BR112022015768A2 - Métodos de tratamento e prevenção de arritmias de enxerto - Google Patents
Métodos de tratamento e prevenção de arritmias de enxertoInfo
- Publication number
- BR112022015768A2 BR112022015768A2 BR112022015768A BR112022015768A BR112022015768A2 BR 112022015768 A2 BR112022015768 A2 BR 112022015768A2 BR 112022015768 A BR112022015768 A BR 112022015768A BR 112022015768 A BR112022015768 A BR 112022015768A BR 112022015768 A2 BR112022015768 A2 BR 112022015768A2
- Authority
- BR
- Brazil
- Prior art keywords
- graft
- prevention
- treatment
- methods
- arrhythmias
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 230000002265 prevention Effects 0.000 title abstract 3
- IYIKLHRQXLHMJQ-UHFFFAOYSA-N amiodarone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN(CC)CC)C(I)=C1 IYIKLHRQXLHMJQ-UHFFFAOYSA-N 0.000 abstract 2
- 229960005260 amiodarone Drugs 0.000 abstract 2
- 206010003119 arrhythmia Diseases 0.000 abstract 2
- 230000006793 arrhythmia Effects 0.000 abstract 2
- 210000004413 cardiac myocyte Anatomy 0.000 abstract 2
- ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 abstract 2
- 229960003825 ivabradine Drugs 0.000 abstract 2
- 210000005003 heart tissue Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
MÉTODOS DE TRATAMENTO E PREVENÇÃO DE ARRITMIAS DE ENXERTO. São descritos neste documento métodos e composições relacionados ao tratamento e à prevenção de uma arritmia de enxerto com uma quantidade eficaz de amiodarona e ivabradina. Também é descrito neste documento um método de transplante de cardiomiócitos, o método compreende: administrar cardiomiócitos diferenciados in vitro ao tecido cardíaco de um indivíduo com necessidade; e administrar ao indivíduo uma quantidade de amiodarona e uma quantidade de ivabradina eficaz para reduzir a arritmia de enxerto no indivíduo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062972330P | 2020-02-10 | 2020-02-10 | |
PCT/US2021/017220 WO2021163037A1 (en) | 2020-02-10 | 2021-02-09 | Methods of treating and preventing engraftment arrhythmias |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022015768A2 true BR112022015768A2 (pt) | 2022-11-22 |
Family
ID=77291628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022015768A BR112022015768A2 (pt) | 2020-02-10 | 2021-02-09 | Métodos de tratamento e prevenção de arritmias de enxerto |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230077983A1 (pt) |
EP (1) | EP4103206A4 (pt) |
JP (1) | JP2023512843A (pt) |
KR (1) | KR20220140532A (pt) |
CN (1) | CN115484966A (pt) |
AU (1) | AU2021218653A1 (pt) |
BR (1) | BR112022015768A2 (pt) |
CA (1) | CA3166678A1 (pt) |
IL (1) | IL295236A (pt) |
MX (1) | MX2022009807A (pt) |
WO (1) | WO2021163037A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023173123A1 (en) * | 2022-03-11 | 2023-09-14 | Sana Biotechnology, Inc. | Genetically modified cells and compositions and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013151755A1 (en) * | 2012-04-04 | 2013-10-10 | University Of Washington Through Its Center For Commercialization | Systems and method for engineering muscle tissue |
EP3288626A4 (en) * | 2015-04-27 | 2019-01-23 | Reflex Medical Inc. | SYSTEMS AND METHODS FOR SYMPATHETIC CARDIO-PULMONARY NEUROMODULATION |
CA3051870A1 (en) * | 2017-03-15 | 2018-09-20 | University Of Washington | Methods and compositions for enhancing cardiomyocyte maturation and engraftment |
-
2021
- 2021-02-09 EP EP21753964.2A patent/EP4103206A4/en active Pending
- 2021-02-09 KR KR1020227029054A patent/KR20220140532A/ko unknown
- 2021-02-09 AU AU2021218653A patent/AU2021218653A1/en active Pending
- 2021-02-09 BR BR112022015768A patent/BR112022015768A2/pt not_active Application Discontinuation
- 2021-02-09 IL IL295236A patent/IL295236A/en unknown
- 2021-02-09 CN CN202180027573.1A patent/CN115484966A/zh active Pending
- 2021-02-09 WO PCT/US2021/017220 patent/WO2021163037A1/en unknown
- 2021-02-09 US US17/798,127 patent/US20230077983A1/en active Pending
- 2021-02-09 MX MX2022009807A patent/MX2022009807A/es unknown
- 2021-02-09 JP JP2022548412A patent/JP2023512843A/ja active Pending
- 2021-02-09 CA CA3166678A patent/CA3166678A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230077983A1 (en) | 2023-03-16 |
WO2021163037A1 (en) | 2021-08-19 |
AU2021218653A1 (en) | 2022-09-01 |
MX2022009807A (es) | 2022-11-10 |
IL295236A (en) | 2022-10-01 |
CN115484966A (zh) | 2022-12-16 |
CA3166678A1 (en) | 2021-08-19 |
EP4103206A1 (en) | 2022-12-21 |
KR20220140532A (ko) | 2022-10-18 |
JP2023512843A (ja) | 2023-03-29 |
EP4103206A4 (en) | 2024-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |