ATE470468T1 - Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung - Google Patents

Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung

Info

Publication number
ATE470468T1
ATE470468T1 AT04780193T AT04780193T ATE470468T1 AT E470468 T1 ATE470468 T1 AT E470468T1 AT 04780193 T AT04780193 T AT 04780193T AT 04780193 T AT04780193 T AT 04780193T AT E470468 T1 ATE470468 T1 AT E470468T1
Authority
AT
Austria
Prior art keywords
aerosol
film
exterior surface
drug composition
substrates
Prior art date
Application number
AT04780193T
Other languages
English (en)
Inventor
Bryson Bennett
Ron Hale
Amy Lu
Daniel Myers
Joshua Rabinowitz
Krishnamohan Sharma
Martin Wensley
Original Assignee
Alexza Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexza Pharmaceuticals Inc filed Critical Alexza Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE470468T1 publication Critical patent/ATE470468T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/047—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters by exothermic chemical reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other Surface Treatments For Metallic Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Chemical Treatment Of Metals (AREA)
AT04780193T 2003-08-04 2004-08-04 Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung ATE470468T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49263003P 2003-08-04 2003-08-04
PCT/US2004/025313 WO2005016421A1 (en) 2003-08-04 2004-08-04 Substrates for drug delivery device and methods of preparing and use

Publications (1)

Publication Number Publication Date
ATE470468T1 true ATE470468T1 (de) 2010-06-15

Family

ID=34193141

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04780193T ATE470468T1 (de) 2003-08-04 2004-08-04 Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung

Country Status (8)

