WO2021102654A1 - 电子烟液 - Google Patents
电子烟液 Download PDFInfo
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- WO2021102654A1 WO2021102654A1 PCT/CN2019/120747 CN2019120747W WO2021102654A1 WO 2021102654 A1 WO2021102654 A1 WO 2021102654A1 CN 2019120747 W CN2019120747 W CN 2019120747W WO 2021102654 A1 WO2021102654 A1 WO 2021102654A1
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- cigarette liquid
- electronic cigarette
- genistein
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- weight
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- TZBJGXHYKVUXJN-UHFFFAOYSA-N Oc(cc1)ccc1C1=COc(cc(cc2O)O)c2C1=O Chemical compound Oc(cc1)ccc1C1=COc(cc(cc2O)O)c2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
Definitions
- This application relates to the field of electronic aerosols or electronic atomization devices, and in particular to an electronic cigarette liquid with functional components.
- the electronic cigarette or electronic atomizer atomizes the smoking material at a low temperature to form an aerosol for the user to inhale, to replace the smoke generated by the traditional tobacco burning at a high temperature.
- the electronic cigarette liquid has a certain impact on the user's experience and taste, and even the health of the human body.
- the present application provides an electronic cigarette liquid containing genistein.
- the electronic cigarette liquid generates an aerosol for inhalation by a user through an atomizing device, and the aerosol contains genistein in an aerosol state.
- the functional structure of genistein in aerosol state is not destroyed and can be more easily absorbed by the human body, thereby achieving anti-oxidation, anti-tumor, and anti-depressant effects.
- the application provides an e-cigarette liquid comprising genistein, wherein the content of the genistein in the e-cigarette liquid is calculated by the total weight of the e-cigarette liquid 0.01% to 3%.
- the present application provides an atomization device, which includes the above-mentioned electronic cigarette liquid.
- Fig. 1A is a chromatogram of the genistein content of an electronic cigarette liquid according to an embodiment of the present application.
- Fig. 1B is a chromatogram of the genistein content of the aerosol generated by the electronic cigarette liquid according to an embodiment of the present application.
- the terms “substantially”, “substantially”, “substantially”, “substantially” and “about” are used to describe and illustrate small changes. When used in conjunction with an event or situation, the term may refer to an example in which the event or situation occurs precisely and an example in which the event or situation occurs very closely.
- the term when used in conjunction with a value, can refer to a range of variation less than or equal to ⁇ 10% of the stated value, such as less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, Less than or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%.
- the difference between two values is less than or equal to ⁇ 10% of the average value of the value (for example, less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, less than Or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%), then the two values can be considered "substantially" the same.
- a list of items connected by the terms “at least one of”, “at least one of”, “at least one of” or other similar terms may mean the listed items Any combination of. For example, if items A and B are listed, then the phrase “at least one of A and B” means only A; only B; or A and B. In another example, if items A, B, and C are listed, then the phrase "at least one of A, B, and C” means only A; or only B; only C; A and B (excluding C); A and C (exclude B); B and C (exclude A); or all of A, B, and C.
- Project A can contain a single element or multiple elements.
- Project B can contain a single element or multiple elements.
- Project C can contain a single element or multiple elements.
- aerosol for user inhalation may include, but is not limited to, aerosols, suspended liquids, low-temperature vapors, and volatile gases.
- the present application provides an electronic cigarette liquid, which contains genistein.
- Genistein a natural phytoestrogens, is the most abundant in soybean isoflavones. Genistein has the properties of estrogen and anti-estrogen, which can scavenge free radicals, anti-oxidation, anti-tumor and anti-depression. In addition, genistein also has the effects of inducing programmed cell death, improving anti-cancer efficacy, and inhibiting angiogenesis. It is a potential cancer chemopreventive agent, and its anti-cancer effect and mechanism have broad application prospects.
- the genistein contained in it can be mixed with the e-liquid through atomization without being damaged by high temperature.
- the aerosol-like genistein can be directly absorbed, thereby having a health effect on the human body.
