WO2021042269A1 - 电子烟液 - Google Patents

电子烟液 Download PDF

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Publication number
WO2021042269A1
WO2021042269A1 PCT/CN2019/104226 CN2019104226W WO2021042269A1 WO 2021042269 A1 WO2021042269 A1 WO 2021042269A1 CN 2019104226 W CN2019104226 W CN 2019104226W WO 2021042269 A1 WO2021042269 A1 WO 2021042269A1
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WIPO (PCT)
Prior art keywords
cigarette liquid
electronic cigarette
gastrodin
liquid
aerosol
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PCT/CN2019/104226
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English (en)
French (fr)
Inventor
许静
姜兴涛
李馨铎
熊赞华
Original Assignee
深圳雾芯科技有限公司
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Priority to PCT/CN2019/104226 priority Critical patent/WO2021042269A1/zh
Publication of WO2021042269A1 publication Critical patent/WO2021042269A1/zh

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Definitions

  • This application relates to the field of electronic aerosols or electronic atomization devices, and in particular to an electronic cigarette liquid.
  • Traditional tobacco smoking has many possible side effects, causing various diseases such as pharyngitis, bronchitis, pneumonia, emphysema, asthma, lung cancer, cardiovascular disease, gastric cancer, and decreased fertility.
  • the smoke generated by traditional tobacco burning at high temperatures often causes an inflammatory response in the user's throat due to excessively high temperature, and the irritating substances released by it may cause the user to be in a state of alertness or excitement.
  • Excessive consumption of traditional tobacco products may cause side effects such as nausea, dizziness, and vomiting among users. In severe cases, it can cause diseases such as bronchitis.
  • the low-temperature atomization in the electronic cigarette liquid is not easy to produce harmful substances such as tar, suspended particles and carbon monoxide that are harmful to human health.
  • harmful substances such as tar, suspended particles and carbon monoxide that are harmful to human health.
  • the harm to users and others is far less than the harm of traditional cigarettes to the human body. Therefore, electronic cigarettes and electronic atomization devices have attracted more and more attention.
  • the present application provides an e-cigarette liquid containing gastrodin.
  • the gas mist generated by the atomization device for the user to inhale the electronic cigarette liquid contains gastrodin and can be absorbed by the human body to play a health care effect.
  • the e-cigarette liquid can reduce the side effects such as inflammation and nausea caused by the user when inhaling the e-cigarette liquid.
  • By inhaling the gastrodin present in the aerosol it can provide the user with a relief and sedative effect, thereby improving the user The experience of using e-cigarette liquid.
  • the present application provides an e-cigarette liquid comprising gastrodin, wherein the weight of the gastrodin in the e-cigarette liquid is about 0.1% to about 0.1% to the total weight of the e-cigarette liquid. About 10%.
  • the present application provides an atomization device, which includes the above-mentioned e-cigarette liquid.
  • the e-cigarette liquid of the present application can relieve symptoms of neurasthenia, insomnia, and headache, and can inhibit side effects such as inflammation, nausea, and excitement during the inhalation process of the messenger. At the same time, it has a protective effect on the liver and can reduce the liver's effects on material metabolism. Burden, and then enhance the user experience.
  • Fig. 1A is a chromatogram of the gastrodin content of the e-cigarette liquid according to an embodiment of the present application.
  • Fig. 1B is a chromatogram of the gastrodin content of the aerosol generated by the electronic cigarette liquid according to an embodiment of the present application.
  • the terms “substantially”, “substantially”, “substantially”, “substantially” and “about” are used to describe and illustrate small changes. When used in conjunction with an event or situation, the term can refer to an example in which the event or situation occurs precisely and an example in which the event or situation occurs very closely.
  • the term when used in conjunction with a value, can refer to a range of variation less than or equal to ⁇ 10% of the stated value, such as less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, Less than or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%.
  • the difference between two values is less than or equal to ⁇ 10% of the average value of the value (for example, less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, less than Or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%), then the two values can be considered "substantially" the same.
  • a list of items connected by the terms “at least one of”, “at least one of”, “at least one of” or other similar terms may mean the listed items Any combination of. For example, if items A and B are listed, then the phrase “at least one of A and B” means only A; only B; or A and B. In another example, if items A, B, and C are listed, then the phrase "at least one of A, B, and C” means only A; or only B; only C; A and B (excluding C); A and C (exclude B); B and C (exclude A); or all of A, B, and C.
  • Project A can contain a single element or multiple elements.
  • Project B can contain a single element or multiple elements.
  • Project C can contain a single element or multiple elements.
