RU2017139096A - Композиция, содержащая биосовместимый матрикс, способ получения композиции - Google Patents

Композиция, содержащая биосовместимый матрикс, способ получения композиции Download PDF

Info

Publication number
RU2017139096A
RU2017139096A RU2017139096A RU2017139096A RU2017139096A RU 2017139096 A RU2017139096 A RU 2017139096A RU 2017139096 A RU2017139096 A RU 2017139096A RU 2017139096 A RU2017139096 A RU 2017139096A RU 2017139096 A RU2017139096 A RU 2017139096A
Authority
RU
Russia
Prior art keywords
tissue
composition
stem cells
mesenchymal stem
paragraphs
Prior art date
Application number
RU2017139096A
Other languages
English (en)
Other versions
RU2758468C2 (ru
RU2017139096A3 (ru
Inventor
ДЮФРАН Дениз
Original Assignee
Университе Католик Де Лувен
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Университе Католик Де Лувен filed Critical Университе Католик Де Лувен
Publication of RU2017139096A publication Critical patent/RU2017139096A/ru
Publication of RU2017139096A3 publication Critical patent/RU2017139096A3/ru
Application granted granted Critical
Publication of RU2758468C2 publication Critical patent/RU2758468C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/33—Fibroblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/386—Ligaments, tendons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3873—Muscle tissue, e.g. sphincter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3882—Hollow organs, e.g. bladder, esophagus, urether, uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/30—Materials or treatment for tissue regeneration for muscle reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Claims (15)

1. Композиция, содержащая биосовместимый матрикс и популяцию мезенхимальных стволовых клеток, при этом популяция мезенхимальных стволовых клеток является преимущественно чистой, в которой мезенхимальные стволовые клетки недифференцированы.
2. Композиция по п. 1, в которой популяция мезенхимальных стволовых клеток содержит менее 25% фибробластов.
3. Композиция по любому из пп. 1-2, в которой мезенхимальные стволовые клетки получены из жировой ткани, костного мозга, ткани пуповины, вартонова студня, околоплодных вод, плаценты, периферической крови, фаллопиевой трубы, роговичной стромы, легких, мышц, кожи, костей, дентина и плодной печени.
4. Композиция по любому из пп. 1-3, в которой мезенхимальные стволовые клетки получены из жировой ткани, предпочтительно из подкожной жировой ткани.
5. Композиция по любому из пп. 1-4, в которой биосовместимый матрикс является ацеллюлярным.
6. Композиция по любому из пп. 1-5, в которой биосовместимый матрикс содержит коллаген.
7. Композиция по любому из пп. 1-6, в которой источником биосовместимого матрикса является человек, свинья, крупный рогатый скот или лошадь.
8. Композиция по любому из пп. 1-7, в которой источником мезенхимальных стволовых клеток является субъект, подлежащий лечению.
9. Композиция по любому из пп. 1-8, для применения при лечении повреждения мягких тканей у нуждающегося в этом субъекта.
10. Композиция для применения по п. 9, в которой мягкая ткань выбрана из группы, включающей кожную ткань, мышечную ткань, дермальную ткань, ткань сухожилия, ткань связки, ткань мениска и ткань мочевого пузыря.
11. Композиция для применения по п. 9 или 10, при этом повреждением мягких тканей является острая или хроническая рана.
12. Композиция для применения по любому из пп. 9-11, при этом повреждение мягкой ткани выбрано из группы, включающей разрывы мягких тканей, кожные раны, кожные ожоги, кожные язвы, хирургические раны, сосудистые заболевания, мышечные заболевания, грыжи и радиационные раны.
13. Композиция для применения по п. 12, при этом кожной раной является диабетическая рана.
14. Композиция для применения по любому из пп. 9-12, которую вводят местно или путем хирургической имплантации.
15. Способ получения композиции, содержащей биосовместимый матрикс и популяцию мезенхимных стволовых клеток, включающий инкубацию преимущественно чистой популяции мезенхимальных стволовых клеток с биосовместимым матриксом, причем мезенхимальные стволовые клетки недифференцированы.
RU2017139096A 2015-05-08 2016-05-09 Композиция, содержащая биосовместимый матрикс, способ получения композиции RU2758468C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562158922P 2015-05-08 2015-05-08
US62/158,922 2015-05-08
EP15179418.7A EP3090764A1 (en) 2015-05-08 2015-07-31 Compositions comprising mesenchymal stem cells and uses thereof
EP15179418.7 2015-07-31
PCT/EP2016/060352 WO2016180789A1 (en) 2015-05-08 2016-05-09 Compositions comprising mesenchymal stem cells and uses thereof