- the content of the genistein in the e-cigarette liquid is approximately, for example, 0.01%, 0.05%, 0.1%, 0.2%, 0.3% , 0.4%, 0.5%, 0.7%, 1.0%, 2.0%, 3.0% or any two of these parts. In some embodiments, the content of the genistein in the e-cigarette liquid is about 0.05% to about 1.0% based on the total weight of the e-cigarette liquid.
- the electronic cigarette liquid of some embodiments of the present application further includes flavor.
- the flavor includes at least one of vanillin, ⁇ -pinene, linalool, cis-jasmone, and phenethyl alcohol.
- Vanillin has a pure vanilla flavor, stable, pure, and odor-free aroma, which can make the aroma in the e-liquid more pure and delicate.
- ⁇ -Pinene has a pure woody aroma, which can make the aroma in the e-liquid more perfect, and has a good regulating effect on other aroma types.
- Linalool has the scent of lily of the valley, the aroma is quite good, it can improve the aroma and taste of the e-liquid, making the aroma in the e-liquid more transparent and fuller.
- the cis-jasmone has a fresh lysine aroma, which can make the aroma in the smoke oil more natural and even.
- Phenyl alcohol has a rose aroma, which can make the aroma in the e-liquid fresher and sweeter.
- adding at least one of the above-mentioned flavors can make the mouthfeel of the e-cigarette liquid containing genistein after atomization more comfortable and milder, enrich the aroma of the smoke, and improve the quality of the smoking
- the flavor further comprises 2,5-dimethylpyrazine, ⁇ -ionone, benzaldehyde, phenylacetaldehyde, nerol, nerolidol, dihydrokiwi fruit lactone, hexanol , Triacetin, geraniol, oxoisophorone, leaf alcohol, indole, furanone (4-hydroxy-2,5-dimethyl-3(2H)-furanone), ethyl butyrate At least one of ester, pineapple ester (allyl 3-cyclohexyl propionate), ⁇ -decanolide, ⁇ -caprolactone, and camphor.
- the flavor in this application may be a flavor in the prior art.
- the flavor components are preferably as shown in Table 1.
- the weight of the flavor in the e-cigarette liquid is about 0.01% to about 10.0% based on the total weight of the e-cigarette liquid, for example, approximately 0.01%, 0.05%, 0.2%, 0.3%. %, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3%, 3.5%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or any two of these weight percentages
- the composition range of the e-liquid can increase the flavor of the electronic cigarette liquid and optimize the taste of the aerosol generated.
- the weight of the flavor in the e-cigarette liquid is approximately 0.5% to 5.0% based on the total weight of the e-cigarette liquid.
- the e-cigarette liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin).
- the weight of propylene glycol in the e-liquid is approximately, for example, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, or any two of these weight percentages; and the weight of glycerol in the e-cigarette liquid is roughly, for example, 30%, 35%, 40%, 45%, 50%, 55% , 60%, 65%, 70% or any two of these weight percentages.
- the weight of the propylene glycol in the electronic cigarette liquid is about 15% to about 60%, and the weight of the glycerol in the electronic cigarette liquid is about 30% to about 70%, so that the electronic cigarette The smoke liquid achieves the best atomization effect and improves the user experience.
- the e-cigarette liquid further includes a cooling agent.
- Cooling agents are additives, which are chemicals that can give users a cooling effect when the product is in use and are not very irritating.
- the cooling agent includes selected from the group consisting of menthol, menthone, isomenthone, 1-menthyl lactate, WS-23 (N,2,3-trimethyl-2-isopropylbutyl Amide), WS-3(N-ethyl-p-menthyl-3-carboxamide), WS-5(N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS-12(N -(4-Methoxyphenyl)-p-menthyl-3-carboxamide) and combinations thereof.
- the weight of the cooling agent in the e-cigarette liquid is about 0.1% to about 10.0%, for example, approximately 0.1%, 0.2%, 0.3%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 10% or any two of these weight percentages in the range to increase the aerosol generated by the e-cigarette liquid for inhalation by the user The taste.
