WO2022121452A1 - 电子烟液及包含其的雾化装置 - Google Patents

电子烟液及包含其的雾化装置 Download PDF

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WO2022121452A1
WO2022121452A1 PCT/CN2021/120664 CN2021120664W WO2022121452A1 WO 2022121452 A1 WO2022121452 A1 WO 2022121452A1 CN 2021120664 W CN2021120664 W CN 2021120664W WO 2022121452 A1 WO2022121452 A1 WO 2022121452A1
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electronic cigarette
cigarette liquid
liquid
acid
nicotine
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PCT/CN2021/120664
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English (en)
French (fr)
Inventor
李锐
姜兴涛
熊赞华
李馨铎
杨学敏
潘松
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深圳雾芯科技有限公司
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Publication of WO2022121452A1 publication Critical patent/WO2022121452A1/zh

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes

Definitions

  • the present application relates to the field of electronic aerosols or electronic atomization devices, and in particular, to an electronic cigarette liquid and an atomization device including the same.
  • Electronic cigarettes Due to the pursuit of personal health, environmental protection and convenience of use, electronic cigarettes are increasingly favored by consumers as a substitute for traditional tobacco.
  • Electronic cigarettes or electronic atomizers replace the smoke produced by the high-temperature combustion of traditional tobacco by atomizing the smoking material at low temperature to form aerosol for users to inhale.
  • the current e-liquid has a poor throat hit, resulting in a poor smoking experience for users. Therefore, there is a need to develop an electronic cigarette liquid that can improve the user's throat hit feeling while ensuring a sense of satisfaction.
  • the present application provides an electronic cigarette liquid, which can improve the user's throat hit feeling while ensuring a sense of satisfaction, so that the user can obtain a better smoking experience.
  • the present application also provides an electronic cigarette liquid, which can simultaneously improve the user's throat hit and satisfaction, and can also reduce health risks caused by nicotine intake.
  • the present application provides an electronic cigarette liquid comprising nicotine and an organic acid, wherein the molar ratio of the organic acid to the nicotine is 0.1:1 to 2:1, and the organic acid comprises Benzoic acid, levulinic acid and lactic acid.
  • the present application provides an atomizing device, which includes the above electronic cigarette liquid.
  • FIG. 2 is a representative current diagram of acetylcholine receptors induced by the e-cigarette liquid of Example 2.
  • FIG. 2 is a representative current diagram of acetylcholine receptors induced by the e-cigarette liquid of Example 2.
  • the terms “substantially,” “substantially,” “substantially,” and “about” are used to describe and account for small variations. When used in conjunction with an event or circumstance, the terms can refer to instances in which the event or circumstance occurs precisely as well as instances in which the event or circumstance occurs proximately.
  • a term when used in conjunction with a numerical value, a term may refer to a range of variation less than or equal to ⁇ 10% of the numerical value, such as less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, Less than or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%.
  • the difference between two values is less than or equal to ⁇ 10% of the mean of the values (eg, less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, less than or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%), then the two values are considered to be "substantially" the same.
  • a list of items joined by the terms "at least one of,” “at least one of,” “at least one of,” or other similar terms may mean the listed items any combination of .
  • the phrase “at least one of A and B” means A only; B only; or A and B.
  • the phrase "at least one of A, B, and C” means A only; or B only; C only; A and B (excluding C); A and C (excluding B); B and C (excluding A); or all of A, B, and C.
  • Item A may contain a single component or multiple components.
  • Item B may contain a single component or multiple components.
  • Item C may contain a single component or multiple components.
  • the present application provides an electronic cigarette liquid comprising nicotine and an organic acid, wherein the molar ratio of the organic acid to the nicotine is 0.1:1 to 2:1, and the organic acid comprises Benzoic acid, levulinic acid and lactic acid.
  • the ratio of protonated nicotine improves the user's throat hit and smoking experience. Therefore, the molar ratio of the organic acid and nicotine in the electronic cigarette liquid of the present application is about 0.1:1 to about 2:1, which can improve the user's throat hit feeling while ensuring the satisfaction, so that the user can obtain the throat hit feeling and The best suction experience is obtained in the balance of two aspects of satisfaction.
  • the inventor further found that adding a certain proportion of benzoic acid, levulinic acid and lactic acid to the electronic cigarette liquid can further improve the user's throat hit feeling while ensuring a sense of satisfaction. Due to the different boiling point characteristics of the three acids, benzoic acid, levulinic acid, and lactic acid, the heating and volatilization sequences of the three acids in different proportions are different, resulting in different proportions of protonated nicotine and non-protonated nicotine in the aerosol. Affects throat hit. Specifically, benzoic acid, levulinic acid, lactic acid, and nicotine are all independently atomized, and the boiling points of the three acids are different from those of nicotine.
  • the ratio of acid and nicotine combined to form protonated nicotine also varied, and the ratio of the three acids to nicotine combined to form salt varied. Therefore, in the present application, by adjusting the proportions of the three acids, the front, middle, and back segments of the aerosol have the same throat hitting feeling, so that the smoker can obtain a smooth throat hitting feeling.
  • the inventor further found that the molecular structure of benzoic acid, levulinic acid and lactic acid can make the electronic cigarette liquid have a better taste.
  • the molar ratio of organic acid to nicotine is from about 0.1:1 to about 2:1.
  • the molar ratio of organic acid to nicotine may be about 0.1:1, about 0.2:1, about 0.3:1, about 0.4:1, about 0.5:1, about 0.6:1, about 0.7:1, about 0.8:1, about 0.9:1, about 1:1, about 1.1:1, about 1.2:1, about 1.3:1, about 1.4:1, about 1.5:1, about 1.6:1, about 1.7:1, About 1.8:1, about 1.9:1, about 2:1, or a range that can be any two of the above, such as about 0.1:1 to about 0.5:1, about 0.1:1 to about 1:1, about 0.5:1 to about 1.5:1, about 0.5:1 to about 2:1, or about 1:1 to about 2:1.
