WO2021046919A1 - 电子烟液 - Google Patents

电子烟液 Download PDF

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Publication number
WO2021046919A1
WO2021046919A1 PCT/CN2019/107941 CN2019107941W WO2021046919A1 WO 2021046919 A1 WO2021046919 A1 WO 2021046919A1 CN 2019107941 W CN2019107941 W CN 2019107941W WO 2021046919 A1 WO2021046919 A1 WO 2021046919A1
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Prior art keywords
cigarette liquid
electronic cigarette
parts
weight
liquid
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PCT/CN2019/107941
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English (en)
French (fr)
Inventor
许静
姜兴涛
李馨铎
熊赞华
罗安
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深圳雾芯科技有限公司
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Publication of WO2021046919A1 publication Critical patent/WO2021046919A1/zh

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes

Definitions

  • This application relates to the field of electronic aerosols or electronic atomization devices, and in particular to an electronic cigarette liquid.
  • the electronic cigarette or electronic atomizer atomizes the smoking material at low temperature to form an aerosol for the user to inhale, to replace the smoke generated by traditional tobacco burning at high temperature.
  • the electronic cigarette liquid has a certain impact on the user's experience and taste, and even the health of the human body.
  • the present application provides an e-cigarette liquid containing melatonin, in which aerosol generated by an atomization device for user inhalation contains melatonin that can produce a soothing and calming effect on humans, and then It is absorbed by the body to achieve the effects of delaying aging and improving sleep.
  • the present application provides an e-cigarette liquid comprising melatonin, wherein the content of the melatonin in the e-cigarette liquid is 0.1% based on the total weight of the e-cigarette liquid To 6%.
  • the present application provides an atomization device, which includes the above-mentioned electronic cigarette liquid.
  • Fig. 1A is a chromatogram of the melatonin content of an electronic cigarette liquid according to an embodiment of the present application.
  • FIG. 1B is a chromatogram of the melatonin content of the aerosol generated by the electronic cigarette liquid according to an embodiment of the present application.
  • the terms “substantially”, “substantially”, “substantially”, “substantially” and “about” are used to describe and illustrate small changes. When used in conjunction with an event or situation, the term can refer to an example in which the event or situation occurs precisely and an example in which the event or situation occurs very closely.
  • the term when used in conjunction with a value, can refer to a range of variation less than or equal to ⁇ 10% of the stated value, such as less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, Less than or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%.
  • the difference between two values is less than or equal to ⁇ 10% of the average value of the value (for example, less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, less than Or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%), then the two values can be considered "substantially" the same.
  • a list of items connected by the terms “at least one of”, “at least one of”, “at least one of” or other similar terms may mean the listed items Any combination of. For example, if items A and B are listed, then the phrase “at least one of A and B” means only A; only B; or A and B. In another example, if items A, B, and C are listed, then the phrase "at least one of A, B, and C” means only A; or only B; only C; A and B (excluding C); A and C (exclude B); B and C (exclude A); or all of A, B, and C.
  • Project A can contain a single element or multiple elements.
  • Project B can contain a single element or multiple elements.
  • Project C can contain a single element or multiple elements.
  • aerosol for user inhalation may include, but is not limited to, aerosols, suspended liquids, low-temperature vapors, and volatile gases.
  • the present application provides an electronic cigarette liquid, which contains melatonin.
  • Melatonin has the functions of scavenging free radicals, anti-oxidation and inhibiting lipid peroxidation to protect cell structure, prevent DNA damage, and reduce the content of peroxides in the body.
  • melatonin also has many physiological functions such as promoting sleep, regulating jet lag, anti-aging, regulating immunity, anti-tumor, etc., and has the effects of delaying aging and improving sleep on the human body.
  • the melatonin contained in it when the e-cigarette liquid is formed into aerosol through the atomization device, due to the effect of low-temperature atomization, the melatonin contained in it can not be damaged by high temperature and mix with the e-cigarette liquid through atomization In the mist, when the user inhales the aerosol, the melatonin can be directly absorbed, thereby having a health care effect on the human body.