Country Link
US (4) US20050034723A1 (de)
EP (1) EP1656171B9 (de)
JP (1) JP4869927B2 (de)
AT (1) ATE470468T1 (de)
AU (1) AU2004264344B2 (de)
CA (1) CA2534566A1 (de)
DE (1) DE602004027638D1 (de)
WO (1) WO2005016421A1 (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE415155T1 (de) * 2001-05-24 2008-12-15 Alexza Pharmaceuticals Inc Verabreichung von alprazolam, estazolam, midazolam oder triazolam durch inhalation
US7766013B2 (en) * 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
EP1392262A1 (de) * 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Verabreichung von arzneimittel-estern durch inhalation
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
EP1446102A1 (de) * 2001-11-21 2004-08-18 Alexza Molecular Delivery Corporation Verabreichung von koffein durch inhalation
US8003080B2 (en) * 2002-05-13 2011-08-23 Alexza Pharmaceuticals, Inc. Delivery of drug amines through an inhalation route
US20060193788A1 (en) * 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
WO2004047844A1 (en) * 2002-11-26 2004-06-10 Alexza Pharmaceuticals, Inc. Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain
AU2003295823B2 (en) * 2002-11-26 2009-11-05 Alexza Pharmaceuticals, Inc. Treatment of headache with antipsychotics delivered by inhalation
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625334B9 (de) 2003-05-21 2012-07-25 Alexza Pharmaceuticals, Inc. Schlag gezündete unabhängige heizeinheit
US7402777B2 (en) * 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
US9675109B2 (en) 2005-07-19 2017-06-13 J. T. International Sa Method and system for vaporization of a substance
US10244793B2 (en) 2005-07-19 2019-04-02 Juul Labs, Inc. Devices for vaporization of a substance
CA2642608C (en) * 2006-01-19 2018-05-29 Optinose As Nasal administration
WO2008080170A1 (en) * 2006-12-22 2008-07-03 Alexza Pharmaceuticals, Inc. Mixed drug aerosol compositiions
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
GB2448183A (en) 2007-04-05 2008-10-08 Optinose As Nasal powder delivery device
US8991402B2 (en) * 2007-12-18 2015-03-31 Pax Labs, Inc. Aerosol devices and methods for inhaling a substance and uses thereof
WO2009102564A2 (en) * 2008-02-11 2009-08-20 Boston Scientific Scimed, Inc. Substrate coating apparatus having a solvent vapor emitter
US7834295B2 (en) * 2008-09-16 2010-11-16 Alexza Pharmaceuticals, Inc. Printable igniters
US20100065052A1 (en) * 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Heating Units
EP2198972A1 (de) 2008-12-18 2010-06-23 Boehringer Ingelheim International GmbH Reservoir und Zerstäuber
US8551454B2 (en) * 2009-03-13 2013-10-08 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
US8277781B2 (en) * 2009-03-13 2012-10-02 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
WO2010105775A2 (de) 2009-03-17 2010-09-23 Boehringer Ingelheim International Gmbh Reservoir und zerstäuber
EP2425224A1 (de) 2009-04-28 2012-03-07 Boehringer Ingelheim International GmbH Verfahren zur prüfung der dichtheit eines mit einem fluid befüllten behälters
US20100300433A1 (en) * 2009-05-28 2010-12-02 Alexza Pharmaceuticals, Inc. Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
US20140158129A1 (en) 2010-09-22 2014-06-12 Clovershield, Inc. Transversely-activated valve for a therapeutic vaporizer bag attachment system
WO2012040512A2 (en) * 2010-09-22 2012-03-29 Joshua Smith Young Therapeutic vaporizer
US11577035B2 (en) 2010-09-22 2023-02-14 Robert Irving Pratt, JR. Therapeutic vaporizer
DE202012013645U1 (de) 2011-08-16 2018-11-22 Juul Labs Uk Holdco Limited Elektronische Vorrichtung zur Verdampfung bei niedriger Temperatur
WO2013098397A2 (en) 2011-12-30 2013-07-04 Philip Morris Products S.A. Aerosol generating device with air flow detection
US10517530B2 (en) 2012-08-28 2019-12-31 Juul Labs, Inc. Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances
US8881737B2 (en) * 2012-09-04 2014-11-11 R.J. Reynolds Tobacco Company Electronic smoking article comprising one or more microheaters
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10512282B2 (en) 2014-12-05 2019-12-24 Juul Labs, Inc. Calibrated dose control