  • the weight of nicotine is greater than about 0% and less than or equal to about 6% based on the total weight of the e-liquid.
  • the weight of nicotine is about 0%, about 0.5%, about 1%, about 1.5%, about 1.55%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6% or a range that can be composed of any two of the above values, such as less than or equal to about 1.55%, less than or equal to about 3%, About 1.55% to about 3%, about 1% to about 3%, about 0.5% to about 2%, or about 2% to about 6%, and the like.
  • the organic acid comprises benzoic acid, levulinic acid, and lactic acid
  • the molar ratio of benzoic acid, levulinic acid, and lactic acid is (0.5-1.5):(0.1-0.3):(0.5-1.1).
  • the molar ratio of benzoic acid, levulinic acid, and lactic acid may be (0.5-1):(0.1-0.3):(0.5-1) or (0.5-1):(0.1-0.2):( 0.5-1).
  • the molar ratio of benzoic acid, levulinic acid, and lactic acid may be 1.5:0.2:1, 1.5:0.2:0.75, 1:0.2:1, 1:0.2:0.5, 1:0.2:0.75 , 1:0.3:0.75, 1:0.1:0.75, 1:0.2:1.02, 0.5:0.2:1, 0.5:0.2:0.5, 0.5:0.2:0.75, or 0.5:0.1:1, etc.
  • the benzoic acid is present in an amount of about 0.1% to about 0.5% by weight based on the total weight of the e-liquid.
  • the weight of benzoic acid is about 0.1%, about 0.11%, about 0.15%, about 0.18%, about 0.2%, about 0.22%, about 0.25%, about 0.25%, based on the total weight of the e-liquid.
  • about 0.28%, about 0.3%, about 0.33%, about 0.35%, about 0.38%, about 0.4%, about 0.42%, about 0.45%, about 0.48%, or about 0.5% or can be a range of any two of the above values, For example, about 0.11% to about 0.22%, about 0.11% to about 0.33%, or about 0.11% to about 0.45%, and the like.
  • the weight of levulinic acid is about 0.001% to about 0.1%, based on the total weight of the e-liquid, for example, it may be about 0.001%, 0.01%, about 0.02%, about 0.03%, about 0.04% , about 0.05%, about 0.06%, about 0.07%, about 0.08%, about 0.09%, about 0.1%, or can be a range of any two of the above values, such as about 0.001% to about 0.05%, about 0.01% to about 0.05 %, about 0.03% to about 0.07%, about 0.01% to about 0.06%, or about 0.02% to about 0.1%, and the like.
  • the lactic acid is about 0.01% to about 0.5% by weight based on the total weight of the e-liquid, eg, about 0.01%, about 0.05%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.16%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, or about 0.5% or can be a range of any two of the above values, such as about 0.01% to About 0.1%, about 0.08% to about 0.12%, about 0.08% to about 0.165%, about 0.1% to about 0.5%, about 0.01% to about 0.5%, or about 0.08% to about 0.45%.
  • the organic acid may also include at least one additional acid of citric acid, lauric acid, malic acid, or succinic acid in addition to benzoic acid, levulinic acid, and lactic acid.
  • the weight of the at least one additional acid in the e-liquid is from about 0% to about 4.5% by weight of the total e-liquid, eg, about 0%, about 0.1%, about 0.12%, about 0.14%, about 0.15%, about 0.17%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5% %, about 4%, about 4.5%, or can be a range of any two of the above values, such as about 0% to about 1%, about 0.05% to about 0.2%, about 0.1% to about 0.3%, about 0.1% to about 0.5%, about 1% to about 2%, about 0.5% to about 3%, or about 1% to about 4.5%.
  • the present application further provides an electronic cigarette liquid comprising organic acids, nicotine and cotinine, the organic acids comprising benzoic acid, levulinic acid and lactic acid.
  • Cotinine is the main metabolite of nicotine absorbed by the body, and although nicotine and cotinine are very similar in structure, the two compounds have significantly different effects on the nervous system.
  • the inventor's research found that cotinine and nicotine have a synergistic effect, and adding cotinine and nicotine together to e-cigarette liquid can effectively improve the user's sense of satisfaction. Therefore, on the basis of containing nicotine, benzoic acid, levulinic acid and lactic acid, the electronic cigarette liquid of the present application may also contain cotinine, so as to improve the user's throat hit and satisfaction at the same time. In addition, the addition of cotinine to the electronic cigarette liquid of the present application can reduce the amount of nicotine, thereby reducing the user's nicotine intake, thereby reducing the health risk caused by nicotine to the user.
  • the weight of cotinine in the e-liquid is from about 0% to about 4.5% based on the total weight of the e-liquid, for example, it can be about 0%, about 0.1%, about 0.5%, about 1% , about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, 4.5% or can be a range of any two of the above values, such as about 0% to about 1%, about 0% to about 2%, about 0.1% to about 1.5%, about 0.1% to about 3%, about 1% to about 2%, about 1% to about 3%, or about 2% to about 4%, and the like.
  • the molar ratio of cotinine to nicotine is from about 0.1:1 to about 1.5:1.
  • the molar ratio of cotinine to nicotine may be about 0.1:1, about 0.2:1, about 0.3:1, about 0.4:1, about 0.5:1, about 0.6:1, about 0.7:1 , about 0.8:1, about 0.9:1, about 1:1, about 1.1:1, about 1.2:1, about 1.3:1, about 1.4:1, about 1.5:1, or a range that can be any two of the above , for example, about 0.1:1 to about 0.5:1, about 0.1:1 to about 1:1, about 0.5:1 to about 1.5:1, about 0.5:1 to about 1:1, or about 1:1 to about 1.5:1: 1.
  • the weight of nicotine is greater than 0% and less than or equal to 6%
  • the weight of cotinine is greater than 0% and less than or equal to 4.5%
  • benzoic acid levulinic acid
  • the total weight of lactic acid is 0.1% to 1%.
  • the molar ratio of protonated nicotine and non-protonated nicotine in the aerosol generated by the heating and atomization of electronic cigarette liquid is about 1:0.1 to about 1:2.5, for example, it may be about 1:0.1, about 1:0.2, about 1:0.3, about 1:0.4, about 1:0.5, about 1:0.6, about 1:0.7, about 1:0.8, about 1:0.9, about 1:1, about 1:1.2, about 1:1.5, about 1:0.7, about 1:2, 1:2.2, 1:2.5, or a range that can be any two of the above, such as about 1:0.1 to about 1:0.5, about 1:0.1 to about 1 :1, about 1:0.1 to about 1:1.5 or about 1:0.1 to about 1:2.
  • the e-liquid further includes a cooling agent.
  • the cooling agent includes menthol, menthone, isomenthone, isopulegol, menthyl acetate, menthyl lactate, WS-23(N,2,3-trimethyl-2-isopulegol) propylbutanamide), WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-5 (N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS- At least one of 12 (N-(4-methoxyphenyl)-p-menthyl-3-carboxamide).
  • the weight of the cooling agent in the e-liquid may be about 0.001% to about 10% by weight of the total e-liquid, such as about 0.001%, about 0.01%, about 0.05%, about 0.1%, About 0.5%, about 1%, about 1.5%, about 3%, about 5%, about 5%, about 7%, about 10%, or a range that can be any two of the above, such as about 0.001% to about 1% , about 0.001% to about 5%, about 0.01% to about 1%, about 0.01% to about 10%, about 0.1% to about 5%, about 0.1% to about 10%, or about 1% to about 10%.
  • the e-liquid further includes a flavor.
  • the flavor includes, but is not limited to, grape flavor, apple flavor, peach flavor, green tea flavor, mint flavor and other commercially available edible flavors.
  • the fragrance may include d-limonene, benzyl alcohol, ethyl butyrate, linalool, isobutyl acetate, isoamyl acetate, benzyl benzoate, leaf alcohol, ethyl propionate, lemon Aldehyde, ⁇ -decalactone, decanal, ethyl acetate, ethyl 2-methylbutyrate, 2-methylbutyl acetate, 2-methylbutanal, myrcene, ethyl hexanoate, peach aldehyde, At least one of ethyl isovalerate, leaf alcohol acetate, acetic acid and benzaldehyde.
  • the weight of the flavor in the e-liquid is about 0.001% to about 10% based on the total weight of the e-liquid, for example, it may be about 0.001%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, about 1%, about 3%, about 5%, about 7%, about 10%, or can be a range of any two of the above values, such as about 0.001% to about 1%, about 0.01% to about 1%, About 0.01% to about 5%, about 0.01% to about 10%, about 0.1% to about 5%, about 0.1% to about 10%, or about 1% to about 10%.
  • the electronic cigarette liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerol).
  • the weight percentage of propylene glycol in the e-liquid is about 15% to 60%, for example, it can be about 15%, about 20%, about 25%, about 30%, About 35%, about 40%, about 50%, about 60%, or can be a range of any two of the above values, such as about 15% to 30%, about 20% to 50%, or about 30% to 60%.
  • the weight percentage of glycerol in the e-liquid may be about 30% to about 70%, for example, it may be about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70% or can be a range of any two of the above values, such as about 30% to 50%, about 40% to 60% or about 50% to 70%.
  • the weight percent of propylene glycol in the e-liquid is about 20% to about 60%, and the weight percent of glycerol in the e-liquid is about 40% to about 70%, so that the e-liquid To achieve the best atomization effect and improve user experience.
  • the base solvent may select any solvent known in the art according to specific requirements, for example, deionized water, propylene glycol, glycerol, and is not limited thereto.
  • the present application provides a method for preparing electronic cigarette liquid, which comprises the following steps: adding benzoic acid, levulinic acid, lactic acid and nicotine to the basic vaping liquid in a specific ratio in the range provided by the embodiment, Mix it well to get e-liquid.
  • benzoic acid, levulinic acid, lactic acid, nicotine, cotinine, essence and/or cooling agent are added to the base liquid in a certain proportion, and are uniformly mixed to obtain the electronic liquid.
  • the present application provides an atomizing device comprising the electronic cigarette liquid according to any one of the above embodiments.
  • the electronic cigarette liquid can be atomized by the atomizing device to generate aerosol for inhalation by the user.
  • the atomizing device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
  • Propylene glycol, glycerol, cooling agent and essence are prepared in the following weight ratio (53.5:44:2:0.5) and mixed evenly to obtain basic smoke liquid.
  • the cooling agent is WS-23, and the essence is grape essence.
  • the nicotine, benzoic acid, levulinic acid, lactic acid (and optional cotinine) are mixed uniformly and added to the base e-liquid to obtain the e-liquid for testing.
  • the respective weights of nicotine, benzoic acid, levulinic acid, lactic acid (and optionally cotinine) in the e-liquids of each comparative example and example are shown in Table 1 below.
  • Example 12 also had succinic acid added.
  • electrophysiological test and taste score test are carried out subsequently.
  • the electrophysiological test results are shown in Figure 1, and the taste score test results are shown in Table 2 below.
  • Electrodes were co-transfected with acetylcholine receptor ⁇ 4 and ⁇ 2 subunits, and electrophysiological experiments were performed after 24 hours of culture.
