HUP0500060A3 - Human coagulation factor vii polypeptides - Google Patents

Human coagulation factor vii polypeptides

Info

Publication number
HUP0500060A3
HUP0500060A3 HU0500060A HUP0500060A HUP0500060A3 HU P0500060 A3 HUP0500060 A3 HU P0500060A3 HU 0500060 A HU0500060 A HU 0500060A HU P0500060 A HUP0500060 A HU P0500060A HU P0500060 A3 HUP0500060 A3 HU P0500060A3
Authority
HU
Hungary
Prior art keywords
factor vii
coagulation factor
vii polypeptides
human coagulation
human
Prior art date
Application number
HU0500060A
Other languages
English (en)
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Publication of HUP0500060A2 publication Critical patent/HUP0500060A2/hu
Publication of HUP0500060A3 publication Critical patent/HUP0500060A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HU0500060A 2001-09-27 2002-09-26 Human coagulation factor vii polypeptides HUP0500060A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101413 2001-09-27
PCT/DK2002/000635 WO2003027147A2 (en) 2001-09-27 2002-09-26 Human coagulation factor vii polypeptides

Publications (2)

Publication Number Publication Date
HUP0500060A2 HUP0500060A2 (hu) 2005-04-28
HUP0500060A3 true HUP0500060A3 (en) 2010-01-28

Family

ID=8160736

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500060A HUP0500060A3 (en) 2001-09-27 2002-09-26 Human coagulation factor vii polypeptides

Country Status (19)

Country Link
EP (1) EP1432794B1 (hu)
JP (1) JP4537059B2 (hu)
KR (1) KR20040039444A (hu)
CN (1) CN1602354A (hu)
AT (1) ATE532858T1 (hu)
AU (1) AU2002333211B2 (hu)
BR (1) BR0212818A (hu)
CA (1) CA2461003A1 (hu)
CZ (1) CZ2004427A3 (hu)
ES (1) ES2376694T3 (hu)
HU (1) HUP0500060A3 (hu)
IL (1) IL160897A0 (hu)
MX (1) MXPA04002833A (hu)
NO (1) NO20041700L (hu)
PL (1) PL368619A1 (hu)
RU (1) RU2325401C2 (hu)
UA (1) UA82177C2 (hu)
WO (1) WO2003027147A2 (hu)
ZA (1) ZA200402262B (hu)

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US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6905683B2 (en) 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
CN101486761A (zh) 2000-09-13 2009-07-22 诺沃挪第克健康护理股份公司 人凝血因子vii变体
AU2002218029A1 (en) 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia
US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
PL373728A1 (en) 2002-04-30 2005-09-05 Maxygen Holdings Ltd. Factor vii or viia polypeptide variants
RU2362807C2 (ru) 2002-06-21 2009-07-27 Ново Нордиск Хелт Кэр Аг Конъюгат полипептида фактора vii, способ его получения, его применение и содержащая его фармацевтическая композиция
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
WO2004029090A1 (en) * 2002-09-25 2004-04-08 Novo Nordisk Health Care Ag Human coagulation factor vii polypeptides
ES2327044T3 (es) 2003-03-20 2009-10-23 Bayer Healthcare Llc Variantes de fvii o fviia.
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
WO2004110469A2 (en) * 2003-06-13 2004-12-23 Novo Nordisk Health Care Ag Formulations comprising factor viia and a factor vii related polypeptide
DE602004025576D1 (de) 2003-06-19 2010-04-01 Bayer Healthcare Llc Varianten der faktor-vii- oder -viia-gla-domäne
CN101870729A (zh) * 2003-09-09 2010-10-27 诺和诺德医疗保健公司 凝固因子ⅶ多肽
WO2005032581A2 (en) 2003-10-07 2005-04-14 Novo Nordisk Health Care Ag Hybrid molecules having factor vii/viia activity
BRPI0416950B8 (pt) 2003-12-01 2021-05-25 Novo Nordisk Healthcare Ag métodos para remover vírus de uma composição do fator vii líquida, para inativar vírus em uma composição do fator vii líquida, e para eliminar em alto nível a presença de vírus ativos em uma composição do fator vii líquida.
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EP1713906A2 (en) * 2004-02-03 2006-10-25 Novo Nordisk Health Care AG Coagulation factor vii/viia variants lacking functional lipid membrane binding domain
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US20080255026A1 (en) 2005-05-25 2008-10-16 Glycopegylated Factor 1X Glycopegylated Factor Ix
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JP5894722B2 (ja) 2005-09-01 2016-03-30 ノボ ノルディスク ヘルス ケア アーゲー 第ｖｉｉ因子ポリペプチドの疎水性相互作用クロマトグラフィ精製
EP1926817A2 (en) 2005-09-14 2008-06-04 Novo Nordisk Health Care AG Human coagulation factor vii polypeptides
ATE485052T1 (de) * 2006-04-07 2010-11-15 Novo Nordisk Healthcare Ag Kovalenter faktor vii-gewebefaktor-komplex
EP2059527B1 (en) 2006-09-01 2014-12-03 Novo Nordisk Health Care AG Modified glycoproteins
EP1952822A1 (en) * 2007-01-26 2008-08-06 Novo Nordisk A/S Factor VII polypeptides with increased affinity to platelets
DK2147096T3 (da) 2007-04-13 2015-06-15 Catalyst Biosciences Inc Modificerede faktor-VII-polypeptider og anvendelser deraf
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TWI538916B (zh) 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
TW201212938A (en) 2010-06-30 2012-04-01 Novo Nordisk As Antibodies that are capable of specifically binding tissue factor pathway inhibitor
RU2013142015A (ru) 2011-03-02 2015-04-10 Ново Нордиск А/С Нацеливание факторов свертывания крови на рецептор tlt-1 на поверхности активированных тромбоцитов
SI2717898T1 (sl) 2011-06-10 2019-07-31 Bioverativ Therapeutics Inc. Spojine prokoagulantov in metode za njihovo uporabo
US20150273027A1 (en) 2012-10-10 2015-10-01 Novo Nordisk Healthcare Ag Liquid pharmaceutical composition of factor vii polypeptide
CN109385443B (zh) * 2017-08-07 2022-08-02 北京睿诚海汇健康科技有限公司 生菜作为宿主在表达凝血因子中的应用
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Also Published As

Publication number Publication date
EP1432794B1 (en) 2011-11-09
MXPA04002833A (es) 2004-07-15
ZA200402262B (en) 2004-06-02
JP2005509413A (ja) 2005-04-14
ES2376694T3 (es) 2012-03-16
RU2325401C2 (ru) 2008-05-27
ATE532858T1 (de) 2011-11-15
NO20041700L (no) 2004-04-26
HUP0500060A2 (hu) 2005-04-28
AU2002333211B2 (en) 2008-05-08
PL368619A1 (en) 2005-04-04
JP4537059B2 (ja) 2010-09-01
WO2003027147A2 (en) 2003-04-03
BR0212818A (pt) 2004-10-05
UA82177C2 (uk) 2008-03-25
IL160897A0 (en) 2004-08-31
KR20040039444A (ko) 2004-05-10
CZ2004427A3 (cs) 2004-08-18
RU2004112768A (ru) 2006-01-10
WO2003027147A3 (en) 2003-11-27
EP1432794A2 (en) 2004-06-30
CA2461003A1 (en) 2003-04-03
CN1602354A (zh) 2005-03-30

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Legal Events

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