JP2014513983A5 - - Google Patents
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- Publication number
- JP2014513983A5 JP2014513983A5 JP2014510518A JP2014510518A JP2014513983A5 JP 2014513983 A5 JP2014513983 A5 JP 2014513983A5 JP 2014510518 A JP2014510518 A JP 2014510518A JP 2014510518 A JP2014510518 A JP 2014510518A JP 2014513983 A5 JP2014513983 A5 JP 2014513983A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- zscan4
- seq
- reprogramming
- contacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001082 somatic cell Anatomy 0.000 claims 11
- 210000004027 cells Anatomy 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 230000001419 dependent Effects 0.000 claims 7
- 101710026246 POU5F1 Proteins 0.000 claims 5
- 101700079116 QSOX1 Proteins 0.000 claims 5
- 101700006931 SOX2 Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 101700066830 PATL2 Proteins 0.000 claims 4
- 101710043199 PIWIL2 Proteins 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 102100006525 KLF4 Human genes 0.000 claims 3
- 101700048573 KLF4 Proteins 0.000 claims 3
- -1 Pramel6 Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 101710032940 LIN28A Proteins 0.000 claims 2
- 102100015262 MYC Human genes 0.000 claims 2
- 108020004999 Messenger RNA Proteins 0.000 claims 2
- 102100019163 POU5F1 Human genes 0.000 claims 2
- 229920002106 messenger RNA Polymers 0.000 claims 2
- 210000001519 tissues Anatomy 0.000 claims 2
- 210000004381 Amniotic Fluid Anatomy 0.000 claims 1
- 210000001130 Astrocytes Anatomy 0.000 claims 1
- 210000003719 B-Lymphocytes Anatomy 0.000 claims 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 1
- 210000000601 Blood Cells Anatomy 0.000 claims 1
- 210000001772 Blood Platelets Anatomy 0.000 claims 1
- 210000003958 Hematopoietic Stem Cells Anatomy 0.000 claims 1
- 210000003494 Hepatocytes Anatomy 0.000 claims 1
- 210000002510 Keratinocytes Anatomy 0.000 claims 1
- 210000004698 Lymphocytes Anatomy 0.000 claims 1
- 210000002901 Mesenchymal Stem Cells Anatomy 0.000 claims 1
- 210000004413 Myocytes, Cardiac Anatomy 0.000 claims 1
- 210000001178 Neural Stem Cells Anatomy 0.000 claims 1
- 210000001744 T-Lymphocytes Anatomy 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 210000004271 bone marrow stromal cells Anatomy 0.000 claims 1
- 210000002317 cardiac myocyte Anatomy 0.000 claims 1
- 210000002919 epithelial cells Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000663 muscle cells Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486004P | 2011-05-13 | 2011-05-13 | |
| US61/486,004 | 2011-05-13 | ||
| US201161529055P | 2011-08-30 | 2011-08-30 | |
| US61/529,055 | 2011-08-30 | ||
| PCT/US2012/037643 WO2012158561A1 (en) | 2011-05-13 | 2012-05-11 | Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017108578A Division JP2017212985A (ja) | 2011-05-13 | 2017-05-31 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513983A JP2014513983A (ja) | 2014-06-19 |
| JP2014513983A5 true JP2014513983A5 (ru) | 2015-07-16 |
| JP6189829B2 JP6189829B2 (ja) | 2017-08-30 |
Family
ID=47177285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510518A Active JP6189829B2 (ja) | 2011-05-13 | 2012-05-11 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
| JP2017108578A Pending JP2017212985A (ja) | 2011-05-13 | 2017-05-31 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017108578A Pending JP2017212985A (ja) | 2011-05-13 | 2017-05-31 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9932560B2 (ru) |
| EP (1) | EP2707479B1 (ru) |
| JP (2) | JP6189829B2 (ru) |
| AU (1) | AU2012256014B2 (ru) |
| CA (1) | CA2835825C (ru) |
| WO (1) | WO2012158561A1 (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012158561A1 (en) | 2011-05-13 | 2012-11-22 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells |
| EP3782628B1 (en) * | 2013-03-15 | 2024-08-07 | Elixirgen Therapeutics, Inc. | Methods of using zscan4 for rejuvenating human cells |
| US20170327796A1 (en) * | 2014-12-18 | 2017-11-16 | University Of Utah Research Foundation | Induced pluripotent stem cell and method for producing the same |
| CN105219729B (zh) * | 2015-09-28 | 2018-09-25 | 首都医科大学宣武医院 | 一种利用非整合质粒载体诱导神经干细胞的方法及其用途 |
| CN106800590B (zh) * | 2015-11-25 | 2021-04-09 | 杭州智鹤丹谷生物医药有限公司 | 一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用 |
| CN110268072B (zh) * | 2016-12-15 | 2023-11-07 | Illumina公司 | 确定旁系同源基因的方法和系统 |
| CN107475378B (zh) * | 2017-08-03 | 2021-03-30 | 复旦大学 | 用于检测女性原发不孕的patl2基因及检测该基因突变的试剂盒 |