Publications (3)

Publication Number Publication Date
RU2017139096A true RU2017139096A (ru) 2019-06-10
RU2017139096A3 RU2017139096A3 (ru) 2019-07-29
RU2758468C2 RU2758468C2 (ru) 2021-10-28

Family

ID=53776428

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017139096A RU2758468C2 (ru) 2015-05-08 2016-05-09 Композиция, содержащая биосовместимый матрикс, способ получения композиции

Country Status (14)

Country Link
US (1) US20180126039A1 (ru)
EP (2) EP3090764A1 (ru)
JP (2) JP6966332B2 (ru)
KR (1) KR20180008526A (ru)
CN (1) CN107810014B (ru)
AU (3) AU2016259737A1 (ru)
BR (1) BR112017024013A2 (ru)
CA (1) CA2985272C (ru)
ES (1) ES2892974T3 (ru)
IL (1) IL255480B (ru)
MX (1) MX2017014245A (ru)
RU (1) RU2758468C2 (ru)
WO (1) WO2016180789A1 (ru)
ZA (1) ZA201707478B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200052302A (ko) * 2017-09-20 2020-05-14 노바딥 바이오사이언시스 에스에이 지방 유래 줄기세포를 포함하는 생체재료 및 이를 생산하는 방법
US11602579B2 (en) 2017-09-20 2023-03-14 Novadip Biosciences Biomaterial comprising adipose-derived stem cells and method for producing the same
CN108359637B (zh) * 2018-02-14 2021-09-28 浙江生创精准医疗科技有限公司 一种宫血干细胞快速扩增的方法
AU2019231273A1 (en) * 2018-03-06 2020-09-24 Epibone, Inc. Injectable off-the- shelf cartilage, tendon, and ligament repair compositions and methods of use
CN112004922A (zh) * 2018-04-25 2020-11-27 北海道公立大学法人札幌医科大学 生物移植用细胞片及其制造方法
WO2020058511A1 (en) * 2018-09-20 2020-03-26 Novadip Biosciences Biomaterial comprising adipose-derived stem cells and gelatin and method for producing the same
CN109224129B (zh) * 2018-09-30 2021-09-24 四川大学华西医院 一种皮肤缺损修复材料
US20200392454A1 (en) * 2019-06-12 2020-12-17 Cryocord Sdn Bhd Production of therapeutics potential mesenchymal stem cells
WO2020262916A1 (ko) * 2019-06-24 2020-12-30 (주)메디노 말초 동맥 질환의 치료용 조성물
CN112760293B (zh) * 2021-01-08 2023-04-18 广东工业大学 一种无异源血清3d培养msc干细胞制备高活性外泌体的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8394371B2 (en) * 2002-02-11 2013-03-12 Neocutis Sa Compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same
JP2004016109A (ja) * 2002-06-17 2004-01-22 Nagoya Industrial Science Research Inst 軟骨細胞様細胞、及びその作製方法
US20040136968A1 (en) * 2002-09-27 2004-07-15 Verigen Ag Autologous cells on a support matrix for tissue repair
US20040101959A1 (en) * 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
RU2358753C2 (ru) * 2003-08-07 2009-06-20 Хилор Лтд. Фармацевтические композиции и способы для ускорения заживления ран
WO2007129453A1 (ja) * 2006-04-19 2007-11-15 National University Corporation Nagoya University 歯周軟組織再生用組成物及びその製造方法
US20090180965A1 (en) * 2008-01-04 2009-07-16 Boston Scientific Scimed, Inc. Methods for repair and regeneration of bone marrow
WO2009155334A1 (en) 2008-06-20 2009-12-23 Escape Therapeutics, Inc. Differentiation of mesenchymal stem cells into fibroblasts, compositions comprising mesenchymal stem cell-derived fibroblasts, and methods of using the same
US20140286911A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
ITMI20100601A1 (it) 2010-04-09 2011-10-10 Luisa Benassi "nuovo sostituto dermico e sua applicazione terapeutica"
JP2012065742A (ja) * 2010-09-22 2012-04-05 Atree Co Ltd コラーゲン／アパタイト配向性材料、及びコラーゲン／アパタイト配向性材料の製造方法
US20120087983A1 (en) * 2010-09-24 2012-04-12 Jointechlabs, Inc. Orthopedic application of encapsulated stem cells
KR101138091B1 (ko) * 2011-08-31 2012-04-24 세원셀론텍(주) 중간엽 줄기세포 기본 배양 배지 조성방법, 중간엽 줄기세포 기본 배양 배지 및 이를 이용하여 배양분화된 세포치료제
WO2014113704A2 (en) * 2013-01-18 2014-07-24 Escape Therapeutics, Inc. Enhanced differentiation of mesenchymal stem cells
JP6081276B2 (ja) * 2013-04-10 2017-02-15 クアーズテック株式会社 細胞培養担体