  • the content of the melatonin in the e-cigarette liquid is approximately, for example, 0.1%, 0.2%, 0.5%, 1.0%, 2.0%, 3.0%, 4.0%, 5.0%, 6.0%, or any two of these parts. In some embodiments, the content of the melatonin in the e-cigarette liquid is about 0.1% to about 6.0% based on the total weight of the e-cigarette liquid, and the melatonin can make the e-cigarette liquid atomized. The taste is more comfortable and milder, enriching the aroma of the smoke and improving the quality of the food.
  • the e-cigarette liquid of some embodiments of the present application further includes a flavor composition, wherein the flavor composition includes the following parts by weight: about 1 to about 10 parts of ⁇ -hexylcinnamaldehyde, about 35 to about 65 parts of linalool, about 0.01 to about 3.0 parts of lavender alcohol, about 20 to about 45 parts of linalyl acetate, about 0.1 to about 10 parts of geranyl acetate, and about 5 to about 20 parts of Lavender acetate.
  • the flavor composition of the present application may be composed of the above parts by weight.
  • the electronic cigarette liquid with the flavor composition can make the user produce a lavender-flavored mouthfeel when inhaled, and can form a uniform and dense aerosol, which effectively improves the user experience.
  • the ⁇ -hexyl cinnamaldehyde may be roughly 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts or these weights.
  • the range of any two of the parts; linalool can be roughly 35 parts, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts or any two of these parts by weight; lavender alcohol can be Approximately 0.01 part, 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.1 part, 0.5 part, 1.0 part, 2.0 part, 3.0 part or any two of these parts by weight range; Linalyl acetate may be roughly It is a range of 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or any two of these parts by weight; geranyl acetate can be roughly 0.1 part, 0.5 part, 1.0 part, 2 parts, 3 parts Parts, 4 parts, 5 parts, 10 parts or any two of these parts by weight; and lavender
  • the flavor composition is an additive, and when added to the e-cigarette liquid, it can make the e-cigarette liquid produce a lavender-flavored taste and olfactory feeling when the e-cigarette liquid is used.
  • the weight of the flavor composition in the e-cigarette liquid is approximately based on the total weight of the e-cigarette liquid, for example, 0.001%, 0.01%, 0.1%, 1% or these weight percentages The range of any two. In some embodiments, the weight of the flavor composition in the e-cigarette liquid is approximately 0.001% to about 1%, so that the generated aerosol has a mild taste, thereby optimizing the user experience.
  • the e-cigarette liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin).
  • the weight of propylene glycol in the e-liquid is approximately, for example, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, or any two of these weight percentages; and the weight of glycerol in the e-cigarette liquid is roughly, for example, 30%, 35%, 40%, 45%, 50%, 55% , 60%, 65%, 70% or any two of these weight percentages.
  • the weight of the propylene glycol in the e-cigarette liquid is about 20% to about 60%, and the weight of the glycerol in the e-cigarette liquid is about 40% to about 70%, so that the electronic cigarette The smoke liquid achieves the best atomization effect and improves the user experience.
  • the basic solvent can be any solvent known in the art, such as deionized water, propylene glycol, and glycerol, according to specific needs, without being limited.
  • the electronic cigarette liquid further includes a cooling agent.
  • Cooling agents are additives, which are chemicals that can give users a cooling effect when the product is in use and are not very irritating.
  • the cooling agent includes selected from the group consisting of menthol, menthone, isomenthone, 1-menthyl lactate, WS-23 (N,2,3-trimethyl-2-isopropylbutyl Amide), WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-5 (N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS-12(N -(4-Methoxyphenyl)-p-menthyl-3-carboxamide) and combinations thereof.
  • the weight of the cooling agent in the e-cigarette liquid is approximately, for example, 0.1%, 0.2%, 0.3%, 0.5%, 1.0%, 1.5% , 2.0%, 2.5%, 5%, 10% or any two of these weight percentages. In some embodiments, the weight of the cooling agent in the e-cigarette liquid is about 1.0% to about 10% based on the total weight of the e-cigarette liquid, so as to improve the user-friendliness of the e-cigarette liquid. The taste of the inhaled aerosol.
  • the e-cigarette liquid further includes nicotine salt.
  • the weight of the nicotine salt in the e-cigarette liquid is approximately, for example, 0.001%, 0.01%, 0.1%, 0.2% , 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10% or any two of these weight percentages.