  • an electrode puller PP-10, Narishige
  • an electrode was obtained by two-step pulling, and the electrode was injected with ordinary potassium inner solution (KCl 120mM, NaCl 30mM, HEPES 10mM, CaCl 2 0.5mM, MgCl 2 1mM, EGTA 5mM, After adjusting the pH to 7.2 using Tris-base and using it after filtration), the water entry resistance was 3–5 M ⁇ .
  • the formula of extracellular fluid is NaCl 150mM, glucose (Glucose.H 2 O) 10 mM, HEPES 10 mM, CaCl 2 2 mM, KCl 5 mM, MgCl 2 1 mM, and the pH was adjusted to 7.4 using Tris-base. All whole-cell currents were recorded using Clampfit in voltage-clamp mode using an Axon 200B amplifier. The clamping voltage is -60mv, the sampling frequency is 10kHz, and the filtering is performed under the condition of 2kHz. The way of administration is to administer twice on the same cell. The first administration was 100 ⁇ M acetylcholine (Ach), and the magnitude of the inward current induced by it was used as a pre-control.
  • the second administration is the dilution of electronic cigarette liquid of different embodiments or comparative examples (the electronic cigarette liquid of both the embodiment and the comparative example is diluted 10,000 times).
  • the current generated by the second administration is compared with the current caused by the first Ach, that is, the normalized current of different examples or comparative examples.
  • FIG. 2 is a representative current diagram of the acetylcholine receptor induced by the e-cigarette liquid of Example 2.
  • Statistical method randomly select 1000 users to use electronic cigarettes to test the e-liquids of the above embodiments and comparative examples, and evaluate their satisfaction and throat hit after the use test, and the evaluation standard is based on a total score of 10 points. , the better the satisfaction or the better the throat hit, the higher the score.
  • Examples 1 to 3 It can be seen from Examples 1 to 3 that cotinine is added to the electronic cigarette liquids of Examples 2 and 3, and the electrophysiological experimental data values are relatively large. Nicotine binds to acetylcholine receptors under the synergistic effect of cotinine and induces them to produce more dopamine, ie, to generate a greater inward current.
  • the electronic cigarette liquid of the present application can effectively improve the throat hit feeling of the electronic cigarette liquid and further enhance the satisfaction by adding nicotine and organic acids and controlling their proportions. Therefore, the electronic cigarette liquid of the present application not only brings a sense of satisfaction to the user, but also brings an appropriate feeling of throat hitting, and the smoking experience is better.
