RU2016151645A - Биспецифические гетеродимерные диантитела и их применение - Google Patents
Биспецифические гетеродимерные диантитела и их применение Download PDFInfo
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- RU2016151645A RU2016151645A RU2016151645A RU2016151645A RU2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A
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- cad
- sequence
- subdomain
- heterodimeric antibody
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Links
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 28
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 28
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 28
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 27
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 27
- 229920001184 polypeptide Polymers 0.000 claims 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 102000000905 Cadherin Human genes 0.000 claims 13
- 108050007957 Cadherin Proteins 0.000 claims 13
- 108010086890 R-cadherin Proteins 0.000 claims 9
- 102100029758 Cadherin-4 Human genes 0.000 claims 7
- 101100123313 Mus musculus H1.8 gene Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102100039875 Histone H3-7 Human genes 0.000 claims 4
- 102100038736 Histone H3.3C Human genes 0.000 claims 4
- 101001035307 Homo sapiens Histone H3-7 Proteins 0.000 claims 4
- 101001031505 Homo sapiens Histone H3.3C Proteins 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 101000897979 Homo sapiens Putative spermatid-specific linker histone H1-like protein Proteins 0.000 claims 2
- 102100021861 Putative spermatid-specific linker histone H1-like protein Human genes 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 210000003679 cervix uteri Anatomy 0.000 claims 2
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- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
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- 210000004696 endometrium Anatomy 0.000 claims 2
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- 102000039446 nucleic acids Human genes 0.000 claims 2
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- 210000001672 ovary Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
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- 210000002307 prostate Anatomy 0.000 claims 2
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- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 210000003932 urinary bladder Anatomy 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 101000714553 Homo sapiens Cadherin-3 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 102000008790 VE-cadherin Human genes 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 108010018828 cadherin 5 Proteins 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
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- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462019762P | 2014-07-01 | 2014-07-01 | |
| US62/019,762 | 2014-07-01 | ||
| US201562148920P | 2015-04-17 | 2015-04-17 | |
| US62/148,920 | 2015-04-17 | ||
| PCT/IB2015/054829 WO2016001810A1 (en) | 2014-07-01 | 2015-06-26 | Bispecific heterodimeric diabodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016151645A true RU2016151645A (ru) | 2018-08-03 |
| RU2016151645A3 RU2016151645A3 (enExample) | 2019-02-20 |
Family
ID=53718063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016151645A RU2016151645A (ru) | 2014-07-01 | 2015-06-26 | Биспецифические гетеродимерные диантитела и их применение |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9884921B2 (enExample) |
| EP (1) | EP3164417A1 (enExample) |
| JP (1) | JP2017520575A (enExample) |
| KR (1) | KR20170010863A (enExample) |
| CN (1) | CN106661119A (enExample) |
| AU (2) | AU2015283704A1 (enExample) |
| BR (1) | BR112016030740A2 (enExample) |
