JP2017527274A5 - - Google Patents
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- Publication number
- JP2017527274A5 JP2017527274A5 JP2017504103A JP2017504103A JP2017527274A5 JP 2017527274 A5 JP2017527274 A5 JP 2017527274A5 JP 2017504103 A JP2017504103 A JP 2017504103A JP 2017504103 A JP2017504103 A JP 2017504103A JP 2017527274 A5 JP2017527274 A5 JP 2017527274A5
- Authority
- JP
- Japan
- Prior art keywords
- binding molecule
- seq
- sequence
- bispecific binding
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029342P | 2014-07-25 | 2014-07-25 | |
| US62/029,342 | 2014-07-25 | ||
| PCT/US2015/041989 WO2016014942A1 (en) | 2014-07-25 | 2015-07-24 | Bispecific her2 and cd3 binding molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527274A JP2017527274A (ja) | 2017-09-21 |
| JP2017527274A5 true JP2017527274A5 (enExample) | 2018-10-18 |
| JP6871155B2 JP6871155B2 (ja) | 2021-05-12 |
Family
ID=53836217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504103A Active JP6871155B2 (ja) | 2014-07-25 | 2015-07-24 | 二重特異性ｈｅｒ２及びｃｄ３結合分子 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10519248B2 (enExample) |
| EP (1) | EP3172236B1 (enExample) |
| JP (1) | JP6871155B2 (enExample) |
| KR (1) | KR102638104B1 (enExample) |
| CN (1) | CN107124884B (enExample) |
| AU (1) | AU2015292374B2 (enExample) |
| BR (1) | BR112017001513A2 (enExample) |
| CA (1) | CA2956014C (enExample) |
| ES (1) | ES2832704T3 (enExample) |
| IL (1) | IL250249B (enExample) |
| MX (1) | MX386342B (enExample) |
| RU (1) | RU2017105849A (enExample) |
| SG (1) | SG11201700506TA (enExample) |
| WO (1) | WO2016014942A1 (enExample) |
| ZA (1) | ZA201701341B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102225489B1 (ko) | 2013-12-17 | 2021-03-10 | 제넨테크, 인크. | 항-cd3 항체 및 이의 사용 방법 |
| JP6871155B2 (ja) | 2014-07-25 | 2021-05-12 | メモリアル スローン ケタリング キャンサー センター | 二重特異性ｈｅｒ２及びｃｄ３結合分子 |
| US11820832B2 (en) | 2014-07-25 | 2023-11-21 | Memorial Sloan Kettering Cancer Center | Bispecific HER2 and CD3 binding molecules |
| EP3916018A1 (en) | 2015-06-16 | 2021-12-01 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| US11466094B2 (en) | 2016-11-15 | 2022-10-11 | Genentech, Inc. | Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies |
| US11046768B2 (en) | 2017-01-27 | 2021-06-29 | Memorial Sloan Kettering Cancer Center | Bispecific HER2 and CD3 binding molecules |
| CA3051484A1 (en) * | 2017-01-27 | 2018-08-02 | Memorial Sloan Kettering Cancer Center | Bispecific her2 and cd3 binding molecules |
| BR112019021182A2 (pt) | 2017-04-24 | 2020-06-02 | Memorial Sloan Kettering Cancer Center | Agentes de anticorpo anti-cd33 |
| CN107854490A (zh) * | 2017-09-26 | 2018-03-30 | 首都医科大学附属北京世纪坛医院 | 一种经修饰的t细胞及其应用 |
| CN118772287A (zh) | 2018-02-08 | 2024-10-15 | 豪夫迈·罗氏有限公司 | 双特异性抗原结合分子和使用方法 |
| US20210017295A1 (en) * | 2018-03-12 | 2021-01-21 | Memorial Sloan Kettering Cancer Center | Bispecific binding agents and uses thereof |
| KR20200135935A (ko) * | 2018-03-27 | 2020-12-04 | 시스트이뮨, 인코포레이티드 | 유도 및 네비게이션 제어 단백질 및 이의 제조 및 사용 방법 |
| CN110357960A (zh) * | 2018-04-10 | 2019-10-22 | 广州爱思迈生物医药科技有限公司 | 抗体及抗体改造方法 |
| WO2019197600A1 (en) * | 2018-04-13 | 2019-10-17 | F. Hoffmann-La Roche Ag | Her2-targeting antigen binding molecules comprising 4-1bbl |
| KR20210009421A (ko) * | 2018-06-14 | 2021-01-26 | 바이오아트라, 엘엘씨 | 다중 특이적 항체 구조체 |
| BR112021008486A2 (pt) * | 2018-11-01 | 2021-10-26 | Shandong New Time Pharmaceutical Co., Ltd | Anticorpo biespecífico e seu uso |