  • the weight of the nicotine salt in the e-cigarette liquid is about 0.001% to about 10.0% based on the total weight of the e-cigarette liquid.
  • the e-cigarette liquid further includes nicotine.
  • the weight of the nicotine in the e-liquid in the e-liquid is approximately, for example, 0.001%, 0.01%, 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, or any two of these weight percentages.
  • the weight of the nicotine in the e-cigarette liquid is about 0.001% to about 5.0% based on the total weight of the e-cigarette liquid.
  • the e-cigarette liquid further includes a fragrance, wherein the fragrance is selected from ⁇ -pinene, ⁇ -terpineol, myrcene, benzaldehyde, ethyl butyrate, isoamyl butyrate, The group consisting of eugenol, ⁇ -caryophyllene, benzyl acetate, butyl acetate, and combinations thereof.
  • the fragrance is selected from ⁇ -pinene, ⁇ -terpineol, myrcene, benzaldehyde, ethyl butyrate, isoamyl butyrate, The group consisting of eugenol, ⁇ -caryophyllene, benzyl acetate, butyl acetate, and combinations thereof.
  • the weight of the flavor in the e-cigarette liquid is about 0.01% to about 5.0% based on the total weight of the e-cigarette liquid, so as to enhance the flavor of the e-cigarette liquid and optimize its production The taste of the aerosol.
  • the present application provides a method for preparing an e-cigarette liquid, which includes the following steps: dissolve a certain amount of melatonin in a basic solvent, then add flavor ingredients, flavor, nicotine or its salt, and then make It is uniformly mixed to obtain an electronic cigarette liquid.
  • the present application provides an atomization device, which includes the electronic cigarette liquid described in any of the foregoing embodiments.
  • the electronic cigarette liquid can be atomized by the atomization device to generate an aerosol for the user to inhale, wherein the aerosol contains melatonin that is not damaged by high temperature, and can produce anti-fatigue and immune regulation after being absorbed by the user , Delay aging, improve sleep and other effects.
  • the atomization device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
  • Propylene glycol and glycerol are blended according to the following weight ratio (32:56) and mixed uniformly to obtain a basic smoke liquid.
  • Flavor preparation :
  • the ⁇ -hexyl cinnamaldehyde, linalool, lavender alcohol, linalyl acetate, geranyl acetate and lavender acetate are mixed in the following weight ratio (1.5:38:0.05:25:0.5:10) to obtain a flavor combination
  • 1 g of melatonin, 0.2 g of flavor composition, 3.0 g of nicotine, 2.0 g of benzoic acid, and 0.02 g of flavor then add to 93.78 g of basic e-liquid, stir evenly, and obtain e-liquid .
  • the ⁇ -hexyl cinnamaldehyde, linalool, lavender alcohol, linalyl acetate, geranyl acetate and lavender acetate are mixed in the following weight ratio (5:60:2:40:8:15) to obtain a flavor combination
  • composition of the fragrance in the above-mentioned embodiment is shown in Table 1 below.
  • Example 1 the e-cigarette liquid of Example 1 and its atomized aerosol were measured for the melatonin content, and the taste scoring test of the e-cigarette liquid of Examples 1-5 was performed.
  • the above test results are used to further illustrate the content of melatonin in the aerosol of the e-cigarette liquid of the present application during use and the improvement of user experience.
  • the melatonin content is measured by Ultra Performance Liquid Chromatography (UPLC).
  • Sample preparation The e-cigarette liquid of Example 1 was used to generate the aerosol for inhalation by the user using the following suction method: the atomization device was an electronic cigarette, the suction time was 3.0 seconds ⁇ 0.1 seconds, and the interval between puffs It is 30.0 seconds ⁇ 0.5 seconds, the number of puffs is 50 times, and the volume of each puff is 55 mL ⁇ 0.3 mL.
  • a Cambridge filter was used to collect the aerosol, and 10 mL of methanol was used to immerse the Cambridge filter. After 30 minutes of ultrasonic extraction, a flue gas extraction solution was obtained. Then, ultra-high performance liquid chromatography (UPLC) was used to determine the melatonin content of the e-cigarette liquid and its aerosol extraction solution.