  • aerosol for user inhalation may include, but is not limited to, aerosols, suspended liquids, low-temperature vapors, and volatile gases.
  • the present application provides an electronic cigarette liquid containing gastrodin, which can have various beneficial effects such as anti-inflammatory, analgesic, sedation and the like while inhaling the atomized electronic cigarette liquid.
  • the present application provides an electronic cigarette liquid, which contains gastrodin.
  • the chemical formula of gastrodin is C 13 H 18 O 7 , and its structural formula is represented by the following formula 1.
  • Gastrodin has anti-inflammatory, analgesic, sedative and other pharmacological activities. It has a certain effect on neurasthenia, insomnia and headache. It also has the effect of calming the liver and protecting the liver. It is the main medicine of traditional Chinese medicine for the treatment of headache, dizziness, limb numbness, and convulsions.
  • the gastrodin contained in it can be mixed into the aerosol by atomization together with the e-cigarette liquid without being damaged, and when the user inhales the aerosol
  • gastrodin can be directly absorbed to have anti-inflammatory, analgesic, and sedative effects, while reducing possible side effects during the inhalation process, such as inflammation, nausea, and vomiting, thereby enhancing the user experience.
  • the weight of the gastrodin in the e-cigarette liquid is approximately, for example, 0.01%, 0.05%, 0.1%, 0.15%, 0.5%, 1.0 %, 1.5%, 5.0%, 10.0%, 15% or any two of these parts.
  • the content of the gastrodin in the e-cigarette liquid is about 0.1% to about 10% based on the total weight of the e-cigarette liquid, which can make the mouthfeel of the e-cigarette liquid more comfortable and more comfortable after being atomized. It is mild, enriches the aroma of the smoke and improves the quality of inhalation.
  • the e-cigarette liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin).
  • the content of propylene glycol in the e-liquid is approximately, for example, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70% or any two of these weight percentages; and the content of glycerol in the e-cigarette liquid is roughly, for example, 20%, 25%, 30%, 35%, 40% , 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80% or any two of these weight percentages.
  • the content of the propylene glycol in the e-cigarette liquid is about 15% to about 60%, and the content of the glycerol in the e-cigarette liquid is about 30% to about 70%, so that the electronic cigarette The smoke liquid achieves the best atomization effect and improves the user experience.
  • the basic solvent can be any solvent known in the art, such as deionized water, propylene glycol, and glycerol, according to specific needs, without being limited.
  • the e-cigarette liquid further comprises a cooling agent, wherein the content of the cooling agent in the e-cigarette liquid, based on the total weight of the e-cigarette liquid, is approximately, for example, 0.01% , 0.1%, 0.2%, 0.3%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10% or any two of these weight percentages.
  • the content of the cooling agent in the e-cigarette liquid is about 0.1% to about 10% based on the total weight of the e-cigarette liquid
  • Cooling agents are additives, which are chemicals that can give users a cooling effect when the product is in use and are not very irritating.
  • the cooling agent includes selected from the group consisting of menthol, menthone, isomenthone, menthyl lactate, WS-23 (N,2,3-trimethyl-2-isopropylbutanamide) , WS-3(N-ethyl-p-menthyl-3-carboxamide), WS-5(N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS-12(N-( 4-methoxyphenyl)-p-menthyl-3-carboxamide), menthyl acetate and combinations thereof.
  • the e-cigarette liquid further includes nicotine salt.
  • the content of the nicotine salt in the e-cigarette liquid is approximately, for example, 0.001%, 0.01%, 0.1%, 1.0% , 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10% or any two of these weight percentages.
  • the content of the nicotine salt in the e-cigarette liquid is about 0.001% to about 10.0% based on the total weight of the e-cigarette liquid.
  • the nicotine salt comprises benzoate.
  • the e-cigarette liquid further includes nicotine.
  • the content of the nicotine in the e-cigarette liquid is approximately, for example, 0.001%, 0.01%, 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, or any two of these weight percentages.
  • the content of the nicotine in the e-cigarette liquid is about 0.001% to about 5.0% based on the total weight of the e-cigarette liquid.
  • the above-mentioned e-cigarette liquid can further include flavor.
  • the flavor includes: at least one of methyl dihydrojasmonate, limonene, linalool, ethyl butyrate, and ⁇ -pinene.
  • Methyl dihydrojasmonate has the fragrance of fresh lysium. Adding to the e-cigarette liquid can make the fragrance in the generated aerosol more natural and longer lasting. Limonene has a lemon-like scent, and when added to the e-cigarette liquid, the aerosol generated can be fuller and sweeter. Linalool has the scent of lily of the valley, and the aroma is quite good. Adding to the e-liquid can improve the aroma and taste of the aerosol generated by the e-liquid, thereby making the aroma of the aerosol generated by the e-liquid more transparent and fuller . Ethyl butyrate has a strong sweet and fruity aroma. Adding to the electronic cigarette liquid can make the aroma in the generated aerosol more sweet and more transparent. ⁇ -Pinene has a pure woody aroma. Adding to the electronic cigarette liquid can make the aroma of the generated aerosol more perfect, and it has a good regulating effect on other flavors.
  • the content of the flavor in the e-cigarette liquid is approximately, for example, 0.01%, 0.1%, 0.25%, 0.5%, 1.0%, 2.0% , 3.0%, 4.0%, 5.0%, 6.0%, 8.0%, 10% or any two of these parts. In some embodiments, the content of the flavor in the e-cigarette liquid is about 0.01% to about 5% based on the total weight of the e-cigarette liquid.
  • the present application provides a method for preparing e-cigarette liquid, which includes the following steps: dissolve a certain amount of gastrodin in a basic solvent, then add flavor ingredients, flavor, and nicotine salt, and then mix them evenly To obtain electronic cigarette liquid.
  • the present application provides an atomization device, wherein the atomization device includes the electronic cigarette liquid in the above embodiment.
  • the e-cigarette liquid can be atomized by the atomizing device to generate an aerosol for the user to inhale, wherein the aerosol contains gastrodin which is not damaged by high temperature, and can produce anti-inflammatory, analgesic, sedative, and sedative after being absorbed by the user. It has pharmacological activities such as calming the liver, and has a certain effect on neurasthenia, insomnia and headache.
  • the atomization device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
  • Example 1 the e-cigarette liquid of Example 1 and its atomized aerosol were subjected to gastrodin content measurement, and the taste scoring test of the e-cigarette liquid of Examples 1-10 was performed.
  • the above test results are used to further illustrate the content of gastrodin in the aerosol of the e-cigarette liquid of the present application during use and the improvement of user experience.
  • Gastrodin content measurement is carried out by ultra performance liquid chromatography (UPLC).
  • Example 1 The e-cigarette liquid of Example 1 was used to generate the aerosol for inhalation by the user using the following suction method: the atomization device was an electronic cigarette, the suction time was 3.0 seconds ⁇ 0.1 seconds, and the interval between puffs It is 30.0 seconds ⁇ 0.5 seconds, the number of puffs is 50 times, and the volume of each puff is 55 mL ⁇ 0.3 mL.
  • a Cambridge filter was used to collect the aerosol, and 10 mL of methanol was used to immerse the Cambridge filter. After 30 minutes of ultrasonic extraction, a flue gas extraction solution was obtained. Then, ultra-high performance liquid chromatography (UPLC) was used to determine the content of gastrodin in the e-cigarette liquid and its aerosol extraction solution.
  • UPLC ultra-high performance liquid chromatography
  • Liquid chromatography test Ultra-high performance liquid chromatography (Waters ACQUITY H-Class) is used to measure the gastrodin content of e-cigarette liquid and its aerosol extraction solution.
  • the liquid chromatographic conditions are as follows: the chromatographic column is HSS T3 C 18 (2.1mm ⁇ 100mm, 1.8 ⁇ m), and the mobile phase is acetonitrile-0.5 % Phosphoric acid solution (3:97, v/v), isocratic elution, flow rate of 0.4mL/min, column temperature of 35°C, injection volume of 3 ⁇ L, and detection wavelength of 270nm.
  • 1A and 1B are respectively chromatograms of gastrodin content measured by UPLC of the e-cigarette liquid and the aerosol generated by the e-cigarette liquid according to an embodiment of the present application.
  • gastrodin is present in the aerosol of the e-cigarette liquid of the present application, and the composition of the gastrodin in the aerosol is basically the same as that of the e-cigarette liquid, which represents the gastrodin in the e-cigarette liquid of the present application
  • the components can be atomized by the atomization device, and then exist in the atomized aerosol without being destroyed. Therefore, gastrodin can be effectively absorbed by the human body through the aerosol after the electronic cigarette, so that the user can achieve the pharmacological effects of the human body while smoking, such as calming, anti-inflammatory, analgesic, and liver-relieving effects.
  • Statistical method Randomly select 1000 users to test the use of the e-cigarette liquid of the above examples 1-10 through e-cigarettes, and evaluate the taste and taste after the use test.
  • the evaluation standard is based on a total score of 10 points. The better or the better the taste, the higher the score.
  • this application provides an e-cigarette liquid containing gastrodin, in which a certain amount of gastrodia can be maintained in the aerosol that is generated by the atomization device for the user to inhale. It is absorbed by the human body, which has the effect of calming, soothing and analgesic, and calming the liver.
  • the aerosol after atomization of the e-cigarette liquid can reduce the sensation of foreign body during inhalation and the possible inflammatory reaction during use. , Thereby enhancing the user experience.

Abstract

一种电子烟液，包含天麻素，其中天麻素在电子烟液中的含量以电子烟液总重计为0.1％至10％。电子烟液经过雾化，其包含的天麻素可随烟液一起雾化出来，被人体吸收，对人体具有镇静、平肝、舒缓及止痛等功效作用，且电子烟液雾化后的气雾能够降低吸入时的异物感以及使用时可能的发炎反应，进而提升使用者体验。

Description

电子烟液 技术领域
本申请涉及电子气雾剂或电子雾化装置的领域，尤其涉及一种电子烟液。
背景技术
传统烟草的吸食具有许多可能的副作用，引发咽喉炎、气管炎、肺炎、肺气肿、哮喘、肺癌、心血管疾病、胃癌、生育能力下降等多种疾病。传统烟草在高温燃烧下所生成的烟气往往由于过高的温度会导致使用者咽喉部位的发炎反应，且其所释放的刺激性物质可能会导致使用者处在警张或亢奋的状态。当过量吸取传统烟草制品时，可能会导致动使用者产生恶心、晕眩、呕吐等副作用，严重则能够引发支气管炎等疾病。
电子烟液中通过低温雾化不易产生对人体健康有害的焦油、悬浮微粒及一氧化碳等有害物质，对使用者和他人造成的危害远远小于传统香烟对人体的危害。因此，电子烟及电子雾化装置引起人们越来越多的关注。
如何通过优化电子烟液中的组成以进一步生成降低对人体有害影响且提高对人体有益影响的用于使用者吸入的气雾，是电子烟产品需要改进的研究方向。
发明内容
本申请通过提供一种含有天麻素的电子烟液，该电子烟液中通过雾化装置所生成用于使用者吸入的气雾中存在天麻素并可被人体吸收起到保健作用。该电子烟液能够降低使用者在抽吸该电子烟液时所引发的发炎、恶心等副作用，通过吸取该气雾中存在的天麻素可以对使用者提供缓解及镇静的效果，进而提高使用者对电子烟液的使用体验。
根据本申请的一个层面，本申请提供了一种电子烟液，其包含天麻素，其中所述天麻素在所述电子烟液中的重量以所述电子烟液总重计为约0.1％至约10％。
根据本申请的另一层面，本申请提供了一种雾化装置，其包含上述电子烟液。
本申请的电子烟液可以对神经衰弱、失眠、头痛症状有缓解作用，且能够抑制使者 在吸取过程中的发炎、恶心、亢奋等副作用，同时对肝脏具有保护作用，能够减轻肝脏对物质代谢的负担，进而提升使用者体验。
本申请实施例的额外层面及优点将部分地在后续说明中描述、显示、或是经由本申请实施例的实施而阐释。
附图说明
图1A是根据本申请实施例的电子烟液的天麻素含量的色谱图。
图1B是根据本申请实施例的电子烟液所生成的气雾的天麻素含量的色谱图。
具体实施方式
本申请的实施例将会被详细的描示在下文中。本申请的实施例不应所述被解释为对本申请的限制。
另外，有时在本文中以范围格式呈现量、比率和其它数值。应理解，此类范围格式是用于便利及简洁起见，且应灵活地理解，不仅包含明确地指定为范围限制的数值，而且包含涵盖于所述范围内的所有个别数值或子范围，如同明确地指定每一数值及子范围一般。
如本文中所使用，术语“大致”、“大体”、“大体上”、“实质”及“约”用以描述及说明小的变化。当与事件或情形结合使用时，所述术语可指代其中事件或情形精确发生的例子以及其中事件或情形极近似地发生的例子。举例来说，当结合数值使用时，术语可指代小于或等于所述数值的±10％的变化范围，例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％。举例来说，如果两个数值之间的差值小于或等于所述值的平均值的±10％(例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％)，那么可认为所述两个数值“大体上”相同。
在具体实施方式及权利要求书中，由术语“中的至少一者”、“中的至少一个”、“中的至少一种”或其他相似术语所连接的项目的列表可意味着所列项目的任何组合。例如，如果列出项目A及B，那么短语“A及B中的至少一者”意味着仅A；仅B；或 A及B。在另一实例中，如果列出项目A、B及C，那么短语“A、B及C中的至少一者”意味着仅A；或仅B；仅C；A及B(排除C)；A及C(排除B)；B及C(排除A)；或A、B及C的全部。项目A可包含单个元件或多个元件。项目B可包含单个元件或多个元件。项目C可包含单个元件或多个元件。
在本文中，用语“用于使用者吸入的气雾”可以包括，但不限于，气溶胶、悬浮液体、低温蒸气及挥发性气体。
本申请提供一种含有天麻素的电子烟液，供使用者在吸入雾化后的电子烟液的同时可以起到消炎、止痛、镇静等多种有益效果。
根据本申请的一个方面，本申请提供了一种电子烟液，所述电子烟液其包含天麻素。
天麻素的化学式为C 13H 18O 7，其结构式如下式一所表示。
Figure PCTCN2019104226-appb-000001
天麻素具有消炎、止痛、镇静等药理活性，对神经衰弱、失眠头痛有一定疗效，还具有平肝护肝作用，是中医治疗头痛眩晕、肢体麻木、惊痛抽搐的主药。在一些实施例中，当电子烟液通过雾化装置形成气雾时，其包含的天麻素能够不受到破坏而与电子烟液一起通过雾化混入气雾中，而当使用者吸入该气雾时，可直接吸收天麻素，起到消炎、止痛、镇静的功效，同时降低吸取过程中可能产生的副作用，例如，发炎、恶心、呕吐，从而提升使用者体验。
在一些实施例中，所述天麻素在电子烟液中的重量，以所述电子烟液的总重量计，大致为，例如，0.01％、0.05％、0.1％、0.15％、0.5％、1.0％、1.5％、5.0％、10.0％、15％或这些份数中任意两者组成的范围。在一些实施例中，所述天麻素在电子烟液中的含量以所述电子烟液总重计为约0.1％至约10％，其能够使电子烟液雾化后的口感更舒适，更温和，丰富了烟的香气，提升了吸取品质。
电子烟液还包含基础溶剂，其中所述基础溶剂包含丙二醇及丙三醇(甘油)。在一些实施例中，以所述电子烟液总重计，丙二醇在电子烟液中的含量大致为，例如，10％、15％、20％、25％、30％、35％、40％、50％、60％、70％或这些重量百分比中任意两者组成的范围；及丙三醇在电子烟液中的含量大致为，例如，20％、25％、30％、35％、40％、45％、50％、55％、60％、65％、70％、75％、80％或这些重量百分比中任意两 者组成的范围。在一些实施例中，所述丙二醇在电子烟液中的含量为约15％至约60％，且所述丙三醇在电子烟液中的含量为约30％至约70％，以使电子烟液达到最佳的雾化效果，提高使用者体验。
本领域技术人员应理解，基础溶剂可以根据具体需求选择本领域任何已知的溶剂，例如，去离子水、丙二醇、丙三醇，而不受其限制。
在一些实施例中，所述电子烟液还进一步包含凉味剂，其中所述凉味剂在电子烟液中的含量，以所述电子烟液的总重计，大致为，例如，0.01％、0.1％、0.2％、0.3％、0.5％、1.0％、1.5％、2.0％、2.5％、5％、7.5％、10％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述凉味剂在电子烟液中的含量以所述电子烟液的总重计为约0.1％至约10％
凉味剂为添加剂，其为能够使产品在使用时让使用者产生清凉效果的感受且刺激性不强的化学物。在一些实施例中，所述凉味剂包括选自由薄荷脑、薄荷酮、异薄荷酮、乳酸薄荷酯、WS-23(N,2,3-三甲基-2-异丙基丁酰胺)、WS-3(N-乙基-对薄荷基-3-甲酰胺)、WS-5(N-(乙氧羰基甲基)-对烷-3-甲酰胺)、WS-12(N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺)、乙酸薄荷酯及其组合所组成的群组。
