RU2016151645A - Биспецифические гетеродимерные диантитела и их применение - Google Patents
Биспецифические гетеродимерные диантитела и их применение Download PDFInfo
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- RU2016151645A RU2016151645A RU2016151645A RU2016151645A RU2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A
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- sequence
- subdomain
- heterodimeric antibody
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Links
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 28
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 28
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 28
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 27
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 27
- 229920001184 polypeptide Polymers 0.000 claims 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 102000000905 Cadherin Human genes 0.000 claims 13
- 108050007957 Cadherin Proteins 0.000 claims 13
- 108010086890 R-cadherin Proteins 0.000 claims 9
- 102100029758 Cadherin-4 Human genes 0.000 claims 7
- 101100123313 Mus musculus H1.8 gene Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102100039875 Histone H3-7 Human genes 0.000 claims 4
- 102100038736 Histone H3.3C Human genes 0.000 claims 4
- 101001035307 Homo sapiens Histone H3-7 Proteins 0.000 claims 4
- 101001031505 Homo sapiens Histone H3.3C Proteins 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 101000897979 Homo sapiens Putative spermatid-specific linker histone H1-like protein Proteins 0.000 claims 2
- 102100021861 Putative spermatid-specific linker histone H1-like protein Human genes 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 210000003679 cervix uteri Anatomy 0.000 claims 2
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- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000004696 endometrium Anatomy 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
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- 210000003739 neck Anatomy 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
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- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
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- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 210000003932 urinary bladder Anatomy 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 101000714553 Homo sapiens Cadherin-3 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 102000008790 VE-cadherin Human genes 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 108010018828 cadherin 5 Proteins 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
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- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462019762P | 2014-07-01 | 2014-07-01 | |
| US62/019,762 | 2014-07-01 | ||
| US201562148920P | 2015-04-17 | 2015-04-17 | |
| US62/148,920 | 2015-04-17 | ||
| PCT/IB2015/054829 WO2016001810A1 (en) | 2014-07-01 | 2015-06-26 | Bispecific heterodimeric diabodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016151645A true RU2016151645A (ru) | 2018-08-03 |
| RU2016151645A3 RU2016151645A3 (enExample) | 2019-02-20 |
Family
ID=53718063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016151645A RU2016151645A (ru) | 2014-07-01 | 2015-06-26 | Биспецифические гетеродимерные диантитела и их применение |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9884921B2 (enExample) |
| EP (1) | EP3164417A1 (enExample) |
| JP (1) | JP2017520575A (enExample) |
| KR (1) | KR20170010863A (enExample) |
| CN (1) | CN106661119A (enExample) |
| AU (2) | AU2015283704A1 (enExample) |
| BR (1) | BR112016030740A2 (enExample) |
| CA (1) | CA2895659A1 (enExample) |
| CO (1) | CO2017000016A2 (enExample) |
| IL (1) | IL249889A0 (enExample) |
| MX (1) | MX2016017393A (enExample) |
| PE (1) | PE20170286A1 (enExample) |