  • UPLC ultra-high performance liquid chromatography
  • Liquid chromatography conditions Waters ACQUITY H-Class HSS T3C 18 column (2.1mm ⁇ 100mm, 1.8 ⁇ m), mobile phase is acetonitrile-water solution (40:60, v/v), isocratic elution, flow rate is 0.3mL/min, column temperature is 35°C , The injection volume is 3 ⁇ L, and the detection wavelength is 223nm.
  • 1A and 1B are chromatograms of melatonin in the electronic content liquid smoke embodiment of the present application and it generates aerosol by UPLC measured.
  • Statistical method Randomly select 1000 users to test the use of the e-cigarette liquid of the above examples 1-5 through e-cigarettes, and evaluate the taste and taste after the use test.
  • the evaluation standard is based on a total score of 10 points. The better or the better the taste, the higher the score.
  • this application provides an e-cigarette liquid, through which the flavor composition contained in the e-cigarette liquid can allow users to produce the flavor of lavender without producing harmful tar and suspended particles. substance.
  • the e-cigarette liquid can form a uniform and strong aerosol when the user inhales, and the aerosol has a soft mouthfeel and does not have a residual sensation, thereby enhancing the user experience.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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Abstract

一种电子烟液，该电子烟液包含褪黑素，其中褪黑素在电子烟液中的含量以电子烟液总重计为0.1％至6％。该电子烟液经过雾化，其包含的褪黑素可随烟液一起雾化出来，被人体吸收，对人体具有延缓衰老、改善睡眠等功效作用。

Description

电子烟液 技术领域
本申请涉及电子气雾剂或电子雾化装置的领域，尤其涉及一种电子烟液。
背景技术
由于对于个人健康、环境保护以及使用便利性的追求，电子烟作为传统烟草的取代品越来越受到消费者的青睐。电子烟或电子雾化器通过将发烟材料低温雾化形成用于使用者吸入的气雾，来取代传统烟草以高温燃烧的方式所产生的烟气。其中，电子烟液对于使用者的体验及口感，甚至对人体的健康具有一定的影响。
通过低温雾化如何进一步生成降低对人体有害影响且提高对人体有益影响的用于使用者吸入的气雾，是电子烟产品需要改进的研究方向。
发明内容
本申请通过提供一种含有褪黑素的电子烟液，该电子烟液中通过雾化装置所生成用于使用者吸入的气雾中存在能够对人产生舒缓、镇静作用的褪黑素，进而被人体吸收以达到延缓衰老、改善睡眠等功效。