US10653180B2 (en) 2013-06-14 2020-05-19 Juul Labs, Inc. Multiple heating elements with separate vaporizable materials in an electric vaporization device
US11554229B2 (en) 2013-03-26 2023-01-17 OptiNose Inc. Nasal administration
JP6046547B2 (ja) * 2013-04-25 2016-12-14 株式会社Ihi ステンレス鋼部品の不動態化処理方法
RU2659887C2 (ru) 2013-05-06 2018-07-04 Джуул Лэбз, Инк. Составы на основе солей никотина для аэрозольных устройств и способы их применения
CN105530916B (zh) 2013-07-11 2020-04-07 艾利斯达医药品公司 与间水杨酸形成的烟碱盐
EP4166019A1 (de) 2013-08-06 2023-04-19 Fontem Ventures B.V. Elektronische rauchvorrichtung und verfahren zur herstellung davon
NZ714528A (en) * 2013-08-20 2020-04-24 Boehringer Ingelheim Vetmedica Gmbh Inhaler
PT3632373T (pt) 2013-08-20 2023-10-24 Boehringer Ingelheim Vetmedica Gmbh Inalador
ES2774718T3 (es) 2013-08-20 2020-07-22 Boehringer Ingelheim Vetmedica Gmbh Inhalador
WO2015042412A1 (en) 2013-09-20 2015-03-26 E-Nicotine Technology. Inc. Devices and methods for modifying delivery devices
TR201802184T4 (tr) 2013-10-10 2018-03-21 Carag Ag Tıkayıcı.
IL308151A (en) 2013-12-05 2023-12-01 Juul Labs Inc Liquid preparations of nicotine for spray devices and methods
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
PT3508080T (pt) 2013-12-23 2021-03-02 Juul Labs Int Inc Sistemas e métodos de dispositivo de vaporização
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US9549573B2 (en) 2013-12-23 2017-01-24 Pax Labs, Inc. Vaporization device systems and methods
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
US20160366947A1 (en) 2013-12-23 2016-12-22 James Monsees Vaporizer apparatus
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
US11478021B2 (en) 2014-05-16 2022-10-25 Juul Labs, Inc. Systems and methods for aerosolizing a vaporizable material
AU2016229119A1 (en) 2015-03-11 2017-10-05 Alexza Pharmaceuticals, Inc. Use of antistatic materials in the airway for thermal aerosol condensation process
CN107427354A (zh) 2015-03-30 2017-12-01 C·R·巴德股份有限公司 向医疗装置施加抗微生物剂
CA2984161A1 (en) * 2015-04-29 2016-11-03 Poda Technologies Ltd. Vaporizer apparatus, device, and methods
US10925316B2 (en) * 2015-06-10 2021-02-23 Philip Morris Products S.A. Electrical aerosol generating system
US10624392B2 (en) * 2015-12-22 2020-04-21 Altria Client Services Llc Aerosol-generating system with motor
MX2018009703A (es) 2016-02-11 2019-07-08 Juul Labs Inc Cartuchos de fijacion segura para dispositivos vaporizadores.
UA125687C2 (uk) 2016-02-11 2022-05-18 Джуул Лебз, Інк. Заповнювальний картридж випарного пристрою та способи його заповнення
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
US10772354B2 (en) * 2016-05-31 2020-09-15 Altria Client Services Llc Heater and wick assembly for an aerosol generating system
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
US11660403B2 (en) 2016-09-22 2023-05-30 Juul Labs, Inc. Leak-resistant vaporizer device
US10524508B2 (en) * 2016-11-15 2020-01-07 Rai Strategic Holdings, Inc. Induction-based aerosol delivery device
MX2019006401A (es) * 2016-12-02 2019-09-04 Vmr Products Llc Vaporizador de combinacion.
HRP20240106T1 (hr) 2016-12-09 2024-04-12 Alexza Pharmaceuticals, Inc. Alprazolam za uporabu u liječenju epilepsije
US10765148B2 (en) * 2016-12-27 2020-09-08 Altria Client Services Llc E-vaping device including e-vaping case with sliding mechanism for initiating vapor generation
EA201991564A1 (ru) * 2017-04-24 2019-09-30 Джапан Тобакко Инк. Генерирующее аэрозоль устройство, способ управления генерирующим аэрозоль устройством и программа
CA3074463A1 (en) 2017-08-28 2019-03-07 Juul Labs, Inc. Wick for vaporizer device
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
EP3809893A1 (de) 2018-06-07 2021-04-28 Juul Labs, Inc. Kartuschen für verdampfervorrichtungen
US11094993B2 (en) * 2018-08-10 2021-08-17 Rai Strategic Holdings, Inc. Charge circuitry for an aerosol delivery device
JP2020058236A (ja) * 2018-10-04 2020-04-16 日本たばこ産業株式会社 吸引成分生成装置、制御回路、吸引成分生成装置の制御方法および制御プログラム
JP7472132B2 (ja) * 2018-11-29 2024-04-22 エシコン・インコーポレイテッド 低温硬化シリコーン潤滑コーティング
EP4323039A1 (de) * 2021-04-14 2024-02-21 The University of North Carolina at Chapel Hill Heisse poröse-feste dosiersysteme und verfahren zur erzeugung therapeutischer aerosole durch verdampfung/kondensation