- the weight of the cooling agent in the e-cigarette liquid is about 1.5% to about 5% based on the total weight of the e-cigarette liquid.
- the e-cigarette liquid further includes nicotine salt.
- the weight of the nicotine salt in the e-cigarette liquid is less than 10%, for example, approximately 0.001%, 0.01%, 0.1% , 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10% or any two of these weight percentages.
- the weight of the nicotine salt in the e-cigarette liquid is about 1.0% to about 10.0% based on the total weight of the e-cigarette liquid.
- the e-cigarette liquid further includes nicotine.
- the weight of the nicotine in the e-liquid in the e-liquid is less than 5%, for example, approximately 0.001%, 0.01%, 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5% or any two of these weight percentages.
- the weight of the nicotine in the e-cigarette liquid is about 0.05% to about 5.0% based on the total weight of the e-cigarette liquid.
- the present application provides a method for preparing an electronic cigarette liquid, which includes the following steps: dissolving a certain amount of genistein in a basic solvent, and then adding flavor, cooling agent, nicotine or a salt thereof. Then, it is uniformly mixed to obtain an electronic cigarette liquid.
- a method for preparing an electronic cigarette liquid which includes the following steps: dissolving a certain amount of genistein in a basic solvent, and then adding flavor, cooling agent, nicotine or a salt thereof. Then, it is uniformly mixed to obtain an electronic cigarette liquid.
- the order of addition of the above-mentioned substances is not limited to the above-defined order, but can be adjusted as required.
- the present application provides an atomization device, which includes the electronic cigarette liquid described in any of the above embodiments.
- the electronic cigarette liquid can be atomized by the atomizing device to generate an aerosol for the user to inhale, wherein the aerosol contains genistein that is not damaged by high temperature, and can produce anti-oxidation and anti-oxidation after being absorbed by the user. Tumor, antidepressant and other effects.
- the atomization device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
- Flavor preparation :
- genistein was added to the basic e-liquid mixed with 49.9 g of propylene glycol and 50 g of glycerol, mixed, and stirred uniformly to obtain an electronic cigarette liquid.
- genistein 0.3 g was added to the basic smoke liquid mixed with 40.3 g of propylene glycol and 48 g of glycerol and mixed, and stirred evenly. Subsequently, 3 g of nicotine, 2.4 g of benzoic acid, 1 g of WS-23, 2 g of menthol and 3 g of flavor 1 were added to obtain an electronic cigarette liquid.
- composition of the fragrance in the above-mentioned embodiment is shown in Table 1 below.
- Example 1 The e-cigarette liquid of Example 1 and its atomized aerosol were measured for the genistein content, and the taste scoring test of the e-cigarette liquid of Examples 1-6 was performed.
- the above test results are used to further illustrate the content of genistein in the aerosol of the e-cigarette liquid of the present application during use, and the improvement of user experience.
- the genistein content is measured by ultra performance liquid chromatography (UPLC).
- the e-cigarette liquid of Example 1 is used to generate aerosol for user inhalation by the following suction methods: the atomization device is an electronic cigarette, the suction time is 3.0 seconds ⁇ 0.1 seconds, and the interval between puffs It is 30.0 seconds ⁇ 0.5 seconds, the number of puffs is 50 times, and the volume of each puff is 55 mL ⁇ 0.3 mL.
- a Cambridge filter was used to collect the aerosol, and 10 mL of methanol was used to immerse the Cambridge filter. After 30 minutes of ultrasonic extraction, a flue gas extraction solution was obtained. Then, ultra-high performance liquid chromatography (UPLC) was used to determine the content of genistein in the e-cigarette liquid and its aerosol extraction solution.
- UPLC ultra-high performance liquid chromatography
- Liquid chromatography conditions Waters ACQUITY H-Class HSS T3C 18 column (2.1mm ⁇ 100mm, 1.8 ⁇ m), mobile phase is acetonitrile-0.1% formic acid solution (40:60, v/v), isocratic elution, flow rate is 0.3mL/min, column The temperature is 35°C, the injection volume is 3 ⁇ L, and the detection wavelength is 260nm.
