WO2021102651A1 - 电子烟液 - Google Patents

电子烟液 Download PDF

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Publication number
WO2021102651A1
WO2021102651A1 PCT/CN2019/120738 CN2019120738W WO2021102651A1 WO 2021102651 A1 WO2021102651 A1 WO 2021102651A1 CN 2019120738 W CN2019120738 W CN 2019120738W WO 2021102651 A1 WO2021102651 A1 WO 2021102651A1
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WIPO (PCT)
Prior art keywords
cigarette liquid
electronic cigarette
pterostilbene
resveratrol
liquid
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PCT/CN2019/120738
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English (en)
French (fr)
Inventor
许静
李馨铎
姜兴涛
吴泽宏
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深圳雾芯科技有限公司
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Priority to PCT/CN2019/120738 priority Critical patent/WO2021102651A1/zh
Publication of WO2021102651A1 publication Critical patent/WO2021102651A1/zh

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes

Definitions

  • This application relates to the field of electronic aerosols or electronic atomization devices, and in particular to an electronic cigarette liquid with functional components.
  • the electronic cigarette or electronic atomizer atomizes the smoking material at a low temperature to form an aerosol for the user to inhale, to replace the smoke generated by the traditional tobacco burning at a high temperature.
  • the electronic cigarette liquid has a certain impact on the user's experience and taste, and even the health of the human body.
  • the present application provides an e-cigarette liquid containing resveratrol, pterostilbene or a combination thereof.
  • the e-cigarette liquid generates an aerosol for the user to inhale through an atomizing device, and the resveratrol in the aerosol state is present.
  • pterostilbene the functional structure of resveratrol and pterostilbene in aerosol state is not destroyed and can be more easily absorbed by the human body, thereby achieving the antioxidant and cardiovascular protection effects on the human body.
  • the application provides an electronic cigarette liquid, which contains at least one of resveratrol and pterostilbene, wherein at least one of the resveratrol and the pterostilbene is in
  • the weight of the electronic cigarette liquid is 0.1% to 10% based on the total weight of the electronic cigarette liquid.
  • the present application provides an atomization device, which includes the above-mentioned electronic cigarette liquid.
  • Fig. 1A is a chromatogram of the resveratrol content of an electronic cigarette liquid according to an embodiment of the present application.
  • FIG. 1B is a chromatogram of the resveratrol content of the aerosol generated by the electronic cigarette liquid according to the embodiment of the present application.
  • Fig. 2A is a chromatogram of the pterostilbene content in the electronic cigarette liquid according to an embodiment of the present application.
  • 2B is a chromatogram of the pterostilbene content of the aerosol generated by the electronic cigarette liquid according to an embodiment of the present application.
  • the terms “substantially”, “substantially”, “substantially”, “substantially” and “about” are used to describe and illustrate small changes. When used in conjunction with an event or situation, the term may refer to an example in which the event or situation occurs precisely and an example in which the event or situation occurs very closely.
  • the term when used in conjunction with a value, can refer to a range of variation less than or equal to ⁇ 10% of the stated value, such as less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, Less than or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%.
  • the difference between two values is less than or equal to ⁇ 10% of the average value of the value (for example, less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, less than Or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%), then the two values can be considered "substantially" the same.
  • a list of items connected by the term "at least one of” or other similar terms can mean any combination of the listed items. For example, if items A and B are listed, then the phrase "at least one of A and B" means only A; only B; or A and B. In another example, if items A, B, and C are listed, then the phrase "at least one of A, B, and C" means only A; or only B; only C; A and B (excluding C); A and C (exclude B); B and C (exclude A); or all of A, B, and C.
  • Project A can contain a single element or multiple elements.
  • Project B can contain a single element or multiple elements.
  • Project C can contain a single component or multiple components.
  • aerosol for user inhalation may include, but is not limited to, aerosols, suspended liquids, low-temperature vapors, and volatile gases.
  • the present application provides an electronic cigarette liquid containing at least one of resveratrol and pterostilbene.
  • Resveratrol is a natural antioxidant that can reduce blood viscosity, inhibit platelet coagulation and vasodilation, keep blood flowing, prevent the occurrence and development of cancer, has anti-atherosclerosis and coronary heart disease, ischemic Prevention and treatment of heart disease and hyperlipidemia. Resveratrol can exert its anti-aging and vascular protection effects by inhibiting the production of reactive oxygen species in the mitochondria of vascular smooth muscle cells.
  • Pterostilbene is C 16 H 16 O 3 , and its structural formula is represented by the following formula 2.
  • Pterostilbene is a chemical component contained in red sandalwood. It is an antifungal active component in dragon's blood products. It has a certain effect on the treatment of cancer, high blood pressure, and hyperlipidemia. Pterostilbene can increase the expression of manganese superoxide dismutase (Mn-SOD) in the mitochondrial matrix by activating and expressing gene sequence Bcl-2 related proteins, thereby inhibiting mitochondrial respiration and reducing peroxidation It produces anti-aging and vascular protection effects.
  • Mn-SOD manganese superoxide dismutase
  • the functional structure of the resveratrol and pterostilbene contained in it is not damaged by the high temperature and can be compared with the e-cigarette due to the effect of low-temperature atomization.
  • the liquid is mixed into the aerosol through atomization, and when the user inhales the aerosol, the aerosol-like resveratrol and pterostilbene can be directly absorbed, thereby having the effect of cardiovascular health care on the human body. While using electronic cigarettes, it reduces the harmful side effects caused by the aerosol to the human body, and achieves the effect of cardiovascular health care.
  • the content of resveratrol in the e-cigarette liquid, based on the total weight of the e-cigarette liquid is approximately, for example, 0.1%, 0.2%, 0.5%, 1.0%, 2.0%, 3.0 %, 4.0%, 5.0%, 10.0%, or any two of these parts.
  • the content of pterostilbene in the e-cigarette liquid, based on the total weight of the e-cigarette liquid is approximately, for example, 0.1%, 0.2%, 0.5%, 1.0%, 2.0%, 3.0%, 4.0%, 5.0%, 10.0%, or a range composed of any two of these parts.
  • the content of at least one of resveratrol and pterostilbene in the e-cigarette liquid is about 0.1% to about 10.0% based on the total weight of the e-cigarette liquid.
  • the electronic cigarette liquid of some embodiments of the present application further includes flavor.
  • the flavor includes at least one of methyl dihydrojasmonate, limonene, linalool, vanillin, and ⁇ -pinene. .
  • Methyl dihydrojasmonate has the fragrance of fresh lysium, which can make the fragrance in the e-liquid more natural and longer lasting.
  • Limonene has a lemon-like aroma, which can make the aroma in the smoke oil fuller and sweeter.
  • Linalool has the scent of lily of the valley, the aroma is quite good, it can improve the aroma and taste of the e-liquid, making the aroma in the e-liquid more transparent and fuller.
  • Vanillin has a pure vanilla flavor, stable, pure, and odor-free aroma, which can make the aroma in the e-liquid more pure and delicate.
  • ⁇ -Pinene has a pure woody aroma, which can make the aroma in the e-liquid more perfect, and has a good regulating effect on other aroma types.
  • the addition of at least one of the above-mentioned flavors can make the e-cigarette liquid containing at least one of resveratrol and pterostilbene more comfortable and milder after being atomized, and enrich the aroma of the smoke. , Thereby improving the quality of sucking food.
  • the flavor further comprises ethyl 2-methylbutyrate, ⁇ -terpineol, ⁇ -decanolide, benzyl alcohol, benzyl benzoate, ethyl propionate, ethyl butyrate, Raspberry ketone, ethyl cinnamate, citronellol, myricetin, leaf alcohol, 2-methylbutyl acetate, benzyl acetate, propyl acetate, neryl acetate, butyl acetate, geranyl acetate, acetic acid At least one of leaf alcohol ester, ethyl acetate, isoamyl acetate, ethyl isobutyrate, isopulegol, and ethyl isovalerate.
  • the weight of the flavor in the e-cigarette liquid is about 0.01% to about 10.0% based on the total weight of the e-cigarette liquid, for example, approximately 0.01%, 0.05%, 0.2%, 0.3%. %, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3%, 3.5%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or any two of these weight percentages
  • the composition range of the e-liquid can increase the flavor of the electronic cigarette liquid and optimize the taste of the aerosol generated.
  • the weight of the flavor in the e-cigarette liquid is about 0.5% to about 5.0% based on the total weight of the e-cigarette liquid.
  • the flavor in this application may be a flavor in the prior art.
  • the flavor components are preferably as shown in Table 1.
  • the e-cigarette liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin).
  • the weight of propylene glycol in the e-liquid is approximately, for example, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, or any two of these weight percentages; and the weight of glycerol in the e-cigarette liquid is roughly, for example, 30%, 35%, 40%, 45%, 50%, 55% , 60%, 65%, 70% or any two of these weight percentages.
  • the weight of the propylene glycol in the electronic cigarette liquid is about 15% to about 60%, and the weight of the glycerol in the electronic cigarette liquid is about 30% to about 70%, so that the electronic cigarette The smoke liquid achieves the best atomization effect and improves the user experience.
  • the e-cigarette liquid further includes a cooling agent.
  • Cooling agents are additives, which are chemicals that can give users a cooling effect when the product is in use and are not very irritating.
  • the cooling agent includes selected from the group consisting of menthol, menthone, isomenthone, 1-menthyl lactate, WS-23 (N,2,3-trimethyl-2-isopropylbutyl Amide), WS-3(N-ethyl-p-menthyl-3-carboxamide), WS-5(N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS-12(N -(4-Methoxyphenyl)-p-menthyl-3-carboxamide) and combinations thereof.
  • the weight of the cooling agent in the e-cigarette liquid is approximately, for example, 0.1%, 0.2%, 0.3%, 0.5%, 1.0%, 1.5% , 2.0%, 2.5%, 5%, 10% or any two of these weight percentages. In some embodiments, the weight of the cooling agent in the e-cigarette liquid is about 0.5% to about 5% based on the total weight of the e-cigarette liquid, so as to increase the amount of the e-cigarette liquid for users The taste of the inhaled aerosol.
  • the e-cigarette liquid further includes nicotine salt.
  • the weight of the nicotine salt in the e-cigarette liquid is less than 10%, such as approximately 0.001%, 0.01%, 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10% or a range composed of any two of these weight percentages.
  • the weight of the nicotine salt in the e-cigarette liquid is about 0.001% to about 10.0% based on the total weight of the e-cigarette liquid.
  • the e-cigarette liquid further includes nicotine.
  • the weight of the nicotine in the e-liquid in the e-liquid is less than 5%, such as approximately 0.001%, 0.01%, 0.1%, 0.2%. %, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5% or any two of these weight percentages.
  • the weight of the nicotine in the e-cigarette liquid is about 0.05% to about 5.0% based on the total weight of the e-cigarette liquid.
  • the present application provides a method for preparing an electronic cigarette liquid, which includes the following steps: dissolving a certain amount of at least one of resveratrol and pterostilbene in a basic solvent, and then adding flavor and cooling flavor Agent, nicotine or its salt. Then, it is uniformly mixed to obtain an electronic cigarette liquid.
  • a method for preparing an electronic cigarette liquid which includes the following steps: dissolving a certain amount of at least one of resveratrol and pterostilbene in a basic solvent, and then adding flavor and cooling flavor Agent, nicotine or its salt. Then, it is uniformly mixed to obtain an electronic cigarette liquid.
  • the order of addition of the above-mentioned substances is not limited to the above-defined order, but can be adjusted as required.
  • the present application provides an atomization device, which includes the electronic cigarette liquid described in any of the foregoing embodiments.
  • the electronic cigarette liquid can be atomized by the atomizing device to generate an aerosol for the user to inhale, wherein the aerosol contains at least one of resveratrol and pterostilbene that is not damaged by high temperature for the user After absorption, it can produce anti-aging and vascular protection effects.
  • the atomization device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
  • Flavor preparation :
  • composition of the fragrance in the above-mentioned embodiment is shown in Table 1 below.
  • the content of resveratrol and pterostilbene were measured for the e-cigarette liquids of Examples 1 and 2 and the aerosol after atomization, and the taste scoring test was performed for the e-cigarette liquids of Examples 1-10.
  • the above test results are used to further illustrate the content of resveratrol and pterostilbene in the aerosol of the electronic cigarette liquid of the present application during use, and the improvement of user experience.
  • the content of resveratrol and pterostilbene is measured by ultra performance liquid chromatography (UPLC).
  • Sample preparation The e-cigarette liquid of Example 1 and Example 2 was used to generate aerosol for user inhalation by the following suction methods:
  • the atomization device was an electronic cigarette, and the suction time was 3.0 seconds ⁇ 0.1 seconds.
  • the interval between puffs is 30.0 seconds ⁇ 0.5 seconds, the number of puffs is 50 times, and the volume of each puff is 55 mL ⁇ 0.3 mL.
  • a Cambridge filter was used to collect the aerosol, and 10 mL of methanol was used to immerse the Cambridge filter. After 30 minutes of ultrasonic extraction, a flue gas extraction solution was obtained.
  • Resveratrol liquid chromatography conditions mobile phase is acetonitrile-0.1% formic acid solution (30:70, v/v), isocratic elution, flow rate is 0.3mL/min, column temperature is 35°C, injection volume is 3 ⁇ L, The detection wavelength is 280nm.
  • Pterostilbene liquid chromatography conditions mobile phase is acetonitrile-0.1% formic acid solution (50:50, v/v), isocratic elution, flow rate is 0.5mL/min, column temperature is 35°C, injection volume is 3 ⁇ L, detection wavelength 303nm.
  • 1A and 1B are respectively the chromatograms of the resveratrol content measured by UPLC of the e-cigarette liquid according to Example 1 of the present application and the aerosol generated therefrom.
  • 2A and 2B are respectively the chromatograms of the pterostilbene content measured by UPLC of the e-cigarette liquid according to Example 2 of the present application and the generated aerosol.
  • resveratrol and pterostilbene are present in the aerosol of the e-cigarette liquid of the present application, and the components of resveratrol and pterostilbene in the aerosol are the same as those in the e-cigarette liquid Basically the same, and avoid being destroyed by high-temperature combustion. Therefore, resveratrol and pterostilbene can be effectively absorbed by the human body through the aerosol after the electronic cigarette, so that the user can achieve the effect of health care for the human body while smoking.
  • Statistical method 1000 users are randomly selected to test the use of the e-cigarette liquids of the above examples 1-10 through e-cigarettes. After the use test, the taste and taste are evaluated. The evaluation standard is based on a total score of 10 points. The better or the better the taste, the higher the score.
  • this application provides an e-cigarette liquid.
  • the resveratrol and pterostilbene contained in the e-cigarette liquid can allow users to inhale the e-cigarette mist at the same time.
  • the aerosol molecules of resveratrol and pterostilbene can achieve human health functions such as antioxidant and cardiovascular protection.
  • the e-cigarette liquid can form a uniform and strong aerosol when the user inhales by adding a specific flavor, and the aerosol has a soft mouthfeel and does not have a residual sensation, thereby optimizing the user experience.

Abstract

一种电子烟液，该电子烟液包含白藜芦醇及紫檀芪中的至少一种，其中白藜芦醇及紫檀芪中的至少一种在电子烟液中的含量以所述电子烟液总重计为0.1％至10％。该电子烟液经过雾化，其包含的白藜芦醇和/或紫檀芪可随烟液一起雾化出来，被人体吸收，对人体具有抗氧化和心血管保护作用。

Description

电子烟液 技术领域
本申请涉及电子气雾剂或电子雾化装置的领域，尤其涉及一种具有功能性成分的电子烟液。
背景技术
由于对于个人健康、环境保护以及使用便利性的追求，电子烟作为传统烟草的取代品越来越受到消费者的青睐。电子烟或电子雾化器通过将发烟材料低温雾化形成用于使用者吸入的气雾，来取代传统烟草以高温燃烧的方式所产生的烟气。其中，电子烟液对于使用者的体验及口感，甚至对人体的健康具有一定的影响。
通过低温雾化如何进一步生成降低对人体有害影响且提高对人体有益影响的用于使用者吸入的气雾，是电子烟产品需要改进的研究方向。
发明内容
本申请通过提供一种含有白藜芦醇、紫檀芪或其组合的电子烟液，该电子烟液通过雾化装置生成供使用者吸入的气雾，其中存在呈气雾状态的白藜芦醇及紫檀芪，呈气雾状态的白藜芦醇及紫檀芪的功能主结构未被破坏且能够更容易被人体吸收，进而达到对人体的抗氧化和心血管保护作用。
根据本申请的一个层面，本申请提供了一种电子烟液，其包含白藜芦醇及紫檀芪中的至少一种，其中所述白藜芦醇及所述紫檀芪中的至少一种在所述电子烟液中的重量以所述电子烟液总重计为0.1％至10％。
根据本申请的又一层面，本申请提供了一种雾化装置，其包含上述电子烟液。
本申请实施例的额外层面及优点将部分地在后续说明中描述、显示、或是经由本申请实施例的实施而阐释。
附图说明
图1A是根据本申请实施例的电子烟液的白藜芦醇含量的色谱图。
图1B是根据本申请实施例的电子烟液所生成的气雾的白藜芦醇含量的色谱图。
图2A是根据本申请实施例的电子烟液的紫檀芪含量的色谱图。
图2B是根据本申请实施例的电子烟液所生成的气雾的紫檀芪含量的色谱图。
具体实施方式
本申请的实施例将会被详细的描示在下文中。本申请的实施例不应所述被解释为对本申请的限制。
另外，有时在本文中以范围格式呈现量、比率和其它数值。应理解，此类范围格式是用于便利及简洁起见，且应灵活地理解，不仅包含明确地指定为范围限制的数值，而且包含涵盖于所述范围内的所有个别数值或子范围，如同明确地指定每一数值及子范围一般。
如本文中所使用，术语“大致”、“大体”、“大体上”、“实质”及“约”用以描述及说明小的变化。当与事件或情形结合使用时，所述术语可指代其中事件或情形精确发生的例子以及其中事件或情形极近似地发生的例子。举例来说，当结合数值使用时，术语可指代小于或等于所述数值的±10％的变化范围，例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％。举例来说，如果两个数值之间的差值小于或等于所述值的平均值的±10％(例如小于或等于±5％、小于或等于±4％、小于或等于±3％、小于或等于±2％、小于或等于±1％、小于或等于±0.5％、小于或等于±0.1％、或小于或等于±0.05％)，那么可认为所述两个数值“大体上”相同。
在具体实施方式及权利要求书中，由术语“中的至少一种”或其他相似术语所连接的项目的列表可意味着所列项目的任何组合。例如，如果列出项目A及B，那么短语“A及B中的至少一种”意味着仅A；仅B；或A及B。在另一实例中，如果列出项目A、B及C，那么短语“A、B及C中的至少一者”意味着仅A；或仅B；仅C；A及B(排除C)；A及C(排除B)；B及C(排除A)；或A、B及C的全部。项目A可包含单个元件或多个元件。项目B可包含单个元件或多个元件。项目C可包含单个元件或多个元 件。
在本文中，用语“用于使用者吸入的气雾”或“气雾”可以包括，但不限于，气溶胶、悬浮液体、低温蒸气及挥发性气体。
根据本申请的一个方面，本申请提供了一种电子烟液，所述电子烟液包含白藜芦醇及紫檀芪中的至少一种。
白藜芦醇的化学式为C 14H 12O 3，其结构式如下式一所表示。
Figure PCTCN2019120738-appb-000001
白藜芦醇是一种天然抗氧化剂，可降低血液粘稠度，抑制血小板凝结和血管舒张，保持血液畅通，可预防癌症的发生及发展，具有抗动脉粥样硬化和冠心病，缺血性心脏病，高血脂的防治作用。白藜芦醇可通过抑制血管平滑肌细胞线粒体中活性氧的产生而发挥其抗衰老及血管保护作用。
紫檀芪的化学式为C 16H 16O 3，其结构式如下式二所表示。
Figure PCTCN2019120738-appb-000002
紫檀芪是紫檀中所含的一种化学成分，属于血竭制品中的抗真菌活性成分，对于癌症，高血压，高血脂的治疗都有一定的效果。紫檀芪可通过对基因序Bcl-2相关蛋白的激活和表达，调高线粒体基质内的锰超氧化物歧化酶(Mn-Superoxide dismutase,Mn-SOD)的表达，进而抑制线粒体呼吸，减少过氧化物的生成而发挥其抗衰老及血管保护作用。
在一些实施例中，当电子烟液通过雾化装置形成气雾时，由于是通过低温雾化的作用，其包含的白藜芦醇及紫檀芪的功能结构能够不受到高温破坏而与电子烟液一起通过雾化混入气雾中，而当使用者吸入该气雾时，可直接吸收气雾状的白藜芦醇及紫檀芪，进而起到对人体的心血管保健功效。在使用电子烟的同时，降低气雾所对人体造成的有害副作用，并达到对心血管保健的作用。
在一些实施例中，白藜芦醇在电子烟液中的含量，以所述电子烟液的总重量计，大致为，例如，0.1％、0.2％、0.5％、1.0％、2.0％、3.0％、4.0％、5.0％、10.0％或这些份数中任意两者组成的范围。在一些实施例中，紫檀芪在电子烟液中的含量，以所述电 子烟液的总重量计，大致为，例如，0.1％、0.2％、0.5％、1.0％、2.0％、3.0％、4.0％、5.0％、10.0％或这些份数中任意两者组成的范围。在一些实施例中，白藜芦醇及紫檀芪中的至少一种在电子烟液中的含量以所述电子烟液总重计为约0.1％至约10.0％。
根据本申请的另一方面，本申请一些实施例的所述电子烟液进一步包括香精。在一些实施例中，所述香精包含二氢茉莉酮酸甲酯、柠檬烯、芳樟醇、香兰素及β-蒎烯中的至少一种。。
二氢茉莉酮酸甲酯具有新鲜莱莉香气，能够使烟油中的香气更天然，更持久。柠檬烯具有类似柠檬的香味，能够使烟油中的香气更加饱满，更加香甜。芳樟醇具有铃兰香气，香气颇佳，能够改善烟油的香气和口感，使烟油中的香气更透发，更饱满。香兰素具有纯纯的香草味道，香气稳定、纯正、无杂味，能够使烟油中的香气更加纯正、细腻。β-蒎烯具有纯正的木香，能够使烟油中的香气更加完美，对其他香型具有很好的调节作用。在一些实施例中，通过添加上述香精中的至少一种能够使含有白藜芦醇及紫檀芪中至少一种的电子烟液经雾化后的口感更舒适，更温和，丰富了烟的香气，从而提升了吸食品质。
在一些实施例中，所述香精还包含2-甲基丁酸乙酯、α-松油醇、γ-癸内酯、苯甲醇、苯甲酸苄酯、丙酸乙酯、丁酸乙酯、覆盆子酮、肉桂酸乙酯、香茅醇、杨梅醛、叶醇、乙酸2-甲基丁酯、乙酸苄酯、乙酸丙酯、乙酸橙花酯、乙酸丁酯、乙酸香叶酯、乙酸叶醇酯、乙酸乙酯、乙酸异戊酯、异丁酸乙酯、异胡薄荷醇及异戊酸乙酯中的至少一种。
在一些实施例中，所述香精在所述电子烟液中的重量以所述电子烟液总重计为约0.01％至约10.0％，例如，大致为0.01％、0.05％、0.2％、0.3％、0.5％、1.0％、1.5％、2.0％、2.5％、3％、3.5％、4％、5％、6％、7％、8％、9％、10％或这些重量百分比中任意两者组成的范围，以增添所述电子烟液的风味及优化其所生成的气雾的口感。在一些实施例中，所述香精在所述电子烟液中的重量以所述电子烟液总重计为约0.5％至约5.0％。本申请中的香精可以是现有技术中的香精，在一些实施例中，所述香精成分优选如表1所示。
电子烟液还包含基础溶剂，其中所述基础溶剂包含丙二醇及丙三醇(甘油)。在一些实施例中，以所述电子烟液总重计，丙二醇在电子烟液中的重量大致为，例如，15％、20％、25％、30％、35％、40％、50％、60％、70％或这些重量百分比中任意两者组成的范围；及丙三醇在电子烟液中的重量大致为，例如，30％、35％、40％、45％、50％、 55％、60％、65％、70％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述丙二醇在电子烟液中的重量为约15％至约60％，且所述丙三醇在电子烟液中的重量为约30％至约70％，以使电子烟液达到最佳的雾化效果，提高使用者体验。
在一些实施例中，所述电子烟液还进一步包含凉味剂。
凉味剂为添加剂，其为能够使产品在使用时让使用者产生清凉效果的感受且刺激性不强的化学物。在一些实施例中，所述凉味剂包括选自由薄荷脑、薄荷酮、异薄荷酮、乳酸l-薄荷酯、WS-23(N,2,3-三甲基-2-异丙基丁酰胺)、WS-3(N-乙基-对薄荷基-3-甲酰胺)、WS-5(N-(乙氧羰基甲基)-对烷-3-甲酰胺)、WS-12(N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺)及其组合所组成的群组。
在一些实施例中，以所述电子烟液总重计，所述凉味剂在电子烟液中的重量大致为，例如，0.1％、0.2％、0.3％、0.5％、1.0％、1.5％、2.0％、2.5％、5％、10％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述凉味剂在电子烟液中的重量以所述电子烟液总重计为约0.5％至约5％，以提高所述电子烟液所生成的用于使用者吸入的气雾的口感。
在一些实施例中，所述电子烟液还包括尼古丁盐。在一些实施例中，以所述电子烟液总重计，所述尼古丁盐在电子烟液中在所述电子烟液中的重量小于10％，例如大致为0.001％、0.01％、0.1％、0.2％、0.5％、1.0％、1.5％、2.0％、2.5％、5％、7.5％、10％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述尼古丁盐在所述电子烟液中的重量以所述电子烟液总重计为约0.001％至约10.0％。
在一些实施例中，所述电子烟液还包括尼古丁。在一些实施例中，以所述电子烟液总重计，所述尼古丁在电子烟液中在所述电子烟液中的重量小于5％，例如大致为0.001％、0.01％、0.1％、0.2％、0.5％、1.0％、1.5％、2.0％、2.5％、5％或这些重量百分比中任意两者组成的范围。在一些实施例中，所述尼古丁在所述电子烟液中的重量以所述电子烟液总重计为约0.05％至约5.0％。
根据本申请一些实施例，本申请提供电子烟液的制备方法，其包含以下步骤：取一定量的白藜芦醇及紫檀芪中的至少一种溶于基础溶剂中，随后加入香精、凉味剂、尼古丁或其盐。然后，使其均匀混合以获得电子烟液。然而本领域熟知的是，上述各物质的添加顺序不局限于如上定义的，而是可以根据需要进行调整。
根据本申请的另一个方面，本申请提供一种雾化装置，其包含上述任一实施例所述 的电子烟液。所述电子烟液可通过所述雾化装置雾化生成供使用者吸入的气雾，其中所述气雾含有不受到高温破坏的白藜芦醇及紫檀芪中的至少一种，供使用者吸收后能够产生抗衰老及血管保护作用。
在一些实施例中，所述雾化装置包括电子烟、超声雾化器或网式雾化器。
实施例
为便于更好地理解本申请，通过以下实例加以说明。这些实例属于本申请的保护范围，但不限制本申请的保护范围。
香精的制备：
按照下表1中的重量比例配置，混合以获得香精。
实施例1