| CN111196856A (zh) * | 2018-11-19 | 2020-05-26 | 三生国健药业（上海）股份有限公司 | 抗her2/pd1双特异性抗体 |
| CA3121168A1 (en) * | 2018-11-30 | 2020-06-04 | Memorial Sloan Kettering Cancer Center | Heterodimeric tetravalency and specificity antibody compositions and uses thereof |
| EP3894601A4 (en) * | 2018-12-11 | 2023-01-11 | The Translational Genomics Research Institute | IDENTIFICATION OF HER2 MUTATIONS IN LUNG CANCER AND METHODS OF TREATMENT |
| CN114502584B (zh) * | 2019-02-22 | 2025-01-10 | 纪念斯隆凯特琳癌症中心 | Cd33抗体和使用所述抗体治疗癌症的方法 |
| AU2020270888A1 (en) * | 2019-04-08 | 2021-11-04 | Memorial Sloan Kettering Cancer Center | CD19 antibodies and methods of using the same |
| IL288024B2 (en) | 2019-05-14 | 2025-12-01 | Provention Bio Inc | Methods and compositions for preventing type |
| CA3139111A1 (en) * | 2019-05-23 | 2020-11-26 | VelosBio Inc. | Anti-ror1/anti-cd3 bispecific binding molecules |
| WO2020264211A1 (en) * | 2019-06-26 | 2020-12-30 | Memorial Sloan Kettering Cancer Center | Anti-cd33 antibodies for treating cancer |
| PE20221511A1 (es) | 2019-12-13 | 2022-10-04 | Genentech Inc | Anticuerpos anti-ly6g6d y metodos de uso |
| IL296566A (en) * | 2020-03-23 | 2022-11-01 | Cytoarm Co Ltd | Bi-specific antibodies for use in producing armed immune cells |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| US20230270857A1 (en) * | 2020-07-28 | 2023-08-31 | Memorial Sloan Kettering Cancer Center | Compositions including ex vivo armed t cells with multi-specific antibodies and uses thereof |
| US20230374150A1 (en) * | 2020-10-12 | 2023-11-23 | Memorial Sloan Kettering Cancer Center | Anti-psma antibodies and uses thereof |
| CA3196539A1 (en) | 2020-11-04 | 2022-05-12 | Chi-Chung Li | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| IL302400A (en) | 2020-11-04 | 2023-06-01 | Genentech Inc | Subcutaneous dosing of bispecific anti-CD20/anti-CD3 antibodies |
| CA3196191A1 (en) | 2020-11-04 | 2022-05-12 | Chi-Chung Li | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| TW202237827A (zh) | 2020-12-03 | 2022-10-01 | 美商世紀治療股份有限公司 | 經基因工程改造之細胞及其用途 |
| CN116635064A (zh) | 2020-12-18 | 2023-08-22 | 世纪治疗股份有限公司 | 具有适应性受体特异性的嵌合抗原受体系统 |
| WO2022241235A1 (en) | 2021-05-14 | 2022-11-17 | Genentech, Inc. | Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin |
| MX2023013851A (es) | 2021-05-24 | 2023-12-08 | Provention Bio Inc | Metodos para el tratamiento de diabetes tipo 1. |
| CN117980888A (zh) * | 2021-08-04 | 2024-05-03 | 阿布普罗公司 | 抗her2抗体及其用途 |
| US20240415888A1 (en) * | 2021-10-20 | 2024-12-19 | Memorial Sloan Kettering Cancer Center | Anti-tshr multi-specific antibodies and uses thereof |
| KR102857671B1 (ko) | 2021-12-29 | 2025-09-10 | 건국대학교 글로컬산학협력단 | 개과 동물의 her2 및 cd3에 특이적으로 결합하는 이중특이적 항체 및 이의 용도 |
| KR102803655B1 (ko) | 2021-12-29 | 2025-05-08 | 건국대학교 글로컬산학협력단 | 개과 동물의 her1 및 cd3에 특이적으로 결합하는 이중특이적 항체 및 이의 용도 |
| WO2023201291A1 (en) | 2022-04-13 | 2023-10-19 | Genentech, Inc. | Pharmaceutical compositions of mosunetuzumab and methods of use |
| AU2024214000A1 (en) * | 2023-02-04 | 2025-08-21 | Imagion Biosystems, Inc. | Method to assess nodal disease using iron oxide nanoparticles in magnetic resonance imaging |
| WO2025076473A1 (en) * | 2023-10-06 | 2025-04-10 | Fred Hutchinson Cancer Center | Proteins bispecific to cd3 and nkg2dl and associated uses thereof |