- 1A and 1B are respectively chromatograms of the genistein content measured by UPLC of the e-cigarette liquid and the aerosol generated therefrom according to an embodiment of the present application.
- genistein is present in the aerosol of the e-cigarette liquid of the present application, and the composition of the genistein in the aerosol is basically the same as that of the e-cigarette liquid, and it is prevented from being destroyed by high-temperature combustion. . Therefore, the genistein can be effectively absorbed by the human body through the aerosol after the electronic cigarette, so that the user can achieve the effect of health care for the human body while smoking.
- Statistical method Randomly select 1000 users to test the use of the e-cigarette liquids of the above examples 1-6 through e-cigarettes, and evaluate their taste and mouthfeel after the use test.
- the evaluation standard is based on a total score of 10 points. The better or the better the taste, the higher the score.
- the e-cigarette liquids of Examples 1-6 of the present application produce aerosols containing genistein for users to inhale after being atomized, regardless of the taste or taste.
- the performance can reach a certain level of customer satisfaction.
- the e-cigarette liquid added with the flavor provided in the example of the present application has a significant improvement in the taste score test.
- this application provides an e-cigarette liquid.
- the genistein contained in the e-cigarette liquid allows users to inhale genistein while inhaling e-cigarette mist.
- the aerosol molecules of flavonoids can achieve anti-oxidation, anti-tumor, anti-depression and other human health effects.
- the e-cigarette liquid can form a uniform and strong aerosol when the user inhales by adding a specific flavor, and the aerosol has a soft mouthfeel and does not have a residual sensation, thereby optimizing the user experience.