在一些实施例中，所述电子烟液还包括尼古丁盐。在一些实施例中，以所述电子烟液总重计，所述尼古丁盐在电子烟液中在所述电子烟液中的含量大致为，例如，0.001％、0.01％、0.1％、1.0％、1.5％、2.0％、2.5％、5％、7.5％、10％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述尼古丁盐在所述电子烟液中的含量以所述电子烟液总重计为约0.001％至约10.0％。
应理解，本领域技术人员可根据实际需求选用本领域中任何已知的尼古丁盐加入电子烟液中，而不受其限制。在一些实施例中，所述尼古丁盐包含苯甲酸盐。
在一些实施例中，所述电子烟液还包括尼古丁。在一些实施例中，以所述电子烟液总重计，所述尼古丁在电子烟液中在所述电子烟液中的含量大致为，例如，0.001％、0.01％、0.1％、0.2％、0.5％、1.0％、1.5％、2.0％、2.5％、5％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述尼古丁在所述电子烟液中的含量以所述电子烟液总重计为约0.001％至约5.0％。
在一些实施例中，上述电子烟液能够进一步包含香精。
在一些实施例中，所述香精包括：二氢茉莉酮酸甲酯、柠檬烯、芳樟醇、丁酸乙酯、 β-蒎烯中的至少一种。
二氢茉莉酮酸甲酯具有新鲜莱莉香气，添加至电子烟液中能够使其所生成的气雾中的香气更天然，更持久。柠檬烯具有类似柠檬的香味，添加至电子烟液中能够使其所生成的气雾更加饱满，更加香甜。芳樟醇具有铃兰香气，香气颇佳，添加至电子烟液中能够改善其所生成的气雾的香气和口感，进而使电子烟液所生成的气雾中的香气更透发，更饱满。丁酸乙酯具有强烈的甜果香味，添加至电子烟液中能够使其所生成的气雾中的香气更香甜，更透发。β-蒎烯具有纯正的木香，添加至电子烟液中能够使其所生成的气雾的香气更加完美，对其他香精具有很好的调节作用。
在一些实施例中，所述香精在电子烟液中的含量，以所述电子烟液的总重量计，大致为，例如，0.01％、0.1％、0.25％、0.5％、1.0％、2.0％、3.0％、4.0％、5.0％、6.0％、8.0％、10％或这些份数中任意两者组成的范围。在一些实施例中，所述香精在所述电子烟液中的含量以所述电子烟液总重计为约0.01％至约5％。
根据本申请一些实施例，本申请提供电子烟液的制备方法，其包含以下步骤：取一定量的天麻素溶于基础溶剂中，随后加入风味成分、香精、尼古丁盐，然后，使其均匀混合以获得电子烟液。
本领域技术人员应理解，本申请实施例的电子烟液可以根据实际制备需求选择任何合适的已知方法制造，而不受其限制。
根据本申请的另一个层面，本申请提供了一种雾化装置，其中所述雾化装置包含上述实施例中的电子烟液。所述电子烟液可通过所述雾化装置雾化生成供使用者吸入的气雾，其中所述气雾含有不受到高温破坏的天麻素，供使用者吸收后能够产生消炎、止痛、镇静、平肝等药理活性，对神经衰弱、失眠头痛有一定疗效。
在一些实施例中，所述雾化装置包括电子烟、超声雾化器或网式雾化器。
实施例
为便于更好地理解本申请，通过以下实例加以说明。这些实例属于本申请的保护范围，但不限制本申请的保护范围。
实施例1
将3克天麻素加入47克丙二醇中，随后加入50克丙三醇混合，搅拌均匀，得到电 子烟液。
实施例2
将3克天麻素加入37克丙二醇中，随后加入2克WS-23及1克薄荷脑混合均匀，再加入57克丙三醇混合，搅拌均匀，得到电子烟液。
实施例3
将2克天麻素加入45克丙二醇中，随后加入2克WS-23、0.76克二氢茉莉酮酸甲酯、0.51克芳樟醇、0.82克柠檬烯、0.008克丁酸乙酯及0.001克β-蒎烯混合均匀，再加入49克丙三醇混合，搅拌均匀，得到电子烟液。
实施例4
将1克天麻素加入44克丙二醇中，随后加入3克尼古丁、2克WS-23、0.76克二氢茉莉酮酸甲酯、0.51克芳樟醇、0.82克柠檬烯、0.008克丁酸乙酯及0.001克β-蒎烯混合均匀，再加入48克丙三醇混合，搅拌均匀，得到电子烟液。
实施例5
将2克天麻素加入40克丙二醇中，随后加入5克尼古丁、1克WS-23、2克薄荷脑、0.76克二氢茉莉酮酸甲酯、0.51克芳樟醇、0.82克柠檬烯、0.008克丁酸乙酯及0.001克β-蒎烯混合均匀，再加入48克丙三醇混合，搅拌均匀，得到电子烟液。
实施例6
