RU2015146869A - Составы на основе солей никотина для аэрозольных устройств и способы их применения - Google Patents
Составы на основе солей никотина для аэрозольных устройств и способы их применения Download PDFInfo
- Publication number
- RU2015146869A RU2015146869A RU2015146869A RU2015146869A RU2015146869A RU 2015146869 A RU2015146869 A RU 2015146869A RU 2015146869 A RU2015146869 A RU 2015146869A RU 2015146869 A RU2015146869 A RU 2015146869A RU 2015146869 A RU2015146869 A RU 2015146869A
- Authority
- RU
- Russia
- Prior art keywords
- acid
- paragraphs
- nicotine salt
- nicotine
- electronic cigarette
- Prior art date
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical class CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims 136
- 239000000203 mixture Substances 0.000 title claims 73
- 238000000034 method Methods 0.000 title claims 57
- 239000000443 aerosol Substances 0.000 title claims 23
- 239000003571 electronic cigarette Substances 0.000 claims 77
- 239000007788 liquid Substances 0.000 claims 73
- 239000002253 acid Substances 0.000 claims 37
- 229960002715 nicotine Drugs 0.000 claims 27
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 17
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 14
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 12
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims 10
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 10
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 10
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 8
- 238000009835 boiling Methods 0.000 claims 8
- 235000011187 glycerol Nutrition 0.000 claims 8
- 238000002844 melting Methods 0.000 claims 8
- 230000008018 melting Effects 0.000 claims 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- 239000005711 Benzoic acid Substances 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 235000010233 benzoic acid Nutrition 0.000 claims 6
- 229960004365 benzoic acid Drugs 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 229940040102 levulinic acid Drugs 0.000 claims 6
- 150000007524 organic acids Chemical group 0.000 claims 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 6
- 229960004889 salicylic acid Drugs 0.000 claims 6
- 239000004334 sorbic acid Substances 0.000 claims 6
- 235000010199 sorbic acid Nutrition 0.000 claims 6
- 229940075582 sorbic acid Drugs 0.000 claims 6
- 235000013311 vegetables Nutrition 0.000 claims 6
- 239000005639 Lauric acid Substances 0.000 claims 5
- 229940107700 pyruvic acid Drugs 0.000 claims 5
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 4
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 4
- 235000019504 cigarettes Nutrition 0.000 claims 4
- 238000005260 corrosion Methods 0.000 claims 4
- 230000007797 corrosion Effects 0.000 claims 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 4
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 4
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims 4
- 239000012458 free base Substances 0.000 claims 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 2
- AIBWPBUAKCMKNS-PPHPATTJSA-N 2-hydroxybenzoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical group OC(=O)C1=CC=CC=C1O.CN1CCC[C@H]1C1=CC=CN=C1 AIBWPBUAKCMKNS-PPHPATTJSA-N 0.000 claims 2
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- MMOPGICOOYBFJU-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-oxopropanoic acid Chemical group CC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 MMOPGICOOYBFJU-UHFFFAOYSA-N 0.000 claims 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 2
- JOOXCMJARBKPKM-UHFFFAOYSA-M 4-oxopentanoate Chemical compound CC(=O)CCC([O-])=O JOOXCMJARBKPKM-UHFFFAOYSA-M 0.000 claims 2
- 125000005523 4-oxopentanoic acid group Chemical group 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- GJMKJBHRQDGHMT-UHFFFAOYSA-N C(C=CC=CC)(=O)O.N1=CC=CC(=C1)C1N(C)CCC1 Chemical group C(C=CC=CC)(=O)O.N1=CC=CC(=C1)C1N(C)CCC1 GJMKJBHRQDGHMT-UHFFFAOYSA-N 0.000 claims 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 235000021314 Palmitic acid Nutrition 0.000 claims 2
- 235000021355 Stearic acid Nutrition 0.000 claims 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 2
- 235000011054 acetic acid Nutrition 0.000 claims 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 2
- VAUQRLHPXWYZRZ-PPHPATTJSA-N benzoic acid 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine Chemical group OC(=O)c1ccccc1.CN1CCC[C@H]1c1cccnc1 VAUQRLHPXWYZRZ-PPHPATTJSA-N 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- ZDBSZLXHLZRTGL-UHFFFAOYSA-N dodecanoic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical group CN1CCCC1C1=CC=CN=C1.CCCCCCCCCCCC(O)=O ZDBSZLXHLZRTGL-UHFFFAOYSA-N 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 235000019634 flavors Nutrition 0.000 claims 2
- 235000019253 formic acid Nutrition 0.000 claims 2