| CA (1) | CA2895659A1 (enExample) |
| CO (1) | CO2017000016A2 (enExample) |
| IL (1) | IL249889A0 (enExample) |
| MX (1) | MX2016017393A (enExample) |
| PE (1) | PE20170286A1 (enExample) |
| PH (1) | PH12016502491A1 (enExample) |
| RU (1) | RU2016151645A (enExample) |
| SG (1) | SG11201609707WA (enExample) |
| TW (2) | TWI659042B (enExample) |
| WO (1) | WO2016001810A1 (enExample) |
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| CN113429484A (zh) | 2014-12-05 | 2021-09-24 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的抗体和使用方法 |
| WO2016090312A1 (en) | 2014-12-05 | 2016-06-09 | Memorial Sloan-Kettering Cancer Center | Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof |
| CA2982682A1 (en) | 2015-04-17 | 2016-10-20 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs for cdh3 and cd3 |
| CA2991799A1 (en) * | 2015-07-15 | 2017-01-19 | Zymeworks Inc. | Drug-conjugated bi-specific antigen-binding constructs |
| US20200270363A1 (en) | 2015-12-25 | 2020-08-27 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
| MA44780A (fr) | 2016-04-28 | 2019-03-06 | Chugai Pharmaceutical Co Ltd | Préparation contenant un anticorps |
| EP3492496A4 (en) * | 2016-07-29 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | BISPECIFIC ANTIBODIES PRESENTING AN INCREASED ALTERNATIVE FUNCTIONAL ACTIVITY OF COFACTOR FVIII |
| CN106496331B (zh) * | 2016-11-08 | 2020-03-13 | 北京智岭生物医药科技有限公司 | 一种FSH-Fc融合蛋白及其制备方法和用途 |
| US11834506B2 (en) | 2017-02-08 | 2023-12-05 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind NKG2D, CD16, and a tumor-associated antigen for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| JP7205995B2 (ja) * | 2017-03-29 | 2023-01-17 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 共刺激性ｔｎｆ受容体に対する二重特異性抗原結合分子 |
| CN110573528B (zh) * | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 针对共刺激性tnf受体的双特异性抗原结合分子 |
| TWI676681B (zh) * | 2017-03-29 | 2019-11-11 | 臺北醫學大學 | 具抗原專一性的t細胞及其用途 |
| CN108866635B (zh) * | 2017-05-09 | 2021-11-26 | 安升（上海）医药科技有限公司 | 多特异性蛋白药物及其文库、以及制备方法和应用 |
| BR112019024742A2 (pt) | 2017-06-02 | 2020-06-16 | Pfizer Inc. | Proteínas robo2 recombinantes, composições, métodos e usos das mesmas |
| JP2020525431A (ja) * | 2017-06-22 | 2020-08-27 | ディベロップメント センター フォー バイオテクノロジーＤｅｖｅｌｏｐｍｅｎｔ Ｃｅｎｔｅｒ Ｆｏｒ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ | がん療法のための標的細胞依存性Ｔ細胞エンゲージメントおよび活性化非対称ヘテロ二量体Ｆｃ−ＳｃＦｖ融合抗体フォーマットおよびその使用 |
| MX2020002710A (es) | 2017-09-29 | 2020-07-20 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno multiespecifica que tiene actividad de sustitucion de la funcion de cofactor del factor viii de coagulacion de sangre (fviii) y formulacion farmaceutica que contiene tal molecula como ingrediente activo. |
| KR101973060B1 (ko) | 2017-10-20 | 2019-04-26 | 주식회사 녹십자 | 항-cd3 항체 및 이를 포함하는 암 치료용 약학적 조성물 |
| CN109706164A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人和猴cd20与效应细胞抗原的桥接分子及其应用 |
| CN109706163A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人与动物靶细胞与效应细胞的桥接分子及其应用 |
| IL274265B1 (en) | 2017-11-01 | 2025-09-01 | Chugai Pharmaceutical Co Ltd | Variant and isoform of an antibody with attenuated biological activity |
| MX2020008333A (es) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales. |
| ES2986967T3 (es) | 2018-02-08 | 2024-11-13 | Dragonfly Therapeutics Inc | Combinaciones de dominios variables de anticuerpos dirigidas al receptor NKG2D |
| BR112020016939A2 (pt) | 2018-02-20 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Proteínas de ligação multiespecíficas que se ligam a cd33, nkg2d, e cd16 e métodos de uso |
| EP3759129A1 (en) | 2018-02-28 | 2021-01-06 | Pfizer Inc | Il-15 variants and uses thereof |
| KR20210018275A (ko) * | 2018-05-07 | 2021-02-17 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양-연관 항원에 결합하는 단백질 |
