RU2018108847A - Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки - Google Patents
Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки Download PDFInfo
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- cells
- differentiation
- pancreatic
- stem cells
- pluripotent stem
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Claims (16)
1. Способ индукции формирования эндокринных кластеров, включающий культивирование панкреатических эндокринных клеток с агонистом рецептора сфингозина-1.
2. Способ по п.1, в котором для обработки панкреатических эндокринных клеток в качестве агониста рецептора сфингозина-1 используют сфингозин-1-фосфат (S1P).
3. Способ по п.1, в котором панкреатические эндокринные клетки получают путем поэтапной дифференцировки плюрипотентных стволовых клеток.
4. Способ по п.3, в котором плюрипотентные стволовые клетки представляют собой плюрипотентные стволовые клетки человека.
5. Способ по п.1, где способ дополнительно содержит:
дифференцировку плюрипотентных стволовых клеток в конечные клетки энтодермы;
дифференцировку конечных клеток энтодермы в клетки первичной кишечной трубки;
дифференцировку клеток первичной кишечной трубки в клетки передней кишки;
дифференцировку клеток передней кишки в клетки-предшественники панкреатических клеток;
дифференцировку клеток-предшественников панкреатических клеток в клетки панкреатической энтодермы; и
дифференцировку клеток панкреатической энтодермы в панкреатические эндокринные клетки.
6. Способ по п.5, где плюрипотентные стволовые клетки представляют собой плюрипотентные стволовые клетки человека.
7. Способ по п.5, где способ дополнительно включает обработку клеток панкреатической энтодермы эфриновым лигандом.
8. Способ по п.7, где эфриновый лиганд представляет собой эфрин А3 или эфрин А4.
9. Способ по п.5, где способ дополнительно включает обработку клеток панкреатической энтодермы активином А или активином С.
10. Способ по п.5, где способ дополнительно включает обработку клеток панкреатической энтодермы семафорином 3А или эпигеном.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201261657160P | 2012-06-08 | 2012-06-08 | |
US61/657,160 | 2012-06-08 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2014153529A Division RU2650813C2 (ru) | 2012-06-08 | 2013-06-06 | Использование лигандов эпинефрина для дифференцирования клеток панкреатической эндодермы |
Publications (2)
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RU2018108847A3 RU2018108847A3 (ru) | 2019-02-26 |
RU2018108847A true RU2018108847A (ru) | 2019-02-26 |
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RU2018108847A RU2018108847A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
RU2018108850A RU2018108850A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
RU2014153529A RU2650813C2 (ru) | 2012-06-08 | 2013-06-06 | Использование лигандов эпинефрина для дифференцирования клеток панкреатической эндодермы |
RU2018108851A RU2018108851A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
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RU2018108850A RU2018108850A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
RU2014153529A RU2650813C2 (ru) | 2012-06-08 | 2013-06-06 | Использование лигандов эпинефрина для дифференцирования клеток панкреатической эндодермы |
RU2018108851A RU2018108851A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
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US (5) | US10066210B2 (ru) |
EP (5) | EP2859091B1 (ru) |
JP (3) | JP6469003B2 (ru) |
KR (4) | KR102468315B1 (ru) |
CN (4) | CN108103005A (ru) |
AR (1) | AR091388A1 (ru) |
AU (4) | AU2013271581B2 (ru) |
BR (1) | BR112014030682A2 (ru) |
CA (2) | CA2875786C (ru) |
DK (1) | DK3450542T3 (ru) |
ES (2) | ES2897649T3 (ru) |
HK (1) | HK1209160A1 (ru) |
IN (1) | IN2014DN10021A (ru) |
MX (1) | MX358590B (ru) |
PH (4) | PH12014502661A1 (ru) |
PL (1) | PL2859091T3 (ru) |
RU (4) | RU2018108847A (ru) |
SG (2) | SG11201408124PA (ru) |
WO (1) | WO2013184888A1 (ru) |
ZA (3) | ZA201802251B (ru) |
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