ATE532858T1 - Menschliche gerinnungsfaktor-vii-polypeptide - Google Patents

Menschliche gerinnungsfaktor-vii-polypeptide

Info

Publication number
ATE532858T1
ATE532858T1 AT02799394T AT02799394T ATE532858T1 AT E532858 T1 ATE532858 T1 AT E532858T1 AT 02799394 T AT02799394 T AT 02799394T AT 02799394 T AT02799394 T AT 02799394T AT E532858 T1 ATE532858 T1 AT E532858T1
Authority
AT
Austria
Prior art keywords
factor vii
clotting factor
vii polypeptides
human clotting
replacement
Prior art date
Application number
AT02799394T
Other languages
English (en)
Inventor
Egon Persson
Ole Olsen
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Application granted granted Critical
Publication of ATE532858T1 publication Critical patent/ATE532858T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
AT02799394T 2001-09-27 2002-09-26 Menschliche gerinnungsfaktor-vii-polypeptide ATE532858T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101413 2001-09-27
PCT/DK2002/000635 WO2003027147A2 (en) 2001-09-27 2002-09-26 Human coagulation factor vii polypeptides

Publications (1)

Publication Number Publication Date
ATE532858T1 true ATE532858T1 (de) 2011-11-15

Family

ID=8160736

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02799394T ATE532858T1 (de) 2001-09-27 2002-09-26 Menschliche gerinnungsfaktor-vii-polypeptide

Country Status (19)

Country Link
EP (1) EP1432794B1 (de)
JP (1) JP4537059B2 (de)
KR (1) KR20040039444A (de)
CN (1) CN1602354A (de)
AT (1) ATE532858T1 (de)
AU (1) AU2002333211B2 (de)
BR (1) BR0212818A (de)
CA (1) CA2461003A1 (de)
CZ (1) CZ2004427A3 (de)
ES (1) ES2376694T3 (de)
HU (1) HUP0500060A3 (de)
IL (1) IL160897A0 (de)
MX (1) MXPA04002833A (de)
NO (1) NO20041700L (de)
PL (1) PL368619A1 (de)
RU (1) RU2325401C2 (de)
UA (1) UA82177C2 (de)
WO (1) WO2003027147A2 (de)
ZA (1) ZA200402262B (de)

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US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
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US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
DE60334983D1 (de) 2002-04-30 2010-12-30 Bayer Healthcare Llc Faktor vii oder faktor viia polypeptidvarianten
PT1517710E (pt) 2002-06-21 2011-07-08 Novo Nordisk Healthcare Ag Glicoformas do factor vii peguilado
ATE454403T1 (de) * 2002-09-25 2010-01-15 Novo Nordisk Healthcare Ag Menschliche koagulationsfaktor vii polypeptide
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
EP2085470B1 (de) 2003-03-20 2012-05-16 Bayer HealthCare LLC FVII oder FVIIa Varianten
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
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RU2373282C2 (ru) 2003-06-19 2009-11-20 Байер Хелткэр Ллк ВАРИАНТЫ ДОМЕНА GLA ФАКТОРА VII ИЛИ VIIa
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WO2005032581A2 (en) 2003-10-07 2005-04-14 Novo Nordisk Health Care Ag Hybrid molecules having factor vii/viia activity
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EP1893632B1 (de) 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selektive reduktion und derivatisierung manipulierter faktor vii proteine mit mindestens einem nichtnativen zystein
EP1904528B1 (de) 2005-07-13 2012-10-31 Novo Nordisk Health Care AG Wirtszellenprotein-knock-out-zellen zur herstellung therapeutischer proteine
EP1924689B1 (de) 2005-09-01 2014-08-13 Novo Nordisk Health Care AG Reinigung von faktor-vii-polypeptiden mittels hydrophober interaktionschromatografie
WO2007031559A2 (en) 2005-09-14 2007-03-22 Novo Nordisk Health Care Ag Human coagulation factor vii polypeptides
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EP2680875B1 (de) 2011-03-02 2019-10-23 Novo Nordisk Health Care AG Gerinnungsfaktor-targeting auf tlt-1 auf aktivierten plättchen
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JP2015534573A (ja) 2012-10-10 2015-12-03 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 第ｖｉｉ因子ポリペプチドの液体医薬組成物
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Also Published As

Publication number Publication date
EP1432794B1 (de) 2011-11-09
ES2376694T3 (es) 2012-03-16
CA2461003A1 (en) 2003-04-03
ZA200402262B (en) 2004-06-02
AU2002333211B2 (en) 2008-05-08
WO2003027147A2 (en) 2003-04-03
HUP0500060A2 (hu) 2005-04-28
IL160897A0 (en) 2004-08-31
WO2003027147A3 (en) 2003-11-27
PL368619A1 (en) 2005-04-04
UA82177C2 (uk) 2008-03-25
CN1602354A (zh) 2005-03-30
JP4537059B2 (ja) 2010-09-01
KR20040039444A (ko) 2004-05-10
MXPA04002833A (es) 2004-07-15
EP1432794A2 (de) 2004-06-30
RU2004112768A (ru) 2006-01-10
CZ2004427A3 (cs) 2004-08-18
HUP0500060A3 (en) 2010-01-28
NO20041700L (no) 2004-04-26
RU2325401C2 (ru) 2008-05-27
JP2005509413A (ja) 2005-04-14
BR0212818A (pt) 2004-10-05

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