根据本申请的一个层面，本申请提供了一种电子烟液，其包含褪黑素，其中所述褪黑素在所述电子烟液中的含量以所述电子烟液总重计为0.1％至6％。
根据本申请的又一层面，本申请提供了一种雾化装置，其包含上述电子烟液。
本申请实施例的额外层面及优点将部分地在后续说明中描述、显示、或是经由本申请实施例的实施而阐释。
附图说明
图1A是根据本申请实施例的电子烟液的褪黑素含量的色谱图。
图1B是根据本申请实施例的电子烟液所生成的气雾的褪黑素含量的色谱图。
具体实施方式
本申请的实施例将会被详细的描示在下文中。本申请的实施例不应所述被解释为对本申请的限制。
另外，有时在本文中以范围格式呈现量、比率和其它数值。应理解，此类范围格式是用于便利及简洁起见，且应灵活地理解，不仅包含明确地指定为范围限制的数值，而且包含涵盖于所述范围内的所有个别数值或子范围，如同明确地指定每一数值及子范围一般。
如本文中所使用，术语“大致”、“大体”、“大体上”、“实质”及“约”用以描述及说明小的变化。当与事件或情形结合使用时，所述术语可指代其中事件或情形精确发生的例子以及其中事件或情形极近似地发生的例子。举例来说，当结合数值使用时，术语可指代小于或等于所述数值的±10％的变化范围，例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％。举例来说，如果两个数值之间的差值小于或等于所述值的平均值的±10％(例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％)，那么可认为所述两个数值“大体上”相同。
在具体实施方式及权利要求书中，由术语“中的至少一者”、“中的至少一个”、“中的至少一种”或其他相似术语所连接的项目的列表可意味着所列项目的任何组合。例如，如果列出项目A及B，那么短语“A及B中的至少一者”意味着仅A；仅B；或A及B。在另一实例中，如果列出项目A、B及C，那么短语“A、B及C中的至少一者”意味着仅A；或仅B；仅C；A及B(排除C)；A及C(排除B)；B及C(排除A)；或A、B及C的全部。项目A可包含单个元件或多个元件。项目B可包含单个元件或多个元件。项目C可包含单个元件或多个元件。
在本文中，用语“用于使用者吸入的气雾”或“气雾”可以包括，但不限于，气溶胶、悬浮液体、低温蒸气及挥发性气体。
根据本申请的一个方面，本申请提供了一种电子烟液，所述电子烟液包含褪黑素。
褪黑素具有清除自由基，抗氧化和抑制脂质的过氧化反应保护细胞结构、防止DNA损伤、降低体内过氧化物的含量等作用。此外，褪黑素还具有促进睡眠、调节时差、抗 衰老、调节免疫、抗肿瘤等多项生理功能，对人体具有延缓衰老、改善睡眠等功效作用。在一些实施例中，当电子烟液通过雾化装置形成气雾时，由于是通过低温雾化的作用，其包含的褪黑素能够不受到高温破坏而与电子烟液一起通过雾化混入气雾中，而当使用者吸入该气雾时，可直接吸收褪黑素，进而起到对人体的保健功效。
在一些实施例中，所述褪黑素在电子烟液中的含量，以所述电子烟液的总重量计，大致为，例如，0.1％、0.2％、0.5％、1.0％、2.0％、3.0％、4.0％、5.0％、6.0％或这些份数中任意两者组成的范围。在一些实施例中，所述褪黑素在电子烟液中的含量以所述电子烟液总重计为约0.1％至约6.0％，所述褪黑素能够使电子烟液雾化后的口感更舒适，更温和，丰富了烟的香气，提升了吸食品质。
根据本申请的另一方面，本申请一些实施例的电子烟液还包含风味组合物，其中所述风味组合物包含以下重量份的物质：约1至约10份的α-己基肉桂醛、约35至约65份芳樟醇、约0.01至约3.0份的薰衣草醇、约20至约45份的乙酸芳樟酯、约0.1至约10份的乙酸香叶酯及约5至约20份的乙酸薰衣草酯。在一些实施例中，本申请的风味组合物可由以上重量份的物质组成。具有风味组合物的电子烟液在吸取时能让使用者产生薰衣草风味的口感，且能够形成气味均匀且浓郁的气雾，有效提升使用者体验。