  • the electronic cigarette liquid of the present application improves the user's sense of satisfaction and reduces the dosage of nicotine, thereby reducing the health risk caused by nicotine intake.

Abstract

一种电子烟液，包含尼古丁和有机酸，其中有机酸与尼古丁的摩尔比为0.1:1至2:1，该有机酸包含苯甲酸、乙酰丙酸和乳酸。该电子烟液可以有效地提升使用者的满足感和击喉感，使使用者获得较好的抽吸体验。此外，提供了一种包含该电子烟液的雾化装置。

Description

电子烟液及包含其的雾化装置 技术领域
本申请涉及电子气雾剂或电子雾化装置的领域，尤其涉及一种电子烟液及包含其的雾化装置。
背景技术
由于对于个人健康、环境保护以及使用便利性的追求，电子烟作为传统烟草的取代品越来越受到消费者的青睐。电子烟或电子雾化器通过将发烟材料低温雾化形成用于使用者吸入的气雾，来取代传统烟草以高温燃烧的方式所产生的烟气。
当前电子烟液的击喉感较差，导致使用者的抽吸体验不佳。因此，需要开发一种可以在确保满足感的同时提升使用者的击喉感的电子烟液。
发明内容
本申请提供了一种电子烟液，所述电子烟液可以在保证满足感的同时提升使用者的击喉感，使使用者获得较好的抽吸体验。
本申请还提供了一种电子烟液，所述电子烟液可以同时提升使用者的击喉感和满足感，并且还可以减少由于尼古丁的摄入所带来的健康风险。
根据本申请的实施例，本申请提供了一种电子烟液，其包含尼古丁和有机酸，其中所述有机酸与所述尼古丁的摩尔比为0.1:1至2:1，所述有机酸包含苯甲酸、乙酰丙酸和乳酸。
根据本申请的又一实施例，本申请提供了一种雾化装置，其包含上述电子烟液。
本申请实施例的额外层面及优点将部分地在后续说明中描述、显示、或是经由本申请实施例的实施而阐释。
附图说明
在下文中将简要地说明为了描述本申请实施例或现有技术所必要的附图以便于描述本申请的实施例。显而易见地，下文描述中的附图仅只是本申请中的部分实施例。对本领域技术人员而言，在不需要创造性劳动的前提下，依然可以根据这些附图中所例示的结构来获得其他实施例的附图。
图1为对比例1至4和实施例1至3的电生理测试结果。
图2为实施例2的电子烟液引起的乙酰胆碱受体代表性电流图。
具体实施方式
本申请的实施例将会被详细的描示在下文中。本申请的实施例不应所述被解释为对本申请的限制。
另外，有时在本文中以范围格式呈现量、比率和其它数值。应理解，此类范围格式是用于便利及简洁起见，且应灵活地理解，不仅包含明确地指定为范围限制的数值，而且包含涵盖于所述范围内的所有个别数值或子范围，如同明确地指定每一数值及子范围一般。
如本文中所使用，术语“大致”、“大体上”、“基本上”及“约”用以描述及说明小的变化。当与事件或情形结合使用时，所述术语可指代其中事件或情形精确发生的例子以及其中事件或情形极近似地发生的例子。举例来说，当结合数值使用时，术语可指代小于或等于所述数值的±10％的变化范围，例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％。举例来说，如果两个数值之间的差值小于或等于所述值的平均值的±10％(例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％)，那么可认为所述两个数值“基本上”相同。
在具体实施方式及权利要求书中，由术语“中的至少一者”、“中的至少一个”、“中的至少一种”或其他相似术语所连接的项目的列表可意味着所列项目的任何组合。例如，如果列出项目A及B，那么短语“A及B中的至少一者”意味着仅A；仅B；或A及B。在另一实例中，如果列出项目A、B及C，那么短语“A、B及C中的至少一者”意味着仅A；或仅B；仅C；A及B(排除C)；A及C(排除B)；B及C(排除A)；或A、B及C的全部。项目A可包含单个组分或多个组分。项目B可包含单个组 分或多个组分。项目C可包含单个组分或多个组分。
若无特别说明，本申请中所用的物质均可商业化购得。
根据本申请的一个方面，本申请提供了一种电子烟液，其包含尼古丁和有机酸，其中所述有机酸与所述尼古丁的摩尔比为0.1:1至2:1，所述有机酸包含苯甲酸、乙酰丙酸和乳酸。
发明人发现，过量的有机酸会导致击喉感下降，但是会使较多尼古丁质子化，从而使尼古丁容易透过血脑屏障，提升满足感；较少量的有机酸会提升气溶胶中非质子化尼古丁的比例，提升使用者的击喉感和抽吸体验。因此，本申请电子烟液中的有机酸与尼古丁的摩尔比为约0.1:1至约2:1，在保证满足感的同时提升使用者的击喉感，使使用者在获得击喉感和满足感两方面平衡中获得最佳抽吸体验。
发明人进一步发现，将一定比例的苯甲酸、乙酰丙酸和乳酸添加到电子烟液中可以在保证满足感的同时进一步提升使用者的击喉感。由于苯甲酸、乙酰丙酸、乳酸这三种酸的沸点特性不同，因此不同比例的三种酸加热挥发的先后顺序不同，从而导致气溶胶中质子化尼古丁和非质子化尼古丁的比例不同，进而影响击喉感。具体而言，苯甲酸、乙酰丙酸、乳酸和尼古丁均为独立雾化，三种酸的沸点与尼古丁的沸点有差别，加热挥发产生的气溶胶中的前中后段的酸的含量不同，酸和尼古丁结合形成质子化尼古丁的比例也有所不同，三种酸和尼古丁结合成盐的比例有所不同。因此，本申请通过调整三种酸的比例使得气溶胶的前中后段的击喉感相当，使抽吸者获得顺滑的击喉感。另外，发明人进一步发现，苯甲酸、乙酰丙酸和乳酸的分子结构可以使电子烟液具有较好的口感。
