TW200836749A - Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof - Google Patents

Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof

Info

Publication number
TW200836749A
TW200836749A TW97100812A TW97100812A TW200836749A TW 200836749 A TW200836749 A TW 200836749A TW 97100812 A TW97100812 A TW 97100812A TW 97100812 A TW97100812 A TW 97100812A TW 200836749 A TW200836749 A TW 200836749A
Authority
TW
Taiwan
Prior art keywords
bortezomib
derivatives
methods
use
compositions including
Prior art date
Application number
TW97100812A
Inventor
Lawrence Akinsanmi
Original Assignee
Vioquest Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US87934407P priority Critical
Application filed by Vioquest Pharmaceuticals Inc filed Critical Vioquest Pharmaceuticals Inc
Publication of TW200836749A publication Critical patent/TW200836749A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds

Abstract

This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.
TW97100812A 2007-01-09 2008-01-09 Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof TW200836749A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US87934407P true 2007-01-09 2007-01-09

Publications (1)

Publication Number Publication Date
TW200836749A true TW200836749A (en) 2008-09-16

Family

ID=39320116

Family Applications (1)

Application Number Title Priority Date Filing Date
TW97100812A TW200836749A (en) 2007-01-09 2008-01-09 Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof

Country Status (2)

Country Link
TW (1) TW200836749A (en)
WO (1) WO2008086005A1 (en)

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US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
CN101484575B (en) 2005-06-08 2013-10-02 森托科尔公司 Cellular therapy for ocular degeneration
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
KR101617243B1 (en) 2007-07-31 2016-05-02 라이프스캔, 인코포레이티드 Differentiation of human embryonic stem cells
BRPI0819609A2 (en) 2007-11-27 2014-10-14 Lifescan Inc Differentiation of human embryonic stem cells
BRPI0908033A2 (en) 2008-02-21 2015-08-04 Centocor Ortho Biotech Inc Surface modified plate method and compositions for cell adhesion, culture and detachment
US20100015711A1 (en) 2008-06-30 2010-01-21 Janet Davis Differentiation of Pluripotent Stem Cells
RU2528861C2 (en) 2008-10-31 2014-09-20 Сентокор Орто Байотек Инк. Differentiation of human embryonic stem cell into pancreatic endocrine cell line
EP2346988B1 (en) 2008-10-31 2017-05-31 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
WO2010059775A1 (en) 2008-11-20 2010-05-27 Centocor Ortho Biotech Inc. Pluripotent stem cell culture on micro-carriers
MX2011005289A (en) 2008-11-20 2011-06-01 Centocor Ortho Biotech Inc Methods and compositions for cell attachment and cultivation on planar substrates.
SG177416A1 (en) 2009-07-20 2012-02-28 Janssen Biotech Inc Differentiation of human embryonic stem cells
CN102482640B (en) 2009-07-20 2015-03-11 詹森生物科技公司 Differentiation Of Human Embryonic Stem Cells
SG177481A1 (en) 2009-07-20 2012-02-28 Janssen Biotech Inc Differentiation of human embryonic stem cells
PL2519231T3 (en) 2009-10-01 2017-09-29 Janssen Pharmaceutica Nv Proteasome inhibitors for treating cancer
BR112012017761A2 (en) 2009-12-23 2015-09-15 Centocor Ortho Biotech Inc differentiation of human embryonic stem cells
CN102712902B (en) 2009-12-23 2019-01-08 詹森生物科技公司 The differentiation of human embryo stem cell
CA2791476A1 (en) 2010-03-01 2011-09-09 Janssen Biotech, Inc. Methods for purifying cells derived from pluripotent stem cells
SG185511A1 (en) 2010-05-12 2012-12-28 Centocor Ortho Biotech Inc Differentiation of human embryonic stem cells
PL2611907T3 (en) 2010-08-31 2016-11-30 Differentiation of pluripotent stem cells
KR101851956B1 (en) 2010-08-31 2018-04-25 얀센 바이오테크 인코포레이티드 Differentiation of human embryonic stem cells
PL2853589T3 (en) 2010-08-31 2018-05-30 Janssen Biotech, Inc Differentiation of human embryonic stem cells
CN105143446A (en) 2011-12-22 2015-12-09 詹森生物科技公司 Differentiation of human embryonic stem cells into single hormonal insulin positive cells
AU2013230020B2 (en) 2012-03-07 2018-08-09 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
CN108103006A (en) 2012-06-08 2018-06-01 詹森生物科技公司 Differentiation of human embryonic stem cells into pancreatic endocrine cells
CA2896750A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
RU2658488C2 (en) 2012-12-31 2018-06-21 Янссен Байотек, Инк. Method for obtaining cells expressing markers characteristic for pancreatic endocrine cells
KR20190009849A (en) 2012-12-31 2019-01-29 얀센 바이오테크 인코포레이티드 Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators
EP3143127A1 (en) 2014-05-16 2017-03-22 Janssen Biotech, Inc. Use of small molecules to enhance mafa expression in pancreatic endocrine cells
CN109563478A (en) 2016-04-14 2019-04-02 詹森生物科技公司 Pluripotent stem cell differentiation is at gut entoderm cell in intestines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2561513C (en) * 2004-03-29 2019-02-26 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds

Also Published As

Publication number Publication date
WO2008086005A1 (en) 2008-07-17

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