| PH (1) | PH12016502491A1 (enExample) |
| RU (1) | RU2016151645A (enExample) |
| SG (1) | SG11201609707WA (enExample) |
| TW (2) | TWI659042B (enExample) |
| WO (1) | WO2016001810A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
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| SG10201913937QA (en) | 2014-12-05 | 2020-03-30 | Memorial Sloan Kettering Cancer Center | Antibodies targeting g-protein coupled receptor and methods of use |
| RS62870B1 (sr) | 2014-12-05 | 2022-02-28 | Memorial Sloan Kettering Cancer Center | Himerni antigenski receptori sa ciljanim delovanjem na receptore spregnute sa g-proteinom i njihove upotrebe |
| AU2016250023B2 (en) | 2015-04-17 | 2022-02-24 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs for CDH3 and CD3 |
| EP3322735A4 (en) | 2015-07-15 | 2019-03-13 | Zymeworks Inc. | ACTIVE CONJUGATED BIS-SPECIFIC ANTIGEN-BONDING CONSTRUCTS |
| JP6954842B2 (ja) | 2015-12-25 | 2021-10-27 | 中外製薬株式会社 | 増強された活性を有する抗体及びその改変方法 |
| JP7320943B2 (ja) | 2016-04-28 | 2023-08-04 | 中外製薬株式会社 | 抗体含有製剤 |
| CN117986372A (zh) * | 2016-07-29 | 2024-05-07 | 中外制药株式会社 | 显示增加的备选fviii辅因子功能活性的双特异性抗体 |
| CN106496331B (zh) * | 2016-11-08 | 2020-03-13 | 北京智岭生物医药科技有限公司 | 一种FSH-Fc融合蛋白及其制备方法和用途 |
| CN110944651A (zh) | 2017-02-08 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 用于自然杀伤细胞激活的多特异性结合蛋白及其治疗癌症的治疗性用途 |
| JP7205995B2 (ja) * | 2017-03-29 | 2023-01-17 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 共刺激性ｔｎｆ受容体に対する二重特異性抗原結合分子 |
| TWI710637B (zh) * | 2017-03-29 | 2020-11-21 | 臺北醫學大學 | 具抗原專一性的t細胞及其用途 |
| CN110573528B (zh) * | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 针对共刺激性tnf受体的双特异性抗原结合分子 |
| CN108866635B (zh) * | 2017-05-09 | 2021-11-26 | 安升（上海）医药科技有限公司 | 多特异性蛋白药物及其文库、以及制备方法和应用 |
| JP7018458B2 (ja) * | 2017-06-02 | 2022-02-10 | ファイザー・インク | 組換えｒｏｂｏ２タンパク質、組成物、方法およびそれらの使用 |
| WO2018237341A1 (en) * | 2017-06-22 | 2018-12-27 | Development Center For Biotechnology | A TARGET CELL-DEPENDENT T CELL ENGAGING AND ACTIVATION ASYMMETRIC HETERODIMERIC Fc-ScFv FUSION ANTIBODY FORMAT FOR CANCER THERAPY |
| UA128389C2 (uk) | 2017-09-29 | 2024-07-03 | Чугаі Сейяку Кабусікі Кайся | Мультиспецифічна антигензв'язувальна молекула, яка має активність заміщувати кофакторну функцію фактора коагуляції крові viii (fviii), та фармацевтичний склад, який містить згадану молекулу як активний інгредієнт |
| KR101973060B1 (ko) | 2017-10-20 | 2019-04-26 | 주식회사 녹십자 | 항-cd3 항체 및 이를 포함하는 암 치료용 약학적 조성물 |
| CN109706163A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人与动物靶细胞与效应细胞的桥接分子及其应用 |
| CN109706164A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人和猴cd20与效应细胞抗原的桥接分子及其应用 |
| AU2018361430B2 (en) | 2017-11-01 | 2025-08-14 | Chugai Seiyaku Kabushiki Kaisha | Antibody variant and isoform with lowered biological activity |
| SG11202007482WA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Antibody variable domains targeting the nkg2d receptor |
| CA3090236A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| KR102832460B1 (ko) | 2018-02-20 | 2025-07-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Cd33, nkg2d, 및 cd16에 결합하는 다중-특이적 결합 단백질, 및 이의 사용 방법 |
| KR20200128116A (ko) | 2018-02-28 | 2020-11-11 | 화이자 인코포레이티드 | Il-15 변이체 및 이의 용도 |
| US20210238290A1 (en) * | 2018-05-07 | 2021-08-05 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and p-cadherin |
| KR20230146098A (ko) * | 2018-05-23 | 2023-10-18 | 화이자 인코포레이티드 | GUCY2c에 특이적인 항체 및 이의 용도 |
| DK3797121T3 (da) | 2018-05-23 | 2024-07-08 | Pfizer | Antistoffer, der er specifikke for CD3, og anvendelser deraf |
| MA53293A (fr) | 2018-08-08 | 2021-11-17 | Dragonfly Therapeutics Inc | Protéines de liaison multi-spécifiques se liant à bcma, nkg2d et cd16, et méthodes d'utilisation |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| MX2021001527A (es) | 2018-08-08 | 2021-06-15 | Dragonfly Therapeutics Inc | Proteínas de unión a nkg2d, cd16 y a un antígeno asociado a tumor. |