在一些实施例的风味组合物中，α-己基肉桂醛可大致为1份、2份、3份、4份、5份、6份、7份、8份、9份、10份或这些重量份中任意两者组成的范围；芳樟醇可大致为35份、40份、45份、50份、55份、60份、65份或这些重量份中任意两者组成的范围；薰衣草醇可大致为0.01份、0.02份、0.03份、0.04份、0.05份、0.1份、0.5份、1.0份、2.0份、3.0份或这些重量份中任意两者组成的范围；乙酸芳樟酯可大致为为20份、25份、30份、35份、40份、45份或这些重量份中任意两者组成的范围；乙酸香叶酯可大致为0.1份、0.5份、1.0份、2份、3份、4份、5份、10份或这些重量份中任意两者组成的范围；及乙酸薰衣草酯可大致为5份、10份、15份、20份或这些重量份中任意两者组成的范围。
风味组合物为添加剂，其添加于电子烟液中时，能够使该电子烟液在使用时让使用者产生薰衣草风味的味觉及嗅觉感受。
在一些实施例中，所述风味组合物在所述电子烟液中的重量以所述电子烟液总重计大致为，例如，0.001％、0.01％、0.1％、1％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述风味组合物在电子烟液中的重量份大致为约0.001％至约1％，以 使其生成的气雾味道温和，从而优化使用者体验。
电子烟液还包含基础溶剂，其中所述基础溶剂包含丙二醇及丙三醇(甘油)。在一些实施例中，以所述电子烟液总重计，丙二醇在电子烟液中的重量大致为，例如，15％、20％、25％、30％、35％、40％、50％、60％、70％或这些重量百分比中任意两者组成的范围；及丙三醇在电子烟液中的重量大致为，例如，30％、35％、40％、45％、50％、55％、60％、65％、70％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述丙二醇在电子烟液中的重量为约20％至约60％，且所述丙三醇在电子烟液中的重量为约40％至约70％，以使电子烟液达到最佳的雾化效果，提高使用者体验。
本领域技术人员应理解，基础溶剂可以根据具体需求选择本领域任何已知的溶剂，例如，去离子水、丙二醇、丙三醇，而不受其限制。
在一些实施例中，所述电子烟液还进一步包含凉味剂。
凉味剂为添加剂，其为能够使产品在使用时让使用者产生清凉效果的感受且刺激性不强的化学物。在一些实施例中，所述凉味剂包括选自由薄荷脑、薄荷酮、异薄荷酮、乳酸l-薄荷酯、WS-23(N,2,3-三甲基-2-异丙基丁酰胺)、WS-3(N-乙基-对薄荷基-3-甲酰胺)、WS-5(N-(乙氧羰基甲基)-对烷-3-甲酰胺)、WS-12(N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺)及其组合所组成的群组。
在一些实施例中，以所述电子烟液总重计，所述凉味剂在电子烟液中的重量大致为，例如，0.1％、0.2％、0.3％、0.5％、1.0％、1.5％、2.0％、2.5％、5％、10％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述凉味剂在电子烟液中的重量以所述电子烟液总重计为约1.0％至约10％，以提高所述电子烟液所生成的用于使用者吸入的气雾的口感。
在一些实施例中，所述电子烟液还包括尼古丁盐。在一些实施例中，以所述电子烟液总重计，所述尼古丁盐在电子烟液中在所述电子烟液中的重量大致为，例如，0.001％、0.01％、0.1％、0.2％、0.5％、1.0％、1.5％、2.0％、2.5％、5％、7.5％、10％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述尼古丁盐在所述电子烟液中的重量以所述电子烟液总重计为约0.001％至约10.0％。
在一些实施例中，所述电子烟液还包括尼古丁。在一些实施例中，以所述电子烟液总重计，所述尼古丁在电子烟液中在所述电子烟液中的重量大致为，例如，0.001％、0.01％、0.1％、0.2％、0.5％、1.0％、1.5％、2.0％、2.5％、5％或这些重量百分比中任意两 者组成的范围。在一些实施例中，所述尼古丁在所述电子烟液中的重量以所述电子烟液总重计为约0.001％、至约5.0％。
在一些实施例中，所述电子烟液进一步包括香精，其中所述香精选自由α-蒎烯、α-松油醇、月桂烯、苯甲醛、丁酸乙酯、丁酸异戊酯、丁香酚、β-石竹烯、乙酸苄酯、乙酸丁酯及其组合所组成的群组。
在一些实施例中，所述香精在所述电子烟液中的重量以所述电子烟液总重计为约0.01％至约5.0％，以增添所述电子烟液的风味及优化其所生成的气雾的口感。