| US20200224172A1 (en) * | 2017-09-19 | 2020-07-16 | The Broad Institute, Inc. | Methods and systems for reconstruction of developmental landscapes by optimal transport analysis |
| CN107988147B (zh) * | 2017-12-19 | 2021-11-09 | 江汉大学 | 基于器官芯片与诱导多能干细胞的定向分化用于3d拟表皮构建的方法 |
| CN110616232B (zh) * | 2019-09-23 | 2023-04-11 | 中国人民解放军陆军军医大学 | Sox30敲除和可恢复型小鼠动物模型构建方法及应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| US5888762A (en) | 1990-06-05 | 1999-03-30 | Centre National De La Recherche Scientifique (Cnrs) | Neurotropic growth factors comprising a homeobox peptide |
| KR100201352B1 (ko) | 1995-03-16 | 1999-06-15 | 성재갑 | 단일주사 백신 제형 |
| US7198784B2 (en) | 1996-10-17 | 2007-04-03 | Oxford Biomedica (Uk) Limited | Retroviral vectors |
| FR2762615B1 (fr) | 1997-04-28 | 1999-07-16 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes et vecteur le contenant |
| JP3526844B2 (ja) | 1999-06-22 | 2004-05-17 | 株式会社ディナベック研究所 | ２つの外来遺伝子を発現させるためのベクター |
| US20110171185A1 (en) | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
| DE19933492B4 (de) | 1999-07-16 | 2008-01-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen, Verfahren zu dessen Herstellung und dessen Verwendung |
| CA2392490A1 (en) | 1999-11-24 | 2001-05-31 | Mcs Micro Carrier Systems Gmbh | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
| US7211247B2 (en) | 2001-04-09 | 2007-05-01 | University Of Southern California | Lentivirus vectors for gene transfer to alveolar epithelial cells |
| US7081489B2 (en) | 2001-08-09 | 2006-07-25 | Florida State University Research Foundation | Polymeric encapsulation of nanoparticles |
| US20040014209A1 (en) | 2002-01-23 | 2004-01-22 | Lassar Andrew B. | Compositions and methods for modulating cell differentiation |
| US7354763B2 (en) | 2002-04-16 | 2008-04-08 | Technion Research & Development Foundation Ltd. | Generating vascular smooth muscle cells in vitro from ES cells |
| AU2003257181A1 (en) | 2002-08-05 | 2004-02-23 | University Of Rochester | Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof |
| KR100591936B1 (ko) | 2002-11-12 | 2006-06-22 | 포휴먼텍(주) | 세포내 ｄｎａ／ｒｎａ 전달 방법, 및 이것의 기초 및임상학적 응용 |
| EP1583473A2 (en) | 2003-01-16 | 2005-10-12 | St. Johns University New York | Nanoparticle based stabilization of ir fluorescent dyes |
| US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| CA2937099A1 (en) | 2004-01-23 | 2005-08-04 | Astellas Institute For Regenerative Medicine | Improved modalities for the treatment of degenerative diseases of the retina |
| WO2006052285A2 (en) | 2004-05-13 | 2006-05-18 | The Trustees Of Columbia University In The City Of New York | Polymeric nanoparticles and nanogels for extraction and release of compounds |
| US20060024331A1 (en) | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
| JP2008528038A (ja) | 2005-01-31 | 2008-07-31 | エス セル インターナショナル ピーティーイー リミテッド | 胚性幹細胞の指示された分化及びその利用 |
| DE602006000381T2 (de) | 2005-04-28 | 2008-12-18 | Nipro Corp., Osaka | Bioabsorbierbare pharmazeutische Zusammensetzung enthaltend einen PLGA-Copolymer |
| CN101189020A (zh) | 2005-05-10 | 2008-05-28 | N·巴拉班 | 用于给予rnaⅲ-抑制肽的组合物 |
| US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| WO2008118957A2 (en) | 2007-03-26 | 2008-10-02 | The Government Of U.S.A As Represented By The Secretary Of The Department Of Health & Human Services | Methods for modulating embryonic stem cell differentiation |
| CN101855350B (zh) | 2008-05-02 | 2014-12-31 | 国立大学法人京都大学 | 核重编程序方法 |
| CA2772619C (en) * | 2009-09-04 | 2019-07-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for enhancing genome stability and telomere elongation in embryonic stem cells |
| WO2012129342A1 (en) | 2011-03-23 | 2012-09-27 | Ko Minoru S H | Compositions and methods for enhancing the pluripotency of stem cells |
| WO2012158561A1 (en) | 2011-05-13 | 2012-11-22 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells |
-
2012
- 2012-05-11 WO PCT/US2012/037643 patent/WO2012158561A1/en active Application Filing
- 2012-05-11 EP EP12785169.9A patent/EP2707479B1/en active Active
- 2012-05-11 JP JP2014510518A patent/JP6189829B2/ja active Active
- 2012-05-11 CA CA2835825A patent/CA2835825C/en active Active
- 2012-05-11 AU AU2012256014A patent/AU2012256014B2/en active Active
- 2012-05-11 US US14/117,589 patent/US9932560B2/en active Active
-
2017
- 2017-05-31 JP JP2017108578A patent/JP2017212985A/ja active Pending
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