RU2013156600A - Стабилизированные жидкие ферментные композиции - Google Patents
Стабилизированные жидкие ферментные композиции Download PDFInfo
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- RU2013156600A RU2013156600A RU2013156600/04A RU2013156600A RU2013156600A RU 2013156600 A RU2013156600 A RU 2013156600A RU 2013156600/04 A RU2013156600/04 A RU 2013156600/04A RU 2013156600 A RU2013156600 A RU 2013156600A RU 2013156600 A RU2013156600 A RU 2013156600A
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- residue
- benzyloxycarbonyl
- amino acid
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- 239000000203 mixture Substances 0.000 title claims abstract 13
- 239000007788 liquid Substances 0.000 title claims abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 14
- 125000000539 amino acid group Chemical group 0.000 claims abstract 8
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims abstract 8
- 108090000787 Subtilisin Proteins 0.000 claims abstract 6
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims abstract 6
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 6
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000006239 protecting group Chemical group 0.000 claims abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 2
- -1 benzyloxycarbonyl (Cbz) group Chemical group 0.000 claims abstract 2
- 239000003599 detergent Substances 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 239000004094 surface-active agent Substances 0.000 claims abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38663—Stabilised liquid enzyme compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21062—Subtilisin (3.4.21.62)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Detergent Compositions (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1. Стабилизированная жидкая композиция, содержащая субтилизин и пептидный альдегид формулы B-B-B-Н, гдеН означает водород;Bпредставляет собой остаток Tyr;Bпредставляет собой один аминокислотный остаток Ala или Val; иBпредставляет собой один аминокислотный остаток с присоединенной бензилоксикарбонильной группой (Cbz), или Впредставляет собой два аминокислотных остатка, содержащих ацетильную (Ас) N-концевую защитную группу.2. Композиция по п. 1, где Bпредставляет собой один остаток Gly, Arg или Leu с присоединенной бензилоксикарбонильной (Cbz) группой.3. Композиция по п. 1, где Bсостоит из двух аминокислотных остатков, содержащих ацетильную (Ас) N-концевую защитную группу, где один из остатков Впредставляет собой Phe, Gly или Leu, а второй остаток Впредставляет собой Phe, Gly, Leu, Tyr или Trp.4. Стабилизированная жидкая композиция, содержащая субтилизин и пептидный альдегид формулы Z-RAY-H, Ac-GAY-H, Z-GAY-H, Z-RVY-H, Z-LVY-H, Ac-LGAY-H, Ac-FGAY-H, Ac-YGAY-H, Ac-FGVY-H или Ac-WLVY-H, где Z представляет собой бензилоксикарбонил, и Ac представляет собой ацетил.5. Композиция по п. 4, представляющий собой Z-RAY-H, Z-GAY-H, Z-RVY-H или Z-LVY-H, где Z представляет собой бензилоксикарбонил.6. Жидкая моющая композиция, включающая поверхностно-активное вещество, субтилизин и пептидный альдегид по любому из пп. 1-5.
Claims (6)
1. Стабилизированная жидкая композиция, содержащая субтилизин и пептидный альдегид формулы B2-B1-B0-Н, где
Н означает водород;
B0 представляет собой остаток Tyr;
B1 представляет собой один аминокислотный остаток Ala или Val; и
B2 представляет собой один аминокислотный остаток с присоединенной бензилоксикарбонильной группой (Cbz), или В2 представляет собой два аминокислотных остатка, содержащих ацетильную (Ас) N-концевую защитную группу.
2. Композиция по п. 1, где B2 представляет собой один остаток Gly, Arg или Leu с присоединенной бензилоксикарбонильной (Cbz) группой.
3. Композиция по п. 1, где B2 состоит из двух аминокислотных остатков, содержащих ацетильную (Ас) N-концевую защитную группу, где один из остатков В2 представляет собой Phe, Gly или Leu, а второй остаток В2 представляет собой Phe, Gly, Leu, Tyr или Trp.