根据本申请一些实施例，本申请提供电子烟液的制备方法，其包含以下步骤：取一定量的褪黑素溶于基础溶剂中，随后加入风味成分、香精、尼古丁或其盐，然后，使其均匀混合以获得电子烟液。
根据本申请的另一个方面，本申请提供一种雾化装置，其包含上述任一实施例所述的电子烟液。所述电子烟液可通过所述雾化装置雾化生成供使用者吸入的气雾，其中所述气雾含有不受到高温破坏的褪黑素，供使用者吸收后能够产生抗疲劳、免疫调节、延缓衰老、改善睡眠等效果。
在一些实施例中，所述雾化装置包括电子烟、超声雾化器或网式雾化器。
实施例
为便于更好地理解本申请，通过以下实例加以说明。这些实例属于本申请的保护范围，但不限制本申请的保护范围。
基础烟液的制备：
将丙二醇和丙三醇按以下重量比(32:56)调配后混合均匀，以获得基础烟液。
香精的制备：
按照下表1中的重量比例配置，混合以获得香精。
实施例1
将3克褪黑素加入97克的基础烟液中混合，搅拌均匀，得到电子烟液。
实施例2
将α-己基肉桂醛、芳樟醇、薰衣草醇、乙酸芳樟酯、乙酸香叶酯及乙酸薰衣草酯按以下重量比(1.5：35：0.05：25：0.5：10)调配混合以获得风味组合物，随后将3克褪 黑素、0.5克的风味组合物加入96.5克的基础烟液中，搅拌均匀，得到电子烟液。
实施例3
将α-己基肉桂醛、芳樟醇、薰衣草醇、乙酸芳樟酯、乙酸香叶酯及乙酸薰衣草酯按以下重量比(1.5：35：0.05：25：0.5：10)调配混合以获得风味组合物，随后将2克褪黑素、0.3克的风味组合物、3.0克的尼古丁与2.0克的苯甲酸混合后加入92.7克的基础烟液中，搅拌均匀，得到电子烟液。
实施例4
将α-己基肉桂醛、芳樟醇、薰衣草醇、乙酸芳樟酯、乙酸香叶酯及乙酸薰衣草酯按以下重量比(1.5：38：0.05：25：0.5：10)调配混合以获得风味组合物，随后将1克褪黑素、0.2克的风味组合物、3.0克的尼古丁、2.0克的苯甲酸与0.02克的香精混合后加入93.78克的基础烟液中，搅拌均匀，得到电子烟液。
实施例5
将α-己基肉桂醛、芳樟醇、薰衣草醇、乙酸芳樟酯、乙酸香叶酯及乙酸薰衣草酯按以下重量比(5：60：2：40：8：15)调配混合以获得风味组合物，随后将0.5克褪黑素、0.1克的风味组合物、2.0克的尼古丁、1.5克的苯甲酸、1.0克的WS-23、0.5克的薄荷脑与1.0克的香精混合后加入93.4克的基础烟液中，搅拌均匀，得到电子烟液。
上述实施例中香精的组成如下表1所示。
表1
Figure PCTCN2019107941-appb-000001
随后将实施例1的电子烟液及其雾化后的气雾进行褪黑素含量测量并对实施例1-5 的电子烟液进行口感评分测试。通过上述测试结果以进一步说明，本申请电子烟液在使用过程中其气雾内褪黑素的含量，以及其对使用者体验的提升。
褪黑素含量测试方式；
褪黑素含量测量是通过超高效液相色谱(UPLC)来进行。
样品制备：将实施例1的电子烟液采用以下抽吸方式来生成其用于使用者吸入的气雾：雾化装置为电子烟，抽吸时间为3.0秒±0.1秒、抽吸之间间隔为30.0秒±0.5秒、抽吸次数为50次、每次抽吸量为55mL±0.3mL。采用剑桥滤片收集气雾，并使用10mL甲醇浸没剑桥滤片，超声提取30min后得烟气萃取溶液。然后采用超高效液相色谱(UPLC)对电子烟液及其气雾萃取溶液进行褪黑素含量测定。
液相色谱条件：Waters ACQUITY
Figure PCTCN2019107941-appb-000002
H-Class HSS T3C 18色谱柱(2.1mm×100mm,1.8μm)，流动相为乙腈-水溶液(40:60，v/v)，等度洗脱，流量为0.3mL/min，柱温35℃，进样量3μL，检测波长223nm。
图1A及1B分别是根据本申请实施例的电子烟液以及其所生成的气雾的通过UPLC所测得的 褪黑素含量的色谱图。
如图1A及1B所示，本申请电子烟液的气雾中存在 褪黑素，其中气雾中 褪黑素的成分与电子烟液中的成分基本相同，而免于被高温燃烧破坏。因此， 褪黑素通过电子烟雾化后的气雾可以有效被人体吸收，进而让使用者在吸烟的同时达到对人体保健的功效。
口感评分测试方法1
请20位评析者按表2中的各个评价指标对上述实施例1-5的电子烟气溶胶体验打分。评测结果如下表3所示.