将3克的白藜芦醇加入47克的丙二醇与50克的丙三醇混合的基础烟液中混合，搅拌均匀，得到电子烟液。
实施例2
将3克的紫檀芪加入47克的丙二醇与50克的丙三醇混合所形成的基础烟液中混合，搅拌均匀，得到电子烟液。
实施例3
将2克的白藜芦醇加入45克的丙二醇与48克的丙三醇混合所形成的基础烟液中混合，搅拌均匀。随后加入2克的薄荷脑及3克的香精2得到电子烟液。
实施例4
将2克的紫檀芪加入45克的丙二醇与48克的丙三醇混合所形成的基础烟液中混合，搅拌均匀。随后加入2克的薄荷脑及3克的香精2得到电子烟液。
实施例5
将1克的白藜芦醇加入43.6克的丙二醇与46克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入3克的尼古丁、2.4克的苯甲酸、2克的薄荷脑及2克的香精1得到电子烟液。
实施例6
将1克的紫檀芪加入43.6克的丙二醇与46克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入3克的尼古丁、2.4克的苯甲酸、2克的薄荷脑及2克的香精1得到电子烟液。
实施例7
将2克的白藜芦醇与2克的紫檀芪加入39.01克的丙二醇与53克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入0.99克的尼古丁、2克的薄荷脑及1克的香精1得到电子烟液。
实施例8
将2克的白藜芦醇与1克的紫檀芪加入40克的丙二醇与50克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入1.8克的尼古丁、1.2克的苯甲酸、2克的WS-23及2克的香精1得到电子烟液。
实施例9
将1克的白藜芦醇与2克的紫檀芪加入37.6克的丙二醇与48克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入3克的尼古丁、2.4克的苯甲酸、1克的WS-23、2克的薄荷脑及3克的香精1得到电子烟液。
实施例10
将1克的白藜芦醇与1克的紫檀芪加入36.5克的丙二醇与46克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入5克的尼古丁、4.5克的苯甲酸、1克的WS-23、1克的薄荷脑及4克的香精1得到电子烟液。
实施例11
将2克的白藜芦醇与1克的紫檀芪加入36.5克的丙二醇与43克的丙三醇混合的基础烟液中混合，搅拌均匀。随后加入4克的尼古丁、4.5克的苯甲酸、2克的WS-23、1克的薄荷脑及6克的香精2得到电子烟液。
上述实施例中香精的组成如下表1所示。
表1
Figure PCTCN2019120738-appb-000003
Figure PCTCN2019120738-appb-000004
将实施例1及实施例2的电子烟液及其雾化后的气雾进行白藜芦醇及紫檀芪含量测量，并对实施例1-10的电子烟液进行口感评分测试。通过上述测试结果以进一步说明，本申请电子烟液在使用过程中其气雾内白藜芦醇及紫檀芪的含量，以及其对使用者体验的提升。
白藜芦醇及 紫檀芪含量测试方式；
白藜芦醇及紫檀芪含量测量是通过超高效液相色谱(UPLC)来进行。
样品制备：将实施例1及实施例2的电子烟液采用以下抽吸方式来生成其用于使用者吸入的气雾：雾化装置为电子烟，抽吸时间为3.0秒±0.1秒、抽吸之间间隔为30.0秒±0.5秒、抽吸次数为50次、每次抽吸量为55mL±0.3mL。采用剑桥滤片收集气雾， 并使用10mL甲醇浸没剑桥滤片，超声提取30min后得烟气萃取溶液。然后采用超高效液相色谱(UPLC，Waters ACQUITY
Figure PCTCN2019120738-appb-000005
H-Class HSS T3C 18色谱柱(2.1mm×100mm,1.8μm))对电子烟液及其气雾萃取溶液进行白藜芦醇及紫檀芪含量测定。
白藜芦醇液相色谱条件：流动相为乙腈-0.1％甲酸溶液(30:70，v/v)，等度洗脱，流量为0.3mL/min，柱温35℃，进样量3μL，检测波长280nm。
紫檀芪液相色谱条件：流动相为乙腈-0.1％甲酸溶液(50:50，v/v)，等度洗脱，流量为0.5mL/min，柱温35℃，进样量3μL，检测波长303nm。
图1A及1B分别是根据本申请实施例1的电子烟液以及其所生成的气雾的通过UPLC所测得的白藜芦醇含量的色谱图。图2A及2B则分别是根据本申请实施例2的电子烟液以及其所生成的气雾的通过UPLC所测得的紫檀芪含量的色谱图。
如图1A、1B、2A及2B所示，本申请电子烟液的气雾中存在白藜芦醇及紫檀芪，其中气雾中白藜芦醇及紫檀芪的成分与电子烟液中的成分基本相同，而免于被高温燃烧破坏。因此，白藜芦醇及紫檀芪通过电子烟雾化后的气雾可以有效被人体吸收，进而让使用者在吸烟的同时达到对人体保健的功效。
口感评分测试方法1
请20位评析者按表2中的各个评价指标对上述实施例1-10的电子烟气溶胶体验打分。评测结果如下表3所示.