4. Стабилизированная жидкая композиция, содержащая субтилизин и пептидный альдегид формулы Z-RAY-H, Ac-GAY-H, Z-GAY-H, Z-RVY-H, Z-LVY-H, Ac-LGAY-H, Ac-FGAY-H, Ac-YGAY-H, Ac-FGVY-H или Ac-WLVY-H, где Z представляет собой бензилоксикарбонил, и Ac представляет собой ацетил.
5. Композиция по п. 4, представляющий собой Z-RAY-H, Z-GAY-H, Z-RVY-H или Z-LVY-H, где Z представляет собой бензилоксикарбонил.
6. Жидкая моющая композиция, включающая поверхностно-активное вещество, субтилизин и пептидный альдегид по любому из пп. 1-5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08153299.6 | 2008-03-26 | ||
| EP08153299 | 2008-03-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010143597/04A Division RU2510662C2 (ru) | 2008-03-26 | 2009-03-26 | Стабилизированные жидкие ферментные композиции |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018131246A Division RU2018131246A (ru) | 2008-03-26 | 2018-08-30 | Стабилизированные жидкие ферментные композиции |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2013156600A true RU2013156600A (ru) | 2015-06-27 |
| RU2668563C2 RU2668563C2 (ru) | 2018-10-02 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010143597/04A RU2510662C2 (ru) | 2008-03-26 | 2009-03-26 | Стабилизированные жидкие ферментные композиции |
| RU2013156600A RU2668563C2 (ru) | 2008-03-26 | 2013-12-19 | Стабилизированные жидкие ферментные композиции |
| RU2018131246A RU2018131246A (ru) | 2008-03-26 | 2018-08-30 | Стабилизированные жидкие ферментные композиции |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010143597/04A RU2510662C2 (ru) | 2008-03-26 | 2009-03-26 | Стабилизированные жидкие ферментные композиции |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018131246A RU2018131246A (ru) | 2008-03-26 | 2018-08-30 | Стабилизированные жидкие ферментные композиции |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9181296B2 (ru) |
| EP (2) | EP2271660B1 (ru) |
| JP (2) | JP5973166B2 (ru) |
| CN (2) | CN107090014B (ru) |
| BR (1) | BRPI0909084B1 (ru) |
| ES (1) | ES2807603T3 (ru) |
| MX (1) | MX2010010348A (ru) |
| PL (1) | PL2271660T3 (ru) |
| RU (3) | RU2510662C2 (ru) |
| WO (1) | WO2009118375A2 (ru) |
Families Citing this family (164)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011076897A1 (en) | 2009-12-22 | 2011-06-30 | Novozymes A/S | Use of amylase variants at low temperature |
| EP2343310A1 (en) | 2010-01-08 | 2011-07-13 | Novozymes A/S | Serine hydrolase formulation |
| EP2357220A1 (en) | 2010-02-10 | 2011-08-17 | The Procter & Gamble Company | Cleaning composition comprising amylase variants with high stability in the presence of a chelating agent |
| EP2534236B1 (en) | 2010-02-10 | 2018-05-30 | Novozymes A/S | Variants and compositions comprising variants with high stability in presence of a chelating agent |
| JP2014511409A (ja) | 2011-02-16 | 2014-05-15 | ノボザイムス アクティーゼルスカブ | 金属プロテアーゼを含む洗剤組成物 |
| WO2012110564A1 (en) | 2011-02-16 | 2012-08-23 | Novozymes A/S | Detergent compositions comprising m7 or m35 metalloproteases |
| MX2013009178A (es) | 2011-02-16 | 2013-08-29 | Novozymes As | Composiciones detergentes que comprenden metaloproteasas. |
| EP2540824A1 (en) | 2011-06-30 | 2013-01-02 | The Procter & Gamble Company | Cleaning compositions comprising amylase variants reference to a sequence listing |
