MX355340B - Diferenciación de células madre embrionarias humanas. - Google Patents

Diferenciación de células madre embrionarias humanas.

Info

Publication number
MX355340B
MX355340B MX2013002405A MX2013002405A MX355340B MX 355340 B MX355340 B MX 355340B MX 2013002405 A MX2013002405 A MX 2013002405A MX 2013002405 A MX2013002405 A MX 2013002405A MX 355340 B MX355340 B MX 355340B
Authority
MX
Mexico
Prior art keywords
differentiation
stem cells
embryonic stem
human embryonic
cells
Prior art date
Application number
MX2013002405A
Other languages
English (en)
Other versions
MX2013002405A (es
Inventor
Benjamin Fryer
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MX2013002405A publication Critical patent/MX2013002405A/es
Publication of MX355340B publication Critical patent/MX355340B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0613—Cells from endocrine organs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/19—Growth and differentiation factors [GDF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a métodos para promover la diferenciación de células madre pluripotentes en células que producen insulina; particularmente, la presente invención proporciona un método para producir una población de células, en donde una cantidad mayor que 80 % de las células en la población expresan marcadores característicos del linaje del endodermo definitivo.
MX2013002405A 2010-08-31 2011-08-17 Diferenciación de células madre embrionarias humanas. MX355340B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37844810P 2010-08-31 2010-08-31
PCT/US2011/048127 WO2012030538A2 (en) 2010-08-31 2011-08-17 Differentiation of human embryonic stem cells

Publications (2)

Publication Number Publication Date
MX2013002405A MX2013002405A (es) 2013-04-05
MX355340B true MX355340B (es) 2018-04-16

Family

ID=45697773

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013002405A MX355340B (es) 2010-08-31 2011-08-17 Diferenciación de células madre embrionarias humanas.

Country Status (15)

Country Link
US (3) US9506036B2 (es)
EP (2) EP3372672A1 (es)
JP (2) JP6168991B2 (es)
KR (1) KR101851956B1 (es)
CN (1) CN103221536B (es)
AR (1) AR082819A1 (es)
AU (1) AU2011296381B2 (es)
BR (1) BR112013004616A2 (es)
CA (1) CA2809300A1 (es)
ES (1) ES2660897T3 (es)
MX (1) MX355340B (es)
PL (1) PL2611909T3 (es)
RU (1) RU2620938C2 (es)
SG (2) SG10201506855RA (es)
WO (1) WO2012030538A2 (es)

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CN103221536B (zh) * 2010-08-31 2016-08-31 詹森生物科技公司 人胚胎干细胞的分化
CN103890167A (zh) 2011-06-21 2014-06-25 诺沃—诺迪斯克有限公司 自多潜能干细胞有效诱导定形内胚层
US20140242038A1 (en) * 2011-10-11 2014-08-28 The Trustees Of Columbia University In The City Of New York Method for generating beta cells
WO2013186946A1 (ja) * 2012-06-11 2013-12-19 国立大学法人北海道大学 多能性幹細胞の選別方法
MX2015017103A (es) 2013-06-11 2016-11-07 Harvard College Celulas beta derivadas de células madre ( sc-beta ) y composiciones y métodos para generarlas.
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
US10190096B2 (en) 2014-12-18 2019-01-29 President And Fellows Of Harvard College Methods for generating stem cell-derived β cells and uses thereof
WO2016100930A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Methods for generating stem cell-derived b cells and methods of use thereof
EP3587560A4 (en) * 2017-01-27 2020-12-16 Kaneka Corporation ENDODERMAL CELL MASS, AND PROCESS FOR PRODUCING ANY CELL MASS AMONG THREE PRIMARY EMBRYONIC SHEET CELL MASSES FROM PLURIPOTENT CELLS
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AU2020283150B2 (en) 2019-05-31 2023-08-17 Viacyte, Inc. Cell encapsulation devices with controlled oxygen diffusion distances
JP2022535239A (ja) 2019-05-31 2022-08-05 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド 生体適合性メンブレン複合体
JP2022534545A (ja) 2019-05-31 2022-08-01 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド 生体適合性メンブレン複合体
WO2022169375A2 (en) * 2021-02-08 2022-08-11 Qatar Foundation For Education, Science And Community Development Generation of induced pluripotent stem cell lines from human patients with mutations in the glucokinase gene

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US20180237752A1 (en) 2018-08-23
RU2620938C2 (ru) 2017-05-30
US9951314B2 (en) 2018-04-24
CN103221536A (zh) 2013-07-24
WO2012030538A3 (en) 2012-06-07
EP2611909B1 (en) 2018-01-17
KR101851956B1 (ko) 2018-04-25
BR112013004616A2 (pt) 2016-07-05
CN103221536B (zh) 2016-08-31
EP2611909A4 (en) 2014-03-05
JP6168991B2 (ja) 2017-07-26
RU2013114373A (ru) 2014-10-10
JP2017038614A (ja) 2017-02-23
CA2809300A1 (en) 2012-03-08
US20120052571A1 (en) 2012-03-01
US9506036B2 (en) 2016-11-29
AU2011296381B2 (en) 2016-03-31
SG187946A1 (en) 2013-03-28
US20170009212A1 (en) 2017-01-12
WO2012030538A2 (en) 2012-03-08
AR082819A1 (es) 2013-01-09
EP2611909A2 (en) 2013-07-10
SG10201506855RA (en) 2015-10-29
ES2660897T3 (es) 2018-03-26
JP2013536685A (ja) 2013-09-26
JP6449829B2 (ja) 2019-01-09
EP3372672A1 (en) 2018-09-12

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