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Abstract
一种电子烟液，该电子烟液包含金雀异黄酮，其中金雀异黄酮在电子烟液中的含量以电子烟液总重计0.01%至3%。该电子烟液经过雾化，其包含的金雀异黄酮可随烟液一起雾化出来，被人体吸收，对人体具有抗氧化、抗肿瘤、抗抑郁等功效作用。本发明还包括一种雾化装置。
Description
本申请涉及电子气雾剂或电子雾化装置的领域，尤其涉及一种具有功能性成分的电子烟液。
由于对于个人健康、环境保护以及使用便利性的追求，电子烟作为传统烟草的取代品越来越受到消费者的青睐。电子烟或电子雾化器通过将发烟材料低温雾化形成用于使用者吸入的气雾，来取代传统烟草以高温燃烧的方式所产生的烟气。其中，电子烟液对于使用者的体验及口感，甚至对人体的健康具有一定的影响。
通过低温雾化如何进一步生成降低对人体有害影响且提高对人体有益影响的用于使用者吸入的气雾，是电子烟产品需要改进的研究方向。
发明内容
本申请提供一种含有金雀异黄酮的电子烟液，该电子烟液通过雾化装置生成一种供使用者吸入的气雾，该气雾中存在呈气雾状态的金雀异黄酮。呈气雾状态的金雀异黄酮的功能结构未被破坏能够更容易被人体吸收，进而达到抗氧化、抗肿瘤、抗抑郁等功效。
根据本申请的一个层面，本申请提供了一种电子烟液，其包含金雀异黄酮，其中所述金雀异黄酮在所述电子烟液中的含量以所述电子烟液总重计为0.01％至3％。
根据本申请的又一层面，本申请提供了一种雾化装置，其包含上述电子烟液。
本申请实施例的额外层面及优点将部分地在后续说明中描述、显示、或是经由本申请实施例的实施而阐释。
图1A是根据本申请实施例的电子烟液的金雀异黄酮含量的色谱图。
图1B是根据本申请实施例的电子烟液所生成的气雾的金雀异黄酮含量的色谱图。
本申请的实施例将会被详细的描示在下文中。本申请的实施例不应所述被解释为对本申请的限制。
另外，有时在本文中以范围格式呈现量、比率和其它数值。应理解，此类范围格式是用于便利及简洁起见，且应灵活地理解，不仅包含明确地指定为范围限制的数值，而且包含涵盖于所述范围内的所有个别数值或子范围，如同明确地指定每一数值及子范围一般。
如本文中所使用，术语“大致”、“大体”、“大体上”、“实质”及“约”用以描述及说明小的变化。当与事件或情形结合使用时，所述术语可指代其中事件或情形精确发生的例子以及其中事件或情形极近似地发生的例子。举例来说，当结合数值使用时，术语可指代小于或等于所述数值的±10％的变化范围，例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％。举例来说，如果两个数值之间的差值小于或等于所述值的平均值的±10％(例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％)，那么可认为所述两个数值“大体上”相同。
在具体实施方式及权利要求书中，由术语“中的至少一者”、“中的至少一个”、“中的至少一种”或其他相似术语所连接的项目的列表可意味着所列项目的任何组合。例如，如果列出项目A及B，那么短语“A及B中的至少一者”意味着仅A；仅B；或A及B。在另一实例中，如果列出项目A、B及C，那么短语“A、B及C中的至少一者”意味着仅A；或仅B；仅C；A及B(排除C)；A及C(排除B)；B及C(排除A)；或A、B及C的全部。项目A可包含单个元件或多个元件。项目B可包含单个元件或多个元件。项目C可包含单个元件或多个元件。
在本文中，用语“用于使用者吸入的气雾”或“气雾”可以包括，但不限于，气溶胶、悬浮液体、低温蒸气及挥发性气体。
根据本申请的一个方面，本申请提供了一种电子烟液，所述电子烟液包含金雀异黄酮。
金雀异黄酮的化学式为C
15H
10O
5，其结构式如下式一所表示。
金雀异黄酮，是一种天然的植物雌激素，在大豆异黄酮中含量最为丰富。金雀异黄酮具有雌激素以及抗雌性激素的性质，其能够清除自由基、抗氧化、抗肿瘤和抗抑郁。此外，金雀异黄酮还具有诱发细胞程序性死亡、提高抗癌药效、抑制血管生成等作用，是一种很有潜力的癌症化学预防剂，其抗癌作用及机制具有广泛的应用前景。在一些实施例中，当电子烟液通过雾化装置形成气雾时，由于是通过低温雾化的作用，其包含的金雀异黄酮能够不受到高温破坏而与电子烟液一起通过雾化混入气雾中，而当使用者吸入该气雾时，可直接吸收气雾状的金雀异黄酮，进而起到对人体的保健功效。