| WO2013004635A1 (en) | 2011-07-01 | 2013-01-10 | Novozymes A/S | Liquid detergent composition |
| CN103649292B (zh) | 2011-07-01 | 2017-11-28 | 诺维信公司 | 稳定化的枯草杆菌蛋白酶组合物 |
| US20140227738A1 (en) | 2011-09-22 | 2014-08-14 | Novozymes A/S | Polypeptides Having Protease Activity and Polynucleotides Encoding Same |
| WO2013076269A1 (en) | 2011-11-25 | 2013-05-30 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| CN107267489A (zh) | 2011-12-20 | 2017-10-20 | 诺维信公司 | 枯草杆菌酶变体和编码它们的多核苷酸 |
| EP2607468A1 (en) | 2011-12-20 | 2013-06-26 | Henkel AG & Co. KGaA | Detergent compositions comprising subtilase variants |
| MX350713B (es) | 2012-02-17 | 2017-09-14 | Novozymes As | Variantes de subtilisina y polinucleotidos que las codifican. |
| EP2628785B1 (en) | 2012-02-17 | 2016-05-18 | Henkel AG & Co. KGaA | Detergent compositions comprising subtilase variants |
| CN104271726B (zh) | 2012-05-01 | 2018-08-24 | 诺维信公司 | 洗涤剂组合物 |
| BR112015003726A2 (pt) | 2012-08-22 | 2019-09-24 | Novozymes As | composição detergente, uso de uma composição e de um polipeptídeo, e, método para remoção de uma nódoa de uma superfície. |
| CN104603266B (zh) | 2012-08-22 | 2017-11-10 | 诺维信公司 | 来自脂环酸芽孢杆菌属的金属蛋白酶 |
| MX2015002211A (es) | 2012-08-22 | 2015-05-08 | Novozymes As | Metaloproteasa de exiguobacterium. |
| CN104869841A (zh) | 2012-12-21 | 2015-08-26 | 诺维信公司 | 具有蛋白酶活性的多肽和编码它的多核苷酸 |
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| US20160024440A1 (en) | 2013-03-14 | 2016-01-28 | Novozymes A/S | Enzyme and Inhibitor Containing Water-Soluble Films |
| EP3569611A1 (en) | 2013-04-23 | 2019-11-20 | Novozymes A/S | Liquid automatic dish washing detergent compositions with stabilised subtilisin |
| EP2992076B1 (en) | 2013-05-03 | 2018-10-24 | Novozymes A/S | Microencapsulation of detergent enzymes |
| US20160145596A1 (en) | 2013-06-27 | 2016-05-26 | Novozymes A/S | Subtilase Variants and Polynucleotides Encoding Same |
| US10378001B2 (en) | 2013-06-27 | 2019-08-13 | Novozymes A/S | Subtilase variants and compositions comprising same |
| CN117904081A (zh) | 2013-07-29 | 2024-04-19 | 诺维信公司 | 蛋白酶变体以及对其进行编码的多核苷酸 |
| EP2832853A1 (en) | 2013-07-29 | 2015-02-04 | Henkel AG&Co. KGAA | Detergent composition comprising protease variants |
| EP3613853A1 (en) | 2013-07-29 | 2020-02-26 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| CN105814200A (zh) | 2013-12-20 | 2016-07-27 | 诺维信公司 | 具有蛋白酶活性的多肽以及编码它们的多核苷酸 |
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| US20170121646A1 (en) | 2014-07-03 | 2017-05-04 | Novozymes A/S | Improved Stabilization of Non-Protease Enzyme |
| US10626388B2 (en) | 2014-07-04 | 2020-04-21 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| EP3327122B1 (en) | 2014-07-04 | 2021-02-17 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| WO2016087619A1 (en) | 2014-12-04 | 2016-06-09 | Novozymes A/S | Liquid cleaning compositions comprising protease variants |
| CA2963331A1 (en) | 2014-12-04 | 2016-06-09 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| ES2763235T3 (es) | 2014-12-15 | 2020-05-27 | Henkel Ag & Co Kgaa | Composición detergente que comprende variantes de subtilasa |