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1514682A (en) * 1923-05-03 1924-11-11 Wilson Harold Electric vaporizer
US1759029A (en) * 1926-01-06 1930-05-20 Climax Engineering Company Stuffing-box packing
CA1107584A (en) * 1977-10-27 1981-08-25 William V. Youdelis Process for surface coating alloys to enhance corrosion resistance
US4935073A (en) * 1981-11-27 1990-06-19 Sri International Process for applying coatings of zirconium and/or titantuim and a less noble metal to metal substrates and for converting the zirconium and/or titanium to an oxide, nitride, carbide, boride or silicide
US4771795A (en) * 1986-05-15 1988-09-20 R. J. Reynolds Tobacco Company Smoking article with dual burn rate fuel element
US4735217A (en) * 1986-08-21 1988-04-05 The Procter & Gamble Company Dosing device to provide vaporized medicament to the lungs as a fine aerosol
US5397652A (en) * 1992-03-27 1995-03-14 The Louis Berkman Company Corrosion resistant, colored stainless steel and method of making same
WO1994009842A1 (en) * 1992-10-28 1994-05-11 Rosen Charles A Method and devices for delivering drugs by inhalation
EP0781258B1 (de) * 1994-09-26 2003-11-05 Steris, Inc. Alkalibehandlung von rostfreiem stahl
WO1999034697A1 (en) * 1998-01-06 1999-07-15 Philip Morris Products Inc. Cigarette having reduced sidestream smoke
US6228445B1 (en) * 1999-04-06 2001-05-08 Crucible Materials Corp. Austenitic stainless steel article having a passivated surface layer
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
MY136453A (en) * 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
US6514482B1 (en) * 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US7594507B2 (en) * 2001-01-16 2009-09-29 Hewlett-Packard Development Company, L.P. Thermal generation of droplets for aerosol
EP1392262A1 (de) * 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Verabreichung von arzneimittel-estern durch inhalation
WO2002094244A2 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of benzodiazepines through an inhalation route
WO2002094242A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of rizatriptan or zolmitriptan through an inhalation route
US6805853B2 (en) * 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
ATE415155T1 (de) * 2001-05-24 2008-12-15 Alexza Pharmaceuticals Inc Verabreichung von alprazolam, estazolam, midazolam oder triazolam durch inhalation
US7645442B2 (en) * 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20030118512A1 (en) * 2001-10-30 2003-06-26 Shen William W. Volatilization of a drug from an inclusion complex
WO2002094232A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of antidepressants through an inhalation route
US20070122353A1 (en) * 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20030138508A1 (en) * 2001-12-18 2003-07-24 Novack Gary D. Method for administering an analgesic
US7766013B2 (en) * 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US7585493B2 (en) * 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
EP1446102A1 (de) * 2001-11-21 2004-08-18 Alexza Molecular Delivery Corporation Verabreichung von koffein durch inhalation
CA2462576A1 (en) * 2001-11-21 2003-06-03 Alexza Molecular Delivery Corporation Open-celled substrates for drug delivery
US20030106551A1 (en) * 2001-12-06 2003-06-12 Sprinkel F. Murphy Resistive heater formed inside a fluid passage of a fluid vaporizing device
US8003080B2 (en) * 2002-05-13 2011-08-23 Alexza Pharmaceuticals, Inc. Delivery of drug amines through an inhalation route
US20060193788A1 (en) * 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
AU2003295823B2 (en) * 2002-11-26 2009-11-05 Alexza Pharmaceuticals, Inc. Treatment of headache with antipsychotics delivered by inhalation
WO2004047844A1 (en) * 2002-11-26 2004-06-10 Alexza Pharmaceuticals, Inc. Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US20050131739A1 (en) * 2003-12-16 2005-06-16 Alexza Molecular Delivery Corporation Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real time
US7402777B2 (en) * 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
AU2004322756B2 (en) * 2004-08-12 2011-04-14 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US20060032496A1 (en) * 2004-08-12 2006-02-16 Alexza Molecular Delivery Corporation Inhalation actuated percussive ignition system
WO2006044421A2 (en) * 2004-10-12 2006-04-27 Alexza Pharmaceuticals, Inc. Cardiac safe, rapid medication delivery
ES2594867T3 (es) * 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco

Also Published As

Publication number Publication date
US20110240014A1 (en) 2011-10-06
JP4869927B2 (ja) 2012-02-08
EP1656171B9 (de) 2010-10-20
AU2004264344A1 (en) 2005-02-24
DE602004027638D1 (de) 2010-07-22
US20140072605A1 (en) 2014-03-13
US20180296568A1 (en) 2018-10-18
EP1656171A1 (de) 2006-05-17
WO2005016421A1 (en) 2005-02-24
CA2534566A1 (en) 2005-02-24
EP1656171B1 (de) 2010-06-09
AU2004264344B2 (en) 2011-02-17
JP2007501073A (ja) 2007-01-25
US20050034723A1 (en) 2005-02-17

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