在一些实施例中，所述金雀异黄酮在电子烟液中的含量，以所述电子烟液的总重量计，大致为，例如，0.01％、0.05％、0.1％、0.2％、0.3％、0.4％、0.5％、0.7％、1.0％、2.0％、3.0％或这些份数中任意两者组成的范围。在一些实施例中，所述金雀异黄酮在电子烟液中的含量以所述电子烟液总重计为约0.05％至约1.0％。
根据本申请的另一方面，本申请一些实施例的所述电子烟液进一步包括香精。在一些实施例中，所述香精包含香兰素、β-蒎烯、芳樟醇、顺式茉莉酮及苯乙醇中的至少一种。
香兰素具有纯纯的香草味道，香气稳定、纯正、无杂味，能够使烟油中的香气更加纯正、细腻。β-蒎烯具有纯正的木香，能够使烟油中的香气更加完美，对其他香型具有很好的调节作用。芳樟醇具有铃兰香气，香气颇佳，能够改善烟油的香气和口感，使烟油中的香气更透发，更饱满。顺式茉莉酮具有新鲜莱莉香气，能够使烟油中的香气更天然，更均匀。苯乙醇具有玫瑰香气，能够使烟油中的香气清新，更香甜。在一些实施例中，通过添加上述香精中的至少一种能够使含有金雀异黄酮的电子烟液经雾化后的口感更舒适，更温和，丰富了烟的香气，从而提升了吸食品质。
在一些实施例中，所述香精还包含2，5-二甲基吡嗪、β-紫罗兰酮、苯甲醛、苯乙醛、橙花醇、橙花叔醇、二氢猕猴桃内脂、己醇、三醋酸甘油酯、香叶醇、氧代异佛尔酮、叶醇、吲哚、呋喃酮(4-羟基-2,5-二甲基-3(2H)-呋喃酮)、丁酸乙酯、菠萝酯(3-环己基丙酸烯丙酯)、γ-癸内酯、γ-辛内酯及樟脑中的至少一种。本申请中的香精可以是现有技术中的香精，在一些实施例中，所述香精成分优选如表1所示。
在一些实施例中，所述香精在所述电子烟液中的重量以所述电子烟液总重计为约0.01％至约10.0％，例如，大致为0.01％、0.05％、0.2％、0.3％、0.5％、1.0％、1.5％、2.0％、2.5％、3％、3.5％、4％、5％、6％、7％、8％、9％、10％或这些重量百分比中任意两者组成的范围，以增添所述电子烟液的风味及优化其所生成的气雾的口感。在一些实施例中，所述香精在所述电子烟液中的重量以所述电子烟液总重计大致为0.5％至5.0％。
电子烟液还包含基础溶剂，其中所述基础溶剂包含丙二醇及丙三醇(甘油)。在一些实施例中，以所述电子烟液总重计，丙二醇在电子烟液中的重量大致为，例如，15％、20％、25％、30％、35％、40％、50％、60％、70％或这些重量百分比中任意两者组成的范围；及丙三醇在电子烟液中的重量大致为，例如，30％、35％、40％、45％、50％、55％、60％、65％、70％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述丙二醇在电子烟液中的重量为约15％至约60％，且所述丙三醇在电子烟液中的重量为约30％至约70％，以使电子烟液达到最佳的雾化效果，提高使用者体验。
在一些实施例中，所述电子烟液还进一步包含凉味剂。
凉味剂为添加剂，其为能够使产品在使用时让使用者产生清凉效果的感受且刺激性不强的化学物。在一些实施例中，所述凉味剂包括选自由薄荷脑、薄荷酮、异薄荷酮、乳酸l-薄荷酯、WS-23(N,2,3-三甲基-2-异丙基丁酰胺)、WS-3(N-乙基-对薄荷基-3-甲酰胺)、WS-5(N-(乙氧羰基甲基)-对烷-3-甲酰胺)、WS-12(N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺)及其组合所组成的群组。
在一些实施例中，以所述电子烟液总重计，所述凉味剂在电子烟液中的重量为约0.1％至约10.0％，例如，大致为0.1％、0.2％、0.3％、0.5％、1.0％、1.5％、2.0％、2.5％、5％、10％或这些重量百分比中任意两者组成的范围，以提高所述电子烟液所生成的用于使用者吸入的气雾的口感。在一些实施例中，所述凉味剂在电子烟液中的重量以所述电子烟液总重计为约1.5％至约5％。
在一些实施例中，所述电子烟液还包括尼古丁盐。在一些实施例中，以所述电子烟液总重计，所述尼古丁盐在电子烟液中在所述电子烟液中的重量小于10％，例如，大致为0.001％、0.01％、0.1％、0.2％、0.5％、1.0％、1.5％、2.0％、2.5％、5％、7.5％、10％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述尼古丁盐在所述电子烟液中的重量以所述电子烟液总重计为约1.0％至约10.0％。
在一些实施例中，所述电子烟液还包括尼古丁。在一些实施例中，以所述电子烟液总重计，所述尼古丁在电子烟液中在所述电子烟液中的重量小于5％，例如，大致为0.001％、0.01％、0.1％、0.2％、0.5％、1.0％、1.5％、2.0％、2.5％、5％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述尼古丁在所述电子烟液中的重量以所述电子烟液总重计为约0.05％至约5.0％。
