ATE342914T1 - Peptidanaloge als selektive inhibitoren der thrombinaktivierung des durch protease aktivierten rezeptors - Google Patents

Peptidanaloge als selektive inhibitoren der thrombinaktivierung des durch protease aktivierten rezeptors

Info

Publication number
ATE342914T1
ATE342914T1 AT00968987T AT00968987T ATE342914T1 AT E342914 T1 ATE342914 T1 AT E342914T1 AT 00968987 T AT00968987 T AT 00968987T AT 00968987 T AT00968987 T AT 00968987T AT E342914 T1 ATE342914 T1 AT E342914T1
Authority
AT
Austria
Prior art keywords
protease
activated receptor
selective inhibitors
peptide analogues
thrombin activation
Prior art date
Application number
AT00968987T
Other languages
English (en)
Inventor
Alvin H Schmaier
Ahmed A K Hasan
Original Assignee
Thromgen Inc
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thromgen Inc, Univ Michigan filed Critical Thromgen Inc
Application granted granted Critical
Publication of ATE342914T1 publication Critical patent/ATE342914T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT00968987T 1999-08-17 2000-08-17 Peptidanaloge als selektive inhibitoren der thrombinaktivierung des durch protease aktivierten rezeptors ATE342914T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/375,808 US6544750B1 (en) 1999-08-17 1999-08-17 Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1

Publications (1)

Publication Number Publication Date
ATE342914T1 true ATE342914T1 (de) 2006-11-15

Family

ID=23482441

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00968987T ATE342914T1 (de) 1999-08-17 2000-08-17 Peptidanaloge als selektive inhibitoren der thrombinaktivierung des durch protease aktivierten rezeptors

Country Status (9)

Country Link
US (1) US6544750B1 (de)
EP (1) EP1212352B1 (de)
JP (1) JP2003507389A (de)
AT (1) ATE342914T1 (de)
AU (1) AU764707B2 (de)
CA (1) CA2382056A1 (de)
DE (1) DE60031422T2 (de)
IL (1) IL148173A0 (de)
WO (1) WO2001012656A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US6841354B2 (en) * 2000-12-21 2005-01-11 Philadelphia, Health & Education Corporation Screening assay for anti-thrombotic/anti-platelet activity
JP2005537245A (ja) * 2002-06-26 2005-12-08 エントレメッド インコーポレイテッド タンパク質活性化レセプターのアンタゴニストを含む組成物および方法
US7074765B2 (en) 2003-05-01 2006-07-11 The Regents Of The University Of Michigan Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
WO2006023844A2 (en) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
DE602005023429D1 (de) 2004-10-19 2010-10-21 Lonza Ag Verfahren zur festphasen-peptidsynthese
CN103384496B (zh) 2010-12-02 2016-10-12 贝克顿·迪金森公司 含有血液稳定剂的血液收集装置
EP2988130A1 (de) * 2014-08-20 2016-02-24 Eppendorf Ag Verfahren zur Beschichtung eines festen Trägers
US20180214476A1 (en) * 2017-02-01 2018-08-02 North Carolina State University Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation
CN113429459B (zh) * 2021-06-16 2022-07-26 昆明医科大学第一附属医院 一种抗血小板多肽及其药物组合物与其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2021951A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
JPH05503712A (ja) 1990-10-11 1993-06-17 プロ―ソマ・サルル 診断方法
US5461032A (en) * 1991-03-01 1995-10-24 Fmc Corporation Insecticidally effective peptides
IE20030749A1 (en) 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
AU2548992A (en) 1991-08-13 1993-03-16 Temple University - Of The Commonwealth System Of Higher Education Modulation of blood pressure and inhibition of platelet activation with kininogen fragment
US5225531A (en) * 1992-04-09 1993-07-06 Washington University Hexapeptide Lys Gly Ala Gly Asp Val
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
US5589458A (en) 1992-11-13 1996-12-31 Thomas Jefferson University Compounds that inhibit T cell proliferation and methods for using the same
US5631131A (en) 1993-03-19 1997-05-20 Universite De Montreal cDNA probes and antibodies for human methenyltetrahydrofolate synthetase
US5491086A (en) 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
US5762939A (en) 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
AU703256B2 (en) * 1995-06-09 1999-03-25 Regents Of The University Of Michigan, The Bradykinin analogs as selective thrombin inhibitors
CA2288027A1 (en) 1997-04-23 1998-10-29 The Regents Of The University Of Michigan Bradykinin analogs as selective inhibitors of cell activation
WO1999040214A2 (en) 1998-02-09 1999-08-12 Genzyme Corporation Nucleic acid delivery vehicles
US6111075A (en) 1998-04-01 2000-08-29 Zymogenetics, Inc. Protese-activated receptor PAR4 (ZCHEMR2)

Also Published As

Publication number Publication date
DE60031422T2 (de) 2007-08-23
IL148173A0 (en) 2002-09-12
EP1212352A1 (de) 2002-06-12
EP1212352B1 (de) 2006-10-18
DE60031422D1 (de) 2006-11-30
CA2382056A1 (en) 2001-02-22
EP1212352A4 (de) 2002-12-04
AU764707B2 (en) 2003-08-28
AU7882200A (en) 2001-03-13
JP2003507389A (ja) 2003-02-25
WO2001012656A1 (en) 2001-02-22
US6544750B1 (en) 2003-04-08

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