将2克天麻素加入45克丙二醇中，随后加入2克尼古丁、1克WS-23、1克薄荷脑、0.76克二氢茉莉酮酸甲酯、0.51克芳樟醇、0.82克柠檬烯、0.008克丁酸乙酯及0.001克β-蒎烯混合均匀，再加入46克丙三醇混合，搅拌均匀，得到电子烟液。
实施例7
将2克天麻素加入45克丙二醇中，随后加入2克尼古丁、1克WS-23、1克薄荷脑及1克二氢茉莉酮酸甲酯混合均匀，再加入48克丙三醇混合，搅拌均匀，得到电子烟液。
实施例8
将2克天麻素加入45克丙二醇中，随后加入2克尼古丁、1克WS-23、1克薄荷脑及1克芳樟醇混合均匀，再加入48克丙三醇混合，搅拌均匀，得到电子烟液。
实施例9
将2克天麻素加入45克丙二醇中，随后加入2克尼古丁、1克WS-23、1克薄荷脑及1克柠檬烯混合均匀，再加入48克丙三醇混合，搅拌均匀，得到电子烟液。
实施例10
将2克天麻素加入45克丙二醇中，随后加入2克尼古丁、1克WS-23、1克薄荷脑、0.95克丁酸乙酯及0.05克β-蒎烯混合均匀，再加入48克丙三醇混合，搅拌均匀，得到电子烟液。
随后将实施例1的电子烟液及其雾化后的气雾进行天麻素含量测量并对实施例1-10的电子烟液进行口感评分测试。通过上述测试结果以进一步说明，本申请电子烟液在使用过程中其气雾内天麻素的含量，以及其对使用者体验的提升。
天麻素含量测试方式；
天麻素含量测量是通过超高效液相色谱(UPLC)来进行。
样品制备：将实施例1的电子烟液采用以下抽吸方式来生成其用于使用者吸入的气雾：雾化装置为电子烟，抽吸时间为3.0秒±0.1秒、抽吸之间间隔为30.0秒±0.5秒、抽吸次数为50次、每次抽吸量为55mL±0.3mL。采用剑桥滤片收集气雾，并使用10mL甲醇浸没剑桥滤片，超声提取30min后得烟气萃取溶液。然后采用超高效液相色谱(UPLC)对电子烟液及其气雾萃取溶液进行天麻素含量测定。
液相色谱测试：采用超高效液相色谱(Waters ACQUITY
Figure PCTCN2019104226-appb-000002
H-Class)对电子烟液及其气雾萃取溶液进行天麻素含量测量，其中液相色谱条件如下：色谱柱为HSS T3 C 18(2.1mm×100mm,1.8μm)，流动相为乙腈-0.5％磷酸溶液(3:97，v/v)，等度洗脱，流量为0.4mL/min，柱温35℃，进样量3μL，检测波长270nm。
图1A及1B分别是根据本申请实施例的的电子烟液以及其所生成的气雾的通过UPLC所测得的天麻素含量的色谱图。
如图1A及1B所示，本申请电子烟液的气雾中存在天麻素，其中气雾中天麻素的成分与电子烟液中的成分基本相同，这代表本申请电子烟液中的天麻素成分能够通过雾化装置来雾化，进而存在于其雾化的气雾中而没有被破坏。因此，天麻素通过电子烟雾化后的气雾可以有效被人体吸收，进而让使用者在吸烟的同时达到其人体的药理作用，例 如，镇定、消炎、止痛、平肝等功效。
口感评分测试方式1；
统计方法：请20位评析者按表1中的各个评价指标对上述实施例1-10的电子烟液所生成的气雾体验打分。
表1
Figure PCTCN2019104226-appb-000003
实施例1-10的电子烟液经过口感评分测试的测试结果如下表2所示。
表2
Figure PCTCN2019104226-appb-000004
Figure PCTCN2019104226-appb-000005
由表2中数据可知，本申请实施例1-10的电子烟液经雾化后所形成的供使用者吸入的气雾，其不论在口感或是口味都显示了其具有良好的使用者体验。此外，通过比较实施例可知，在电子烟液添加香精，可以进一步提升电子烟液所生成的气雾的口味及口感。
口感评分测试方式2；
统计方法：随机选取1000使用者通过电子烟对上述实施例1-10的电子烟液进行使用测试，待使用测试后对其口味及口感进行评价，其中评价标准以总分10分计，口味越佳或口感越好则分数越高。
实施例1-4的电子烟液经过口感评分测试的测试结果如下表3所示。
表3
Figure PCTCN2019104226-appb-000006
由表3中数据可进一步得知，本申请的电子烟液所生成的用于使用者吸入的气雾对使用者而言，不论是专业的评析者或是一般使用者，皆具有良好的口感及味道。而通过添加香精，则可以进一步提高使用者对电子烟液的使用体验。
通过本申请上述实施例应可了解，本申请提供了一种含有天麻素的电子烟液，该电 子烟液中通过雾化装置所生成用于使用者吸入的气雾中能够保持一定含量的天麻素，进而被人体吸收，从而起到对人体的镇静、舒缓及止痛、平肝等功效作用，且该电子烟液雾化后的气雾能够降低吸入时的异物感以及使用时可能的发炎反应，进而提升使用者体验。