根据本申请一些实施例，本申请提供电子烟液的制备方法，其包含以下步骤：取一定量的金雀异黄酮溶于基础溶剂中，随后加入香精、凉味剂、尼古丁或其盐。然后，使其均匀混合以获得电子烟液。然而本领域熟知的是，上述各物质的添加顺序不局限于如上定义的，而是可以根据需要进行调整。
根据本申请的另一个方面，本申请提供一种雾化装置，其包含上述任一实施例所述的电子烟液。所述电子烟液可通过所述雾化装置雾化生成供使用者吸入的气雾，其中所述气雾含有不受到高温破坏的金雀异黄酮，供使用者吸收后能够产生抗氧化、抗肿瘤、抗抑郁等效果。
在一些实施例中，所述雾化装置包括电子烟、超声雾化器或网式雾化器。
实施例
为便于更好地理解本申请，通过以下实例加以说明。这些实例属于本申请的保护范围，但不限制本申请的保护范围。
香精的制备：
按照下表1中的重量比例配置，混合以获得香精。
实施例1
将0.1克的金雀异黄酮加入49.9克的丙二醇与50克的丙三醇混合的基础烟液中混合，搅拌均匀，得到电子烟液。
实施例2
将0.1克的金雀异黄酮加入41.9克的丙二醇与53克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入2克的薄荷脑及3克的香精2得到电子烟液。
实施例3
将0.2克的金雀异黄酮加入42.81克的丙二醇与53克的丙三醇混合的基础烟液中混 合，搅拌均匀。随后加入0.99克的尼古丁、2克的薄荷脑及1克的香精1得到电子烟液。
实施例4
将0.2克的金雀异黄酮加入42.8克的丙二醇与50克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入1.8克的尼古丁、1.2克的苯甲酸、2克的WS-23及2克的香精1得到电子烟液。
实施例5
将0.3克的金雀异黄酮加入40.3克的丙二醇与48克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入3克的尼古丁、2.4克的苯甲酸、1克的WS-23、2克的薄荷脑及3克的香精1得到电子烟液。
实施例6
将0.3克的金雀异黄酮加入38.2克的丙二醇与46克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入5克的尼古丁、4.5克的苯甲酸、1克的WS-23、1克的薄荷脑及4克的香精1得到电子烟液。
实施例7
将1.2克的金雀异黄酮加入38.3克的丙二醇与43克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入4克的尼古丁、4.5克的苯甲酸、2克的WS-23、1克的薄荷脑及6克的香精2得到电子烟液。
上述实施例中香精的组成如下表1所示。
表1
将实施例1的电子烟液及其雾化后的气雾进行金雀异黄酮含量测量，并对实施例1-6的电子烟液进行口感评分测试。通过上述测试结果以进一步说明，本申请电子烟液在使用过程中其气雾内金雀异黄酮的含量，以及其对使用者体验的提升。
金雀异黄酮含量测试方式；
金雀异黄酮含量测量是通过超高效液相色谱(UPLC)来进行。
样品制备：将实施例1的电子烟液采用以下抽吸方式来生成其用于使用者吸入的气雾：雾化装置为电子烟，抽吸时间为3.0秒±0.1秒、抽吸之间间隔为30.0秒±0.5秒、抽吸次数为50次、每次抽吸量为55mL±0.3mL。采用剑桥滤片收集气雾，并使用10mL甲醇浸没剑桥滤片，超声提取30min后得烟气萃取溶液。然后采用超高效液相色谱(UPLC)对电子烟液及其气雾萃取溶液进行金雀异黄素含量测定。
液相色谱条件：Waters ACQUITY
H-Class HSS T3C
18色谱柱(2.1mm×100mm,1.8μm)，流动相为乙腈-0.1％甲酸溶液(40:60，v/v)，等度洗脱，流量为0.3mL/min，柱温35℃，进样量3μL，检测波长260nm。
图1A及1B分别是根据本申请实施例的电子烟液以及其所生成的气雾的通过UPLC所测得的金雀异黄酮含量的色谱图。
如图1A及1B所示，本申请电子烟液的气雾中存在金雀异黄酮，其中气雾中金雀异黄酮的成分与电子烟液中的成分基本相同，而免于被高温燃烧破坏。因此，金雀异黄酮通过电子烟雾化后的气雾可以有效被人体吸收，进而让使用者在吸烟的同时达到对人体保健的功效。
口感评分测试方法1
请20位评析者按表2中的各个评价指标对上述实施例1-6的电子烟气溶胶体验打分。 评测结果如下表3所示.