- 239000001530 fumaric acid Substances 0.000 claims 2
- 239000000174 gluconic acid Substances 0.000 claims 2
- 235000012208 gluconic acid Nutrition 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 150000004715 keto acids Chemical class 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 229940058352 levulinate Drugs 0.000 claims 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 2
- 229960004488 linolenic acid Drugs 0.000 claims 2
- 239000001630 malic acid Substances 0.000 claims 2
- 235000011090 malic acid Nutrition 0.000 claims 2
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 claims 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 2
- 229960002446 octanoic acid Drugs 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 235000021313 oleic acid Nutrition 0.000 claims 2
- 235000019260 propionic acid Nutrition 0.000 claims 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 2
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 claims 2
- 239000008117 stearic acid Substances 0.000 claims 2
- 239000011975 tartaric acid Substances 0.000 claims 2
- 235000002906 tartaric acid Nutrition 0.000 claims 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 claims 1
- SZGXANVUJLMLCM-UHFFFAOYSA-N C(C(=O)C)(=O)O.C(CCCCCCCCCCC)(=O)O Chemical compound C(C(=O)C)(=O)O.C(CCCCCCCCCCC)(=O)O SZGXANVUJLMLCM-UHFFFAOYSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 229940033355 lauric acid Drugs 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F47/00—Smokers' requisites not otherwise provided for
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Manufacture Of Tobacco Products (AREA)
Claims (104)
1. Способ доставки никотина пользователю, который предусматривает применение пользователем электронной сигареты, при этом электронная сигарета содержит состав на основе соли никотина, включающий соль никотина в биологически приемлемом жидком носителе, а кислота, используемая для образования указанной соли никотина, характеризуется давлением паров >20 ммHg при 200°C, и предусматривает вдыхание аэрозоля, полученного из состава на основе соли никотина, нагретого при помощи электронной сигареты.
2. Способ доставки никотина пользователю, который предусматривает применение пользователем электронной сигареты, при этом электронная сигарета содержит состав на основе соли никотина, включающий соль никотина в биологически приемлемом жидком носителе, а кислота, используемая для образования указанной соли никотина, характеризуется давлением паров от около 20 до 200 ммHg при 200°C, и предусматривает вдыхание аэрозоля, полученного из состава на основе соли никотина, нагретого при помощи электронной сигареты.
3. Способ доставки никотина пользователю, который предусматривает применение пользователем электронной сигареты, при этом электронная сигарета содержит состав на основе соли никотина, включающий соль никотина в биологически приемлемом жидком носителе, а кислота, используемая для образования указанной соли никотина, характеризуется также температурой плавления <160°C, температурой кипения >160°C и разницей между температурой плавления и температурой кипения, составляющей по меньшей мере 50°, и предусматривает вдыхание аэрозоля, полученного из состава на основе соли никотина, нагретого при помощи электронной сигареты.
4. Способ доставки никотина пользователю, который предусматривает применение пользователем электронной сигареты, при этом электронная сигарета содержит состав на основе соли никотина, включающий соль никотина в биологически приемлемом жидком носителе, а кислота, используемая для образования указанной соли никотина, характеризуется также температурой плавления, которая по меньшей мере на 40° ниже рабочей температуры электронной сигареты, температурой кипения, которая не более чем на 40° ниже рабочей температуры электронной сигареты, и разницей между температурой плавления и температурой кипения, составляющей по меньшей мере 50°, и предусматривает вдыхание аэрозоля, полученного из состава на основе соли никотина, нагретого при помощи электронной сигареты.
5. Способ по любому из пп. 1-3, в котором рабочая температура составляет от 150 до 250°C.
6. Способ по любому из пп. 1-3, в котором рабочая температура составляет от 180 до 220°C.
7. Способ по любому из пп. 1-3, в котором рабочая температура составляет около 200°C.
8. Способ по п. 4, в котором рабочая температура составляет от 150 до 250°C.
9. Способ по п. 4, в котором рабочая температура составляет от 180 до 220°C.
10. Способ по п. 4, в котором рабочая температура составляет около 200°C.
11. Способ по любому из пп. 1-4, 8-10, в котором аэрозоль содержит конденсат соли никотина.
12. Способ по любому из пп. 1-4, 8-10, в котором аэрозоль содержит конденсат свободного основания никотина.
13. Способ по любому из пп. 1-4, 8-10, в котором аэрозоль содержит конденсат свободного основания никотина и конденсат носителя.