表2
Figure PCTCN2019107941-appb-000003
Figure PCTCN2019107941-appb-000004
表3
Figure PCTCN2019107941-appb-000005
口感评分测试方式2；
统计方法：随机选取1000使用者通过电子烟对上述实施例1-5的电子烟液进行使用测试，待使用测试后对其口味及口感进行评价，其中评价标准以总分10分计，口味越佳或口感越好则分数越高。
实施例1-4的电子烟液经过口感评分测试的测试结果如下表4所示。
表4
Figure PCTCN2019107941-appb-000006
Figure PCTCN2019107941-appb-000007
由表2-4中数据可知，本申请实施例1-5的电子烟液经雾化后能产生的具有薰衣草风味的供使用者吸入的气雾，其不论在口感或是口味的表现上都能有效的提升客户的满意度。
通过本申请上述实施例应可了解，本申请提供了一种电子烟液，通过该电子烟液中包含的风味组合物，能够让使用者产生薰衣草的风味，且不产生焦油与悬浮微粒等有害物质。同时，该电子烟液在使用者抽吸时能够形成气味均匀且浓郁的气雾，而该气雾口感柔顺且不具有残留感，从而提升使用者体验。
虽然已参考本申请的特定实施例描述并说明本申请，但是这些描述和说明并不限制本申请。所属领域的技术人员可清晰地理解，在不脱离如由所附权利要求书定义的本申请的真实精神和范围的情况下，可进行各种改变(例如对本申请的风味组合物中的成分进行适当增加、减少和改变)，以使特定情形、材料、物质组成、物质、方法或过程适宜于本申请的目标、精神和范围。所有此类修改都意图在此所附权利要求书的范围内。虽然已参考按特定次序执行的特定操作描述本文中所公开的方法，但应理解，可在不脱离本申请的教示的情况下组合、细分或重新排序这些操作以形成等效方法。因此，除非本文中特别指示，否则操作的次序和分组并非本申请的限制。

Claims (12)

  1. 一种电子烟液，其包含褪黑素，其中所述褪黑素在所述电子烟液中的重量以所述电子烟液总重计为0.1％至6％。
  2. 根据权利要求1所述的电子烟液，其进一步包含风味组合物。
  3. 根据权利要求2所述的风味组合物，其包含以下重量份的物质：
    1至10份的α-己基肉桂醛、35至65份芳樟醇、0.01至3.0份的薰衣草醇、20至45份的乙酸芳樟酯、0.1至10份的乙酸香叶酯及5至20份的乙酸薰衣草酯。
  4. 根据权利要求2所述的电子烟液，其中所述风味组合物在所述电子烟液中的重量以所述电子烟液总重计为0.001％至1％。
  5. 根据权利要求1至4中任一权利要求所述的电子烟液，其进一步包括凉味剂，其中所述凉味剂选自由薄荷脑、薄荷酮、异薄荷酮、乳酸l-薄荷酯、WS-23(N,2,3-三甲基-2-异丙基丁酰胺)、WS-3(N-乙基-对薄荷基-3-甲酰胺)、WS-5(N-(乙氧羰基甲基)-对烷-3-甲酰胺)、WS-12(N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺)及其组合所组成的群组。
  6. 根据权利要求5所述的电子烟液，其中所述凉味剂在所述电子烟液中的重量以所述电子烟液总重计为0.01％至10％。
  7. 根据权利要求1至4中任一权利要求所述的电子烟液，其进一步包括尼古丁盐，且所述尼古丁盐在所述电子烟液中的重量以所述电子烟液总重计为0.001％至10.0％。
  8. 根据权利要求1至4中任一权利要求所述的电子烟液，其进一步包含尼古丁，且所述尼古丁在所述电子烟液中的重量以所述电子烟液总重计为0.001％至5.0％。
  9. 根据权利要求1至4中任一权利要求所述的电子烟液，其进一步包括香精，其中所述香精选自由α-蒎烯、α-松油醇、月桂烯、苯甲醛、丁酸乙酯、丁酸异戊酯、丁香酚、β-石竹烯、乙酸苄酯、乙酸丁酯及其组合所组成的群组。
  10. 根据权利要求9所述的电子烟液，其中所述香精在所述电子烟液中的重量以所述电子烟液总重计为0.01％至5.0％。
  11. 一种雾化装置，其包含权利要求1至10中任一权利要求所述的电子烟液。
  12. 根据权利要求11所述的雾化装置，其中所述雾化装置包括电子烟、超声雾化器或网式雾化器。
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