RU2016137744A - Составы полимеров для носослёзной стимуляции - Google Patents
Составы полимеров для носослёзной стимуляции Download PDFInfo
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0546—Nasal electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
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- A—HUMAN NECESSITIES
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07C233/00—Carboxylic acid amides
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/20—Esters of polyhydric alcohols or phenols, e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
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- C—CHEMISTRY; METALLURGY
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- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B1/00—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors
- H01B1/06—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances
- H01B1/12—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances organic substances
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B1/00—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors
- H01B1/06—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances
- H01B1/12—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances organic substances
- H01B1/124—Intrinsically conductive polymers
- H01B1/125—Intrinsically conductive polymers comprising aliphatic main chains, e.g. polyactylenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0492—Patch electrodes
- A61N1/0496—Patch electrodes characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49885—Assembling or joining with coating before or during assembling
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Claims (40)
1. Электропроводящий гидрогель, содержащий:
первый мономер;
второй мономер; и
фотосенсибилизатор,
при этом первый мономер является акрилатным мономером, а электропроводящий гидрогель имеет одно или более свойств, адаптирующих его к применению вместе с устройством назальной стимуляции.
2. Электропроводящий гидрогель по п. 1, отличающийся тем, что первый мономер и второй мономер одинаковые.
3. Электропроводящий гидрогель по п. 1, отличающийся тем, что акрилатный мономер является монофункциональным мономером, бифункциональным мономером, трифункциональным мономером, или их прекурсором или производным.
4. Электропроводящий гидрогель по п. 3, отличающийся тем, что монофункциональный мономер выбран из группы, состоящей из акриловой кислоты, бутилакрилата, бутилметакрилата, 2-хлорэтилвинилового эфира, этилакрилата, 2-этилгексилакрилата, фурфурилового акрилата, глицерин монометакрилата, гидроксиэтилметакрилата, метакриловой кислоты, метоксиполиэтиленгликоль диметакрилата и метоксиполиэтиленгликоль моноакрилата.
5. Электропроводящий гидрогель по п. 3, отличающийся тем, что бифункциональный мономер выбран из группы, состоящей из диэтиленгликоль диакрилата, этиленгликоль диметакрилата, неопентилгликоль диакрилата, полиэтиленгликоль диакрилата, триэтиленгликоль диакрилата и N,N'-диметилен бисакриламида.
6. Электропроводящий гидрогель по п. 3, отличающийся тем, что трифункциональный мономер выбран из группы, состоящей из пентаэритритолтриакрилата, пропоксилированного гликоля триакрилата, триметилпропантриакрилата и триметилолпропантриметакрилата.
7. Электропроводящий гидрогель по п. 1, отличающийся тем, что второй мономер выбран из группы, состоящей из диметилакриламида, глицидилметакрилата, N-винилпирролидона и 1,4-бутандиолдиакрилата.
8. Электропроводящий гидрогель по п. 1, отличающийся тем, что фотосенсибилизатор выбран из группы, состоящей из ацилфосфиноксидов, бисацилфосфиноксидов, 2,2-диметокси-1,2-дифенилэтан-1-она (фотосенсибилизатор Igracure®), простых эфиров бензоина, бензильных кеталей, альфа-диалкоксиацетофенонов, альфа-гидроксиалкилфенонов, альфа-аминоалкилфенонов, бензофенонов, тиоксантонов и их комбинаций, и производных.
9. Электропроводящий гидрогель по п. 8, отличающийся тем, что ацилфосфиноксид выбран из группы, состоящей из 2,4,6-триметилбензоилдифенилфосфин оксида; бензоилдифенилфосфин оксида; 2,4,6-триметилбензоилметоксифенилфосфин оксида; фталоил-бис(дифенилфосфин оксида); тетрафтортерефталоил-бис(дифенилфосфин оксида); 2,6-дифторбензоилдифенилфосфин оксида; (1-нафтоил)дифенилфосфин оксида; а также их комбинаций.
10. Электропроводящий гидрогель по п. 9, отличающийся тем, что фотосенсибилизатором является 2,4,6-триметилбензоилдифенилфосфин оксид.
11. Электропроводящий гидрогель по п. 1, отличающийся тем, что одна или более характеристик, адаптирующих его к применению вместе с устройством назальной стимуляции выбраны из группы, состоящей из удельного электрического сопротивления, максимального уровеня гидратации, предела прочности при растяжении, модуля Юнга, температуры стеклования и плотности поперечных связей.
12. Электропроводящий гидрогель по п. 11, отличающийся тем, что удельное электрическое сопротивление находится в диапазоне от около 150 до около 800 Ом⋅см.
13. Электропроводящий гидрогель по п. 11, отличающийся тем, что максимальный уровень гидратации находится в диапазоне от около 35% до около 80% по массе.
14. Электропроводящий гидрогель по п. 11, отличающийся тем, что предел прочности при растяжении находится в диапазоне от около 35% до около 100% при 30% относительной влажности.
15. Электропроводящий гидрогель по п. 11, отличающийся тем, что температура стеклования находится в диапазоне от около 5 до около 25°C.
16. Электропроводящий гидрогель по п. 11, отличающийся тем, что густота поперечных связей находится в диапазоне от около 0,01 до около 0,10 моль/моль.
17. Электропроводящий гидрогель по п. 1, дополнительно содержащий разбавитель.