14. Способ по любому из пп. 1-4, 8-10, в котором аэрозоль содержит конденсат свободного основания никотина и конденсат кислоты.
15. Способ по любому из пп. 1-4, 8-10, в котором аэрозоль содержит конденсат в виде частиц размером от около 0,1 микрона до около 5 мкм.
16. Способ по любому из пп. 1-4, 8-10, в котором аэрозоль содержит конденсат в виде частиц размером от около 0,1 микрона до около 1 или 2 мкм.
17. Способ по любому из пп. 1-4, 8-10, в котором аэрозоль содержит конденсат в виде частиц размером от около 0,1 микрона до около 0,7 мкм.
18. Способ по любому из пп. 1-4, 8-10, в котором аэрозоль содержит конденсат в виде частиц размером от около 0,3 микрона до около 0,4 мкм.
19. Способ по любому из пп. 1-4, 8-10, в котором кислота представляет собой карбоновую кислоту.
20. Способ по любому из пп. 1-4, 8-10, в котором кислота, используемая для образования указанной соли никотина, представляет собой органическую кислоту.
21. Способ по п. 20, в котором органическая кислота представляет собой монокарбоновую кислоту, ароматическую кислоту или кетокислоту.
22. Способ по п. 20, в котором органическая кислота представляет собой муравьиную кислоту, уксусную кислоту, пропионовую кислоту, масляную кислоту, валериановую кислоту, капроновую кислоту, каприловую кислоту, каприновую кислоту, лимонную кислоту, лауриновую кислоту, миристиновую кислоту, пальмитиновую кислоту, стеариновую кислоту, олеиновую кислоту, линолевую кислоту, линоленовую кислоту, фенилуксусную кислоту, бензойную кислоту, пировиноградную кислоту, левулиновую кислоту, винную кислоту, молочную кислоту, малоновую кислоту, янтарную кислоту, фумаровую кислоту, финнаровую кислоту, глюконовую кислоту, сахарную кислоту, салициловую кислоту, сорбиновую кислоту, малоновую кислоту или яблочную кислоту.
23. Способ по любому из пп. 1-4, 8-10, в котором кислота, используемая для образования соли никотина, представляет собой салициловую кислоту.
24. Способ по любому из пп. 1-4, 8-10, в котором кислота, используемая для образования соли никотина, представляет собой бензойную кислоту.
25. Способ по любому из пп. 1-4, 8-10, в котором кислота, используемая для образования соли никотина, представляет собой пировиноградную кислоту.
26. Способ по любому из пп. 1-4, 8-10, в котором кислота, используемая для образования соли никотина, представляет собой сорбиновую кислоту.
27. Способ по любому из пп. 1-4, 8-10, в котором кислота, используемая для образования соли никотина, представляет собой лауриновую кислоту.
28. Способ по любому из пп. 1-4, 8-10, в котором кислота, используемая для образования соли никотина, представляет собой левулиновую кислоту.
29. Способ по любому из пп. 1-4, 8-10, в котором указанная соль никотина представляет собой пируват никотина.
30. Способ по любому из пп. 1-4, 8-10, в котором указанная соль никотина представляет собой салицилат никотина.
31. Способ по любому из пп. 1-4, 8-10, в котором указанная соль никотина представляет собой сорбат никотина.
32. Способ по любому из пп. 1-4, 8-10, в котором указанная соль никотина представляет собой лаурат никотина.
33. Способ по любому из пп. 1-4, 8-10, в котором указанная соль никотина представляет собой левулинат никотина.
34. Способ по любому из пп. 1-4, 8-10, в котором указанная соль никотина представляет собой бензоат никотина.
35. Способ по любому из пп. 1-4, 8-10, 21 - 22, в котором жидкий носитель представляет собой глицерин, пропиленгликоль, триметиленгликоль, воду, этанол или их комбинации.
36. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором жидкий носитель содержит пропиленгликоль и растительный глицерин.
37. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором жидкий носитель содержит от 20 до 50% пропиленгликоля и от 80 до 50% растительного глицерина.
38. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором жидкий носитель содержит 30% пропиленгликоля и 70% растительного глицерина.
39. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором соль никотина берут в количестве, образующем от около 0,5% до около 20% никотина во вдыхаемом аэрозоле.
40. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором соль никотина берут в количестве, образующем от около 1% до около 20% никотина во вдыхаемом аэрозоле.
41. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором концентрация никотина в жидком составе равна от около 1 вес.% до около 25 вес.%.
42. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором концентрация никотина в жидком составе равна от около 1 вес.% до около 2 вес.%.
43. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором концентрация никотина в жидком составе равна от около 1 вес.% до около 18 вес.%.
44. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором концентрация никотина в жидком составе равна от около 1 вес.% до около 15 вес.%.
45. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором концентрация никотина в жидком составе равна от около 4 вес.% до около 12 вес.%.
46. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором концентрация никотина в жидком составе равна около 4 вес.%.
47. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором концентрация никотина в жидком составе равна около 2 вес.%.
48. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором состав также содержит ароматизатор.
49. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором состав не вызывает коррозии электронной сигареты.
50. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором кислота устойчива при рабочей температуре или ниже рабочей температуры или при температуре около 200°C.
51. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором кислота не разлагается при рабочей температуре или ниже рабочей температуры или при температуре около 200°C.
52. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором кислота не окисляется при рабочей температуре, или ниже рабочей температуры, или при температуре около 200°C.
53. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором состав не вызывает коррозии электронной сигареты.
54. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором состав является нетоксичным для пользователя электронной сигареты.
55. Способ по любому из пп. 1-4, 8-10, 21 и 22, в котором состав содержит также одну или более дополнительных солей никотина в биологически приемлемом жидком носителе, пригодном для получения вдыхаемого аэрозоля при нагревании.
56. Способ по п. 55, в котором вторая кислота, используемая для образования дополнительной соли никотина, выбрана из группы, состоящей из салициловой кислоты, сорбиновой кислоты, бензойной кислоты, пировиноградной кислоты, лауриновой кислоты и левулиновой кислоты.
57. Жидкий состав на основе соли никотина в электронной сигарете для получения вдыхаемого аэрозоля при нагревании в электронной сигарете, причем этот состав в сигарете содержит соль никотина в биологически приемлемом жидком носителе, а кислота, используемая для образования указанной соли никотина, характеризуется давлением паров >20 ммHg при 200°C.
58. Жидкий состав на основе соли никотина в электронной сигарете для получения вдыхаемого аэрозоля при нагревании в электронной сигарете, причем этот состав в сигарете содержит соль никотина в биологически приемлемом жидком носителе, а кислота, используемая для образования указанной соли никотина, характеризуется давлением паров от около 20 до 200 ммHg при 200°C.
59. Жидкий состав на основе соли никотина в электронной сигарете для получения вдыхаемого аэрозоля при нагревании в электронной сигарете, причем этот состав в сигарете содержит соль никотина в биологически приемлемом жидком носителе, а кислота, используемая для образования указанной соли никотина, характеризуется также температурой плавления <160°C, температурой кипения >160°C и разницей между температурой плавления и температурой кипения по меньшей мере 50°.
60. Жидкий состав на основе соли никотина в электронной сигарете для получения вдыхаемого аэрозоля при нагревании в электронной сигарете, причем этот состав в сигарете содержит соль никотина в биологически приемлемом жидком носителе, а кислота, используемая для образования указанной соли никотина, характеризуется также температурой плавления, которая по меньшей мере на 40° ниже рабочей температуры электронной сигареты, температурой кипения, которая не более чем на 40° ниже рабочей температуры электронной сигареты, и разницей между температурой плавления и температурой кипения, составляющей по меньшей мере 50°.
61. Жидкий состав на основе соли никотина в электронной сигарете по любому из п.п. 57-59, который нагревается в электронной сигарете до рабочей температуры от 150 до 250°C.
62. Жидкий состав на основе соли никотина в электронной сигарете по любому из п.п. 57-59, который нагревается в электронной сигарете до рабочей температуры от 180 до 220°C.
63. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-59, который нагревается в электронной сигарете до рабочей температуры около 200°C.
64. Жидкий состав на основе соли никотина в электронной сигарете по п. 60, рабочая температура в которой составляет от 150 до 250°C.
65. Жидкий состав на основе соли никотина в электронной сигарете по п. 60, рабочая температура в которой составляет от 180 до 220°C.
66. Жидкий состав на основе соли никотина в электронной сигарете по п. 60, рабочая температура в которой составляет около 200°C.
67. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором кислота, используемая для образования соли никотина, представляет собой карбоновую кислоту.
68. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором кислота, используемая для образования соли никотина, представляет собой органическую кислоту.