表2
Figure PCTCN2019120738-appb-000006
Figure PCTCN2019120738-appb-000007
表3
Figure PCTCN2019120738-appb-000008
口感评分测试方式2；
统计方法：随机选取1000使用者通过电子烟对上述实施例1-10的电子烟液进行使用测试，待使用测试后对其口味及口感进行评价，其中评价标准以总分10分计，口味越佳或口感越好则分数越高。
实施例1-10的电子烟液经过口感评分测试的测试结果如下表4所示。
表4
Figure PCTCN2019120738-appb-000009
由表2-4中数据可知，本申请实施例1-10的电子烟液，经雾化后所产生的具有白藜芦醇及紫檀芪的供使用者吸入的气雾，其不论在口感或是口味的表现上都能达到一定的客户的满意度。此外，相较于实施例1及2，添加了本申请实施例提供的香精的电子烟液在口感评分测试上都有显著的提升。
通过比较实施例3-11可知，本申请的电子烟液中的香精浓度在0.5wt％至5.0wt％的范围内具有最佳的使用者体验。
通过本申请上述实施例应可了解，本申请提供了一种电子烟液，通过该电子烟液中包含的白藜芦醇及紫檀芪，能够让使用者在吸入电子烟气雾的同时摄入白藜芦醇及紫檀芪的气雾分子，从而达到抗氧化和心血管保护作用等人体保健功效。同时，该电子烟液通过添加特定香精在使用者抽吸时能够形成气味均匀且浓郁的气雾，而该气雾口感柔顺且不具有残留感，从而优化使用者体验。
虽然已参考本申请的特定实施例描述并说明本申请，但是这些描述和说明并不限制本申请。所属领域的技术人员可清晰地理解，在不脱离如由所附权利要求书定义的本申请的真实精神和范围的情况下，可进行各种改变(例如对本申请的香精组份中的成分进行适当增加、减少和改变)，以使特定情形、材料、物质组成、物质、方法或过程适宜于本申请的目标、精神和范围。所有此类修改都意图在此所附权利要求书的范围内。虽 然已参考按特定次序执行的特定操作描述本文中所公开的方法，但应理解，可在不脱离本申请的教示的情况下组合、细分或重新排序这些操作以形成等效方法。因此，除非本文中特别指示，否则操作的次序和分组并非本申请的限制。

Claims (10)

  1. 一种电子烟液，其包含白藜芦醇及紫檀芪中的至少一种，其中所述白藜芦醇及所述紫檀芪中的至少一种在所述电子烟液中的重量以所述电子烟液总重计为0.1％至10％。
  2. 根据权利要求1所述的电子烟液，其进一步包括香精。
  3. 根据权利要求2所述的电子烟液，其中所述香精包含二氢茉莉酮酸甲酯、柠檬烯、芳樟醇、香兰素及β-蒎烯中的至少一种。
  4. 根据权利要求2或3所述的电子烟液，其中所述香精在所述电子烟液中的重量以所述电子烟液总重计为小于10.0％。
  5. 根据权利要求1所述的电子烟液，其进一步包括凉味剂，其中所述凉味剂选自由薄荷脑、薄荷酮、异薄荷酮、乳酸l-薄荷酯、WS-23(N,2,3-三甲基-2-异丙基丁酰胺)、WS-3(N-乙基-对薄荷基-3-甲酰胺)、WS-5(N-(乙氧羰基甲基)-对烷-3-甲酰胺)、WS-12(N-(4-甲氧基苯基)-对薄荷基-3-羧酰胺)及其组合所组成的群组。
  6. 根据权利要求5所述的电子烟液，其中所述凉味剂在所述电子烟液中的重量以所述电子烟液总重计为小于10％。
  7. 根据权利要求1所述的电子烟液，其进一步包括尼古丁盐，且所述尼古丁盐在所述电子烟液中的重量以所述电子烟液总重计小于10.0％。
  8. 根据权利要求1所述的电子烟液，其进一步包含尼古丁，且所述尼古丁在所述电子烟液中的重量以所述电子烟液总重计小于5.0％。
  9. 一种雾化装置，其包含权利要求1至8中任一权利要求所述的电子烟液。
  10. 根据权利要求9所述的雾化装置，其中所述雾化装置包括电子烟、超声雾化器或网式雾化器。
PCT/CN2019/120738 2019-11-25 2019-11-25 电子烟液 WO2021102651A1 (zh)

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US20160050969A1 (en) * 2014-08-25 2016-02-25 Kedar Prasad Micronutrient formulation in electronic cigarettes
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