| WO2025085781A1 (en) | 2023-10-19 | 2025-04-24 | Genentech, Inc. | Combinations of il15/il15r alpha heterodimeric fc-fusion proteins and her2xcd3 bispecific antibodies for the treatment of her2-positive cancers |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5885573A (en) * | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| CA2569509C (en) | 2004-06-03 | 2014-08-12 | Novimmune S.A. | Anti-cd3 antibodies and methods of use thereof |
| WO2008119567A2 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific cd3-epsilon binding domain |
| ES2589769T3 (es) | 2009-02-27 | 2016-11-16 | Massachusetts Institute Of Technology | Proteínas modificadas con alta afinidad por quelatos de DOTA |
| CA3051311A1 (en) * | 2010-05-27 | 2011-12-01 | Genmab A/S | Monoclonal antibodies against her2 |
| KR101834026B1 (ko) * | 2010-06-19 | 2018-03-02 | 메모리얼 슬로안-케터링 캔서 센터 | 항-ｇｄ2 항체 |
| AU2012245116A1 (en) | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
| SMT201900500T1 (it) * | 2011-05-08 | 2019-11-13 | Legochem Biosciences Inc | Coniugati di agente protettivo-proteina e metodo per preparare i medesimi |
| ES2758884T3 (es) * | 2011-06-24 | 2020-05-06 | Stephen D Gillies | Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas |
| IN2014CN04039A (enExample) * | 2011-11-02 | 2015-10-23 | Ajinomoto Kk | |
| WO2013188693A1 (en) * | 2012-06-15 | 2013-12-19 | Imaginab, Inc. | Antigen binding constructs to cd3 |
| CN112079929A (zh) * | 2012-11-21 | 2020-12-15 | 武汉友芝友生物制药有限公司 | 双特异性抗体 |
| DK3406633T3 (da) * | 2013-07-25 | 2022-03-28 | Cytomx Therapeutics Inc | Multispecifikke antistoffer, multispecifikke aktiverbare antistoffer og fremgangsmåder til anvendelse heraf |
| NZ760065A (en) | 2013-12-17 | 2022-12-23 | Genentech Inc | Methods of treating cancers using pd-1 axis binding antagonists and taxanes |
| JP6871155B2 (ja) | 2014-07-25 | 2021-05-12 | メモリアル スローン ケタリング キャンサー センター | 二重特異性ｈｅｒ２及びｃｄ３結合分子 |
| WO2016130539A2 (en) | 2015-02-09 | 2016-08-18 | Memorial Sloan Kettering Cancer Center | Multi-specific antibodies with affinity for human a33 antigen and dota metal complex and uses thereof |
| US11046768B2 (en) | 2017-01-27 | 2021-06-29 | Memorial Sloan Kettering Cancer Center | Bispecific HER2 and CD3 binding molecules |
| CA3051484A1 (en) | 2017-01-27 | 2018-08-02 | Memorial Sloan Kettering Cancer Center | Bispecific her2 and cd3 binding molecules |
-
2015
- 2015-07-24 JP JP2017504103A patent/JP6871155B2/ja active Active
- 2015-07-24 WO PCT/US2015/041989 patent/WO2016014942A1/en not_active Ceased
- 2015-07-24 AU AU2015292374A patent/AU2015292374B2/en active Active
- 2015-07-24 CN CN201580051950.XA patent/CN107124884B/zh active Active
- 2015-07-24 KR KR1020177004024A patent/KR102638104B1/ko active Active
- 2015-07-24 RU RU2017105849A patent/RU2017105849A/ru not_active Application Discontinuation
- 2015-07-24 BR BR112017001513-7A patent/BR112017001513A2/pt not_active Application Discontinuation
- 2015-07-24 ES ES15750184T patent/ES2832704T3/es active Active
- 2015-07-24 CA CA2956014A patent/CA2956014C/en active Active
- 2015-07-24 SG SG11201700506TA patent/SG11201700506TA/en unknown
- 2015-07-24 MX MX2017001031A patent/MX386342B/es unknown
- 2015-07-24 EP EP15750184.2A patent/EP3172236B1/en active Active
- 2015-07-24 US US15/328,288 patent/US10519248B2/en active Active
-
2017
- 2017-01-23 IL IL250249A patent/IL250249B/en active IP Right Grant
- 2017-02-22 ZA ZA2017/01341A patent/ZA201701341B/en unknown
-
2019
- 2019-12-13 US US16/714,636 patent/US11987642B2/en active Active
-
2025
- 2025-02-10 US US19/049,937 patent/US20260071005A1/en active Pending
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