245B2 (en) 2019-05-31 2023-10-05 Viacyte, Inc. A biocompatible membrane composite
EP3976237A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. Cell encapsulation devices with controlled oxygen diffusion distances
US20220234006A1 (en) 2019-05-31 2022-07-28 W. L. Gore & Associates, Inc. A biocompatible membrane composite
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CN110540962B (en) * 2019-08-28 2022-02-25 北京协同创新研究院 Method for preparing human definitive endoderm cells
KR20230044455A (en) * 2020-07-30 2023-04-04 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 Bladder organoids and methods for their preparation

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