在一些实施例中，有机酸与尼古丁的摩尔比为约0.1:1至约2:1。在一些实施例中，有机酸与尼古丁的摩尔比可以为约0.1:1、约0.2:1、约0.3:1、约0.4:1、约0.5:1、约0.6:1、约0.7:1、约0.8:1、约0.9:1、约1:1、约1.1:1、约1.2:1、约1.3:1、约1.4:1、约1.5:1、约1.6:1、约1.7:1、约1.8:1、约1.9:1、约2:1或可以为以上任意两数值组成的范围，例如约0.1:1至约0.5:1、约0.1:1至约1:1、约0.5:1至约1.5:1、约0.5:1至约2:1或约1:1至约2:1。
在一些实施例中，以电子烟液的总重计，尼古丁的重量大于约0％且小于等于约6％。例如，在一些实施例中，以电子烟液的总重计，尼古丁的重量为约0％、约0.5％、约1％、约1.5％、约1.55％、约2％、约2.5％、约3％、约3.5％、约4％、约4.5％、约5％、约5.5％、约6％或可以为以上任意两数值组成的范围，例如小于等于约1.55％、小于等于 约3％、约1.55％-约3％、约1％-约3％、约0.5％-约2％或约2％-约6％等。
在一些实施例中，有机酸包含苯甲酸、乙酰丙酸和乳酸，苯甲酸、乙酰丙酸和乳酸的摩尔比为(0.5-1.5):(0.1-0.3):(0.5-1.1)。在一些实施例中，苯甲酸、乙酰丙酸和乳酸的摩尔比可以为(0.5-1):(0.1-0.3):(0.5-1)或(0.5-1):(0.1-0.2):(0.5-1)。例如，在一些实施例中，苯甲酸、乙酰丙酸和乳酸的摩尔比可以为1.5:0.2:1、1.5:0.2:0.75、1:0.2:1、1:0.2:0.5、1:0.2:0.75、1:0.3:0.75、1:0.1:0.75、1:0.2:1.02、0.5:0.2:1、0.5:0.2:0.5、0.5:0.2:0.75或0.5:0.1:1等。
在一些实施例中，以电子烟液的总重计，苯甲酸的重量为约0.1％至约0.5％。例如，在一些实施例中，以电子烟液的总重计，苯甲酸的重量为约0.1％、约0.11％、约0.15％、约0.18％、约0.2％、约0.22％、约0.25％、约0.28％、约0.3％、约0.33％、约0.35％、约0.38％、约0.4％、约0.42％、约0.45％、约0.48％或约0.5％或可以为以上任意两数值组成的范围，例如约0.11％至约0.22％、约0.11％至约0.33％或约0.11％至约0.45％等。
在一些实施例中，以电子烟液的总重计，乙酰丙酸的重量为约0.001％至约0.1％，例如可以为约0.001％、0.01％、约0.02％、约0.03％、约0.04％、约0.05％、约0.06％、约0.07％、约0.08％、约0.09％、约0.1％或可以为以上任意两数值组成的范围，例如约0.001％至约0.05％、约0.01％至约0.05％、约0.03％至约0.07％、约0.01％至约0.06％或约0.02％至约0.1％等。
在一些实施例中，以电子烟液的总重计，乳酸的重量为约0.01％至约0.5％，例如，约0.01％、约0.05％、约0.08％、约0.1％、约0.12％、约0.15％、约0.16％、约0.2％、约0.25％、约0.3％、约0.35％、约0.4％、约0.45％或约0.5％或可以为以上任意两数值组成的范围，例如约0.01％至约0.1％、约0.08％至约0.12％、约0.08％至约0.165％、约0.1％至约0.5％、约0.01％至约0.5％或约0.08％至约0.45％。
在一些实施例中，在苯甲酸、乙酰丙酸和乳酸的基础上，有机酸还可以包括柠檬酸、月桂酸、苹果酸或琥珀酸中的至少一种额外酸。发明人发现，通过电子烟液中的有机酸种类的合理搭配，可以使产生的质子化尼古丁在气溶胶中分布更均衡。
在一些实施例中，所述至少一种额外酸在电子烟液中的重量以电子烟液总重计为约0％至约4.5％，例如，约0％、约0.1％、约0.12％、约0.14％、约0.15％、约0.17％、约0.2％、约0.3％、约0.4％、约0.5％、约1％、约1.5％、约2％、约2.5％、约3％、约3.5％、约4％、约4.5％或可以为以上任意两数值组成的范围，例如约0％至约1％、约0.05％至约0.2％、约0.1％至约0.3％、约0.1％至约0.5％、约1％至约2％、约0.5％至约3％或约 1％至约4.5％。
根据本申请的另一个方面，本申请进一步提供了一种电子烟液，其包含有机酸、尼古丁和可替宁，所述有机酸包含苯甲酸、乙酰丙酸和乳酸。
可替宁是尼古丁被人体吸收后的主要代谢物，尽管尼古丁和可替宁在结构上非常相似，但这两种化合物对神经系统的影响却有显著不同。
发明人研究发现，可替宁与尼古丁具有协同作用，将可替宁与尼古丁一起加入电子烟液中，可以有效地提升使用者的满足感。因此，在包含尼古丁、苯甲酸、乙酰丙酸和乳酸的基础上，本申请的电子烟液还可以包含可替宁，以同时提升使用者的击喉感和满足感。并且，本申请的电子烟液因可替宁的加入可以减少尼古丁的用量，因此降低了使用者的尼古丁摄入量，从而减少尼古丁对使用者造成的健康风险。
在一些实施例中，可替宁在电子烟液中的重量以电子烟液总重计为约0％至约4.5％，例如可以为约0％、约0.1％、约0.5％、约1％、约1.5％、约2％、约2.5％、约3％、约3.5％、约4％、4.5％或可以为以上任意两数值组成的范围，例如约0％至约1％、约0％至约2％、约0.1％至约1.5％、约0.1％至约3％、约1％至约2％、约1％至约3％或约2％至约4％等。
在一些实施例中，可替宁与尼古丁的摩尔比为约0.1:1至约1.5:1。在一些实施例中，可替宁与尼古丁的摩尔比可以为约0.1:1、约0.2:1、约0.3:1、约0.4:1、约0.5:1、约0.6:1、约0.7:1、约0.8:1、约0.9:1、约1:1、约1.1:1、约1.2:1、约1.3:1、约1.4:1、约1.5:1或可以为以上任意两数值组成的范围，例如约0.1:1至约0.5:1、约0.1:1至约1:1、约0.5:1至约1.5:1、约0.5:1至约1:1或约1:1至约1.5:1。