| MX2020012607A (es) | 2018-05-23 | 2021-01-29 | Pfizer | Anticuerpos especificos para gucy2c y sus usos. |
| FI3797121T3 (fi) | 2018-05-23 | 2024-08-22 | Pfizer | Cd3:lle spesifisiä vasta-aineita ja niiden käyttöjä |
| KR102835308B1 (ko) | 2018-08-08 | 2025-07-21 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| SG11202100883SA (en) | 2018-08-08 | 2021-02-25 | Dragonfly Therapeutics Inc | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| CN113260379B (zh) * | 2018-12-21 | 2022-09-02 | 浙江时迈药业有限公司 | 蛋白酶可切割的双特异性抗体及其用途 |
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| CN110357969B (zh) * | 2019-05-27 | 2022-03-08 | 北京志道生物科技有限公司 | 一种GLP1-EGFa异源二聚体蛋白、功能及方法 |
| US11339159B2 (en) | 2019-07-17 | 2022-05-24 | Pfizer Inc. | Toll-like receptor agonists |
| CN113416258B (zh) * | 2019-10-24 | 2023-08-29 | 北京免疫方舟医药科技有限公司 | 一种多特异性抗体及其制备方法和用途 |
| US11702474B2 (en) | 2019-12-17 | 2023-07-18 | Pfizer Inc. | Antibodies specific for CD47, PD-L1, and uses thereof |
| TW202128176A (zh) | 2019-12-18 | 2021-08-01 | 美商輝瑞股份有限公司 | 使用蛋白精胺酸甲基轉移酶５（ｐｒｍｔ５）抑制劑之每日一次癌症治療方案 |
| US20240209061A1 (en) | 2020-03-09 | 2024-06-27 | Pfizer Inc. | Fusion proteins and uses thereof |
| AU2021268340A1 (en) | 2020-05-06 | 2022-12-08 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and CLEC12A |
| JP2023524854A (ja) | 2020-05-13 | 2023-06-13 | ファイザー・インク | がんを処置するための方法、治療、および使用 |
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-
2015
- 2015-06-26 CN CN201580035515.8A patent/CN106661119A/zh active Pending
- 2015-06-26 KR KR1020167036814A patent/KR20170010863A/ko not_active Ceased
- 2015-06-26 PE PE2016002813A patent/PE20170286A1/es unknown
- 2015-06-26 US US14/751,704 patent/US9884921B2/en not_active Expired - Fee Related
- 2015-06-26 WO PCT/IB2015/054829 patent/WO2016001810A1/en not_active Ceased
- 2015-06-26 MX MX2016017393A patent/MX2016017393A/es unknown
- 2015-06-26 SG SG11201609707WA patent/SG11201609707WA/en unknown
- 2015-06-26 JP JP2016575335A patent/JP2017520575A/ja active Pending
- 2015-06-26 AU AU2015283704A patent/AU2015283704A1/en not_active Abandoned
- 2015-06-26 CA CA2895659A patent/CA2895659A1/en not_active Abandoned
- 2015-06-26 RU RU2016151645A patent/RU2016151645A/ru not_active Application Discontinuation
- 2015-06-26 EP EP15741347.7A patent/EP3164417A1/en not_active Withdrawn
- 2015-06-26 BR BR112016030740-2A patent/BR112016030740A2/pt not_active Application Discontinuation
- 2015-06-29 TW TW104120955A patent/TWI659042B/zh not_active IP Right Cessation
- 2015-06-29 TW TW107142295A patent/TW201936638A/zh unknown
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2016
- 2016-12-13 PH PH12016502491A patent/PH12016502491A1/en unknown
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- 2017-01-03 CO CONC2017/0000016A patent/CO2017000016A2/es unknown
- 2017-12-13 US US15/840,019 patent/US20180155452A1/en not_active Abandoned
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2018
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| MX2016017393A (es) | 2017-09-05 |
| CN106661119A (zh) | 2017-05-10 |
| AU2018274919A1 (en) | 2019-01-03 |
| US20180155452A1 (en) | 2018-06-07 |
| US20160002357A1 (en) | 2016-01-07 |
| BR112016030740A2 (pt) | 2018-02-20 |
| PE20170286A1 (es) | 2017-03-30 |
| WO2016001810A1 (en) | 2016-01-07 |
| KR20170010863A (ko) | 2017-02-01 |
| EP3164417A1 (en) | 2017-05-10 |
| SG11201609707WA (en) | 2017-01-27 |
| US9884921B2 (en) | 2018-02-06 |
| RU2016151645A3 (enExample) | 2019-02-20 |
| JP2017520575A (ja) | 2017-07-27 |
| TW201612194A (en) | 2016-04-01 |
| TW201936638A (zh) | 2019-09-16 |
| IL249889A0 (en) | 2017-03-30 |
| TWI659042B (zh) | 2019-05-11 |
| AU2015283704A1 (en) | 2016-12-15 |
| CA2895659A1 (en) | 2016-01-01 |
| PH12016502491A1 (en) | 2017-03-22 |
| CO2017000016A2 (es) | 2017-05-19 |
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