Also Published As

Publication number Publication date
AU2020207792A1 (en) 2020-08-06
JP6966332B2 (ja) 2021-11-17
CN107810014A (zh) 2018-03-16
EP3294356B1 (en) 2021-07-07
CN107810014B (zh) 2021-05-28
KR20180008526A (ko) 2018-01-24
ZA201707478B (en) 2020-05-27
BR112017024013A2 (pt) 2018-07-17
IL255480B (en) 2021-07-29
EP3294356A1 (en) 2018-03-21
WO2016180789A1 (en) 2016-11-17
ES2892974T3 (es) 2022-02-07
AU2022241581A1 (en) 2022-10-27
CA2985272A1 (en) 2016-11-17
RU2758468C2 (ru) 2021-10-28
EP3090764A1 (en) 2016-11-09
AU2016259737A1 (en) 2017-11-30
MX2017014245A (es) 2018-06-28
JP2018515211A (ja) 2018-06-14
US20180126039A1 (en) 2018-05-10
IL255480A (en) 2018-01-31
RU2017139096A3 (ru) 2019-07-29
CA2985272C (en) 2023-10-17
JP2021184828A (ja) 2021-12-09

Similar Documents

Publication Publication Date Title
RU2017139096A (ru) Композиция, содержащая биосовместимый матрикс, способ получения композиции
JP2021184828A5 (ru)
Hyakusoku et al. Color atlas of burn reconstructive surgery
Klasen History of free skin grafting: knowledge or empiricism?
WO2011022045A3 (en) Apparatus and process for generating and harvesting adult stem cells and fluid associated with it from skin and omentum for medical, cosmetic, and veterinary use
Morimoto et al. The rapid inactivation of porcine skin by applying high hydrostatic pressure without damaging the extracellular matrix
Di Filippo et al. Effects of pure and ozonated sunflower seed oil (Helianthus annuus) on hypergranulation tissue formation, infection and healing of equine lower limb wounds
Kosaka et al. Pincer nails treated using zigzag nail bed flap method: results of 71 toenails
Son et al. A new mechanism associated with compositae graft success
Thammannagowda et al. Comparison between peroneus brevis flap and reverse sural artery flap for coverage of lower one-third leg defects
Wade The sword and the knife: a comparison of Ancient Egyptian treatment of sword injuries and present day knife trauma.
Sarkar et al. Bioactive wound dressings for the management of chronic non healing ulcers (CNHU)–A review of clinical and translational studies
Kabala-Dzik et al. Influence of honey-balm on the rate of scare formation during experimental burn wound healing in pigs
BR112022015768A2 (pt) Métodos de tratamento e prevenção de arritmias de enxerto
RU2420242C1 (ru) Способ хирургического лечения седловидной деформации спинки носа
Kubanov et al. Modern methods of the treatment of hereditary epidermolysis bullosa
Daugherty et al. Skin and skin substitutes—an overview
Jaffary et al. Review on using platelet rich plasma in hair loss and hair transplantation
RU2339399C2 (ru) Способ лечения ран мягких тканей
Zhang et al. Efecto del Puente Alogénico de Nervio Envuelto en Membrana Amniótica sobre la Lesión de Nervio Periférico
Gümüş Negative pressure dressing for the treatment of high-voltage electrical burn injury
Chen et al. Disruption Of Mechanotransduction Signaling Preserves Fibroblast Heterogeneity And Promotes Tissue Regeneration In Healing Wounds
Lazzaretti APPLICATION OF TOPICAL NEGATIVE PRESSURE (VACUUM-ASSISTED CLOSURE) MANAGING THE HORSE'S WOUNDS: LITERATURE REVIEW AND THREE YEARS EXPERIENCE.
Brennan et al. Equine wound management
RU2639788C2 (ru) Способ получения свободного расщепленного кожного аутотрансплантата

Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20191115

FZ9A Application not withdrawn (correction of the notice of withdrawal)

Effective date: 20191224