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| DK200101090A (da) | 2001-07-12 | 2001-08-16 | Novozymes As | Subtilase variants |
| WO2003041680A1 (en) | 2001-11-13 | 2003-05-22 | The Procter & Gamble Company | Topical compositions containing enzymes stabilized with inhibitors |
| GB0207430D0 (en) * | 2002-03-28 | 2002-05-08 | Unilever Plc | Liquid cleaning compositionsand their use |
| AU2004236308B2 (en) | 2003-05-07 | 2010-09-09 | Maxygen, Inc. | Variant subtilisin enzymes (subtilases) |
| WO2005105826A1 (ja) | 2004-04-28 | 2005-11-10 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | チロペプチンａ類縁体 |
| WO2007058333A1 (ja) | 2005-11-16 | 2007-05-24 | Kao Corporation | 複合粒子 |
| BRPI0712344A2 (pt) | 2006-06-05 | 2012-01-31 | Procter & Gamble | estabilização de enzimas |
| CA2652792A1 (en) * | 2006-06-05 | 2007-12-21 | The Procter & Gamble Company | Enzyme stabilization |
| JP2010501024A (ja) | 2006-06-05 | 2010-01-14 | ザ プロクター アンド ギャンブル カンパニー | 酵素安定剤 |
| DK2147098T3 (da) * | 2007-04-30 | 2013-10-14 | Danisco Us Inc | Anvendelse af proteinhydrolysater til stabilisering af metalloprotease-detergent-formuleringer |
| US20090209447A1 (en) | 2008-02-15 | 2009-08-20 | Michelle Meek | Cleaning compositions |
| BRPI0909390B1 (pt) | 2008-04-01 | 2020-08-18 | Novozymes A/S | processo para a preparação de barras de sabão para lavagem de roupa |
| CN102209776B (zh) | 2008-11-13 | 2013-11-27 | 诺维信公司 | 洗涤剂组合物 |
-
2009
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- 2009-03-26 JP JP2011501232A patent/JP5973166B2/ja active Active
- 2009-03-26 BR BRPI0909084-3A patent/BRPI0909084B1/pt active IP Right Grant
- 2009-03-26 EP EP09724752.2A patent/EP2271660B1/en active Active
- 2009-03-26 EP EP20172820.1A patent/EP3725797A1/en active Pending
- 2009-03-26 ES ES09724752T patent/ES2807603T3/es active Active
- 2009-03-26 WO PCT/EP2009/053580 patent/WO2009118375A2/en active Application Filing
- 2009-03-26 CN CN201610983448.9A patent/CN107090014B/zh active Active
- 2009-03-26 RU RU2010143597/04A patent/RU2510662C2/ru active
- 2009-03-26 MX MX2010010348A patent/MX2010010348A/es active IP Right Grant
- 2009-03-26 CN CN200980110696.0A patent/CN101981049B/zh active Active
- 2009-03-26 PL PL09724752T patent/PL2271660T3/pl unknown
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- 2015-05-07 JP JP2015094574A patent/JP2015180736A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3725797A1 (en) | 2020-10-21 |
| PL2271660T3 (pl) | 2020-11-02 |
| US20110039752A1 (en) | 2011-02-17 |
| RU2510662C2 (ru) | 2014-04-10 |
| RU2668563C2 (ru) | 2018-10-02 |
| CN107090014B (zh) | 2023-04-25 |
| BRPI0909084A2 (pt) | 2015-08-11 |
| RU2010143597A (ru) | 2012-05-10 |
| JP2015180736A (ja) | 2015-10-15 |
| ES2807603T3 (es) | 2021-02-23 |
| MX2010010348A (es) | 2010-11-09 |
| US9181296B2 (en) | 2015-11-10 |
| BRPI0909084B1 (pt) | 2020-11-03 |
| RU2018131246A3 (ru) | 2021-11-12 |
| EP2271660A2 (en) | 2011-01-12 |
| JP5973166B2 (ja) | 2016-08-23 |
| WO2009118375A3 (en) | 2010-02-25 |
| WO2009118375A2 (en) | 2009-10-01 |
| CN107090014A (zh) | 2017-08-25 |
| RU2018131246A (ru) | 2020-03-02 |
| CN101981049A (zh) | 2011-02-23 |
| JP2011515449A (ja) | 2011-05-19 |
| EP2271660B1 (en) | 2020-05-06 |
| CN101981049B (zh) | 2016-11-09 |
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