表2
表3
口感评分测试方式2；
统计方法：随机选取1000使用者通过电子烟对上述实施例1-6的电子烟液进行使用测试，待使用测试后对其口味及口感进行评价，其中评价标准以总分10分计，口味越 佳或口感越好则分数越高。
实施例1-6的电子烟液经过口感评分测试的测试结果如下表4所示。
表4
由表2-4中数据可知，本申请实施例1-6的电子烟液，经雾化后所产生的具有金雀异黄酮的供使用者吸入的气雾，其不论在口感或是口味的表现上都能达到一定的客户的满意度。此外，相较于实施例1，添加了本申请实施例提供的香精的电子烟液在口感评分测试上都有显著的提升。
通过比较实施例2-7可知，本申请的电子烟液中的香精浓度在0.5wt％至5.0wt％的范围内具有最佳的使用者体验。
通过本申请上述实施例应可了解，本申请提供了一种电子烟液，通过该电子烟液中包含的金雀异黄酮，能够让使用者在吸入电子烟气雾的同时摄入金雀异黄酮的气雾分子，从而达到抗氧化、抗肿瘤、抗抑郁等人体保健功效。同时，该电子烟液通过添加特定香精在使用者抽吸时能够形成气味均匀且浓郁的气雾，而该气雾口感柔顺且不具有残留感，从而优化使用者体验。
虽然已参考本申请的特定实施例描述并说明本申请，但是这些描述和说明并不限制本申请。所属领域的技术人员可清晰地理解，在不脱离如由所附权利要求书定义的本申请的真实精神和范围的情况下，可进行各种改变(例如对本申请的香精组份中的成分进行适当增加、减少和改变)，以使特定情形、材料、物质组成、物质、方法或过程适宜于本申请的目标、精神和范围。所有此类修改都意图在此所附权利要求书的范围内。虽然已参考按特定次序执行的特定操作描述本文中所公开的方法，但应理解，可在不脱离 本申请的教示的情况下组合、细分或重新排序这些操作以形成等效方法。因此，除非本文中特别指示，否则操作的次序和分组并非本申请的限制。
Claims (10)
- 一种电子烟液，其包含金雀异黄酮，其中所述金雀异黄酮在所述电子烟液中的重量以所述电子烟液总重计为0.01％至3％。
- 根据权利要求1所述的电子烟液，其进一步包括香精。
- 根据权利要求2所述的电子烟液，其中所述香精包含香兰素、β-蒎烯、芳樟醇、顺式茉莉酮及苯乙醇中的至少一种。
- 根据权利要求2或3所述的电子烟液，其中所述香精在所述电子烟液中的重量以所述电子烟液总重计为小于10.0％。
- 根据权利要求1所述的电子烟液，其进一步包括凉味剂，其中所述凉味剂选自由薄荷脑、薄荷酮、异薄荷酮、乳酸l-薄荷酯、WS-23(N,2,3-三甲基-2-异丙基丁酰胺)、WS-3(N-乙基-对薄荷基-3-甲酰胺)、WS-5(N-(乙氧羰基甲基)-对烷-3-甲酰胺)、WS-12(N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺)及其组合所组成的群组。
- 根据权利要求5所述的电子烟液，其中所述凉味剂在所述电子烟液中的重量以所述电子烟液总重计为小于10％。
- 根据权利要求1所述的电子烟液，其进一步包括尼古丁盐，且所述尼古丁盐在所述电子烟液中的重量以所述电子烟液总重计小于10.0％。
- 根据权利要求1所述的电子烟液，其进一步包含尼古丁，且所述尼古丁在所述电子烟液中的重量以所述电子烟液总重计小于5.0％。
- 一种雾化装置，其包含权利要求1至8中任一权利要求所述的电子烟液。
- 根据权利要求9所述的雾化装置，其中所述雾化装置包括电子烟、超声雾化器或网式雾化器。
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