在一些实施例中，以电子烟液的总重计，尼古丁的重量为大于0％且小于等于6％，可替宁的重量为大于0％且小于等于4.5％，苯甲酸、乙酰丙酸和乳酸的总重量为0.1％至1％。
在一些实施例中，在电子烟液加热雾化产生的气溶胶中，质子化尼古丁和非质子化尼古丁的摩尔比为约1:0.1至约1:2.5，例如可以为约1:0.1、约1:0.2、约1:0.3、约1:0.4、约1:0.5、约1:0.6、约1:0.7、约1:0.8、约1:0.9、约1:1、约1:1.2、约1:1.5、约1:0.7、约1:2、1:2.2、1:2.5或可以为以上任意两数值组成的范围，例如约1:0.1至约1:0.5、约1:0.1至约1:1、约1:0.1至约1:1.5或约1:0.1至约1:2。
在一些实施例中，电子烟液进一步包括凉味剂。在一些实施例中，凉味剂包括薄荷 脑、薄荷酮、异薄荷酮、异胡薄荷醇、乙酸薄荷酯、乳酸薄荷酯、WS-23(N,2,3-三甲基-2-异丙基丁酰胺)、WS-3(N-乙基-对薄荷基-3-甲酰胺)、WS-5(N-(乙氧羰基甲基)-对烷-3-甲酰胺)、WS-12(N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺)中的至少一种。
在一些实施例中，凉味剂在电子烟液中的重量以电子烟液总重计可以为约0.001％至约10％，例如约0.001％、约0.01％、约0.05％、约0.1％、约0.5％、约1％、约1.5％、约3％、约5％、约5％、约7％、约10％或可以为以上任意两数值组成的范围，例如约0.001％至约1％、约0.001％至约5％、约0.01％至约1％、约0.01％至约10％、约0.1％至约5％、约0.1％至约10％或约1％至约10％。
在一些实施例中，电子烟液进一步包括香精。在一些实施例中，该香精包括但不限于葡萄香精、苹果香精、桃子香精、绿茶香精、薄荷香精等可商业化购买的食用香精。
在一些实施例中，香精可以包括d-苧烯、苯甲醇、丁酸乙酯、芳樟醇、乙酸异丁酯、乙酸异戊酯、苯甲酸苄酯、叶醇、丙酸乙酯、柠檬醛、γ-癸内酯、癸醛、乙酸乙酯、2-甲基丁酸乙酯、乙酸2-甲基丁酯、2-甲基丁醛、月桂烯、己酸乙酯、桃醛、异戊酸乙酯、乙酸叶醇酯、乙酸、苯甲醛中的至少一种。
在一些实施例中，香精在电子烟液中的重量以电子烟液总重计为约0.001％至约10％，例如可以为约0.001％、约0.01％、约0.05％、约0.1％、约0.5％、约1％、约3％、约5％、约7％、约10％或可以为以上任意两数值组成的范围，例如约0.001％至约1％、约0.01％至约1％、约0.01％至约5％、约0.01％至约10％、约0.1％至约5％、约0.1％至约10％或约1％至约10％。
电子烟液还包含基础溶剂，其中基础溶剂包含丙二醇及丙三醇(甘油)。在一些实施例中，以电子烟液总重计，丙二醇在电子烟液中的重量百分比为约15％至60％，例如可以为约15％、约20％、约25％、约30％、约35％、约40％、约50％、约60％或可以为以上任意两数值组成的范围，例如约15％至30％、约20％至50％或约30％至60％。在一些实施例中，以电子烟液总重计，丙三醇在电子烟液中的重量百分比可以为约30％至约70％，例如可以为约30％、约35％、约40％、约45％、约50％、约55％、约60％、约65％、约70％或可以为以上任意两数值组成的范围，例如约30％至50％、约40％至60％或约50％至70％。
在一些实施例中，丙二醇在电子烟液中的重量百分比为约20％至约60％，且丙三醇在电子烟液中的重量百分比为约40％至约70％，以使电子烟液达到最佳的雾化效果， 提高使用者体验。
本领域技术人员应理解，基础溶剂可以根据具体需求选择本领域任何已知的溶剂，例如，去离子水、丙二醇、丙三醇，而不受其限制。
根据本申请一些实施例，本申请提供电子烟液的制备方法，其包含以下步骤：将苯甲酸、乙酰丙酸、乳酸和尼古丁按实施例提供的范围中的特定比例加入至基础烟液中，使其均匀混合以获得电子烟液。在一些实施例中，将苯甲酸、乙酰丙酸、乳酸、尼古丁、可替宁、香精和/或凉味剂按一定比例加入至基础烟液中，使其均匀混合以获得电子烟液。
根据本申请的另一个方面，本申请提供一种雾化装置，其包含上述任一实施例所述的电子烟液。所述电子烟液可通过所述雾化装置雾化生成供使用者吸入的气雾。
在一些实施例中，所述雾化装置包括电子烟、超声雾化器或网式雾化器。
实施例
为便于更好地理解本申请，通过以下实例加以说明。这些实例属于本申请的保护范围，但不限制本申请的保护范围。
基础烟液的制备：
将丙二醇、丙三醇、凉味剂和香精按以下重量比(53.5:44:2:0.5)调配后混合均匀，以获得基础烟液。
其中凉味剂为WS-23，香精为葡萄香精。
电子烟液的制备：
将尼古丁、苯甲酸、乙酰丙酸、乳酸(和任选的可替宁)混合均匀后加入到基础烟油中得测试用电子烟液。各对比例和实施例的电子烟液中的尼古丁、苯甲酸、乙酰丙酸、乳酸(和任选的可替宁)的各自重量如下表1所示。实施例12还添加有琥珀酸。
上述对比例和实施例的电子烟液完成后，随后进行电生理测试和口感评分测试。电生理测试结果如图1所示，口感评分测试结果如下表2所示。
电生理测试方法：
细胞共转染乙酰胆碱受体α4和β2亚基，培养24h后进行电生理实验。使用电极拉制仪(PP-10，Narishige)，通过两步法拉制得到电极，电极中注入普通钾内液(KCl 120mM,NaCl 30mM,HEPES 10mM,CaCl 2 0.5mM,MgCl 2 1mM,EGTA 5mM,使用 Tris-base调节pH至7.2，过滤后使用)后，入水电阻为3–5MΩ。细胞外液配方为NaCl150mM,葡萄糖(Glucose.H 2O)10mM,HEPES 10mM,CaCl 2 2mM,KCl 5mM,MgCl 21mM,使用Tris-base调节pH至7.4。所有全细胞电流均是使用Axon 200B放大器，在电压钳模式下使用Clampfit记录得到。钳制电压为-60mv，采样频率为10kHz,在2kHz条件下进行滤波。给药方式采取在同一个细胞上面两次给药的方式。第一次给药为100μM乙酰胆碱(Ach)，以其诱导的内向电流大小做为前对照。第二次给药为不同实施例或对比例的电子烟液稀释物(实施例和对比例的电子烟液均采取一万倍稀释)。以第二次给药产生的电流比上第一次Ach引起的电流，即为不同实施例或对比例的归一化的电流。图2为实施例2的电子烟液引起的乙酰胆碱受体代表性电流图。