69. Жидкий состав на основе соли никотина в электронной сигарете по п. 68, в котором органическая кислота представляет собой монокарбоновую кислоту, ароматическую кислоту или кетокислоту.
70. Жидкий состав на основе соли никотина в электронной сигарете по п. 68, в котором органическая кислота представляет собой муравьиную кислоту, уксусную кислоту, пропионовую кислоту, масляную кислоту, валериановую кислоту, капроновую кислоту, каприловую кислоту, каприновую кислоту, лимонную кислоту, лауриновую кислоту, миристиновую кислоту, пальмитиновую кислоту, стеариновую кислоту, олеиновую кислоту, линолевую кислоту, линоленовую кислоту, фенилуксусную кислоту, бензойную кислоту, пировиноградную кислоту, левулиновую кислоту, винную кислоту, молочную кислоту, малоновую кислоту, янтарную кислоту, фумаровую кислоту, финнаровую кислоту, глюконовую кислоту, сахарную кислоту, салициловую кислоту, сорбиновую кислоту, малоновую кислоту или яблочную кислоту.
71. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором кислота, используемая для образования соли никотина, представляет собой салициловую кислоту.
72. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором кислота, используемая для образования соли никотина, представляет собой бензойную кислоту.
73. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором кислота, используемая для образования соли никотина, представляет собой пировиноградную кислоту.
74. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором кислота, используемая для образования соли никотина, представляет собой сорбиновую кислоту.
75. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором кислота, используемая для образования соли никотина, представляет собой лауриновую кислоту.
76. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором кислота, используемая для образования соли никотина, представляет собой левулиновую кислоту.
77. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором указанная соль никотина представляет собой пируват никотина.
78. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, где указанная соль никотина представляет собой салицилат никотина.
79. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором указанная соль никотина представляет собой сорбат никотина.
80. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором указанная соль никотина представляет собой лаурат никотина.
81. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором указанная соль никотина представляет собой левулинат никотина.
82. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, в котором указанная соль никотина представляет собой бензоат никотина.
83. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, в котором жидкий носитель представляет собой глицерин, пропиленгликоль, триметиленгликоль, воду, этанол или их комбинации.
84. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, в котором жидкий носитель содержит пропиленгликоль и растительный глицерин.
85. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, в котором жидкий носитель содержит от 20 до 50% пропиленгликоля и от 80 до 50% растительного глицерина.
86. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, в котором жидкий носитель содержит 30% пропиленгликоля и 70% растительного глицерина.
87. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, в котором соль никотина содержится в количестве, образующем от около 0,5% до около 20% никотина во вдыхаемом аэрозоле.
88. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, в котором соль никотина содержится в количестве, образующем от около 1% до около 20% никотина во вдыхаемом аэрозоле.
89. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, концентрация никотина в котором составляет от около 1 вес.% до около 25 вес.%.
90. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, концентрация никотина в котором составляет от около 1 вес.% до около 20 вес.%.
91. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, концентрация никотина в котором составляет от около 1вес.% до около 18вес.%.
92. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, концентрация никотина в котором составляет от около 1вес.% до около 15вес.%.
93. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, концентрация никотина в котором составляет от около 4вес.% до около 12вес.%.
94. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, концентрация никотина в котором составляет около 4вес.%.
95. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, концентрация никотина в котором составляет около 2вес.%.
96. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, который также содержит ароматизатор.
97. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, который не вызывает коррозии электронной сигареты.
98. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, в котором кислота устойчива при температуре ниже рабочей температуры или равной рабочей температуре или около при 200°C.
99. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, в котором кислота не разлагается при температуре ниже рабочей температуры или равной рабочей температуре или около при 200°C.
100. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, в котором кислота не окисляется при температуре ниже рабочей температуры, или равной рабочей температуре, или около при 200°C.
101. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, который не вызывает коррозии электронной сигареты.
102. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, который является нетоксичным для пользователя электронной сигареты.
103. Жидкий состав на основе соли никотина в электронной сигарете по любому из пп. 57-60, 64-66, 69, 70, содержащий также одну или более дополнительных солей никотина в биологически приемлемом жидком носителе, пригодном для получения вдыхаемого аэрозоля при нагревании.
104. Жидкий состав на основе соли никотина в электронной сигарете по п. 103, в котором вторая кислота, используемая для образования дополнительной соли никотина, выбрана из группы, состоящей из салициловой кислоты, сорбиновой кислоты, бензойной кислоты, пировиноградной кислоты лауриновой кислоты и левулиновой кислоты.
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