虽然已参考本申请的特定实施例描述并说明本申请，但是这些描述和说明并不限制本申请。所属领域的技术人员可清晰地理解，在不脱离如由所附权利要求书定义的本申请的真实精神和范围的情况下，可进行各种改变，以使特定情形、材料、物质组成、物质、方法或过程适宜于本申请的目标、精神和范围。所有此类修改都意图在此所附权利要求书的范围内。虽然已参考按特定次序执行的特定操作描述本文中所公开的方法，但应理解，可在不脱离本申请的教示的情况下组合、细分或重新排序这些操作以形成等效方法。因此，除非本文中特别指示，否则操作的次序和分组并非本申请的限制。
前文概述本申请的若干实施例及细节方面的特征。本申请中描述的实施例可容易地用作用于设计或修改其它过程的基础以及用于执行相同或相似目的和/或获得引入本文中的实施例的相同或相似优点的结构。此类等效构造并不脱离本申请的精神和范围，并且可在不脱离本申请的精神和范围的情况下作出各种改变、替代和变化。

Claims (10)

  1. 一种电子烟液，其包含天麻素，其中所述天麻素在所述电子烟液中的重量以所述电子烟液总重计为0.1％至10％。
  2. 根据权利要求1所述的电子烟液，其进一步包含尼古丁盐，且所述尼古丁盐在所述电子烟液中的重量以所述电子烟液总重计为0.001％至10％。
  3. 根据权利要求1所述的电子烟液，其进一步包含尼古丁，且所述尼古丁在所述电子烟液中的重量以所述电子烟液总重计为0.001％至5％。
  4. 根据权利要求1至3中任一权利要求所述的电子烟液，其进一步包含香精。
  5. 根据权利要求4所述的电子烟液，其中所述香精中包括：二氢茉莉酮酸甲酯、柠檬烯、芳樟醇、丁酸乙酯或β-蒎烯中的至少一种。
  6. 根据权利要求5所述的电子烟液，其中所述香精在所述电子烟液中的重量以所述电子烟液总重计为0.001％至5％。
  7. 根据权利要求1至3中任一权利要求所述的电子烟液，其进一步包含凉味剂；其中所述凉味剂选自由薄荷脑、薄荷酮、异薄荷酮、乳酸薄荷酯、N,2,3-三甲基-2-异丙基丁酰胺、N-乙基-对薄荷基-3-甲酰胺、N-(乙氧羰基甲基)-对烷-3-甲酰胺、N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺、乙酸薄荷酯及其组合所组成的群组。
  8. 根据权利要求7所述的电子烟液，其中所述凉味剂在所述电子烟液中的重量以所述电子烟液总重计为0.1％至10％。
  9. 一种雾化装置，其包含权利要求1至8中任一权利要求所述的电子烟液。
  10. 根据权利要求9所述的雾化装置，其中所述雾化装置包括电子烟、超声雾化器或网式雾化器。
PCT/CN2019/104226 2019-09-03 2019-09-03 电子烟液 WO2021042269A1 (zh)

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CN104489908A (zh) * 2014-12-17 2015-04-08 贵州中烟工业有限责任公司 一种电子烟烟液
CN104544545A (zh) * 2014-12-31 2015-04-29 贵州中烟工业有限责任公司 一种具有降血压功能的电子烟烟液
US20160198759A1 (en) * 2015-01-13 2016-07-14 Zip Llc E-cigarette or vaping fluid
CN105876867A (zh) * 2016-04-29 2016-08-24 张家界久瑞生物科技有限公司 一种含杜仲提取物的电子烟液及其制备方法

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CN103622154A (zh) * 2013-12-17 2014-03-12 郑悦 电子烟液及其制备方法
CN104489908A (zh) * 2014-12-17 2015-04-08 贵州中烟工业有限责任公司 一种电子烟烟液
CN104544545A (zh) * 2014-12-31 2015-04-29 贵州中烟工业有限责任公司 一种具有降血压功能的电子烟烟液
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