口感评分测试方法：
统计方法：随机选取1000使用者通过电子烟对上述实施例和对比例的电子烟液进行使用测试，待使用测试后对其满足感及击喉感进行评价，其中评价标准以总分10分计，满足感越好或击喉感越好则分数越高。
表1
Figure PCTCN2021120664-appb-000001
Figure PCTCN2021120664-appb-000002
Figure PCTCN2021120664-appb-000003
(表1中的“-”表示不适用)。
表2
  满足感 击喉感
对比例1 9 3
对比例2 5 2
对比例3 6 1
对比例4 5.1 8
对比例5 5.4 7
对比例6 5.6 6
实施例1 6.8 7
实施例2 7 7
对比例7 9.5 3
实施例3 7.5 7
实施例4 4.5 10
实施例5 6.7 5.8
实施例6 5 9
实施例7 5.1 8
实施例8 4.7 9
实施例9 7.3 7
实施例10 5.3 7.5
实施例11 6.4 6.1
实施例12 7.7 5.1
对比例8 8 0
对比例9 3.9 10
根据对比例4至对比例6以及实施例1至实施例9可以得知，当电子烟液中的有机酸与尼古丁的摩尔比在0.1:1至2:1范围内，选择合适比例的苯甲酸、乙酰丙酸和乳酸可以给使用者带来满足感的同时带来适当的击喉感，抽吸体验较好。
从实施例1至实施例3可以看出，实施例2和实施例3的电子烟液中添加有可替宁，电生理实验数据值较大，这是由于实施例2和实施例3中的尼古丁在可替宁的协同作用下与乙酰胆碱受体结合并诱导其产生较多的多巴胺，即，产生较大的内向电流。
本申请的电子烟液通过添加尼古丁和有机酸并控制它们的比例，可以有效地改善电子烟液的击喉感，并进一步提升满足感。因此，本申请的电子烟液在给使用者带来满足感的同时带来适当的击喉感，抽吸体验较好。
本申请的电子烟液通过添加可替宁和尼古丁提高了使用者的满足感，减少了尼古丁定的用量，从而可以减少尼古丁摄入所带来的健康风险。
整个说明书中对“一些实施例”、“部分实施例”、“一个实施例”、“另一举例”、“举例”、“具体举例”或“部分举例”的引用，其所代表的意思是在本申请中的至少一个实施例或举例包含了该实施例或举例中所描述的特定特征、结构、材料或特性。因此，在整个说明书中的各处所出现的描述，例如：“在一些实施例中”、“在实施例中”、“在一个实施例中”、“在另一个举例中”，“在一个举例中”、“在特定举例中”或“举例“，其不必然是引用本申请中的相同的实施例或示例。此外，本文中的特定特征、结构、材料或特性可以以任何合适的方式在一个或多个实施例或举例中结合。
尽管已经演示和描述了说明性实施例，本领域技术人员应该理解上述实施例不能被解释为对本申请的限制，并且可以在不脱离本申请的精神、原理及范围的情况下对实施例进行改变，替代和修改。

Claims (16)

  1. 一种电子烟液，其包含尼古丁和有机酸，其中所述有机酸与所述尼古丁的摩尔比为0.1:1至2:1，所述有机酸包含苯甲酸、乙酰丙酸和乳酸。
  2. 根据权利要求1所述的电子烟液，其中以所述电子烟液的总重计，所述尼古丁的重量为大于0％且小于等于6％。
  3. 根据权利要求1所述的电子烟液，其中所述苯甲酸、所述乙酰丙酸和所述乳酸的摩尔比为(0.5-1.5):(0.1-0.3):(0.5-1.1)。
  4. 根据权利要求1所述的电子烟液，其中以所述电子烟液的总重计，所述苯甲酸的重量为0.1％至0.5％。
  5. 根据权利要求1所述的电子烟液，其中以所述电子烟液的总重计，所述乙酰丙酸的重量为0.001％至0.1％。
  6. 根据权利要求1所述的电子烟液，其中以所述电子烟液的总重计，所述乳酸的重量为0.01％至0.5％。
  7. 根据权利要求1所述的电子烟液，其中所述电子烟液还包括可替宁，以所述电子烟液的总重计，所述可替宁的重量为大于0％且小于等于4.5％。
  8. 根据权利要求7所述的电子烟液，其中所述可替宁与所述尼古丁的摩尔比为0.1:1至1.5:1。
  9. 根据权利要求1所述的电子烟液，其中在所述电子烟液加热雾化产生的气溶胶中，质子化尼古丁和非质子化尼古丁的摩尔比为1:0.1至1:2.5。
  10. 根据权利要求1所述的电子烟液，其中所述电子烟液还包含柠檬酸、月桂酸、苹果酸或琥珀酸中的至少一种。
  11. 根据权利要求1所述的电子烟液，其中所述电子烟液进一步包含凉味剂，其中所述凉味剂包括薄荷脑、薄荷酮、异薄荷酮、异胡薄荷醇、乙酸薄荷酯、乳酸薄荷酯、WS-23、WS-3、WS-5中的至少一种。
  12. 根据权利要求11所述的电子烟液，其中所述凉味剂在所述电子烟液中的重量以所述电子烟液总重计为0.001％至10％。
  13. 根据权利要求1所述的电子烟液，其中所述电子烟液进一步包含香精，其中所述香精包 括d-苧烯、苯甲醇、丁酸乙酯、芳樟醇、乙酸异丁酯、乙酸异戊酯、苯甲酸苄酯、叶醇、丙酸乙酯、柠檬醛、γ-癸内酯、癸醛、乙酸乙酯、2-甲基丁酸乙酯、乙酸2-甲基丁酯、2-甲基丁醛、月桂烯、己酸乙酯、桃醛、异戊酸乙酯、乙酸叶醇酯、乙酸或苯甲醛中的至少一种。
  14. 根据权利要求13所述的电子烟液，其中所述香精在所述电子烟液中的重量以所述电子烟液总重计为0.001％至10％。
  15. 一种雾化装置，其包含权利要求1至14中任一权利要求所述的电子烟液。
  16. 根据权利要求15所述的雾化装置，其中所述雾化装置包括电子烟、超声雾化器或网式雾化器。
PCT/CN2021/120664 2020-12-07 2021-09-26 电子烟液及包含其的雾化装置 WO2022121452A1 (zh)

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