| CN113260379B (zh) * | 2018-12-21 | 2022-09-02 | 浙江时迈药业有限公司 | 蛋白酶可切割的双特异性抗体及其用途 |
| WO2020128893A1 (en) | 2018-12-21 | 2020-06-25 | Pfizer Inc. | Combination treatments of cancer comprising a tlr agonist |
| CN110357969B (zh) * | 2019-05-27 | 2022-03-08 | 北京志道生物科技有限公司 | 一种GLP1-EGFa异源二聚体蛋白、功能及方法 |
| US11339159B2 (en) | 2019-07-17 | 2022-05-24 | Pfizer Inc. | Toll-like receptor agonists |
| CN113416258B (zh) * | 2019-10-24 | 2023-08-29 | 北京免疫方舟医药科技有限公司 | 一种多特异性抗体及其制备方法和用途 |
| PE20230160A1 (es) | 2019-12-17 | 2023-02-01 | Pfizer | Anticuerpos especificos para cd47, pd-l1 y sus usos |
| CA3164804A1 (en) | 2019-12-18 | 2021-06-24 | Pfizer Inc. | Once daily cancer treatment regimen with a prmt5 inhibitor |
| CA3174908A1 (en) | 2020-03-09 | 2021-09-16 | Pfizer Inc. | Fusion proteins and uses thereof |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| MX2022014180A (es) | 2020-05-13 | 2022-12-02 | Pfizer | Metodos, terapias y usos para tratar cancer. |
| JP2023533793A (ja) | 2020-07-17 | 2023-08-04 | ファイザー・インク | 治療用抗体およびそれらの使用 |
| JP2023540795A (ja) | 2020-09-14 | 2023-09-26 | ファイザー・インク | がんを処置するための方法、治療、および使用 |
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-
2015
- 2015-06-26 US US14/751,704 patent/US9884921B2/en not_active Expired - Fee Related
- 2015-06-26 CA CA2895659A patent/CA2895659A1/en not_active Abandoned
- 2015-06-26 KR KR1020167036814A patent/KR20170010863A/ko not_active Ceased
- 2015-06-26 PE PE2016002813A patent/PE20170286A1/es unknown
- 2015-06-26 RU RU2016151645A patent/RU2016151645A/ru not_active Application Discontinuation
- 2015-06-26 EP EP15741347.7A patent/EP3164417A1/en not_active Withdrawn
- 2015-06-26 AU AU2015283704A patent/AU2015283704A1/en not_active Abandoned
- 2015-06-26 BR BR112016030740-2A patent/BR112016030740A2/pt not_active Application Discontinuation
- 2015-06-26 JP JP2016575335A patent/JP2017520575A/ja active Pending
- 2015-06-26 SG SG11201609707WA patent/SG11201609707WA/en unknown
- 2015-06-26 MX MX2016017393A patent/MX2016017393A/es unknown
- 2015-06-26 WO PCT/IB2015/054829 patent/WO2016001810A1/en not_active Ceased
- 2015-06-26 CN CN201580035515.8A patent/CN106661119A/zh active Pending
- 2015-06-29 TW TW104120955A patent/TWI659042B/zh not_active IP Right Cessation
- 2015-06-29 TW TW107142295A patent/TW201936638A/zh unknown
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2016
- 2016-12-13 PH PH12016502491A patent/PH12016502491A1/en unknown
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2017
- 2017-01-01 IL IL249889A patent/IL249889A0/en unknown
- 2017-01-03 CO CONC2017/0000016A patent/CO2017000016A2/es unknown
- 2017-12-13 US US15/840,019 patent/US20180155452A1/en not_active Abandoned
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2018
- 2018-12-05 AU AU2018274919A patent/AU2018274919A1/en not_active Abandoned
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| US9884921B2 (en) | 2018-02-06 |
| SG11201609707WA (en) | 2017-01-27 |
| WO2016001810A1 (en) | 2016-01-07 |
| TW201612194A (en) | 2016-04-01 |
| PH12016502491A1 (en) | 2017-03-22 |
| CO2017000016A2 (es) | 2017-05-19 |
| US20160002357A1 (en) | 2016-01-07 |
| US20180155452A1 (en) | 2018-06-07 |
| JP2017520575A (ja) | 2017-07-27 |
| TWI659042B (zh) | 2019-05-11 |
| AU2018274919A1 (en) | 2019-01-03 |
| AU2015283704A1 (en) | 2016-12-15 |
| CA2895659A1 (en) | 2016-01-01 |
| IL249889A0 (en) | 2017-03-30 |
| TW201936638A (zh) | 2019-09-16 |
| MX2016017393A (es) | 2017-09-05 |
| BR112016030740A2 (pt) | 2018-02-20 |
| EP3164417A1 (en) | 2017-05-10 |
| RU2016151645A3 (enExample) | 2019-02-20 |
| PE20170286A1 (es) | 2017-03-30 |
| CN106661119A (zh) | 2017-05-10 |
| KR20170010863A (ko) | 2017-02-01 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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