SG11202000263QA - Immunomodulatory retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy - Google Patents

Immunomodulatory retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy

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Publication number
SG11202000263QA
SG11202000263QA SG11202000263QA SG11202000263QA SG11202000263QA SG 11202000263Q A SG11202000263Q A SG 11202000263QA SG 11202000263Q A SG11202000263Q A SG 11202000263QA SG 11202000263Q A SG11202000263Q A SG 11202000263QA SG 11202000263Q A SG11202000263Q A SG 11202000263QA
Authority
SG
Singapore
Prior art keywords
international
california
pct
retinoid
combination
Prior art date
Application number
SG11202000263QA
Inventor
Roshantha A Chandraratna
Martin E Sanders
Original Assignee
Io Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Io Therapeutics Inc filed Critical Io Therapeutics Inc
Publication of SG11202000263QA publication Critical patent/SG11202000263QA/en

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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau Iiiimmomiolollmomioloommolomoimiolomovoimill (43) International Publication Date 17 January 2019 (17.01.2019) (10) International Publication Number WO 2019/014492 Al WIPO I PCT (51) International Patent Classification: A61K 31/47 (2006.01) C07C 13/48 (2006.01) A61K 31/4709 (2006.01) (21) International Application Number: PCT/US2018/041892 (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 12 July 2018 (12.07.2018) English English 62/532,233 13 July 2017 (13.07.2017) US 62/552,814 31 August 2017 (31.08.2017) US (71) Applicant: I0 THERAPEUTICS, INC. [US/US]; 1805 East Garry Avenue, Santa Ana, California 92705 (US). (72) Inventors: CHANDRARATNA, Roshantha A.; 26242 Via Corrizo, San Juan Capistrano, California 92675 (US). SANDERS, Martin E.; c/o Io Therapeutics, INC., 1920 4th Avenue, #2704, Seattle, Washington 98101 (US). CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (74) Agent: CULLMAN, Louis C. et al.; K&L Gates LLP, 1 Park Plaza, Twelfth Floor, Irvine, California 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, — (54) Title: IMMUNOMODULATORY RETINOID AND REXINOID COMPOUNDS IN COMBINATION WITH IMMUNE MOD- ULATORS FOR CANCER IMMUNOTHERAPY RAft:x RARP RARy 0 1 8' 1 0' 1Cr io 4 3 Concentration (ntii FIG. 1 (57) : Disclosed herein are methods for treating cancer comprising administering CAR-modified immune cells and at least ,41 , ) one Retinoic Acid Receptor and/or Retinoid X Receptor active agent.
SG11202000263QA 2017-07-13 2018-07-12 Immunomodulatory retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy SG11202000263QA (en)

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