18. Электропроводящий гидрогель по п. 17, отличающийся тем, что разбавитель выбран из группы, состоящей из глицерина, изопропанола, метанола, полиэтиленгликоля, воды и их комбинаций.
19. Электропроводящий гидрогель по п. 1, дополнительно содержащий гидратирующую среду.
20. Способ получения электропроводящего гидрогеля, включающий следующие этапы:
смешивание первого мономера, второго мономера и фотосенсибилизатора для приготовления состава, при этом первый мономер является акрилатным мономером; и
облучение состава УФ-излучением для поперечного сшивания состава.
21. Поперечно сшитый, электропроводящий гидрогель, получаемый посредством смешивания первого мономера, второго мономера и фотосенсибилизатора для приготовления состава, при этом первый мономер является акрилатным мономером; заливки в форму или формовки состава; и облучения состава УФ-излучением для поперечного сшивания состава.
22. Способ стимулирования слезных желез, включающий:
расположение разветвления устройства назальной стимуляции вплотную к носовой ткани или ткани придаточной стимулируемой пазухи, при этом разветвление имеет дистальный конец и электропроводящий гидрогель, размещенный на дистальном конце; и
приведение в действие устройства назальной стимуляции, чтобы обеспечить электрическое стимулирование ткани носа или придаточной пазухи,
при этом электропроводящий гидрогель используется для улучшения электрического контакта между устройством назальной стимуляции и тканью носа или придаточной пазухи.
23. Устройство назальной стимуляции, содержащее:
многоразовый корпус;
одноразовый компонент, съемно прикрепленный к многоразовому корпусу и содержащий разветвление, имеющее дистальный конец, отходящий от многоразового корпуса, когда прикреплен к нему;
электрод, размещенный внутри разветвления; и
электропроводящий гидрогель на дистальном конце разветвления,
при этом электропроводящий гидрогель содержит первый мономер; второй мономер; и фотосенсибилизатор, и при этом первый мономер является акрилатным мономером, а электропроводящий гидрогель имеет одно или более свойств, адаптирующих его к применению вместе с устройством назальной стимуляции.
24. Способ изготовления устройства назальной стимуляции, включающий формовку гидрогеля в сборке наконечника устройства и прикрепление сборки наконечника к базовой части устройства.
25. Способ изготовления гидрогеля для использования в качестве электрического контакта в устройстве назальной стимуляции, включающий создание гидрофильной поверхности на гидрогеле.
26. Способ улучшения электрического контакта между электродом устройства назальной стимуляции и тканью носа или придаточной пазухи, включающий изготовление гидрогеля и создание гидрофильной поверхности на гидрогеле, при этом гидрофильная поверхность создается посредством обработки гидрогеля плазмой низкого давления, нанесением гидрофильного полимера на гидрогель с использованием плазменной полимеризации, подверганием гидрогеля воздействию водного раствора гидроксида натрия или добавлением поверхностно-активного вещества к гидрогелю при приготовлении его состава.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
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US201461944340P | 2014-02-25 | 2014-02-25 | |
US61/944,340 | 2014-02-25 | ||
US201462027139P | 2014-07-21 | 2014-07-21 | |
US62/027,139 | 2014-07-21 | ||
US201462035221P | 2014-08-08 | 2014-08-08 | |
US62/035,221 | 2014-08-08 | ||
US201462067350P | 2014-10-22 | 2014-10-22 | |
US62/067,350 | 2014-10-22 | ||
PCT/US2015/017379 WO2015130707A2 (en) | 2014-02-25 | 2015-02-24 | Polymer formulations for nasolacrimal stimulation |
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RU2016137744A true RU2016137744A (ru) | 2018-03-29 |
RU2016137744A3 RU2016137744A3 (ru) | 2019-03-12 |
RU2698711C2 RU2698711C2 (ru) | 2019-08-29 |
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RU2016137744A RU2698711C2 (ru) | 2014-02-25 | 2015-02-24 | Составы полимеров для носослёзной стимуляции |
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US (4) | US9770583B2 (ru) |
EP (2) | EP3689338A1 (ru) |
JP (2) | JP6604963B2 (ru) |
CN (2) | CN106470673B (ru) |
AU (1) | AU2015223184B2 (ru) |
CA (1) | CA2940533A1 (ru) |
ES (1) | ES2812752T3 (ru) |
MX (2) | MX2016011118A (ru) |
RU (1) | RU2698711C2 (ru) |
SA (1) | SA516371733B1 (ru) |
WO (1) | WO2015130707A2 (ru) |
ZA (1) | ZA201605563B (ru) |
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US9956397B2 (en) | 2018-05-01 |
CA2940533A1 (en) | 2015-09-03 |
EP3110405A4 (en) | 2017-10-18 |
EP3689338A1 (en) | 2020-08-05 |
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US20210069496A1 (en) | 2021-03-11 |
US20150238754A1 (en) | 2015-08-27 |
ZA201605563B (en) | 2017-09-27 |
US10799696B2 (en) | 2020-10-13 |
WO2015130707A2 (en) | 2015-09-03 |
CN111298285A (zh) | 2020-06-19 |
CN106470673A (zh) | 2017-03-01 |
MX2020003142A (es) | 2020-07-28 |
US9770583B2 (en) | 2017-09-26 |
JP2020022785A (ja) | 2020-02-13 |
JP6604963B2 (ja) | 2019-11-20 |
CN106470673B (zh) | 2020-01-31 |
AU2015223184B2 (en) | 2020-07-02 |
JP2017509747A (ja) | 2017-04-06 |
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